D:Dental Calculus

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pChart

Disease Term
Synonyms CALCULUS DENTAL, Tartar
Documents 30
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dental Calculus. They are ordered first by their relevance to Dental Calculus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56 5.00
2 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56 5.00
3 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56 5.00
4 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55 5.00
5 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55 5.00
6 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48 5.00
7 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48 5.00
8 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
9 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
10 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22 5.00
11 INT173599 Binding of MMP1 and Mmp1a 1 0.06 0.5 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dental Calculus. They are ordered first by their pain relevance and then by number of times they were reported in Dental Calculus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 97.92
2 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 94.84
3 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 94.84
4 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 94.52
5 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06 85.24
6 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 83.60
7 INT97318 Gene_expression of SPARC 11 0.67 5.07 1.59 83.60
8 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 79.84
9 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 79.84
10 INT173579 Negative_regulation of FDFT1 2 0.03 1.09 0.23 76.68
11 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 65.76
12 INT97128 Localization of SPP1 32 0.80 21.75 4.02 57.04
13 INT310131 Binding of TINF2 1 0.02 0.15 0 50.92
14 INT185095 Negative_regulation of Binding of Uso1 1 0.19 0.32 0 49.16
15 INT185096 Binding of Uso1 1 0.17 0.32 0 48.72
16 INT75497 Regulation of JUN 28 0.61 11.04 7.09 28.24
17 INT75503 Regulation of Gene_expression of JUN 6 0.21 2.87 1.11 28.24
18 INT67936 Transcription of JUN 18 0.52 9.52 4.13 26.08
19 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 25.52
20 INT173593 Localization of FBLIM1 1 0.01 0 0.44 23.64
21 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 20.00
22 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 15.64
23 INT173583 Negative_regulation of Binding of TIMP1 1 0.13 0 0.48 15.64
24 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 15.08
25 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 11.92
26 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 11.40
27 INT173584 Localization of IL17A 14 0.74 10.83 5.19 9.72
28 INT173589 Localization of OSM 4 0.58 1.65 1.07 9.32
29 INT131200 Gene_expression of TNKS 5 0.65 1.24 1.04 8.64
30 INT310132 Gene_expression of TINF2 1 0.03 0.15 0 8.64
31 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
32 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
33 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
34 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
35 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
36 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
37 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
38 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
39 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
40 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
41 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
42 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
43 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
44 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
45 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
46 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
47 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
48 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
49 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
50 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
51 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
52 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
53 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
54 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
55 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
56 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
57 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
58 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
59 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
60 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
61 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
62 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
63 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
64 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
65 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
66 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
67 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
68 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
69 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
70 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
71 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
72 INT103210 Localization of MMP1 43 0.78 12.15 15.13 5.00
73 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
74 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
75 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
76 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
77 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
78 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63 5.00
79 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
80 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
81 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
82 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 5.00
83 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
84 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 5.00
85 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
86 INT15026 Negative_regulation of Localization of NA 26 0.36 3.76 10.69 5.00
87 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 5.00
88 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 5.00
89 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 5.00
90 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
91 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 5.00
92 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
93 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
94 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
95 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 5.00
96 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
97 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 5.00
98 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
99 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 5.00
100 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41 5.00
101 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 5.00
102 INT107242 Binding of MMP3 14 0.47 12.06 5.11 5.00
103 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
104 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82 5.00
105 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8 5.00
106 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
107 INT28030 Binding of Otc 5 0.37 2.72 4.3 5.00
108 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 5.00
109 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21 5.00
110 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 5.00
111 INT169475 Localization of HRAS 14 0.73 9.02 3.9 5.00
112 INT133312 Binding of MMP9 25 0.42 16.79 3.83 5.00
113 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61 5.00
114 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 5.00
115 INT61500 Binding of FN1 39 0.48 27.33 3.13 5.00
116 INT28094 Binding of PTH 29 0.37 13.57 3.09 5.00
117 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 5.00
118 INT59321 Transcription of Il1 13 0.50 9.73 2.68 5.00
119 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6 5.00
120 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 5.00
121 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 5.00
122 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
123 INT116280 Transcription of Mmp13 11 0.67 6.52 2.06 5.00
124 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
125 INT130728 Binding of MMP1 14 0.47 4.7 1.95 5.00
126 INT173576 Negative_regulation of FDPS 25 0.57 8.42 1.91 5.00
127 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83 5.00
128 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75 5.00
129 INT47889 Binding of MMP2 9 0.41 6.37 1.68 5.00
130 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 5.00
131 INT74586 Negative_regulation of MMP8 6 0.27 1.68 1.64 5.00
132 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 5.00
133 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29 5.00
134 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
135 INT24819 Positive_regulation of VTN 8 0.49 3.52 1.23 5.00
136 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 5.00
137 INT259692 Gene_expression of TNFAIP8L2 3 0.06 3.94 1.13 5.00
138 INT120514 Negative_regulation of Gene_expression of Otc 4 0.41 1.19 1.08 5.00
139 INT96581 Negative_regulation of Negative_regulation of MMP2 4 0.57 3.1 1.04 5.00
140 INT173552 Protein_catabolism of Mmp13 5 0.96 3.05 1.01 5.00
141 INT130005 Protein_catabolism of MMP13 4 0.36 3.02 0.95 5.00
142 INT173581 Gene_expression of ADAM12 4 0.38 1.46 0.83 5.00
143 INT188166 Transcription of ALPP 9 0.56 4.34 0.62 5.00
144 INT129304 Gene_expression of CA5P 8 0.57 4.52 0.57 5.00
145 INT259689 Gene_expression of KRT35 1 0.03 6.1 0.52 5.00
146 INT259690 Localization of TNFAIP8L2 2 0.06 1.94 0.51 5.00
147 INT222884 Negative_regulation of Transcription of Il1 3 0.05 2.68 0.49 5.00
148 INT130732 Binding of MMP14 4 0.36 2.58 0.47 5.00
149 INT173582 Negative_regulation of Localization of COL5A2 6 0.05 3.24 0.41 5.00
150 INT85937 Protein_catabolism of ALB 6 0.86 4.31 0.38 5.00
151 INT173575 Binding of MMP13 2 0.35 0.79 0.36 5.00
152 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
153 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32 5.00
154 INT173586 Binding of MMP8 1 0.08 0.78 0.29 5.00
155 INT258727 Localization of Apcs 2 0.37 2.49 0.28 5.00
156 INT173590 Binding of RSPO3 1 0.36 0.15 0.25 5.00
157 INT173580 Gene_expression of ADAM10 1 0.11 0.17 0.2 5.00
158 INT270788 Regulation of AMH 4 0.54 7.54 0.2 5.00
159 INT259688 Positive_regulation of Localization of TNFAIP8L2 1 0.04 1.14 0.19 5.00
160 INT258726 Positive_regulation of Nfxl1 1 0.05 1.89 0.18 5.00
161 INT173577 Gene_expression of ADAM15 1 0.09 0.17 0.17 5.00
162 INT159860 Regulation of CDC42EP5 4 0.05 0.9 0.16 5.00
163 INT259693 Positive_regulation of Gene_expression of KRT35 1 0.03 1.22 0.04 5.00
164 INT173594 Protein_catabolism of MMP8 1 0.19 0.25 0.04 5.00
165 INT306056 Binding of TNKS 2 0.36 0.97 0.03 5.00
166 INT173588 Negative_regulation of CDC42EP5 2 0.01 1.08 0.03 5.00
167 INT259687 Binding of KRT35 1 0.02 0.55 0 5.00
168 INT200395 Gene_expression of DUOXA1 2 0.11 0.59 0 5.00
169 INT200390 Localization of DUOXA1 2 0.13 0 0 5.00
170 INT275258 Binding of DUOXA1 1 0.06 0 0 5.00
171 INT259691 Gene_expression of PRCD 1 0.02 1.13 0 5.00
172 INT66973 Gene_expression of Ua1 2 0.01 2.22 0 5.00
173 INT310130 Protein_catabolism of SKP1 1 0.03 0.14 0 5.00
174 INT310134 Positive_regulation of SBF1 1 0.01 0 0 5.00
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