D:Dental Caries

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Disease Term
Synonyms CARIES DENTAL, DECAY DENTAL, DENTAL DECAY, DENTAL WHITE SPOT, Dental White Spots, Spot White, Spots White, WHITE SPOT, WHITE SPOT DENTAL, WHITE SPOTS, White Spots Dental
Documents 394
Hot Single Events 41
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dental Caries. They are ordered first by their relevance to Dental Caries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97 63.72
2 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97 63.72
3 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05 12.56
4 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25 5.00
5 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
6 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85 5.00
7 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 5.00
8 INT260433 Dbi Positive_regulation of Cd8a 1 0.00 0.13 0.3 5.00
9 INT260438 Binding of Cd4 and Mx1 1 0.00 1.52 0.29 5.00
10 INT260434 Binding of Cd8a and Mx1 1 0.00 1.52 0.29 5.00
11 INT260423 IFNA1 Positive_regulation of Gene_expression of VEGFA 1 0.01 1.28 0.26 5.00
12 INT246971 Binding of Clns1a and Csf2 1 0.10 1.31 0.22 5.00
13 INT260437 Positive_regulation of Tlr7 Positive_regulation of Positive_regulation of Il12a 1 0.03 0.27 0.21 5.00
14 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21 5.00
15 INT260441 Negative_regulation of Tlr7 Negative_regulation of Positive_regulation of IFNA1 1 0.05 0.96 0.21 5.00
16 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2 5.00
17 INT246970 Binding of Clns1a and Dcps 1 0.05 0.42 0.18 5.00
18 INT246968 Binding of Csf2 and Dcps 1 0.14 0.42 0.18 5.00
19 INT260442 Binding of IFNA1 and Il6 1 0.01 1.07 0.07 5.00
20 INT260439 Positive_regulation of Binding of IFNA1 and Il6 1 0.01 1.08 0.07 5.00
21 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05 5.00
22 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0 5.00
23 INT288983 Binding of DEFB1 and HPR 1 0.01 0 0 5.00
24 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0 5.00
25 INT337708 Naf1 Regulation of Gene_expression of Tp53 1 0.09 0.22 0 5.00
26 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 5.00
27 INT288982 Binding of CD79A and SFTPA2 1 0.00 0.06 0 5.00
28 INT337707 Naf1 Regulation of Gene_expression of Bcl2 1 0.11 0.57 0 5.00
29 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 5.00
30 INT288981 Binding of DEFB1 and PTPN22 1 0.11 0 0 5.00
31 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 5.00
32 INT288984 DEFB1 Positive_regulation of GGH 1 0.01 0 0 5.00
33 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dental Caries. They are ordered first by their pain relevance and then by number of times they were reported in Dental Caries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3410 Positive_regulation of Artles 9 0.04 2.57 2.5 100.00
2 INT192670 Binding of Dntcs1 1 0.01 0.83 0 100.00
3 INT11304 Negative_regulation of Artles 3 0.02 0.77 0.59 99.66
4 INT36675 Negative_regulation of Pepd 3 0.47 8.99 0.63 98.04
5 INT91160 Binding of DMBT1 9 0.26 3.12 0.37 97.80
6 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 96.96
7 INT59175 Localization of TNMD 4 0.70 4.14 0.71 96.92
8 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 96.36
9 INT10476 Binding of ALOX5 26 0.36 7.69 3.2 94.96
10 INT152885 Localization of Itgam 16 0.73 7.62 1.43 94.64
11 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 94.48
12 INT142732 Negative_regulation of STATH 3 0.42 1.72 0.16 94.48
13 INT14500 Positive_regulation of Gene_expression of CST3 9 0.67 7.46 1.87 93.08
14 INT150703 Positive_regulation of Gene_expression of Ltf 1 0.08 1.83 0.06 93.08
15 INT677 Positive_regulation of CST3 20 0.67 17.47 6 92.84
16 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 92.84
17 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 92.44
18 INT44066 Gene_expression of Ltf 20 0.77 15.09 4.57 92.44
19 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 91.48
20 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 90.16
21 INT209334 Regulation of Filipino 1 0.09 1.4 0.29 89.92
22 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 89.88
23 INT679 Negative_regulation of CST3 7 0.57 4.63 1.22 89.64
24 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 88.04
25 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 87.28
26 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 87.28
27 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 86.48
28 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 86.48
29 INT4863 Positive_regulation of ap 22 0.37 9.13 6.11 86.40
30 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 86.40
31 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 86.32
32 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 86.32
33 INT199030 Regulation of TMTC1 1 0.11 0.85 0 85.60
34 INT150709 Regulation of TROVE2 1 0.03 1.74 0.07 84.20
35 INT209335 Regulation of Gene_expression of Filipino 1 0.07 0.91 0.04 82.36
36 INT137204 Localization of Itgax 6 0.70 3.86 0.67 82.00
37 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 81.72
38 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 81.36
39 INT137205 Localization of Dspp 2 0.07 0.42 0.2 81.04
40 INT209336 Gene_expression of Filipino 5 0.10 4.75 1.2 80.88
41 INT39413 Negative_regulation of SNRPB 7 0.31 2.57 2.36 80.24
42 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 79.72
43 INT6852 Localization of TNF 883 0.81 705.95 270.84 79.72
44 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 79.72
45 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 78.80
46 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 75.76
47 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 75.64
48 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 75.44
49 INT92612 Transcription of Pepd 1 0.55 1.71 0.08 73.28
50 INT170444 Binding of Gopc 172 0.39 45.05 20.71 71.20
51 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 69.40
52 INT174689 Gene_expression of Tlr7 11 0.67 8.24 1.56 69.20
53 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 69.00
54 INT137201 Gene_expression of Ly75 2 0.28 3.28 0.36 69.00
55 INT124634 Binding of MIP 2 0.35 0.46 0.31 68.68
56 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 68.60
57 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 68.40
58 INT9884 Localization of CD79A 41 0.78 21.75 3.06 67.48
59 INT113891 Binding of Gsr 5 0.21 4.86 0.42 67.44
60 INT137202 Positive_regulation of Ly75 1 0.18 0.29 0.07 67.32
61 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 66.24
62 INT55964 Localization of PHB2 1 0.39 0.79 0.07 65.76
63 INT183680 Localization of Tlr3 6 0.71 1.69 0.39 65.60
64 INT171117 Binding of Itgam 35 0.36 14.87 2.76 65.44
65 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 63.68
66 INT204135 Localization of SPHAR 1 0.01 0.77 0.43 63.52
67 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 63.16
68 INT256900 Gene_expression of TNMD 19 0.68 7.36 0.64 63.04
69 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 63.04
70 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 63.04
71 INT134379 Binding of Trpa1 13 0.48 7.16 7.27 62.80
72 INT148288 Gene_expression of CCL15 9 0.25 6.53 3.41 61.84
73 INT239412 Binding of ABL1 8 0.28 5.39 0.18 61.84
74 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 60.48
75 INT144908 Gene_expression of SEA 15 0.52 3.81 0.79 60.48
76 INT135990 Positive_regulation of Gene_expression of Cd86 34 0.69 12.02 4.53 60.28
77 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 60.28
78 INT9210 Regulation of IL6 166 0.62 125.61 49.95 59.28
79 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 59.20
80 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 59.04
81 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 58.96
82 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 58.68
83 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37 57.64
84 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 57.36
85 INT179176 Negative_regulation of Asl 1 0.30 0.79 0.1 57.04
86 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 53.28
87 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 53.28
88 INT130036 Gene_expression of Emr1 7 0.75 1.47 0.38 52.32
89 INT125008 Negative_regulation of DEFB1 2 0.40 0.19 0.07 52.04
90 INT102353 Positive_regulation of HLA-DQA2 6 0.06 4.07 0.82 51.32
91 INT137203 Positive_regulation of Emr1 3 0.45 2.34 0.24 51.32
92 INT316540 Binding of MRSD 1 0.42 0 0 50.00
93 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 48.32
94 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 47.32
95 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 47.32
96 INT14884 Positive_regulation of Gene_expression of SFTPA1 32 0.25 20.37 26.09 47.32
97 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 47.32
98 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 47.32
99 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26 47.32
100 INT24725 Positive_regulation of Gene_expression of VIP 10 0.69 5.35 2.63 47.32
101 INT64682 Positive_regulation of Gene_expression of NPY 4 0.49 3.19 1.96 47.32
102 INT186921 Protein_catabolism of DEFB1 9 0.23 1.85 0.35 47.20
103 INT28030 Binding of Otc 5 0.37 2.72 4.3 46.96
104 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 46.92
105 INT223959 Localization of Bglap 10 0.77 11.25 1.74 46.24
106 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 46.08
107 INT145959 Negative_regulation of DSPP 19 0.57 2.75 1.21 46.00
108 INT16180 Regulation of DSPP 6 0.53 4.63 0.28 43.92
109 INT193312 Localization of DSPP 8 0.74 1.88 0.18 43.44
110 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24 43.28
111 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 43.04
112 INT240424 Binding of Ctsa 4 0.20 3.94 0.16 42.64
113 INT240422 Negative_regulation of Binding of Ctsa 1 0.23 0.47 0 42.64
114 INT215117 Gene_expression of Ctsa 14 0.33 8.66 1.18 41.92
115 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 41.88
116 INT12082 Localization of IL6 365 0.81 241.78 105.78 41.48
117 INT3520 Binding of Csf2 27 0.43 9.68 6.08 37.64
118 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47 36.88
119 INT125007 Gene_expression of DEFB1 30 0.60 4.14 1.32 36.48
120 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 36.28
121 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 33.64
122 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 32.96
123 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 32.96
124 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 32.96
125 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75 32.96
126 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 32.36
127 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 32.32
128 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 31.36
129 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 30.00
130 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 28.80
131 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 27.04
132 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 24.04
133 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 23.68
134 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 23.68
135 INT202577 Localization of DIO2 9 0.56 1.3 2.97 14.24
136 INT4342 Localization of ALPP 27 0.69 15.19 5.32 14.00
137 INT14572 Binding of INS 205 0.48 175.43 13.38 13.84
138 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 13.60
139 INT86294 Regulation of Gene_expression of Mmp2 3 0.60 1.12 1.62 13.48
140 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 13.44
141 INT204363 Gene_expression of VIS1 6 0.19 2.49 0.21 13.44
142 INT196468 Protein_catabolism of ALPP 3 0.34 0.31 0.18 13.44
143 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 12.92
144 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 12.48
145 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 12.32
146 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 12.28
147 INT120432 Regulation of Trpa1 22 0.61 9.65 12.36 10.84
148 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 10.44
149 INT220292 Binding of AFM 3 0.10 1.15 0.25 6.64
150 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 6.20
151 INT187530 Regulation of Cq1 3 0.02 0.38 0 5.44
152 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
153 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
154 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
155 INT1352 Localization of Acot1 728 0.80 73.01 296.01 5.00
156 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
157 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
158 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
159 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 5.00
160 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
161 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
162 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
163 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
164 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
165 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
166 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
167 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
168 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
169 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
170 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
171 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
172 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
173 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
174 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 5.00
175 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
176 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
177 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
178 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
179 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 5.00
180 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
181 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
182 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
183 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
184 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
185 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
186 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
187 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
188 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
189 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 5.00
190 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
191 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
192 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98 5.00
193 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
194 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
195 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
196 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
197 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
198 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
199 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
200 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 5.00
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