D:Dental Plaque

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pChart

Disease Term
Synonyms Plaque Dental
Documents 70
Hot Single Events 14
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dental Plaque. They are ordered first by their relevance to Dental Plaque and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75 82.72
2 INT240586 IRF7 Positive_regulation of Positive_regulation of IFNA1 1 0.01 0.44 0.03 5.00
3 INT288983 Binding of DEFB1 and HPR 1 0.01 0 0 5.00
4 INT288982 Binding of CD79A and SFTPA2 1 0.00 0.06 0 5.00
5 INT288981 Binding of DEFB1 and PTPN22 1 0.11 0 0 5.00
6 INT135179 DCSTAMP Positive_regulation of Gene_expression of TNFSF11 1 0.06 0 0 5.00
7 INT288984 DEFB1 Positive_regulation of GGH 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dental Plaque. They are ordered first by their pain relevance and then by number of times they were reported in Dental Plaque. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215360 Binding of HSPE1 1 0.36 3.63 0.92 95.00
2 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 93.20
3 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 93.20
4 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 90.76
5 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 85.32
6 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 85.32
7 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 84.96
8 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 84.96
9 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 84.24
10 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27 83.64
11 INT215362 Positive_regulation of Gene_expression of HSPE1 1 0.44 1.82 0.71 83.52
12 INT215366 Gene_expression of HSPE1 12 0.74 6.39 1.39 83.52
13 INT215371 Positive_regulation of HSPE1 1 0.66 3.4 0.95 83.12
14 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 82.72
15 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 79.80
16 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 79.80
17 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 79.80
18 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75 79.80
19 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 74.68
20 INT222884 Negative_regulation of Transcription of Il1 3 0.05 2.68 0.49 74.68
21 INT59321 Transcription of Il1 13 0.50 9.73 2.68 74.16
22 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 73.80
23 INT92311 Regulation of SIL1 7 0.44 6.2 1.61 70.60
24 INT215363 Regulation of HSPD1 4 0.51 2.74 0.99 70.60
25 INT215359 Regulation of Gene_expression of SIL1 2 0.14 1.11 0.37 70.60
26 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38 70.00
27 INT81575 Gene_expression of SIL1 29 0.25 19.76 1.24 70.00
28 INT258726 Positive_regulation of Nfxl1 1 0.05 1.89 0.18 68.32
29 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 66.28
30 INT142732 Negative_regulation of STATH 3 0.42 1.72 0.16 65.28
31 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 64.16
32 INT125008 Negative_regulation of DEFB1 2 0.40 0.19 0.07 56.52
33 INT16180 Regulation of DSPP 6 0.53 4.63 0.28 49.92
34 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24 49.24
35 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 49.16
36 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 49.16
37 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 49.16
38 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 49.16
39 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 46.28
40 INT61500 Binding of FN1 39 0.48 27.33 3.13 39.72
41 INT186921 Protein_catabolism of DEFB1 9 0.23 1.85 0.35 38.24
42 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 35.04
43 INT108790 Gene_expression of RGS1 2 0.58 4.36 1.76 35.04
44 INT213442 Gene_expression of CXCL3 8 0.57 6.3 1.41 35.04
45 INT65977 Gene_expression of RCAN1 6 0.70 3.72 0.59 35.04
46 INT240593 Gene_expression of Naip1 1 0.02 2.01 0.49 35.04
47 INT240595 Gene_expression of CSPG4P2Y 1 0.03 1.87 0.41 35.04
48 INT27881 Binding of HSPD1 10 0.31 9.2 1.78 34.44
49 INT134651 Binding of TLR4 89 0.48 66.96 23.19 29.88
50 INT220292 Binding of AFM 3 0.10 1.15 0.25 23.64
51 INT215361 Regulation of HSPE1 1 0.43 1.4 0.34 20.40
52 INT125007 Gene_expression of DEFB1 30 0.60 4.14 1.32 10.60
53 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 10.48
54 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 10.48
55 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 10.48
56 INT756 Gene_expression of C3 138 0.75 100.6 19.2 10.48
57 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 10.48
58 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28 10.48
59 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27 10.48
60 INT152647 Gene_expression of IRF7 2 0.57 4 0.4 10.48
61 INT240587 Gene_expression of Slk 1 0.58 0.6 0.08 10.48
62 INT240594 Gene_expression of Serpinb2 1 0.18 0.68 0.08 10.48
63 INT215373 Negative_regulation of Gene_expression of HSPE1 1 0.56 0.56 0.14 6.60
64 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 6.08
65 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 6.08
66 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
67 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
68 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
69 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
70 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
71 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
72 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
73 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
74 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
75 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
76 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
77 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
78 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
79 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
80 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
81 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
82 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 5.00
83 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
84 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
85 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
86 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
87 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
88 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
89 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
90 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
91 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
92 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
93 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
94 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
95 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
96 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
97 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
98 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
99 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
100 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
101 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
102 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
103 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
104 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
105 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
106 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
107 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
108 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
109 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
110 INT11335 Regulation of Ptger2 46 0.51 22.3 15.42 5.00
111 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
112 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
113 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
114 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
115 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
116 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
117 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
118 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
119 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
120 INT15026 Negative_regulation of Localization of NA 26 0.36 3.76 10.69 5.00
121 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
122 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
123 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 5.00
124 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
125 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
126 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
127 INT72219 Gene_expression of METTL3 45 0.24 9.58 7.61 5.00
128 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
129 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
130 INT91509 Localization of CYC1 39 0.78 34.74 7.17 5.00
131 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 5.00
132 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
133 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
134 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 5.00
135 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
136 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
137 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 5.00
138 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
139 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82 5.00
140 INT85415 Positive_regulation of IL9 10 0.28 6.93 4.71 5.00
141 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
142 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
143 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 5.00
144 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06 5.00
145 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95 5.00
146 INT169475 Localization of HRAS 14 0.73 9.02 3.9 5.00
147 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7 5.00
148 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
149 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
150 INT17993 Negative_regulation of RASA1 8 0.41 7.34 2.62 5.00
151 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 5.00
152 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34 5.00
153 INT27880 Positive_regulation of HSPD1 17 0.65 18.16 2.23 5.00
154 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14 5.00
155 INT97898 Regulation of FGF2 8 0.60 3.85 2.09 5.00
156 INT172554 Positive_regulation of Gene_expression of Mmp1a 7 0.16 4.48 2.05 5.00
157 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 5.00
158 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
159 INT32431 Gene_expression of HTC2 17 0.75 9.72 1.93 5.00
160 INT135187 Transcription of TNFRSF11B 9 0.70 3.53 1.87 5.00
161 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83 5.00
162 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82 5.00
163 INT47615 Negative_regulation of DNASE1 9 0.58 3.62 1.74 5.00
164 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 5.00
165 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 5.00
166 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 5.00
167 INT95566 Positive_regulation of Positive_regulation of IL12A 10 0.41 7.47 1.43 5.00
168 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29 5.00
169 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25 5.00
170 INT24819 Positive_regulation of VTN 8 0.49 3.52 1.23 5.00
171 INT157372 Gene_expression of MAP4K1 11 0.78 10.03 1.2 5.00
172 INT72218 Regulation of METTL3 5 0.08 1.62 1.14 5.00
173 INT52546 Gene_expression of NR3C2 10 0.65 1.09 1.1 5.00
174 INT123144 Positive_regulation of DEFB1 4 0.45 2.12 1.08 5.00
175 INT131200 Gene_expression of TNKS 5 0.65 1.24 1.04 5.00
176 INT193069 Positive_regulation of Gene_expression of CD38 4 0.15 4.06 1.01 5.00
177 INT5679 Negative_regulation of RNASE1 7 0.40 2.39 1 5.00
178 INT29788 Gene_expression of DNASE1L1 3 0.03 0.61 0.99 5.00
179 INT164066 Negative_regulation of SIL1 3 0.21 2.75 0.96 5.00
180 INT56151 Positive_regulation of Positive_regulation of CD8A 11 0.34 9.74 0.94 5.00
181 INT77947 Regulation of Gene_expression of IL12A 6 0.24 5.23 0.94 5.00
182 INT7351 Gene_expression of NPS 5 0.58 1.87 0.88 5.00
183 INT77663 Positive_regulation of CDK5R1 3 0.67 0.43 0.79 5.00
184 INT70019 Binding of BCL2 25 0.47 17.55 0.79 5.00
185 INT144908 Gene_expression of SEA 15 0.52 3.81 0.79 5.00
186 INT176489 Gene_expression of MCAM 18 0.68 3.92 0.78 5.00
187 INT17227 Gene_expression of 16S 11 0.75 2.65 0.76 5.00
188 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 5.00
189 INT188166 Transcription of ALPP 9 0.56 4.34 0.62 5.00
190 INT129304 Gene_expression of CA5P 8 0.57 4.52 0.57 5.00
191 INT31402 Gene_expression of AFM 5 0.49 0.34 0.56 5.00
192 INT46045 Negative_regulation of Gene_expression of C3 5 0.30 3.15 0.45 5.00
193 INT132496 Regulation of Gene_expression of CASP3 6 0.20 4.59 0.42 5.00
194 INT85937 Protein_catabolism of ALB 6 0.86 4.31 0.38 5.00
195 INT91160 Binding of DMBT1 9 0.26 3.12 0.37 5.00
196 INT135188 Transcription of TNFSF11 4 0.59 0.72 0.36 5.00
197 INT240601 Positive_regulation of Gene_expression of CXCL3 3 0.43 2.84 0.34 5.00
198 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32 5.00
199 INT263021 Transcription of DEFB1 2 0.21 0.8 0.32 5.00
200 INT81574 Positive_regulation of SIL1 21 0.67 10.85 0.31 5.00
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