D:Dentinogenesis Imperfecta

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Disease Term
Synonyms Dentin Hereditary Opalescent, Dentinogenesis Imperfectas, Dentins Hereditary Opalescent, Hereditary Opalescent Dentin, Hereditary Opalescent Dentins, Imperfecta Dentinogenesis, IMPERFECTAS DENTINOGENESIS, Opalescent Dentin Hereditary, Opalescent Dentins Hereditary
Documents 15
Hot Single Events 11
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dentinogenesis Imperfecta. They are ordered first by their relevance to Dentinogenesis Imperfecta and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0 100.00
2 INT255385 Binding of COL1A2 and DSPP 1 0.40 0.12 0 61.36
3 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dentinogenesis Imperfecta. They are ordered first by their pain relevance and then by number of times they were reported in Dentinogenesis Imperfecta. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234962 Positive_regulation of Gene_expression of DSG1 5 0.48 5.41 0.37 100.00
2 INT140647 Gene_expression of DSG1 45 0.75 27.95 1.33 100.00
3 INT234950 Binding of DSG1 29 0.36 23.67 0.69 100.00
4 INT167750 Positive_regulation of Gene_expression of DSPP 2 0.50 3.13 0 100.00
5 INT234937 Localization of DSG1 5 0.66 4.14 0 100.00
6 INT234943 Phosphorylation of DSG1 2 0.48 1.81 0 100.00
7 INT234940 Regulation of DSG1 2 0.21 2.29 0 100.00
8 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 99.44
9 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24 98.04
10 INT193312 Localization of DSPP 8 0.74 1.88 0.18 91.40
11 INT16180 Regulation of DSPP 6 0.53 4.63 0.28 85.00
12 INT89128 Binding of DSPP 7 0.32 2.24 0.98 54.72
13 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 50.88
14 INT255387 Phosphorylation of DSPP 1 0.71 0 0 50.00
15 INT180369 Binding of ENAM 6 0.24 8.53 0.08 25.76
16 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 16.28
17 INT206980 Gene_expression of Ambn 1 0.50 1.96 0.03 15.84
18 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
19 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
20 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
21 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
22 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
23 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
24 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
25 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
26 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
27 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
28 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
29 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
30 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
31 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
32 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
33 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 5.00
34 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
35 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 5.00
36 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
37 INT22082 Localization of Ceacam1 13 0.80 2.44 2.48 5.00
38 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 5.00
39 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 5.00
40 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 5.00
41 INT22081 Regulation of Ceacam1 8 0.23 4.11 0.95 5.00
42 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 5.00
43 INT58566 Regulation of Gene_expression of Pth 5 0.58 2.3 0.38 5.00
44 INT39911 Negative_regulation of Positive_regulation of Pth 5 0.41 2.57 0.37 5.00
45 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 5.00
46 INT181614 Positive_regulation of TDO2 2 0.45 2.18 0.18 5.00
47 INT180360 Gene_expression of ENAM 2 0.45 3.58 0 5.00
48 INT206981 Gene_expression of Enam 1 0.57 0.67 0 5.00
49 INT206982 Negative_regulation of TDO2 2 0.19 1.51 0 5.00
50 INT272178 Regulation of Gene_expression of Ceacam1 1 0.04 0.81 0 5.00
51 INT332156 Positive_regulation of Ppib 1 0.05 0.3 0 5.00
52 INT332157 Positive_regulation of Lepre1 1 0.17 0.3 0 5.00
53 INT332158 Positive_regulation of Crtap 1 0.49 0.3 0 5.00
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