D:Denys-drash Syndrome

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Disease Term
Synonyms Denys Drash Syndrome, Drash Syndrome, Nephropathy Pseudohermaphroditism Wilms Tumor, Nephropathy Pseudohermaphroditism Wilms Tumour, Pseudohermaphroditism Nephron Disorder Wilm S Tumor, Pseudohermaphroditism Nephron Disorder Wilm S Tumour, Syndrome Denys Drash, Wilms Tumor Pseudohermaphroditism, WILMS TUMOR PSEUDOHERMAPHRODITISM NEPHROPATHY, WILMS TUMOR PSEUODOHERMAPHRODITISM GLOMERULOPATHY, Wilms Tumour Pseudohermaphroditism
Documents 5
Hot Single Events 0
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Denys-drash Syndrome. They are ordered first by their relevance to Denys-drash Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT276590 Binding of Wt1 and KTWS 1 0.02 0.3 0 20.72
2 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12 5.00
3 INT295866 Dss1 Positive_regulation of PSS 1 0.01 0.07 0.05 5.00
4 INT295854 Srpk2 Regulation of Localization of Srsf1 1 0.21 0 0.04 5.00
5 INT276583 Binding of Wt1 and IgG 1 0.07 0 0.04 5.00
6 INT295867 Srsf1 Regulation of VEGFA 1 0.10 0 0.03 5.00
7 INT295858 Prkca Positive_regulation of Gtf3a 1 0.00 0 0 5.00
8 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0 5.00
9 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0 5.00
10 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0 5.00
11 INT276585 Binding of Trpc5 and Trpc6 1 0.17 0.26 0 5.00
12 INT295869 Binding of VEGFA and Srsf1 1 0.17 0 0 5.00
13 INT295870 Gene_expression of Srpk1 Negative_regulation of VEGFA 1 0.11 0 0 5.00
14 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
15 INT295856 Binding of Prkca and Srsf1 1 0.10 0 0 5.00
16 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0 5.00
17 INT295855 Prkca Positive_regulation of Akt1 1 0.02 0 0 5.00
18 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0 5.00
19 INT295871 Binding of RNPS1 and Srpk2 1 0.01 0.76 0 5.00
20 INT276591 Binding of Actn1 and KTWS 1 0.02 0.41 0 5.00
21 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
22 INT295859 Srsf1 Positive_regulation of Binding of U2af2 1 0.01 0 0 5.00
23 INT276587 Binding of Iqgap1 and Nphs1 1 0.08 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Denys-drash Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Denys-drash Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT276576 Negative_regulation of KTWS 1 0.02 0.75 0 50.48
2 INT276530 Negative_regulation of Wt1 5 0.53 2.97 0 50.48
3 INT90491 Binding of Igf1 25 0.44 9.75 1.36 37.36
4 INT295864 Phosphorylation of RNPS1 1 0.02 0.81 0.04 27.16
5 INT276574 Gene_expression of KTWS 1 0.04 0.5 0.08 19.40
6 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 16.60
7 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 13.68
8 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 13.68
9 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 13.68
10 INT85462 Binding of KTWS 3 0.31 2.91 0.54 9.36
11 INT168975 Binding of Wt1 14 0.43 7.37 0.07 9.36
12 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
13 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
14 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
15 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
16 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
17 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
18 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
19 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
20 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
21 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
22 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
23 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
24 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
25 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
26 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
27 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
28 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
29 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36 5.00
30 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35 5.00
31 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
32 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
33 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
34 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
35 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
36 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
37 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 5.00
38 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
39 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
40 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
41 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
42 INT26584 Gene_expression of Nes 76 0.75 24.03 4.17 5.00
43 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
44 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
45 INT146693 Gene_expression of Mbl1 17 0.59 10.99 3.13 5.00
46 INT276520 Gene_expression of Iqgap1 2 0.76 8.67 3.1 5.00
47 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 5.00
48 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
49 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
50 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
51 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
52 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
53 INT6301 Positive_regulation of Trpc6 8 0.67 4.15 1.59 5.00
54 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
55 INT60600 Binding of PSS 5 0.32 3.59 1.42 5.00
56 INT217514 Gene_expression of Dss1 12 0.47 7.6 1.35 5.00
57 INT145128 Gene_expression of Trpc6 12 0.75 5.59 1.17 5.00
58 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16 5.00
59 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
60 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
61 INT169561 Negative_regulation of Dss1 8 0.28 4.92 1.01 5.00
62 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
63 INT124092 Gene_expression of Myo1b 3 0.41 1.22 0.82 5.00
64 INT24845 Gene_expression of Gnptg 9 0.48 11.42 0.8 5.00
65 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
66 INT143445 Protein_catabolism of VEGFA 12 0.85 4.14 0.72 5.00
67 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
68 INT87199 Negative_regulation of PSS 9 0.50 5.66 0.68 5.00
69 INT15852 Positive_regulation of PSS 7 0.40 4.6 0.67 5.00
70 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
71 INT79459 Protein_catabolism of Prkca 2 1.00 0.09 0.6 5.00
72 INT276535 Binding of Iqgap1 2 0.47 2.16 0.59 5.00
73 INT174873 Regulation of Transcription of VEGFA 8 0.43 3.71 0.55 5.00
74 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
75 INT167897 Gene_expression of Ppp1r9b 3 0.58 0.32 0.48 5.00
76 INT152023 Regulation of Vegfa 4 0.52 3.99 0.41 5.00
77 INT202616 Binding of U2af2 3 0.01 0.31 0.39 5.00
78 INT172798 Gene_expression of Vegfb 4 0.41 4.64 0.35 5.00
79 INT75628 Gene_expression of Dst 4 0.60 0.78 0.31 5.00
80 INT31964 Localization of Trpc6 4 0.65 0.63 0.3 5.00
81 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 5.00
82 INT273657 Negative_regulation of Negative_regulation of Dss1 2 0.13 0.91 0.29 5.00
83 INT114703 Positive_regulation of Wt1 5 0.46 4.25 0.24 5.00
84 INT295826 Gene_expression of Cd3eap 3 0.14 0.57 0.22 5.00
85 INT232067 Gene_expression of RNPC3 6 0.65 0.95 0.2 5.00
86 INT283243 Negative_regulation of Vegfb 4 0.30 0.65 0.18 5.00
87 INT295836 Localization of Srsf1 1 0.70 0.16 0.13 5.00
88 INT243073 Gene_expression of Gsn 5 0.68 1.47 0.12 5.00
89 INT178195 Localization of Wt1 4 0.69 2.64 0.1 5.00
90 INT295848 Negative_regulation of Srpk1 1 0.35 0.63 0.1 5.00
91 INT276543 Regulation of Iqgap1 2 0.27 0.49 0.08 5.00
92 INT295820 Phosphorylation of Srsf1 1 0.71 1.35 0.07 5.00
93 INT247569 Positive_regulation of Regulation of VEGFA 6 0.48 4.15 0.07 5.00
94 INT295845 Positive_regulation of Gene_expression of Srsf1 1 0.60 0.97 0.05 5.00
95 INT295824 Positive_regulation of Gene_expression of Srpk1 1 0.41 0.39 0.05 5.00
96 INT295851 Gene_expression of Srpk1 1 0.46 1.72 0.05 5.00
97 INT295844 Positive_regulation of Binding of Srsf1 1 0.40 0.34 0.05 5.00
98 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05 5.00
99 INT295846 Negative_regulation of Map3k11 1 0.01 0.08 0.05 5.00
100 INT295852 Positive_regulation of Localization of Srsf1 1 0.40 0.08 0.05 5.00
101 INT295843 Binding of Srsf1 1 0.42 0.44 0.04 5.00
102 INT295822 Regulation of Localization of Srsf1 1 0.53 0 0.04 5.00
103 INT295847 Negative_regulation of Phosphorylation of Srsf1 1 0.37 0 0.04 5.00
104 INT295840 Positive_regulation of Regulation of Vegfa 1 0.12 0 0.03 5.00
105 INT295837 Phosphorylation of Srpk1 1 0.49 0.55 0.03 5.00
106 INT240711 Gene_expression of Srsf1 3 0.67 1.99 0.03 5.00
107 INT276541 Regulation of Myo6 1 0.04 0 0 5.00
108 INT295842 Phosphorylation of Srpk2 1 0.38 0.42 0 5.00
109 INT295833 Localization of Srpk1 1 0.42 0 0 5.00
110 INT276526 Gene_expression of Myh10 1 0.67 1.4 0 5.00
111 INT276571 Negative_regulation of Binding of KTWS 1 0.02 0 0 5.00
112 INT295823 Regulation of Positive_regulation of Srpk1 1 0.27 0 0 5.00
113 INT276521 Binding of Trpc5 1 0.18 0.25 0 5.00
114 INT276547 Positive_regulation of Binding of Wt1 1 0.63 0.29 0 5.00
115 INT295828 Positive_regulation of Gene_expression of Srpk2 1 0.32 1.93 0 5.00
116 INT276540 Positive_regulation of Gene_expression of Myh10 1 0.52 1.02 0 5.00
117 INT295832 Positive_regulation of Srsf1 1 0.60 0.24 0 5.00
118 INT276536 Regulation of Pls3 1 0.11 0 0 5.00
119 INT276553 Gene_expression of Actn4 1 0.60 0.31 0 5.00
120 INT214046 Gene_expression of UTRN 2 0.26 0.73 0 5.00
121 INT295835 Positive_regulation of Positive_regulation of Ccna1 1 0.06 0.74 0 5.00
122 INT276545 Gene_expression of Pls3 1 0.10 0 0 5.00
123 INT276579 Regulation of KTWS 1 0.01 0 0 5.00
124 INT276525 Localization of Myh9 1 0.58 0.16 0 5.00
125 INT295863 Regulation of Phosphorylation of SRSF6 1 0.07 0.31 0 5.00
126 INT276572 Negative_regulation of Localization of KTWS 1 0.02 0 0 5.00
127 INT276529 Gene_expression of Spnb2 1 0.57 0.37 0 5.00
128 INT276548 Gene_expression of Dbn1 1 0.53 0.38 0 5.00
129 INT295853 Negative_regulation of Gene_expression of Srpk2 1 0.20 0 0 5.00
130 INT276578 Positive_regulation of KTWS 1 0.03 0.42 0 5.00
131 INT276528 Regulation of Myh9 1 0.23 0 0 5.00
132 INT276549 Binding of Actn4 1 0.32 0.61 0 5.00
133 INT241410 Gene_expression of Myh9 2 0.56 0.54 0 5.00
134 INT276524 Regulation of Myo18a 1 0.04 0 0 5.00
135 INT276537 Localization of Myh10 1 0.65 0.16 0 5.00
136 INT276555 Gene_expression of Actn1 1 0.59 0.76 0 5.00
137 INT295818 Negative_regulation of Zfp667 1 0.01 0.27 0 5.00
138 INT276533 Localization of Dbn1 1 0.56 0.16 0 5.00
139 INT276522 Binding of Dbn1 1 0.29 0 0 5.00
140 INT295831 Transcription of Vegfb 1 0.01 0 0 5.00
141 INT276551 Positive_regulation of Localization of Wt1 1 0.45 0 0 5.00
142 INT276575 Transcription of KTWS 1 0.04 0 0 5.00
143 INT295829 Positive_regulation of Localization of Srpk1 1 0.28 0 0 5.00
144 INT295860 Phosphorylation of SRSF6 1 0.13 0.25 0 5.00
145 INT257642 Gene_expression of Nphs1 4 0.66 0.96 0 5.00
146 INT295849 Positive_regulation of Phosphorylation of Srsf1 1 0.60 0.64 0 5.00
147 INT295830 Positive_regulation of Positive_regulation of Srpk1 1 0.41 0 0 5.00
148 INT202857 Gene_expression of Spna2 2 0.49 0.37 0 5.00
149 INT295819 Negative_regulation of Gene_expression of Srpk1 1 0.25 0 0 5.00
150 INT276519 Regulation of Wt1 2 0.24 1.7 0 5.00
151 INT276544 Gene_expression of Flna 3 0.63 1.97 0 5.00
152 INT276534 Negative_regulation of Binding of Wt1 1 0.38 0 0 5.00
153 INT276539 Regulation of Dbn1 1 0.09 0 0 5.00
154 INT295861 Binding of RNPS1 1 0.01 0.76 0 5.00
155 INT276518 Gene_expression of Flnc 1 0.37 0.54 0 5.00
156 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 5.00
157 INT295839 Binding of Srpk1 1 0.22 1.2 0 5.00
158 INT276573 Positive_regulation of Localization of KTWS 1 0.03 0 0 5.00
159 INT295850 Positive_regulation of Ccna1 1 0.09 1.23 0 5.00
160 INT276523 Negative_regulation of Gene_expression of Flna 2 0.48 0.8 0 5.00
161 INT276580 Localization of KTWS 1 0.04 0 0 5.00
162 INT276550 Transcription of Wt1 2 0.66 1.35 0 5.00
163 INT295834 Positive_regulation of Srpk1 1 0.41 0 0 5.00
164 INT295827 Gene_expression of Srpk2 1 0.36 1.25 0 5.00
165 INT276527 Gene_expression of Shroom1 1 0.03 0 0 5.00
166 INT110740 Binding of Trpc6 2 0.39 1.11 0 5.00
167 INT295862 Regulation of SRSF6 1 0.07 0.31 0 5.00
168 INT276546 Regulation of Myo1b 1 0.16 0 0 5.00
169 INT295841 Gene_expression of Ccna1 1 0.10 0.49 0 5.00
170 INT276542 Binding of Myh9 1 0.40 0.61 0 5.00
171 INT276554 Binding of Myh10 1 0.32 0 0 5.00
172 INT276552 Gene_expression of Flnb 1 0.31 0.54 0 5.00
173 INT295838 Positive_regulation of Phosphorylation of Srpk1 1 0.30 0.26 0 5.00
174 INT276577 Positive_regulation of Binding of KTWS 1 0.03 0.29 0 5.00
175 INT295825 Positive_regulation of Gene_expression of Ccna1 1 0.09 0.49 0 5.00
176 INT295821 Binding of Srpk2 1 0.22 0.75 0 5.00
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