D:Desmoid Disease

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Disease Term
Synonyms Aggressive Fibromatoses, Aggressive Fibromatosis, Desmoid, DESMOIDS, Fibromatoses Aggressive, Fibromatosis Aggressive
Documents 151
Hot Single Events 53
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Desmoid Disease. They are ordered first by their relevance to Desmoid Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42 82.48
2 INT202310 Binding of PDGFB and Pdgfrb 1 0.11 0.39 0.04 78.92
3 INT286110 Binding of Rpe65 and Gopc 1 0.01 1.97 0 71.28
4 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 70.88
5 INT202313 Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb 1 0.14 1 0.29 5.00
6 INT202314 Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb 1 0.14 1 0.29 5.00
7 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 5.00
8 INT202312 PDGFB Positive_regulation of Gene_expression of Col7a1 1 0.01 0.7 0.16 5.00
9 INT202311 PDGFB Positive_regulation of Gene_expression of Fn1 1 0.02 0.7 0.16 5.00
10 INT252177 VEGFA Regulation of Gene_expression of CPOX 1 0.03 0.56 0.14 5.00
11 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
12 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
13 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13 5.00
14 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12 5.00
15 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12 5.00
16 INT287893 VEGFA Positive_regulation of Localization of WISP1 1 0.03 1.23 0.1 5.00
17 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1 5.00
18 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08 5.00
19 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08 5.00
20 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08 5.00
21 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05 5.00
22 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05 5.00
23 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0 5.00
24 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 5.00
25 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0 5.00
26 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0 5.00
27 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0 5.00
28 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0 5.00
29 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0 5.00
30 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0 5.00
31 INT287891 Binding of CDH1 and KRT20 1 0.00 0.5 0 5.00
32 INT231519 Binding of PAX7 and POMT1 1 0.02 0.78 0 5.00
33 INT231521 Binding of IARS and POMT1 1 0.03 0.72 0 5.00
34 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0 5.00
35 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0 5.00
36 INT231520 Binding of PAX7 and GOPC 1 0.09 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Desmoid Disease. They are ordered first by their pain relevance and then by number of times they were reported in Desmoid Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 100.00
2 INT116836 Binding of FAP 6 0.37 6.76 1.47 100.00
3 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 100.00
4 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 99.96
5 INT130343 Gene_expression of CTNND2 5 0.75 6.98 1.38 99.84
6 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 99.84
7 INT244618 Regulation of TRERF1 2 0.07 1.43 0.28 99.74
8 INT74528 Negative_regulation of PDGFB 11 0.40 10.34 1.48 99.70
9 INT260174 Gene_expression of Rpe65 29 0.78 4.2 0.19 99.60
10 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 99.28
11 INT70897 Positive_regulation of Gene_expression of PDGFB 15 0.57 13.04 3.52 99.28
12 INT68564 Binding of Fap 6 0.32 6.75 0.65 99.16
13 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 98.92
14 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 98.88
15 INT182664 Positive_regulation of Gene_expression of Fap 1 0.16 4.01 0 98.88
16 INT18995 Binding of CEL 23 0.47 14.46 4.5 98.74
17 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 98.36
18 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 98.36
19 INT23955 Regulation of Vim 16 0.25 14.21 2.04 98.24
20 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 98.00
21 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04 97.88
22 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 97.64
23 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 97.32
24 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 97.32
25 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 97.24
26 INT38343 Regulation of IGFBP1 8 0.35 3.6 1.75 96.92
27 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 95.92
28 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 95.60
29 INT225667 Transcription of Apc 3 0.52 3.73 0.32 95.28
30 INT286108 Negative_regulation of Afap1 1 0.08 3.35 0.18 95.00
31 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 94.64
32 INT63121 Binding of APC 29 0.41 23.02 3.8 94.60
33 INT66933 Binding of AXIN1 6 0.32 1.8 0.16 94.60
34 INT73627 Binding of Fap 8 0.36 11.14 0.4 94.12
35 INT123738 Regulation of Fap 2 0.39 2.59 0.08 93.28
36 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 92.64
37 INT74527 Positive_regulation of PDGFB 14 0.38 13.31 2.54 91.68
38 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 91.36
39 INT228059 Protein_catabolism of CTNND2 1 0.64 1.86 0.28 88.80
40 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 87.04
41 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 85.36
42 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 84.24
43 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18 84.24
44 INT180036 Positive_regulation of D7Cwr3P 2 0.03 4.58 0.54 84.00
45 INT286102 Positive_regulation of Fap 5 0.30 8.58 0.04 83.84
46 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3 83.60
47 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25 83.60
48 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 83.44
49 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 82.96
50 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 82.96
51 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 82.72
52 INT23660 Negative_regulation of Fap 5 0.35 8.93 0.95 81.60
53 INT225029 Gene_expression of TRERF1 3 0.53 1.62 0.08 80.40
54 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 79.96
55 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23 79.56
56 INT144023 Negative_regulation of Positive_regulation of Pdgfrb 2 0.42 1.43 0.13 79.56
57 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 79.48
58 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 79.36
59 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 79.24
60 INT74529 Binding of PDGFB 13 0.36 7.41 0.62 78.92
61 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 77.36
62 INT183629 Gene_expression of Ctnnd2 14 0.75 11.78 0.48 75.96
63 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44 75.68
64 INT217905 Phosphorylation of CSNK1A1 3 0.54 2.14 0.05 71.12
65 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 69.16
66 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17 69.16
67 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 65.84
68 INT192343 Positive_regulation of Phosphorylation of TXK 4 0.06 1.42 0.37 64.08
69 INT103767 Phosphorylation of DDR1 6 0.20 4.67 1.56 61.84
70 INT192347 Phosphorylation of TXK 12 0.22 6.71 0.36 61.84
71 INT202308 Phosphorylation of PDGFB 1 0.34 0.43 0.03 61.84
72 INT171716 Regulation of Fap 4 0.27 4.05 0.23 61.00
73 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 59.28
74 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 58.96
75 INT286097 Binding of Afap1 1 0.05 1.72 0 57.92
76 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 52.64
77 INT286095 Gene_expression of Afap1 1 0.09 2.42 0.03 52.40
78 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 52.00
79 INT47311 Gene_expression of Sts 12 0.58 11.02 0.44 48.40
80 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59 44.16
81 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 34.72
82 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06 34.72
83 INT115889 Binding of Fas 27 0.36 28.87 4.08 32.88
84 INT265588 Localization of Fap 4 0.47 5.67 0 30.64
85 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 27.12
86 INT59784 Binding of DES 22 0.47 19.48 2.27 26.36
87 INT183360 Binding of Cr2 13 0.27 7.68 2.19 26.36
88 INT183359 Binding of Sema4d 1 0.03 1.89 0.33 26.36
89 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74 19.76
90 INT202307 Regulation of Gene_expression of PDGFB 2 0.26 1.24 0.71 15.60
91 INT202302 Regulation of Gene_expression of Pdgfrb 1 0.22 1.03 0.03 15.60
92 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68 14.96
93 INT242822 Transcription of Fap 1 0.18 1.2 0 14.24
94 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 10.52
95 INT26585 Gene_expression of Vim 117 0.77 39.97 6 10.52
96 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 10.52
97 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62 10.52
98 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 10.52
99 INT248470 Gene_expression of Ighmbp2 5 0.75 3.32 0.68 10.52
100 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.92
101 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.48
102 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
103 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
104 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
105 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
106 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
107 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
108 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
109 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
110 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
111 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 5.00
112 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 5.00
113 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
114 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
115 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
116 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
117 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
118 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
119 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
120 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
121 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
122 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
123 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
124 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
125 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
126 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 5.00
127 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
128 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
129 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
130 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
131 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
132 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
133 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
134 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
135 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
136 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
137 INT103262 Localization of Nav1 53 0.81 19.23 34.44 5.00
138 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
139 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
140 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
141 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
142 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
143 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
144 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 5.00
145 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 5.00
146 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
147 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
148 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
149 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
150 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 5.00
151 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
152 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
153 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
154 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
155 INT106097 Localization of pr 20 0.62 12.01 19.46 5.00
156 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
157 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
158 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 5.00
159 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 5.00
160 INT35487 Localization of PTGER2 103 0.46 51.24 17.45 5.00
161 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
162 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
163 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
164 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
165 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
166 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
167 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
168 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
169 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
170 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
171 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
172 INT174844 Binding of Fig4 81 0.41 18.03 12.87 5.00
173 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
174 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
175 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
176 INT1762 Negative_regulation of PTGER2 64 0.43 28.21 11.27 5.00
177 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
178 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 5.00
179 INT6361 Localization of Edn1 30 0.81 19.09 9.7 5.00
180 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
181 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
182 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
183 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78 5.00
184 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 5.00
185 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
186 INT171715 Gene_expression of Sema5b 46 0.31 6.46 7.48 5.00
187 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
188 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
189 INT175482 Positive_regulation of Gene_expression of CALM1 12 0.44 3.47 6.54 5.00
190 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
191 INT93007 Regulation of Gene_expression of CALM1 7 0.41 3.47 6.08 5.00
192 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
193 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
194 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58 5.00
195 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 5.00
196 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 5.00
197 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
198 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
199 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75 5.00
200 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
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