D:Developmental Disabilities

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Disease Term
Synonyms Child Development Deviation, CHILD DEVELOPMENT DEVIATIONS, Child Development Disorder, CHILD DEVELOPMENT DISORDERS, Child Development Disorders Specific, Development Deviation Child, Development Deviations Child, Development Disorder Child, Development Disorders Child, Developmental Delay Disorder, Developmental Delay Disorders
Documents 96
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Developmental Disabilities. They are ordered first by their relevance to Developmental Disabilities and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
2 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54 5.00
3 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 5.00
4 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16 5.00
5 INT204497 Fmr1 Regulation of Positive_regulation of Gria1 1 0.04 1.75 0.14 5.00
6 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13 5.00
7 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1 5.00
8 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08 5.00
9 INT204479 Fmr1 Negative_regulation of Mtap1b 1 0.23 0.68 0 5.00
10 INT204485 Binding of Cish and Fmr1 1 0.01 0 0 5.00
11 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0 5.00
12 INT204503 Binding of Fmr1 and RNPC3 1 0.01 0 0 5.00
13 INT204495 Fmr1 Negative_regulation of Transcription of Mtap1b 1 0.22 0.68 0 5.00
14 INT204499 App Regulation of Fmr1 1 0.50 0.59 0 5.00
15 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0 5.00
16 INT204480 Fmr1 Negative_regulation of Positive_regulation of Scn10a 1 0.17 0.74 0 5.00
17 INT204502 Binding of App and RNPC3 1 0.01 0.09 0 5.00
18 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0 5.00
19 INT204474 Fmr1 Negative_regulation of Transcription of Map1b 1 0.41 0.68 0 5.00
20 INT204490 Binding of Fmr1 and Scn10a 1 0.15 0 0 5.00
21 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0 5.00
22 INT204488 Binding of Fmr1 and Ncl 1 0.12 0.61 0 5.00
23 INT204486 Fmr1 Negative_regulation of Scn10a 1 0.17 0.74 0 5.00
24 INT204484 Binding of Fmr1 and Iqcg 1 0.01 0.21 0 5.00
25 INT204504 Binding of Cish and RNPC3 1 0.00 0 0 5.00
26 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0 5.00
27 INT204475 Fmr1 Negative_regulation of Map1b 1 0.41 0.68 0 5.00
28 INT204483 Binding of Ncl and Hnrnpa2b1 1 0.02 0 0 5.00
29 INT204498 Binding of Fmr1 and 7G1 1 0.39 0.15 0 5.00
30 INT204496 App Positive_regulation of Scn10a 1 0.20 0.48 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Developmental Disabilities. They are ordered first by their pain relevance and then by number of times they were reported in Developmental Disabilities. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT54233 Negative_regulation of Axtav 1 0.00 0.1 0.28 99.68
2 INT204463 Gene_expression of Fmr1 50 0.78 23.73 0.78 97.76
3 INT151539 Negative_regulation of Fmr1 9 0.59 11.85 0.87 97.76
4 INT204468 Negative_regulation of Gene_expression of Fmr1 5 0.59 7.5 0.19 97.76
5 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 96.04
6 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 91.92
7 INT11625 Localization of App 98 0.78 55.46 20.86 87.32
8 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 81.36
9 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 76.84
10 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 69.88
11 INT17493 Binding of Ar 14 0.48 3.62 0.6 64.76
12 INT324672 Negative_regulation of Gene_expression of CEBPZ 2 0.36 2.75 0.48 56.04
13 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 55.32
14 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 53.28
15 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 50.00
16 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 50.00
17 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 50.00
18 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 43.44
19 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 19.76
20 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
21 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
22 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
23 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
24 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
25 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
26 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
27 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
28 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
29 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 5.00
30 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
31 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
32 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
33 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
34 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 5.00
35 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 5.00
36 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
37 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
38 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
39 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
40 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
41 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
42 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
43 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 5.00
44 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
45 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 5.00
46 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
47 INT605 Regulation of Acot1 61 0.62 10.7 26.34 5.00
48 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
49 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
50 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
51 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 5.00
52 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 5.00
53 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
54 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
55 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
56 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
57 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
58 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
59 INT69311 Gene_expression of Scn10a 31 0.78 15.54 14.64 5.00
60 INT15246 Regulation of FOS 32 0.60 15.34 12.94 5.00
61 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
62 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
63 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03 5.00
64 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
65 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 5.00
66 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
67 INT1252 Binding of Ache 46 0.48 9.94 10.25 5.00
68 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18 5.00
69 INT108643 Gene_expression of Dlg4 61 0.76 8.63 8.58 5.00
70 INT86867 Regulation of CREB1 15 0.46 4.95 7.28 5.00
71 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23 5.00
72 INT16268 Binding of HTR3A 15 0.47 7.38 7.18 5.00
73 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
74 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76 5.00
75 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
76 INT69561 Positive_regulation of GSTM1 23 0.50 5.69 6.36 5.00
77 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
78 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07 5.00
79 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84 5.00
80 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
81 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
82 INT204449 Gene_expression of T 17 0.32 9.77 4.77 5.00
83 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 5.00
84 INT47044 Positive_regulation of ORM1 5 0.68 0.58 4.46 5.00
85 INT10842 Transcription of Gh 18 0.64 2.94 4.13 5.00
86 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 5.00
87 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59 5.00
88 INT224413 Positive_regulation of CIMT 25 0.68 23.61 3.14 5.00
89 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96 5.00
90 INT178772 Transcription of App 17 0.70 10.79 2.79 5.00
91 INT24904 Negative_regulation of PAPPA 13 0.57 9.93 2.74 5.00
92 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 5.00
93 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58 5.00
94 INT82730 Transcription of Scn10a 3 0.69 2.5 2.53 5.00
95 INT29228 Negative_regulation of Binding of NCOR2 4 0.02 0.62 2.47 5.00
96 INT222892 Binding of CACNA2D2 2 0.23 2.78 2.42 5.00
97 INT33170 Binding of Chrm1 11 0.48 1.58 2.1 5.00
98 INT151538 Positive_regulation of Fmr1 21 0.68 12.24 2.07 5.00
99 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03 5.00
100 INT107905 Gene_expression of BCL2L11 9 0.75 7.58 1.92 5.00
101 INT351284 Regulation of Localization of AP1M2 1 0.04 0.85 1.9 5.00
102 INT351285 Localization of AP1M2 1 0.07 0.79 1.89 5.00
103 INT198748 Regulation of Gene_expression of Dlg4 10 0.44 2.16 1.85 5.00
104 INT84820 Negative_regulation of Negative_regulation of Ngf 5 0.59 2.5 1.79 5.00
105 INT94934 Negative_regulation of COX1 3 0.57 3.27 1.75 5.00
106 INT157720 Localization of ADHD1 15 0.64 15.84 1.69 5.00
107 INT2847 Positive_regulation of Negative_regulation of Ache 8 0.49 1.09 1.65 5.00
108 INT151543 Binding of Fmr1 56 0.48 19.4 1.65 5.00
109 INT95226 Gene_expression of AHSA1 5 0.49 3.62 1.52 5.00
110 INT152939 Regulation of Dlg4 9 0.60 1.09 1.49 5.00
111 INT224414 Regulation of CIMT 15 0.39 11.75 1.42 5.00
112 INT65892 Negative_regulation of Binding of Gh 8 0.32 3.61 1.38 5.00
113 INT46206 Positive_regulation of Scn10a 11 0.60 6.57 1.38 5.00
114 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34 5.00
115 INT38964 Negative_regulation of Lsd 3 0.37 0.52 1.32 5.00
116 INT165994 Gene_expression of NANS 12 0.65 3.47 1.22 5.00
117 INT151542 Positive_regulation of Positive_regulation of Fmr1 4 0.58 2.17 1.2 5.00
118 INT162831 Regulation of ARSD 13 0.35 6.17 1.19 5.00
119 INT58211 Gene_expression of FURIN 7 0.57 0.62 1.15 5.00
120 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81 5.00
121 INT204461 Localization of Scn10a 4 0.31 2.58 0.79 5.00
122 INT280447 Negative_regulation of Positive_regulation of MOCS1 1 0.00 0.75 0.69 5.00
123 INT231558 Regulation of LRP5 2 0.24 1.02 0.68 5.00
124 INT142827 Regulation of Gene_expression of CREB1 3 0.61 0.39 0.61 5.00
125 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46 5.00
126 INT204452 Binding of Fxr1 10 0.40 4.48 0.45 5.00
127 INT257849 Binding of CST7 2 0.18 0 0.44 5.00
128 INT251659 Positive_regulation of Prdx6 2 0.11 2.07 0.36 5.00
129 INT202863 Binding of Hnrnpa2b1 3 0.08 0.23 0.34 5.00
130 INT141647 Gene_expression of NLN 3 0.65 0.17 0.32 5.00
131 INT181059 Gene_expression of Rnase1 5 0.25 0.98 0.19 5.00
132 INT177609 Negative_regulation of GREM1 4 0.06 1.73 0.19 5.00
133 INT251660 Positive_regulation of Positive_regulation of Prdx6 1 0.04 0.09 0.17 5.00
134 INT171218 Gene_expression of Mtap1b 8 0.45 1.04 0.16 5.00
135 INT195744 Gene_expression of XIST 3 0.65 1.61 0.12 5.00
136 INT204447 Binding of Ncl 3 0.18 1.99 0.11 5.00
137 INT204471 Gene_expression of Ybx1 2 0.16 0.87 0.09 5.00
138 INT204442 Regulation of Gene_expression of Fmr1 2 0.44 0.3 0.08 5.00
139 INT204466 Negative_regulation of Regulation of Fmr1 2 0.43 0.97 0.08 5.00
140 INT204458 Regulation of Positive_regulation of Fmr1 1 0.44 0.8 0.07 5.00
141 INT204457 Regulation of Binding of Fmr1 2 0.45 0.4 0.06 5.00
142 INT251664 Positive_regulation of PSG1 1 0.08 0.37 0.05 5.00
143 INT251662 Gene_expression of PSG1 1 0.10 0.38 0.05 5.00
144 INT251663 Regulation of PSG1 1 0.02 0.39 0.05 5.00
145 INT204460 Positive_regulation of Gene_expression of Fmr1 7 0.61 6.19 0.03 5.00
146 INT204443 Gene_expression of Fxr2 2 0.73 1.13 0.03 5.00
147 INT204473 Transcription of Map1b 1 0.67 0.68 0 5.00
148 INT244258 Negative_regulation of Gene_expression of UBE3A 1 0.59 0.82 0 5.00
149 INT204467 Negative_regulation of Binding of Fmr1 3 0.57 1.43 0 5.00
150 INT204464 Binding of Scn10a 1 0.15 1.16 0 5.00
151 INT244259 Gene_expression of UBE3A 4 0.78 1.91 0 5.00
152 INT204459 Gene_expression of Ncl 2 0.35 2.08 0 5.00
153 INT315136 Gene_expression of TSIX 1 0.19 0.52 0 5.00
154 INT204455 Regulation of Binding of Scn10a 1 0.18 0.72 0 5.00
155 INT204445 Positive_regulation of Gene_expression of Mtap1b 1 0.37 0.66 0 5.00
156 INT204448 Localization of Hnrnpa2b1 1 0.12 0.68 0 5.00
157 INT204446 Localization of Fmr1 5 0.79 1.12 0 5.00
158 INT204462 Transcription of Mtap1b 1 0.37 0.68 0 5.00
159 INT204456 Positive_regulation of Mtap1b 1 0.11 0.66 0 5.00
160 INT204472 Binding of RNPC3 6 0.06 1.65 0 5.00
161 INT244260 Negative_regulation of UBE3A 1 0.59 0.86 0 5.00
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