D:Diabetes Complications

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Disease Term
Synonyms COMPLICATIONS OF DIABETES MELLITUS, Diabetes Complication, Diabetes Mellitus Complication, DIABETES MELLITUS COMPLICATIONS, Diabetes Related Complication, Diabetes Related Complications, Diabetic Complication, DIABETIC COMPLICATIONS
Documents 407
Hot Single Events 200
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diabetes Complications. They are ordered first by their relevance to Diabetes Complications and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT353489 Negative_regulation of Aldh2 Negative_regulation of Prkag1 1 0.00 0.84 0.07 99.92
2 INT196337 Binding of CDSN and HBM 1 0.00 0.79 0.08 98.08
3 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14 93.98
4 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13 89.04
5 INT236077 Binding of HLA-DQB1 and TNF 1 0.29 1.06 0 88.76
6 INT236076 Binding of HLA-DQB1 and LTA 1 0.25 1.06 0 88.56
7 INT236079 Binding of AGER and HLA-DQB1 1 0.25 1.06 0 88.24
8 INT232575 SNRNP70 Regulation of SOD1 1 0.12 0.65 0 87.36
9 INT236078 Binding of AGER and HLA-DMA 1 0.08 0.81 0 86.24
10 INT305334 Jun Positive_regulation of Gene_expression of Tcstv1 1 0.00 1.04 0.27 81.16
11 INT196338 Binding of CDSN and HRASLS 1 0.00 0.64 0 80.92
12 INT285979 Ros1 Positive_regulation of Trib3 2 0.02 2.18 0.2 79.32
13 INT332687 Ros1 Positive_regulation of Crk 1 0.17 0.77 0.12 79.32
14 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 79.28
15 INT266395 Renbp Positive_regulation of Ager 1 0.00 0.31 0 79.00
16 INT332685 Trib3 Positive_regulation of Binding of Ros1 1 0.01 0.74 0.12 78.64
17 INT330120 Bdkrb2 Regulation of Bdkrb1 1 0.19 1.26 0.38 76.80
18 INT330124 Positive_regulation of Bdkrb1 Positive_regulation of RT1-O2-ps 1 0.02 1.97 1.3 75.88
19 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03 65.20
20 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04 61.84
21 INT205555 Sst Negative_regulation of Ins1 1 0.05 0.77 0.14 60.48
22 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 56.64
23 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73 53.40
24 INT321399 Positive_regulation of SETD7 Positive_regulation of SETDB1 1 0.00 1.25 0.06 51.68
25 INT321398 SETD7 Positive_regulation of SETDB1 1 0.00 0.62 0.03 51.12
26 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12 44.92
27 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 42.24
28 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 42.24
29 INT264864 Cd38 Positive_regulation of Localization of INS 1 0.06 0.51 0 39.52
30 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 29.76
31 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04 27.68
32 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61 27.16
33 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 25.36
34 INT266407 Binding of ALB and Ager 1 0.00 1.42 0 25.36
35 INT266409 Binding of ALB and Renbp 1 0.00 1.41 0 24.96
36 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39 20.16
37 INT266382 Binding of Col4a1 and Fn1 1 0.00 0.82 0.39 20.16
38 INT258636 Binding of Alb and Is(HSR;1)1Icg 1 0.05 0 0.44 17.84
39 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38 17.76
40 INT246217 Cdkn1b Positive_regulation of VEGFA 1 0.03 1.13 0 15.16
41 INT246218 Fn1 Positive_regulation of VEGFA 1 0.03 1.13 0 15.16
42 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18 10.28
43 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6 8.00
44 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
45 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
46 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
47 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 5.00
48 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3 5.00
49 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26 5.00
50 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84 5.00
51 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69 5.00
52 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65 5.00
53 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 5.00
54 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56 5.00
55 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
56 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 5.00
57 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34 5.00
58 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32 5.00
59 INT314211 Ngf Positive_regulation of Gene_expression of Agtrap 1 0.04 1.15 1.3 5.00
60 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27 5.00
61 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24 5.00
62 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24 5.00
63 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22 5.00
64 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15 5.00
65 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91 5.00
66 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88 5.00
67 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
68 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76 5.00
69 INT107028 KNG1 Regulation of Des 1 0.01 1.7 0.76 5.00
70 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
71 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67 5.00
72 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
73 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 5.00
74 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 5.00
75 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61 5.00
76 INT317638 Ins1 Positive_regulation of Gene_expression of Drd1a 1 0.14 0.86 0.59 5.00
77 INT317634 Ins1 Positive_regulation of Drd1a 1 0.14 0.86 0.59 5.00
78 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
79 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57 5.00
80 INT317637 Ngf Regulation of Creb1 1 0.10 0.11 0.57 5.00
81 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57 5.00
82 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56 5.00
83 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 5.00
84 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54 5.00
85 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 5.00
86 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
87 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46 5.00
88 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
89 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46 5.00
90 INT317640 Slc3a1 Positive_regulation of Creb1 1 0.12 0.58 0.46 5.00
91 INT317636 Creb1 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.55 0.45 5.00
92 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43 5.00
93 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43 5.00
94 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
95 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 5.00
96 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37 5.00
97 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37 5.00
98 INT266402 Binding of S100P and Ager 1 0.00 2.25 0.35 5.00
99 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34 5.00
100 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34 5.00
101 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34 5.00
102 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34 5.00
103 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33 5.00
104 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33 5.00
105 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33 5.00
106 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32 5.00
107 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
108 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32 5.00
109 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
110 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31 5.00
111 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 5.00
112 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31 5.00
113 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31 5.00
114 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3 5.00
115 INT237745 Binding of Lgals3 and Lgals3bp 1 0.24 1.36 0.28 5.00
116 INT237750 Lgals3bp Positive_regulation of Binding of Lgals3 and Lgals3 1 0.30 1.36 0.28 5.00
117 INT237752 Lgals3bp Positive_regulation of Binding of Lgals3 and Lgals3bp 1 0.26 1.36 0.28 5.00
118 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28 5.00
119 INT237753 Lgals3 Positive_regulation of Binding of Lgals3 and Lgals3bp 1 0.30 1.36 0.28 5.00
120 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27 5.00
121 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27 5.00
122 INT265830 KNG1 Positive_regulation of Localization of BGN 1 0.02 0.33 0.27 5.00
123 INT271453 Thy1 Regulation of Thy1 Regulation of Col1a1 1 0.04 0.61 0.25 5.00
124 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
125 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25 5.00
126 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25 5.00
127 INT230460 Binding of TLR2 and TLR6 2 0.07 1.9 0.25 5.00
128 INT271445 Thy1 Regulation of Acta2 1 0.02 0.62 0.25 5.00
129 INT237749 Prkcg Regulation of Transcription of Pcgf1 1 0.14 0.68 0.25 5.00
130 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 5.00
131 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24 5.00
132 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24 5.00
133 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
134 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23 5.00
135 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23 5.00
136 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22 5.00
137 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22 5.00
138 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22 5.00
139 INT237748 Negative_regulation of Jak3 Negative_regulation of Positive_regulation of Stat3 1 0.25 1.01 0.22 5.00
140 INT321979 Negative_regulation of Klk1c8 Negative_regulation of Positive_regulation of Ins1 1 0.04 0.81 0.22 5.00
141 INT321980 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Ins1 1 0.16 0.81 0.22 5.00
142 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21 5.00
143 INT228457 Negative_regulation of Ins1 Positive_regulation of Gene_expression of Trpv1 1 0.05 1.01 0.21 5.00
144 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21 5.00
145 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 5.00
146 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21 5.00
147 INT266401 S100b Positive_regulation of S100b Positive_regulation of Ager 1 0.01 0.96 0.21 5.00
148 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 5.00
149 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2 5.00
150 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2 5.00
151 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2 5.00
152 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
153 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2 5.00
154 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2 5.00
155 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2 5.00
156 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2 5.00
157 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
158 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
159 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
160 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 5.00
161 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 5.00
162 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18 5.00
163 INT305335 Olfr927-ps1 Negative_regulation of Akr1b3 1 0.02 1.6 0.17 5.00
164 INT172829 Binding of Nfkb1 and ISYNA1 1 0.00 2.06 0.17 5.00
165 INT172820 Binding of Nfkb1 and T2dm2 1 0.00 2.14 0.17 5.00
166 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17 5.00
167 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17 5.00
168 INT266417 Binding of TGM2 and S100a11 1 0.01 0.86 0.16 5.00
169 INT353861 Binding of Mgp and Phdlc1 1 0.01 5.09 0.16 5.00
170 INT355410 Ins1 Regulation of Gene_expression of Dbi 1 0.07 0.57 0.16 5.00
171 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16 5.00
172 INT271444 Binding of Lox and Eln 1 0.21 0.82 0.16 5.00
173 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16 5.00
174 INT238825 LTF Regulation of Localization of RBP4 1 0.05 1.08 0.16 5.00
175 INT172837 ROS1 Positive_regulation of Nfkb1 1 0.00 2.11 0.16 5.00
176 INT266412 Binding of S100A12 and Ager 1 0.01 1.03 0.15 5.00
177 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15 5.00
178 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14 5.00
179 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14 5.00
180 INT355408 Ins1 Regulation of Dbi 1 0.07 0.58 0.14 5.00
181 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13 5.00
182 INT266403 Negative_regulation of Binding of S100P and Ager 1 0.00 0.74 0.13 5.00
183 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13 5.00
184 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.00
185 INT237746 Prkcg Regulation of Pcgf1 1 0.14 0.34 0.12 5.00
186 INT230760 VEGFA Positive_regulation of Flt1 1 0.03 0.96 0.12 5.00
187 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12 5.00
188 INT300570 Binding of IL1RN and SUGT1P2 1 0.01 0.43 0.12 5.00
189 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12 5.00
190 INT228455 Ins1 Positive_regulation of Prkca 1 0.02 0.98 0.12 5.00
191 INT186243 IL36RN Positive_regulation of B4GALNT1 1 0.00 0.43 0.12 5.00
192 INT228458 Ins1 Positive_regulation of Trpv1 1 0.06 0.98 0.12 5.00
193 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12 5.00
194 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
195 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12 5.00
196 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12 5.00
197 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 5.00
198 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
199 INT242881 SPI1 Negative_regulation of Regulation of TLR2 1 0.04 1.13 0.11 5.00
200 INT266384 Binding of Ager and S100a6 1 0.01 1.32 0.11 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diabetes Complications. They are ordered first by their pain relevance and then by number of times they were reported in Diabetes Complications. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59 99.92
2 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 99.92
3 INT133331 Positive_regulation of Gene_expression of Lgals3 5 0.59 5.14 1.35 99.92
4 INT69485 Regulation of Bcl2a1c 14 0.34 9.99 0.13 99.92
5 INT158864 Negative_regulation of Aldh2 25 0.58 10.92 3.81 99.92
6 INT238807 Localization of HSPB2 1 0.75 2.27 0.04 99.92
7 INT240853 Regulation of Irs2 2 0.45 1.1 0.03 99.84
8 INT157378 Gene_expression of PDR 14 0.53 11.46 0.64 99.80
9 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 99.78
10 INT238808 Binding of HSPB2 1 0.30 2.21 0.08 99.76
11 INT4415 Gene_expression of Cacna1g 6 0.65 4.64 0.22 99.62
12 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.60
13 INT184281 Binding of AGER 25 0.37 23.06 7.32 99.60
14 INT145384 Binding of LTA 10 0.32 4.4 0.66 99.60
15 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 99.60
16 INT65295 Negative_regulation of Bdkrb2 9 0.37 6.36 6.49 99.60
17 INT121954 Binding of Mthfr 17 0.44 13.47 4.66 99.44
18 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 99.40
19 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 99.40
20 INT144198 Positive_regulation of HSPB2 7 0.48 5.66 0.11 99.40
21 INT240825 Gene_expression of Irs2 14 0.78 3.88 0.32 99.32
22 INT30517 Negative_regulation of Bdkrb1 16 0.58 16.52 16.88 99.28
23 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 99.24
24 INT115528 Binding of Ros1 37 0.41 22.96 5.5 99.16
25 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15 99.16
26 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 99.16
27 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 99.12
28 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 99.08
29 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56 98.88
30 INT140244 Positive_regulation of Akr1b3 3 0.69 2.8 1.12 98.80
31 INT812 Localization of INS 1026 0.81 515.6 145.31 98.76
32 INT1114 Localization of Ins1 748 0.80 192.95 165.48 98.76
33 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 98.72
34 INT93009 Regulation of HBN1 24 0.17 17.6 2.03 98.68
35 INT278334 Negative_regulation of Hsp90ab1 3 0.30 4.34 0.68 98.60
36 INT178615 Binding of SOD2 12 0.48 6.93 1.51 98.56
37 INT232580 Protein_catabolism of SOD2 2 0.97 1.22 0.16 98.56
38 INT7339 Localization of CALM1 46 0.75 16.15 16.47 98.52
39 INT170284 Gene_expression of Arsb 9 0.65 9.12 0.63 98.40
40 INT147880 Regulation of SRGN 28 0.33 13.99 0.9 98.20
41 INT31989 Binding of SOD1 43 0.47 19.38 2.55 98.20
42 INT204330 Protein_catabolism of SOD1 8 0.84 4.75 0.1 98.20
43 INT353488 Negative_regulation of Prkag1 1 0.01 0.92 0.1 98.08
44 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 97.84
45 INT73101 Regulation of RT1-Hb-ps1 3 0.09 4.73 1.25 97.66
46 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 97.60
47 INT13354 Transcription of TNF 108 0.72 85.81 42.32 97.60
48 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 97.60
49 INT69486 Negative_regulation of Bcl2a1c 34 0.10 19.03 0.6 97.48
50 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 97.44
51 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 97.28
52 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71 97.28
53 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 97.20
54 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33 97.00
55 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 96.92
56 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 96.50
57 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 96.36
58 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 96.36
59 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49 96.32
60 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 96.22
61 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 95.64
62 INT115202 Positive_regulation of Positive_regulation of Ednra 2 0.39 2.88 0.49 95.44
63 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 95.28
64 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 95.28
65 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68 95.16
66 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 94.96
67 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 94.96
68 INT228167 Negative_regulation of Peg10 18 0.02 7.64 0.54 94.68
69 INT155838 Binding of GGT1 7 0.47 13.27 1.11 94.24
70 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 94.24
71 INT264857 Negative_regulation of Gene_expression of Cd38 1 0.34 1.57 0.12 94.00
72 INT98260 Negative_regulation of Gene_expression of Bdkrb1 4 0.57 5.98 6.7 93.96
73 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 93.88
74 INT39712 Binding of pad 82 0.48 110.92 10.33 93.84
75 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 93.84
76 INT79928 Positive_regulation of Localization of ALB 10 0.60 8.96 1.05 93.84
77 INT27554 Regulation of Eln 6 0.52 6.76 0.39 93.80
78 INT12054 Negative_regulation of MIA3 32 0.45 23.2 6.18 93.80
79 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 93.72
80 INT68545 Negative_regulation of Sord 1 0.43 1.63 0.18 93.56
81 INT94784 Binding of ROS1 113 0.40 71.57 10.26 93.56
82 INT68544 Regulation of Negative_regulation of Sord 1 0.33 0.52 0.03 93.56
83 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 93.52
84 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21 93.44
85 INT61301 Positive_regulation of Gene_expression of Bdkrb1 7 0.68 16.95 15.44 93.44
86 INT65500 Gene_expression of App 605 0.78 429.94 98.31 93.28
87 INT6484 Binding of IL1B 122 0.47 75.84 35.07 93.24
88 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 93.20
89 INT137616 Gene_expression of Cd38 19 0.67 9.37 2.54 93.16
90 INT18773 Localization of ALB 117 0.80 69.18 13.8 92.92
91 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 92.92
92 INT240765 Positive_regulation of Pon1 16 0.67 12.06 0.48 92.84
93 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 92.84
94 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 92.64
95 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 92.48
96 INT51777 Regulation of Negative_regulation of Akr1b1 4 0.45 2.91 1.48 92.48
97 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69 92.40
98 INT107173 Phosphorylation of App 20 0.82 12.64 5.3 92.40
99 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73 92.40
100 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 92.16
101 INT142626 Negative_regulation of Localization of ALB 9 0.55 6.63 2.24 92.08
102 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 92.00
103 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 91.92
104 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 91.80
105 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 91.80
106 INT246756 Binding of Ogg1 1 0.32 2.24 0 91.76
107 INT185154 Regulation of T2dm2 2 0.02 3.23 0.08 91.68
108 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 91.44
109 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 91.40
110 INT252017 Binding of Prl3d1 1 0.03 0.97 0.31 91.24
111 INT252011 Binding of Abcd1 1 0.21 0.97 0.31 91.24
112 INT196392 Negative_regulation of Positive_regulation of Ros1 7 0.17 4.94 0.88 90.96
113 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38 90.92
114 INT23199 Binding of LDLR 22 0.47 17.08 1.16 90.88
115 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 90.88
116 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 90.80
117 INT168861 Positive_regulation of Gene_expression of Cd38 2 0.50 2.01 1.47 90.80
118 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 90.72
119 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 90.60
120 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15 90.48
121 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 90.40
122 INT34604 Binding of Ada 11 0.31 4.15 3.1 90.08
123 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 90.04
124 INT894 Binding of Avp 84 0.48 29.16 29.63 89.96
125 INT190519 Positive_regulation of Positive_regulation of Ros1 14 0.32 9.99 1.52 89.64
126 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 89.60
127 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 89.60
128 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 89.60
129 INT1004 Regulation of Sst 140 0.62 18.52 94.84 89.56
130 INT141642 Positive_regulation of Ctsa 5 0.49 2.87 1.27 89.08
131 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 89.04
132 INT29333 Positive_regulation of Enpep 8 0.70 3.22 3.25 89.00
133 INT2562 Positive_regulation of Gusb 9 0.69 2.92 1.59 89.00
134 INT16060 Positive_regulation of Ctsd 7 0.70 2.99 0.86 89.00
135 INT29334 Positive_regulation of Positive_regulation of Enpep 2 0.47 1.12 0.44 89.00
136 INT178243 Positive_regulation of Hexa 1 0.19 1.1 0.05 89.00
137 INT246743 Negative_regulation of Ogg1 1 0.52 5.27 0 88.96
138 INT290870 Negative_regulation of MNT 1 0.05 1.61 0 88.88
139 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 88.72
140 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 88.64
141 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 88.64
142 INT14572 Binding of INS 205 0.48 175.43 13.38 88.60
143 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 88.52
144 INT320000 Regulation of Gene_expression of Bcl2a1c 1 0.22 0.58 0 88.52
145 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 88.32
146 INT217539 Localization of INSM1 1 0.04 7.01 0.2 88.32
147 INT34669 Localization of Hypism 8 0.25 10.79 1.2 88.28
148 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 87.92
149 INT1005 Localization of Sst 385 0.81 26.31 244.56 87.92
150 INT14098 Regulation of Gene_expression of Sst 13 0.44 4.01 12.92 87.92
151 INT240788 Gene_expression of Bcl2a1c 8 0.37 7.35 0.03 87.68
152 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 87.44
153 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 87.28
154 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41 87.04
155 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 86.88
156 INT257329 Gene_expression of RT1-O2-ps 5 0.02 8.38 7.25 86.84
157 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 86.76
158 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 86.56
159 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 86.56
160 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65 86.56
161 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05 86.56
162 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 86.44
163 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 86.44
164 INT88223 Gene_expression of Bdkrb2 17 0.69 13.94 11.44 86.20
165 INT88221 Positive_regulation of Gene_expression of Bdkrb2 5 0.36 3.35 3.91 86.20
166 INT259241 Negative_regulation of ED 3 0.37 5.09 0.34 85.92
167 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 85.80
168 INT255001 Negative_regulation of RT1-Hb-ps1 9 0.11 12.94 3.09 85.76
169 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 85.72
170 INT290795 Gene_expression of Slc2a2 3 0.44 1.22 0.16 85.60
171 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 85.52
172 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 85.48
173 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 85.44
174 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 85.44
175 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 85.40
176 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 85.32
177 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 85.32
178 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 85.24
179 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 85.12
180 INT308613 Regulation of Ly6 1 0.05 2.65 0.74 85.12
181 INT251 Regulation of INS 398 0.62 232.47 55.04 85.04
182 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 84.92
183 INT147616 Negative_regulation of Positive_regulation of Parp1 3 0.43 2.53 0.84 84.76
184 INT141185 Regulation of Ros1 30 0.24 20.73 8.88 84.72
185 INT3039 Positive_regulation of Gene_expression of MIA3 11 0.12 7.32 0.46 84.64
186 INT204527 Regulation of TLR9 7 0.40 2.88 0.12 84.60
187 INT217538 Negative_regulation of Gene_expression of INSM1 1 0.02 1.05 0 84.48
188 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68 84.40
189 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74 84.40
190 INT142049 Regulation of Mthfr 6 0.41 4.73 2 84.40
191 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 84.32
192 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 84.20
193 INT39879 Positive_regulation of Gene_expression of Fn1 12 0.41 12.69 0.78 84.12
194 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 84.00
195 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 84.00
196 INT183459 Phosphorylation of Ucp1 1 0.31 0.71 0.03 83.96
197 INT217537 Gene_expression of INSM1 1 0.04 5.1 0.04 83.88
198 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 83.76
199 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 83.72
200 INT10056 Positive_regulation of Fabp6 77 0.59 36.99 16.8 83.28
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