D:Diabetic Foot Ulcer

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Disease Term
Synonyms Chronic Foot Ulcer, Chronic Foot Ulcers, DIABETIC FEET, DIABETIC FOOT, Diabetic Foot Ulcers, Diabetic Ulcer, DIABETIC ULCERS, Feet Diabetic, Foot Diabetic, Foot Ulcer, FOOT ULCER DIABETIC
Documents 328
Hot Single Events 71
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diabetic Foot Ulcer. They are ordered first by their relevance to Diabetic Foot Ulcer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT303456 Binding of USE1 and PDGFC 1 0.01 0.68 0 99.44
2 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69 95.36
3 INT334393 IL6 Positive_regulation of Tnf 1 0.16 1.41 0.35 95.36
4 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 94.72
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 93.92
6 INT303439 Egf Positive_regulation of Gene_expression of Fn1 1 0.05 0.82 0 86.56
7 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18 53.44
8 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23 50.00
9 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 43.76
10 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 7.36
11 INT225020 Binding of PDGFB and Mtpn 1 0.01 0.15 0 6.96
12 INT225001 Binding of Mtpn and Trib3 1 0.00 0.15 0 5.68
13 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4 5.00
14 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
15 INT225025 IL1B Positive_regulation of Positive_regulation of Cxcl1 1 0.04 0.32 0.49 5.00
16 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
17 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
18 INT225021 PDGFB Positive_regulation of Ccl21 1 0.10 0.07 0.3 5.00
19 INT225026 PDGFB Positive_regulation of Gene_expression of Ccl21 1 0.10 0.07 0.3 5.00
20 INT303440 Egf Positive_regulation of Gene_expression of Col7a1 1 0.07 0.92 0.28 5.00
21 INT333246 Binding of Cxcr4 and Cxcl12 3 0.34 0.99 0.27 5.00
22 INT272024 Gene_expression of GOPC Positive_regulation of Localization of COL7A1 1 0.10 0.86 0.14 5.00
23 INT232592 Binding of Csf2 and Gtf3a 1 0.02 0.47 0.14 5.00
24 INT225024 PDGFB Positive_regulation of Gene_expression of Cxcl5 1 0.16 0.08 0.13 5.00
25 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07 5.00
26 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07 5.00
27 INT225023 PDGFB Regulation of Transcription of Ccl21 1 0.11 0 0.06 5.00
28 INT225022 PDGFB Regulation of Ccl21 1 0.11 0 0.06 5.00
29 INT232590 Csf2 Positive_regulation of Serpina5 1 0.17 0.65 0.05 5.00
30 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
31 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03 5.00
32 INT232591 Binding of Csf2 and Wbc1 1 0.06 0.47 0.03 5.00
33 INT317842 Hdlcl1 Positive_regulation of Ldlr 1 0.00 1.11 0 5.00
34 INT224993 INCENP Regulation of PDGFB 1 0.00 0 0 5.00
35 INT290861 MNT Positive_regulation of INS 1 0.03 1.78 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diabetic Foot Ulcer. They are ordered first by their pain relevance and then by number of times they were reported in Diabetic Foot Ulcer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 99.84
2 INT209356 Regulation of SLC9A6 2 0.39 5.61 0.14 99.68
3 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 99.64
4 INT37227 Regulation of EGF 19 0.45 11.16 5.17 99.44
5 INT11157 Binding of EGF 88 0.48 53.73 21.25 99.44
6 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.28
7 INT209354 Gene_expression of SLC9A6 15 0.58 37.52 0.29 99.24
8 INT217428 Positive_regulation of Gene_expression of SLC9A6 3 0.29 4.99 0 99.24
9 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.12
10 INT144391 Gene_expression of RETN 42 0.75 40.48 10.47 98.92
11 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 98.92
12 INT286072 Negative_regulation of Gene_expression of pr 1 0.03 0.79 0 98.84
13 INT276437 Binding of Spir1 4 0.12 6.56 0 98.68
14 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71 98.56
15 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 98.52
16 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 98.36
17 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 98.32
18 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 98.24
19 INT229632 Binding of PADI4 21 0.48 37.45 0.34 98.16
20 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 97.72
21 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 97.52
22 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 97.52
23 INT125138 Positive_regulation of RETN 13 0.67 11.94 2.34 97.36
24 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94 96.04
25 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77 96.04
26 INT3520 Binding of Csf2 27 0.43 9.68 6.08 95.64
27 INT257453 Positive_regulation of USE1 12 0.20 6.7 0.94 95.44
28 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92 95.24
29 INT293714 Regulation of Localization of Fgf2 2 0.45 0.1 0.14 95.24
30 INT229631 Positive_regulation of Gene_expression of PADI4 1 0.43 6.24 0 95.16
31 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 94.80
32 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 94.80
33 INT118124 Binding of USE1 24 0.16 16.64 5.44 94.48
34 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 94.44
35 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7 94.44
36 INT167203 Binding of PRNP 25 0.48 20.09 1.84 94.20
37 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 94.12
38 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 94.04
39 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 94.04
40 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 93.72
41 INT88006 Positive_regulation of GDNF 5 0.45 2.55 2.14 93.72
42 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 93.04
43 INT10207 Gene_expression of PADI4 22 0.75 23.49 1.74 92.98
44 INT177341 Negative_regulation of HMHB1 21 0.03 12.48 1.25 92.96
45 INT23375 Binding of ENG 17 0.47 6.02 6.46 91.68
46 INT21682 Binding of CD34 18 0.47 13.19 1.47 91.68
47 INT164514 Binding of THY1 3 0.34 1.23 0.27 91.68
48 INT39000 Regulation of pr 24 0.44 12.51 4.36 91.52
49 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 91.52
50 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 91.32
51 INT101239 Gene_expression of NTF3 9 0.76 5.91 2.97 91.32
52 INT217425 Regulation of Localization of SLC9A6 1 0.25 1.87 0.09 90.28
53 INT39712 Binding of pad 82 0.48 110.92 10.33 90.04
54 INT217431 Positive_regulation of Localization of SLC9A6 1 0.27 7.38 0.12 89.64
55 INT192975 Localization of SLC9A6 7 0.43 14.24 0.24 89.20
56 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 88.96
57 INT10166 Localization of Tnf 237 0.81 153.95 88.64 88.96
58 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 88.48
59 INT299242 Positive_regulation of Wasf1 1 0.04 0.64 0 88.48
60 INT299244 Positive_regulation of Positive_regulation of Wasf1 1 0.04 0.64 0 88.48
61 INT160568 Positive_regulation of PADI4 7 0.45 10.5 0.41 88.36
62 INT155007 Positive_regulation of Gene_expression of RETN 4 0.27 9.17 1.3 87.60
63 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49 86.96
64 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 86.56
65 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 85.92
66 INT303459 Transcription of PRNP 4 0.69 1.44 0.08 85.60
67 INT229788 Negative_regulation of SPTLC1 1 0.38 4.82 3.53 85.44
68 INT217427 Transcription of SLC9A6 1 0.38 4.64 0 84.60
69 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 83.12
70 INT615 Regulation of Alb 66 0.62 33.43 15.33 82.16
71 INT14572 Binding of INS 205 0.48 175.43 13.38 80.84
72 INT155006 Regulation of RETN 9 0.45 7.31 1.7 79.96
73 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 79.32
74 INT217429 Positive_regulation of SLC9A6 22 0.38 42.17 0.67 77.72
75 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 77.72
76 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 77.72
77 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 77.72
78 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 77.60
79 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 74.20
80 INT20216 Localization of NGF 40 0.80 18.16 16.61 74.00
81 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 73.44
82 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 70.56
83 INT298013 Binding of MNS1 1 0.35 1.14 0.13 70.56
84 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1 68.88
85 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 67.08
86 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 67.04
87 INT74145 Localization of CPQ 2 0.68 1.7 1.01 66.32
88 INT61975 Positive_regulation of TBP 5 0.28 4.01 0.4 61.60
89 INT183753 Regulation of HBM 24 0.39 13.13 1.79 60.72
90 INT174838 Localization of INCENP 80 0.64 19.05 12.89 60.32
91 INT133144 Localization of Mtpn 18 0.24 7.88 2.77 60.00
92 INT101922 Regulation of MICA 2 0.39 2.64 0.15 59.96
93 INT269047 Binding of Ereg 3 0.09 1.07 0 59.84
94 INT334392 Regulation of PADI4 2 0.22 3.42 0 59.28
95 INT279190 Binding of Areg 2 0.11 1.07 0 58.88
96 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 57.92
97 INT23653 Binding of Egf 22 0.36 11.34 4.12 57.76
98 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 57.36
99 INT251 Regulation of INS 398 0.62 232.47 55.04 57.04
100 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 55.92
101 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 55.28
102 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 53.36
103 INT7678 Localization of Alb 142 0.81 80.93 22.49 51.52
104 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 50.40
105 INT110319 Positive_regulation of SRGN 10 0.40 6.2 0.56 50.36
106 INT812 Localization of INS 1026 0.81 515.6 145.31 50.00
107 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 50.00
108 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 50.00
109 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 50.00
110 INT238874 Positive_regulation of Binding of pad 1 0.03 1.64 0.05 50.00
111 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19 49.84
112 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 47.48
113 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 46.64
114 INT185156 Gene_expression of T2dm2 9 0.45 10.44 0.56 44.80
115 INT7723 Localization of Hgf 10 0.46 6.28 0.68 44.44
116 INT228271 Localization of Fgf7 2 0.28 1.59 0.39 44.44
117 INT289722 Localization of Pgf 3 0.45 0.63 0.04 44.44
118 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 43.44
119 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 43.44
120 INT98017 Protein_catabolism of Gtf3a 10 0.11 6.16 0.83 42.72
121 INT19293 Protein_catabolism of FN1 7 0.95 5.15 2.97 42.12
122 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 41.36
123 INT217426 Positive_regulation of Binding of SLC9A6 1 0.27 2.04 0 40.96
124 INT209355 Binding of SLC9A6 8 0.42 14.9 0.09 40.00
125 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 39.04
126 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 39.04
127 INT167955 Positive_regulation of Positive_regulation of pr 3 0.68 0.56 0.15 37.52
128 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 34.24
129 INT252 Localization of GH1 529 0.80 227.4 122.05 33.68
130 INT249 Localization of GHRH 215 0.80 78.02 51.87 33.68
131 INT34777 Localization of IGF1 82 0.80 42.68 8.62 33.68
132 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 33.68
133 INT9191 Localization of EDN1 94 0.81 57.01 14.78 32.72
134 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 32.24
135 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 31.68
136 INT307558 Gene_expression of Prelid1 1 0.07 1.74 0.41 31.20
137 INT138307 Regulation of Tcm 15 0.39 4.1 0.81 29.20
138 INT256229 Protein_catabolism of EDNRB 3 0.64 0.96 0.14 26.48
139 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 24.84
140 INT70895 Localization of PDGFB 20 0.52 8.98 3.4 24.72
141 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 24.72
142 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 24.16
143 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 23.92
144 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 14.72
145 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75 14.72
146 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74 13.40
147 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 13.20
148 INT6884 Negative_regulation of pr 20 0.42 13.18 7.97 9.80
149 INT7459 Positive_regulation of Lpl 15 0.70 6.96 1.81 9.12
150 INT295960 Binding of Wnt1 1 0.07 0.97 0 8.68
151 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 7.36
152 INT10237 Binding of EDN1 40 0.48 16 8.48 7.36
153 INT172961 Localization of Egf 26 0.71 16.74 1.81 7.20
154 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
155 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
156 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
157 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
158 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
159 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
160 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
161 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
162 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
163 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
164 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
165 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
166 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
167 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
168 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
169 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
170 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
171 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 5.00
172 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
173 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
174 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
175 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
176 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
177 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
178 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
179 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
180 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
181 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
182 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
183 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
184 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
185 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
186 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 5.00
187 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
188 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
189 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
190 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
191 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
192 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
193 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
194 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 5.00
195 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
196 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 5.00
197 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
198 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
199 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
200 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
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