D:Diabetic Nephropathy

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Disease Term
Synonyms Asymmetrical Motor Diabetic Neuropathy, Autonomic Neuropathy, Diabetic Glomeruloscerosis, Diabetic Glomerulosclerosis, Diabetic Kidney Disease, Diabetic Kidney Diseases, Diabetic Nephropathies, Glomerulosclerosis Diabetic, Glomerulosclerosis Nodular, Intracapillary Glomerulosclerosis, KIDNEY DISEASE DIABETIC
Documents 705
Hot Single Events 175
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diabetic Nephropathy. They are ordered first by their relevance to Diabetic Nephropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT153620 Binding of Ntrk1 and WNK1 1 0.02 0.85 0.12 99.00
2 INT122927 Ntrk1 Positive_regulation of SPTLC1 1 0.00 0.65 0.09 98.24
3 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43 92.48
4 INT164676 Negative_regulation of Binding of NGF and Ngfr 1 0.00 0.5 0.08 86.64
5 INT164675 Binding of NGF and Ngfr 1 0.00 0.5 0.08 86.28
6 INT308648 Binding of sps and Gopc 1 0.01 2.71 0 84.16
7 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36 84.08
8 INT235956 Binding of Aqp4 and NMO-IgG 1 0.04 4.53 0.5 83.00
9 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44 80.08
10 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44 80.08
11 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22 75.00
12 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49 75.00
13 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32 75.00
14 INT89514 Pnoc Regulation of Gene_expression of Fos 1 0.47 0.98 0.93 75.00
15 INT89515 Pnoc Regulation of Gene_expression of Fosl1 1 0.09 0.98 0.93 75.00
16 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18 62.72
17 INT328377 Binding of GAST and Ghrl 1 0.03 0.62 0.43 60.24
18 INT267923 Negative_regulation of Dpp4 Positive_regulation of Glp1r 1 0.00 0.23 0.05 58.72
19 INT191900 Binding of EXOSC10 and COPD 1 0.01 0.53 0 46.32
20 INT235968 NMO-IgG Positive_regulation of Nqo1 1 0.00 2.11 0.03 35.60
21 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 25.36
22 INT284519 NOVA2 Positive_regulation of Gene_expression of CX3CL1 1 0.07 1.49 0.2 22.56
23 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 18.48
24 INT238871 Binding of INS and ARMC9 1 0.10 0.31 0 14.92
25 INT238872 Positive_regulation of Binding of INS and ARMC9 1 0.14 0.31 0 14.92
26 INT230854 INS Regulation of Positive_regulation of SNAP47 1 0.09 1.03 0.03 8.48
27 INT230851 INS Regulation of VCAM1 1 0.07 1.02 0.03 6.32
28 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13 6.00
29 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
30 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
31 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
32 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 5.00
33 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16 5.00
34 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83 5.00
35 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 5.00
36 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84 5.00
37 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8 5.00
38 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 5.00
39 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
40 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
41 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
42 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53 5.00
43 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 5.00
44 INT216919 Ngf Positive_regulation of Gene_expression of P2rx3 1 0.18 0.69 0.53 5.00
45 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
46 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46 5.00
47 INT328385 Binding of GHS and Ghrl 1 0.15 1.89 0.45 5.00
48 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42 5.00
49 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
50 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
51 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
52 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33 5.00
53 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32 5.00
54 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
55 INT235971 Positive_regulation of Binding of Nqo1 and NMO-IgG 1 0.00 1.86 0.32 5.00
56 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
57 INT328299 Binding of GHRH and GHS 1 0.07 2.21 0.31 5.00
58 INT235958 Binding of Ighg1 and Aqp4 1 0.14 1.32 0.3 5.00
59 INT235977 Binding of AQP4 and Ighg1 1 0.03 1.31 0.3 5.00
60 INT235957 Binding of Mog and Bcr 1 0.02 1.13 0.29 5.00
61 INT235962 Binding of Bcr and Trav6-3 1 0.00 1.12 0.29 5.00
62 INT235966 Binding of Mog and Trav6-3 1 0.01 1.07 0.29 5.00
63 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 5.00
64 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26 5.00
65 INT235959 Nqo1 Positive_regulation of Localization of Aqp4 1 0.02 1.39 0.26 5.00
66 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
67 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25 5.00
68 INT328378 GH1 Regulation of Gene_expression of Ghrl 1 0.02 0.39 0.25 5.00
69 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25 5.00
70 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 5.00
71 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24 5.00
72 INT311531 IMMT Negative_regulation of Gene_expression of ROS1 1 0.11 1.09 0.24 5.00
73 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24 5.00
74 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24 5.00
75 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24 5.00
76 INT235967 Binding of Ighm and Nqo1 1 0.00 1.45 0.23 5.00
77 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
78 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23 5.00
79 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
80 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22 5.00
81 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 5.00
82 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 5.00
83 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
84 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
85 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
86 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
87 INT328310 DBT Positive_regulation of Localization of GH1 1 0.00 0 0.19 5.00
88 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 0.03 0.72 0.18 5.00
89 INT355569 IRF6 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17 5.00
90 INT355566 IL1RL1 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17 5.00
91 INT328386 GHS Positive_regulation of Localization of Ghrl 1 0.10 0.88 0.17 5.00
92 INT328379 Ghrl Positive_regulation of CRH 1 0.16 1.17 0.16 5.00
93 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14 5.00
94 INT328374 GHRH Positive_regulation of Ghrl 1 0.13 0.26 0.13 5.00
95 INT328384 Ghrl Positive_regulation of ALPL 1 0.01 0.93 0.13 5.00
96 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.00
97 INT328309 GHS Positive_regulation of Localization of GH1 1 0.04 0.99 0.12 5.00
98 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
99 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 5.00
100 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
101 INT328313 Binding of CD36 and LDLR 1 0.00 0.63 0.11 5.00
102 INT328294 GHS Positive_regulation of Localization of GHRH 1 0.10 0.12 0.11 5.00
103 INT328370 Binding of CD36 and Fabp1 1 0.01 0.64 0.11 5.00
104 INT328364 Binding of GHRH and Ghrl 1 0.09 0.2 0.1 5.00
105 INT328297 GHRH Positive_regulation of Transcription of GH1 1 0.04 0.26 0.1 5.00
106 INT328372 Ghrl Positive_regulation of Transcription of GH1 1 0.04 0.27 0.1 5.00
107 INT280053 Negative_regulation of Dpp4 Negative_regulation of Protein_catabolism of Zglp1 1 0.02 0.71 0.1 5.00
108 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 5.00
109 INT184537 Ccl2 Positive_regulation of Spp1 1 0.34 1.37 0.09 5.00
110 INT184542 Positive_regulation of Ccl2 Positive_regulation of Gpbar1 1 0.10 1.39 0.09 5.00
111 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09 5.00
112 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09 5.00
113 INT184538 Positive_regulation of Ccl2 Positive_regulation of Spp1 1 0.34 1.38 0.09 5.00
114 INT184541 Ccl2 Positive_regulation of Gpbar1 1 0.10 1.37 0.09 5.00
115 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
116 INT328311 Binding of GH1 and GHS 1 0.02 0.14 0.09 5.00
117 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09 5.00
118 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 5.00
119 INT184539 Spp1 Positive_regulation of Gpbar1 1 0.03 1.37 0.09 5.00
120 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 5.00
121 INT307665 Binding of Mpz and Pmp22 1 0.34 0.39 0.08 5.00
122 INT328373 Negative_regulation of Ghrl Positive_regulation of Localization of GH1 1 0.05 0.31 0.08 5.00
123 INT307666 Binding of Pmp22 and Gjb1 1 0.31 0.38 0.08 5.00
124 INT235964 Binding of Atp9a and Aqp4 1 0.01 0.55 0.08 5.00
125 INT307663 Binding of Pmp22 and Egr2 1 0.33 0.39 0.08 5.00
126 INT328302 Gene_expression of GHS Positive_regulation of Gene_expression of GH1 1 0.03 0.17 0.08 5.00
127 INT307664 Binding of Pmp22 and LOC689781 1 0.03 0.39 0.08 5.00
128 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
129 INT328306 GH1 Positive_regulation of Localization of INS 1 0.01 0.12 0.07 5.00
130 INT328366 GPR39 Regulation of Localization of Ghrl 1 0.11 0.2 0.07 5.00
131 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 5.00
132 INT230853 Binding of SELE and VWF 1 0.06 1.3 0.07 5.00
133 INT328380 AR Negative_regulation of Gene_expression of Ghrl 1 0.01 0.55 0.07 5.00
134 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07 5.00
135 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 5.00
136 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07 5.00
137 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07 5.00
138 INT328305 GHS Positive_regulation of Localization of INS 1 0.02 0.07 0.05 5.00
139 INT328387 INS Negative_regulation of Gene_expression of Ghrl 1 0.01 0.6 0.05 5.00
140 INT328371 Ghrl Negative_regulation of INS 1 0.03 0.13 0.05 5.00
141 INT328376 Ghrl Negative_regulation of SST 1 0.03 0.13 0.05 5.00
142 INT328383 Ghrl Negative_regulation of MBOAT4 1 0.26 0 0.05 5.00
143 INT328367 KISS1 Positive_regulation of Localization of Gnrh1 1 0.00 0 0.05 5.00
144 INT328308 CRH Negative_regulation of KISS1 1 0.02 0 0.05 5.00
145 INT328292 KISS1 Positive_regulation of Localization of PLOD1 1 0.00 0 0.05 5.00
146 INT235963 Snta1 Regulation of Gene_expression of Aqp4 1 0.41 0.23 0.05 5.00
147 INT280057 Zglp1 Positive_regulation of Transcription of INS 1 0.04 0.52 0.05 5.00
148 INT328293 Binding of JAG2 and GHS 1 0.03 0.09 0.05 5.00
149 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
150 INT328365 Binding of JAG2 and Ghrl 1 0.03 0.07 0.05 5.00
151 INT308649 Binding of Ppp1r13b and Iars 1 0.01 0.29 0.04 5.00
152 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04 5.00
153 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
154 INT204172 Regulation of Binding of Cs and Nox1 1 0.08 1.01 0.04 5.00
155 INT328303 Gene_expression of GHS Positive_regulation of Gene_expression of GHRH 1 0.09 0.19 0.04 5.00
156 INT328301 GHRH Positive_regulation of SCG5 1 0.24 0.13 0.04 5.00
157 INT328363 Ghrl Negative_regulation of PLOD1 1 0.02 0.11 0.04 5.00
158 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
159 INT311535 ROS1 Negative_regulation of CA2 1 0.19 0.61 0.04 5.00
160 INT328295 GHRH Positive_regulation of GHS 1 0.10 0.13 0.04 5.00
161 INT204173 Binding of Cs and Nox1 1 0.07 1 0.04 5.00
162 INT328332 Ghrl Negative_regulation of Abo 1 0.01 0 0.04 5.00
163 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
164 INT328312 GHS Positive_regulation of Localization of PRL 1 0.02 0.21 0.03 5.00
165 INT328362 LYPLA1 Regulation of Ghrl 1 0.04 0.07 0.03 5.00
166 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03 5.00
167 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03 5.00
168 INT328381 Ghrl Positive_regulation of NPY 1 0.06 0.15 0.03 5.00
169 INT328304 POMC Positive_regulation of Localization of CRH 1 0.07 0.22 0.03 5.00
170 INT191899 Binding of EXOSC10 and PNN 1 0.00 0.96 0.03 5.00
171 INT351466 NMD3 Positive_regulation of Protein_catabolism of UPF1 1 0.00 0.54 0 5.00
172 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 5.00
173 INT328298 GHRH Negative_regulation of Localization of GHS 1 0.08 0.84 0 5.00
174 INT328369 Ghrl Negative_regulation of CRH 1 0.16 0.15 0 5.00
175 INT311534 Binding of CISH and NFE2L2 1 0.02 0.64 0 5.00
176 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 5.00
177 INT323120 Negative_regulation of Irs2 Positive_regulation of Positive_regulation of Akt1 1 0.37 0 0 5.00
178 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0 5.00
179 INT238870 INS Positive_regulation of Gene_expression of GCG 1 0.39 1.06 0 5.00
180 INT335042 Binding of CNBP and ANAPC16 1 0.01 0.4 0 5.00
181 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0 5.00
182 INT328296 GHRH Negative_regulation of Localization of GH1 1 0.03 0.84 0 5.00
183 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0 5.00
184 INT232574 ROS1 Positive_regulation of PRKCA 1 0.13 0.69 0 5.00
185 INT183462 Agt Positive_regulation of Ros1 1 0.02 0.11 0 5.00
186 INT232575 SNRNP70 Regulation of SOD1 1 0.12 0.65 0 5.00
187 INT290861 MNT Positive_regulation of INS 1 0.03 1.78 0 5.00
188 INT351465 PRSS1 Regulation of Gene_expression of IKBKAP 1 0.00 0.65 0 5.00
189 INT235960 Binding of Aqp4 and H47 1 0.01 0.13 0 5.00
190 INT323122 2.5-3-fold Positive_regulation of Gene_expression of Akt1 1 0.01 0 0 5.00
191 INT328368 Ghrl Positive_regulation of INS 1 0.04 0.22 0 5.00
192 INT232576 ROS1 Positive_regulation of Localization of OLR1 1 0.04 0.7 0 5.00
193 INT121225 Positive_regulation of Ngf Positive_regulation of Ntrk1 2 0.49 0 0 5.00
194 INT323121 Negative_regulation of Irs2 Negative_regulation of Positive_regulation of Akt1 1 0.34 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diabetic Nephropathy. They are ordered first by their pain relevance and then by number of times they were reported in Diabetic Nephropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13 100.00
2 INT72115 Regulation of Localization of Gal 1 0.60 0.29 0.24 100.00
3 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 99.98
4 INT9191 Localization of EDN1 94 0.81 57.01 14.78 99.96
5 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.96
6 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 99.96
7 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.68
8 INT1005 Localization of Sst 385 0.81 26.31 244.56 99.68
9 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.68
10 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.60
11 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 99.60
12 INT5099 Localization of Gal 46 0.81 10.66 18.93 99.52
13 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.44
14 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 99.40
15 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.36
16 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 99.32
17 INT141502 Positive_regulation of CX3CL1 21 0.55 25.8 8.88 99.24
18 INT157467 Positive_regulation of Gene_expression of CX3CL1 6 0.55 16.67 8.84 99.24
19 INT157465 Positive_regulation of Gene_expression of CX3CR1 5 0.49 8.9 6.62 99.24
20 INT157464 Positive_regulation of CX3CR1 2 0.68 2.97 1.92 99.24
21 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75 99.08
22 INT157466 Gene_expression of CX3CR1 14 0.76 20.6 10.76 99.08
23 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 98.92
24 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 98.84
25 INT1352 Localization of Acot1 728 0.80 73.01 296.01 98.84
26 INT276 Regulation of Ache 83 0.62 16.75 25.99 98.80
27 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 98.76
28 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 98.76
29 INT15581 Localization of Myo5a 1 0.14 0.46 0.57 98.74
30 INT15582 Localization of Stzid 1 0.01 0.46 0.57 98.74
31 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 98.72
32 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 98.64
33 INT88133 Positive_regulation of Spp1 8 0.66 10.07 1.33 98.64
34 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 98.64
35 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57 98.64
36 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 98.60
37 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.56
38 INT284522 Positive_regulation of Binding of CX3CL1 1 0.23 1.44 0.13 98.36
39 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 98.32
40 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 98.32
41 INT10706 Regulation of Il6 150 0.62 93.23 62.34 98.24
42 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45 98.24
43 INT389 Gene_expression of Ace 21 0.67 10.31 8.1 98.16
44 INT7678 Localization of Alb 142 0.81 80.93 22.49 98.12
45 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 98.08
46 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07 98.08
47 INT117518 Transcription of Ccl2 12 0.68 11.12 3.61 98.08
48 INT121141 Transcription of Spp1 6 0.34 5.02 0.38 98.08
49 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 98.00
50 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 97.80
51 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 97.76
52 INT61094 Gene_expression of Pdgfc 3 0.09 1.97 1.21 97.76
53 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 97.68
54 INT165493 Binding of CX3CL1 5 0.21 3.08 1.41 97.68
55 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 97.52
56 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26 97.52
57 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 97.20
58 INT164452 Gene_expression of Sptlc1 1 0.65 1.36 0.29 97.20
59 INT72114 Positive_regulation of Localization of Gal 3 0.60 1.4 1.54 97.20
60 INT2366 Binding of Cck 192 0.48 30.64 163.46 97.00
61 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 96.84
62 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 96.80
63 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 96.80
64 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 96.60
65 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 96.60
66 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 96.24
67 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 96.04
68 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18 95.88
69 INT213244 Positive_regulation of Gene_expression of DBP 4 0.22 1.99 0.04 95.88
70 INT323288 Regulation of Gene_expression of DBP 1 0.19 0.25 0 95.88
71 INT104502 Gene_expression of Abcc2 26 0.78 8.37 9.65 95.68
72 INT184551 Gene_expression of Gpbar1 1 0.14 5.59 0 95.36
73 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59 95.32
74 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 95.28
75 INT77887 Negative_regulation of Spt 7 0.50 3.9 0.54 95.20
76 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 94.80
77 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 94.80
78 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 94.64
79 INT8621 Gene_expression of Padi4 3 0.52 0.76 0.15 94.48
80 INT212089 Gene_expression of NOXO1 4 0.10 2.05 0.21 94.32
81 INT256230 Positive_regulation of Gene_expression of NOXO1 1 0.09 0.75 0 94.32
82 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 93.92
83 INT70970 Binding of COPD 144 0.42 180.34 18.29 93.36
84 INT307657 Gene_expression of Mfn2 1 0.67 0.53 0.17 93.08
85 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 93.00
86 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 93.00
87 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 92.96
88 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 92.92
89 INT62688 Binding of Wnk1 2 0.17 2.83 0.63 92.92
90 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 92.60
91 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 92.60
92 INT164451 Positive_regulation of Gene_expression of Zmat3 7 0.02 3.38 0.44 92.60
93 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 92.40
94 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 92.40
95 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 92.36
96 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 92.24
97 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 92.20
98 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 92.00
99 INT3439 Localization of Abat 1017 0.78 112.39 727.06 91.96
100 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 91.20
101 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74 91.00
102 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4 90.88
103 INT204171 Negative_regulation of Positive_regulation of Ide 2 0.06 1.73 0.16 90.88
104 INT204168 Positive_regulation of Negative_regulation of Ide 2 0.29 1.34 0.1 90.88
105 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 90.84
106 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 90.36
107 INT70341 Gene_expression of Gfer 1 0.03 0.8 0.56 90.24
108 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 90.12
109 INT5993 Positive_regulation of Nts 122 0.70 26.82 70.45 90.08
110 INT771 Regulation of Nts 93 0.61 13.13 53.57 90.08
111 INT60618 Regulation of Positive_regulation of Nts 1 0.44 2.63 2.62 90.08
112 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 90.04
113 INT12061 Negative_regulation of LNPEP 19 0.58 5.52 2.14 90.00
114 INT158326 Phosphorylation of Tie1 1 0.16 0.8 0.45 89.76
115 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 89.68
116 INT2406 Gene_expression of CCK 85 0.78 28.04 46.67 89.60
117 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 89.56
118 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 89.44
119 INT9310 Negative_regulation of Ssr1 20 0.49 6.55 4.73 89.16
120 INT1114 Localization of Ins1 748 0.80 192.95 165.48 89.04
121 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 88.92
122 INT12757 Negative_regulation of Positive_regulation of Acot1 16 0.42 2.27 8.25 88.68
123 INT62610 Phosphorylation of Ntrk1 5 0.56 1.64 2.68 88.68
124 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 88.36
125 INT812 Localization of INS 1026 0.81 515.6 145.31 88.32
126 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 88.24
127 INT77246 Positive_regulation of WNK1 5 0.10 4.24 1.13 88.20
128 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13 88.16
129 INT156734 Gene_expression of BBC3 3 0.58 2.41 0.46 87.88
130 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37 87.72
131 INT144750 Gene_expression of Slc2a2 2 0.20 0.86 0 87.64
132 INT240853 Regulation of Irs2 2 0.45 1.1 0.03 87.60
133 INT240825 Gene_expression of Irs2 14 0.78 3.88 0.32 87.12
134 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 87.12
135 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26 87.12
136 INT127507 Negative_regulation of Positive_regulation of Trpv5 1 0.02 2.29 1.78 86.72
137 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 86.72
138 INT19511 Localization of Il6 212 0.81 118.17 67.67 86.68
139 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 86.24
140 INT118179 Positive_regulation of Trpv5 4 0.68 2.4 1.97 86.20
141 INT89592 Localization of Ccl5 10 0.61 7.65 3.62 86.00
142 INT72865 Localization of Icam1 12 0.68 8.18 2.24 86.00
143 INT65430 Localization of Vcam1 4 0.75 2.53 0.2 86.00
144 INT18933 Binding of GER 11 0.37 11.56 0.3 85.68
145 INT88785 Positive_regulation of Epb4.1l5 2 0.06 2.51 1.55 85.16
146 INT114218 Gene_expression of Wt1 1 0.62 2.43 0.17 85.12
147 INT137860 Positive_regulation of Hr 2 0.14 3.9 1.16 85.08
148 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 84.64
149 INT61096 Negative_regulation of Regulation of Fos 5 0.42 2.12 2.77 84.60
150 INT120286 Positive_regulation of Abcc2 11 0.70 4.71 6.2 84.56
151 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 84.52
152 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 84.52
153 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 84.12
154 INT120056 Gene_expression of NFIC 6 0.14 2.89 0.53 84.00
155 INT164450 Positive_regulation of Gene_expression of Sptlc1 1 0.39 0.53 0.09 83.92
156 INT5587 Regulation of Fos 191 0.62 40.81 99.7 83.64
157 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 83.36
158 INT20205 Binding of IgG 108 0.46 66.68 8.57 83.00
159 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 82.96
160 INT3309 Binding of CP 25 0.47 17.87 6.62 82.72
161 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 82.28
162 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36 82.24
163 INT143337 Binding of Aqp4 30 0.40 23.73 4.24 81.96
164 INT228506 Regulation of PES1 1 0.34 2.81 1.2 81.92
165 INT3039 Positive_regulation of Gene_expression of MIA3 11 0.12 7.32 0.46 81.92
166 INT79928 Positive_regulation of Localization of ALB 10 0.60 8.96 1.05 81.68
167 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 81.48
168 INT73797 Negative_regulation of Gene_expression of MIA3 14 0.10 10.65 1.25 81.48
169 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 80.96
170 INT127508 Phosphorylation of Trpv5 1 0.03 1.15 0.93 80.92
171 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 80.56
172 INT4891 Transcription of Calca 81 0.72 35.27 53.75 80.48
173 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84 80.48
174 INT284521 Negative_regulation of CX3CL1 11 0.27 13.86 1.87 80.12
175 INT165492 Negative_regulation of Gene_expression of CX3CL1 1 0.20 6.76 0.68 80.12
176 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 79.60
177 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 79.60
178 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 79.60
179 INT55309 Positive_regulation of Ssr1 20 0.46 5.97 5.74 79.48
180 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 79.20
181 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 79.12
182 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 78.84
183 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 78.72
184 INT184549 Positive_regulation of Gpbar1 1 0.13 10.35 0.19 78.56
185 INT18773 Localization of ALB 117 0.80 69.18 13.8 78.40
186 INT105021 Binding of GOPC 187 0.40 60.39 20.38 78.32
187 INT81956 Positive_regulation of Protein_catabolism of SPTLC1 1 0.06 0.16 0 78.20
188 INT71150 Binding of NGF 22 0.46 13.67 14.81 78.08
189 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35 78.04
190 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36 77.80
191 INT55907 Binding of Ngfr 13 0.47 5.79 3.75 77.72
192 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62 77.48
193 INT41789 Negative_regulation of Moxd2 6 0.57 4.03 2.49 77.28
194 INT91099 Gene_expression of MFN2 2 0.67 1.32 0.07 77.28
195 INT91101 Gene_expression of GARS 1 0.32 0.95 0.07 77.28
196 INT81957 Protein_catabolism of SPTLC1 1 0.10 0.15 0 77.24
197 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 76.44
198 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 76.32
199 INT47692 Negative_regulation of Positive_regulation of Bdnf 18 0.59 9.64 13.14 76.32
200 INT237655 Binding of Sfn 1 0.42 3.62 2.55 76.08
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