D:Diabetic Retinopathy

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Disease Term
Synonyms Age Related Macular Degeneration Diabetic Retinopathy, Diabetic Maculopathy, Diabetic Retinal Haemorrhage, Diabetic Retinal Hemorrhage, Diabetic Retinopathies, Diabetic Retinopathy Nephropathy, NON PROLIFERATIVE RETINOPATHY, PERIPHERAL NON PROLIFERATIVE RETINOPATHY, PROLIFERATIVE DIABETIC RETINOPATHY, Proliferative Retinopathy, Retinopathies Diabetic
Documents 402
Hot Single Events 200
Hot Interactions 33

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diabetic Retinopathy. They are ordered first by their relevance to Diabetic Retinopathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT321967 Binding of PDR and PVR 1 0.01 2.32 0 100.00
2 INT237750 Lgals3bp Positive_regulation of Binding of Lgals3 and Lgals3 1 0.30 1.36 0.28 99.28
3 INT237752 Lgals3bp Positive_regulation of Binding of Lgals3 and Lgals3bp 1 0.26 1.36 0.28 99.28
4 INT237753 Lgals3 Positive_regulation of Binding of Lgals3 and Lgals3bp 1 0.30 1.36 0.28 99.28
5 INT233929 PPARA Negative_regulation of ras 1 0.02 2.39 0.22 99.24
6 INT237745 Binding of Lgals3 and Lgals3bp 1 0.24 1.36 0.28 98.64
7 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 98.56
8 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17 96.24
9 INT274284 AGT Positive_regulation of Binding of VEGFA 1 0.01 0.99 0.03 95.68
10 INT274285 AGT Positive_regulation of Gene_expression of VEGFA 1 0.01 0.98 0.03 95.68
11 INT274288 AGT Positive_regulation of Gene_expression of Vegfa 1 0.07 0.98 0.03 95.68
12 INT262820 Binding of Aif1 and Serpinf1 1 0.01 1.3 0.27 94.96
13 INT355435 Trib3 Positive_regulation of Eif2ak2 1 0.01 0.61 0 93.36
14 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05 93.24
15 INT355450 Pdia3 Regulation of Transcription of TNF 1 0.00 0.59 0 92.92
16 INT355436 Pdia3 Regulation of Transcription of Ddit3 1 0.04 0.59 0 92.92
17 INT246217 Cdkn1b Positive_regulation of VEGFA 1 0.03 1.13 0 92.48
18 INT246218 Fn1 Positive_regulation of VEGFA 1 0.03 1.13 0 92.48
19 INT262826 Serpinf1 Negative_regulation of Gene_expression of TNF 1 0.29 1.83 0.28 90.96
20 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17 88.32
21 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73 88.24
22 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73 88.24
23 INT241031 Gopc Positive_regulation of Hmbs 1 0.04 0.83 0 87.92
24 INT241029 Agtrap Positive_regulation of Hmbs 1 0.07 0.83 0 87.92
25 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 87.84
26 INT241025 Gopc Positive_regulation of Gene_expression of Agtrap 1 0.20 0.83 0 87.32
27 INT241028 Agtrap Positive_regulation of Gene_expression of Gopc 1 0.20 0.83 0 87.32
28 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06 86.64
29 INT241027 Positive_regulation of Agtr2 Positive_regulation of Protein_catabolism of Sypl 1 0.00 0.85 0 85.80
30 INT355445 Gene_expression of Pdia3 Negative_regulation of Gene_expression of TNF 1 0.00 1.31 0 85.36
31 INT355447 Gene_expression of Pdia3 Negative_regulation of Transcription of TNF 1 0.00 1.8 0.06 84.04
32 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06 84.04
33 INT245825 Plg Positive_regulation of Gene_expression of Serpinf1 1 0.21 1.01 0.04 83.84
34 INT355449 Binding of Pdia3 and Positive_regulation of Transcription of TNF 1 0.00 1.15 0.06 78.32
35 INT355443 Binding of Pdia3 and Positive_regulation of Gene_expression of TNF 1 0.00 1.15 0.06 78.32
36 INT355437 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of Ddit3 1 0.04 0.47 0 78.32
37 INT355448 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of TNF 1 0.00 0.47 0 78.32
38 INT355440 Binding of Pdia3 and Positive_regulation of Transcription of VEGFA 1 0.01 1.15 0.06 77.60
39 INT355446 Binding of Pdia3 and Positive_regulation of Gene_expression of VEGFA 1 0.01 1.15 0.06 77.60
40 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 77.60
41 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06 77.12
42 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06 77.12
43 INT262620 Renbp Positive_regulation of Ager Positive_regulation of Rpe 1 0.00 0.81 0 76.96
44 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0 76.36
45 INT141760 Nfkb1 Regulation of CADM1 1 0.02 1.18 0.16 75.00
46 INT141761 Nfkb1 Regulation of Positive_regulation of CADM1 1 0.01 1.21 0.16 75.00
47 INT141759 Nfkb1 Regulation of PECAM1 1 0.01 1.18 0.16 75.00
48 INT141753 Nfkb1 Regulation of Ptgs2 1 0.16 1.18 0.16 75.00
49 INT141754 Nfkb1 Regulation of Positive_regulation of Ptgs2 1 0.16 1.21 0.16 75.00
50 INT141762 Nfkb1 Regulation of Positive_regulation of PECAM1 1 0.01 1.21 0.16 75.00
51 INT245826 Plg Regulation of Gene_expression of Serpinf1 1 0.09 1.57 0.04 74.48
52 INT245833 Plg Negative_regulation of VEGFA 1 0.05 2.21 0.04 74.40
53 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03 73.72
54 INT355442 Pdia3 Regulation of Gene_expression of TNF 1 0.00 0.44 0 73.72
55 INT237749 Prkcg Regulation of Transcription of Pcgf1 1 0.14 0.68 0.25 68.96
56 INT237746 Prkcg Regulation of Pcgf1 1 0.14 0.34 0.12 68.96
57 INT262817 Serpinf1 Regulation of Positive_regulation of 1190002H23Rik 1 0.06 1.3 0.22 64.68
58 INT241024 Mapk1 Positive_regulation of Gene_expression of Gopc 1 0.21 0.85 0 63.12
59 INT241023 Mapk1 Positive_regulation of Gene_expression of Agtrap 1 0.40 0.85 0 63.12
60 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 62.72
61 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26 62.12
62 INT355444 Gene_expression of Pdia3 Negative_regulation of TNF 1 0.00 1.29 0.06 61.68
63 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06 61.28
64 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28 60.80
65 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08 60.80
66 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08 60.80
67 INT237748 Negative_regulation of Jak3 Negative_regulation of Positive_regulation of Stat3 1 0.25 1.01 0.22 59.52
68 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39 58.00
69 INT300986 Negative_regulation of MAPK8 Negative_regulation of Localization of TNF 1 0.01 1.25 0.03 58.00
70 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 56.80
71 INT240435 JUN Positive_regulation of Gene_expression of CPOX 1 0.01 0.81 0.18 54.64
72 INT262815 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.39 2.73 0.44 52.76
73 INT262819 Gene_expression of Serpinf1 Negative_regulation of Binding of 1190002H23Rik 1 0.05 2.66 0.43 52.76
74 INT256104 Binding of Serpina3k and Positive_regulation of Positive_regulation of Hspg2 1 0.03 1 0 52.48
75 INT277089 VEGFA Positive_regulation of Icam1 1 0.02 1.74 0.09 50.00
76 INT277091 VEGFA Positive_regulation of Fas 1 0.03 1.72 0.09 50.00
77 INT277090 VEGFA Positive_regulation of Negative_regulation of Faslg 1 0.02 1.67 0.09 50.00
78 INT355441 VEGFA Positive_regulation of Gene_expression of Ddit3 1 0.05 0.43 0.03 50.00
79 INT355415 Binding of TNF and VEGFA 1 0.00 0 0 50.00
80 INT329648 Flt1 Positive_regulation of Positive_regulation of VEGFA 1 0.03 0.58 0 46.68
81 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0 45.32
82 INT245832 VEGFA Positive_regulation of Phosphorylation of Ocln 1 0.04 1.61 0 44.88
83 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0 43.48
84 INT355408 Ins1 Regulation of Dbi 1 0.07 0.58 0.14 42.44
85 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12 41.20
86 INT295871 Binding of RNPS1 and Srpk2 1 0.01 0.76 0 40.44
87 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 37.28
88 INT283122 Binding of Dag1 and Sptbn1 1 0.00 0.07 0 37.12
89 INT172833 Binding of FFAR1 and T2dm2 1 0.00 1.55 0 36.92
90 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82 35.36
91 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4 35.36
92 INT321969 Negative_regulation of Rock1 Negative_regulation of VEGFA 1 0.03 0.65 0 32.88
93 INT316217 BDKRB1 Positive_regulation of BDKRB2 1 0.09 0.71 0.03 30.64
94 INT316218 GOPC Positive_regulation of BDKRB2 1 0.08 0.71 0.03 30.64
95 INT256072 Serpina3k Negative_regulation of Positive_regulation of Ros1 1 0.04 0.49 0 30.36
96 INT262618 Binding of SOAT1 and Kras 1 0.00 0.81 0.12 27.36
97 INT339570 Gene_expression of Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.5 0.23 24.64
98 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22 18.96
99 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 11.60
100 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 11.60
101 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 11.16
102 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 11.16
103 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 10.76
104 INT355410 Ins1 Regulation of Gene_expression of Dbi 1 0.07 0.57 0.16 10.72
105 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22 9.20
106 INT198536 Cox11 Negative_regulation of HK1 1 0.22 0.08 0.41 7.32
107 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22 7.24
108 INT352217 Tlr4 Positive_regulation of Binding of Tbce 1 0.03 0.8 0.07 5.36
109 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
110 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
111 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
112 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 5.00
113 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9 5.00
114 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 5.00
115 INT269191 Binding of Grin1 and Grin3a 2 0.32 1.05 1.09 5.00
116 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09 5.00
117 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93 5.00
118 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81 5.00
119 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69 5.00
120 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
121 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67 5.00
122 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
123 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64 5.00
124 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64 5.00
125 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63 5.00
126 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 5.00
127 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6 5.00
128 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56 5.00
129 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
130 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54 5.00
131 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 5.00
132 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 5.00
133 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
134 INT252426 Binding of SLURP1 and Negative_regulation of Gene_expression of TNF 1 0.01 1.13 0.49 5.00
135 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 5.00
136 INT240441 Ltb4r1 Positive_regulation of PPARA 1 0.03 1.01 0.47 5.00
137 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
138 INT240442 Binding of PPARA and Ltb4r1 1 0.02 0.94 0.46 5.00
139 INT252425 Positive_regulation of AR Positive_regulation of Gene_expression of CXCL10 1 0.00 0.9 0.44 5.00
140 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43 5.00
141 INT216737 Binding of ADORA2B and TCFL5 1 0.03 0.05 0.39 5.00
142 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 5.00
143 INT216738 Binding of ATP6V0A1 and TCFL5 1 0.01 0.06 0.38 5.00
144 INT262824 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.39 1.56 0.37 5.00
145 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
146 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36 5.00
147 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35 5.00
148 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35 5.00
149 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
150 INT240434 PPARA Negative_regulation of Gene_expression of CPOX 1 0.03 0.64 0.33 5.00
151 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33 5.00
152 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33 5.00
153 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32 5.00
154 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
155 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
156 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 5.00
157 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 5.00
158 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28 5.00
159 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
160 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
161 INT198538 Binding of HK1 and Cox11 1 0.14 0 0.24 5.00
162 INT252427 IGKV2D-29 Regulation of Gene_expression of AR 1 0.02 0 0.24 5.00
163 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24 5.00
164 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
165 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23 5.00
166 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
167 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22 5.00
168 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22 5.00
169 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 5.00
170 INT182816 EEF1A2 Negative_regulation of CRP 1 0.28 1.84 0.21 5.00
171 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 5.00
172 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
173 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2 5.00
174 INT174861 Binding of FGF2 and VEGFA 1 0.34 0.59 0.2 5.00
175 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
176 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2 5.00
177 INT175909 Binding of ROS1 and CNBP 1 0.01 1.78 0.19 5.00
178 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19 5.00
179 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
180 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
181 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
182 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 5.00
183 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 5.00
184 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
185 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
186 INT216841 TCIRG1 Negative_regulation of ADCY1 1 0.01 0.35 0.18 5.00
187 INT262818 Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.45 0.71 0.18 5.00
188 INT262822 Serpinf1 Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.07 1.27 0.18 5.00
189 INT216842 ATP6V0A1 Negative_regulation of ADCY1 1 0.01 0.35 0.18 5.00
190 INT330514 Vegfa Positive_regulation of VEGFA 1 0.18 0.5 0.18 5.00
191 INT198523 Ranbp2 Negative_regulation of Cox11 1 0.42 0 0.17 5.00
192 INT198540 Ranbp2 Negative_regulation of HK1 1 0.19 0 0.17 5.00
193 INT172829 Binding of Nfkb1 and ISYNA1 1 0.00 2.06 0.17 5.00
194 INT172820 Binding of Nfkb1 and T2dm2 1 0.00 2.14 0.17 5.00
195 INT252423 Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 5.00
196 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
197 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16 5.00
198 INT252428 Negative_regulation of Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 5.00
199 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 5.00
200 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diabetic Retinopathy. They are ordered first by their pain relevance and then by number of times they were reported in Diabetic Retinopathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT159060 Localization of PDR 8 0.65 10.45 0.96 100.00
2 INT157378 Gene_expression of PDR 14 0.53 11.46 0.64 100.00
3 INT233921 Binding of PDR 6 0.14 7.03 0.75 100.00
4 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 100.00
5 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 100.00
6 INT74260 Positive_regulation of Serping1 5 0.64 6.05 0.8 100.00
7 INT233923 Regulation of Localization of PDR 1 0.08 2.04 0.18 100.00
8 INT233922 Positive_regulation of Localization of PDR 1 0.09 2.01 0.18 100.00
9 INT135885 Negative_regulation of PDR 5 0.46 2.66 0.19 100.00
10 INT242922 Positive_regulation of Gene_expression of amd 2 0.43 5.99 0.1 100.00
11 INT80939 Positive_regulation of PDR 8 0.55 5.43 0.67 100.00
12 INT233924 Negative_regulation of Gene_expression of PDR 1 0.08 1.3 0.17 100.00
13 INT233925 Regulation of Gene_expression of PDR 1 0.08 1.29 0.16 100.00
14 INT288032 Negative_regulation of Localization of PDR 1 0.20 1.24 0.19 100.00
15 INT93350 Binding of Lepr 17 0.05 27.21 1.5 99.92
16 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 99.92
17 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 99.92
18 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.90
19 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.88
20 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.84
21 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 99.84
22 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22 99.84
23 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14 99.84
24 INT196395 Transcription of Ros1 3 0.23 1.58 0 99.84
25 INT256089 Regulation of Gene_expression of Serpina3k 1 0.44 0.86 0.1 99.84
26 INT114220 Negative_regulation of Gene_expression of Cdkn1b 4 0.33 4.11 1.23 99.84
27 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.80
28 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.80
29 INT151527 Positive_regulation of Olfr148 4 0.40 3.76 0.35 99.80
30 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 99.76
31 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 99.76
32 INT11476 Positive_regulation of H2-K1 17 0.26 9.48 2.23 99.72
33 INT342320 Positive_regulation of Irf6 1 0.44 1.08 0.13 99.72
34 INT342327 Positive_regulation of Erap1 1 0.43 1.1 0.13 99.72
35 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 99.64
36 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42 99.64
37 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 99.62
38 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71 99.62
39 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69 99.60
40 INT173159 Localization of PPARA 96 0.74 64.55 10.26 99.60
41 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.56
42 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 99.56
43 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.56
44 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07 99.56
45 INT110069 Regulation of Negative_regulation of ras 3 0.26 4.38 0.3 99.56
46 INT28088 Binding of Alb 34 0.47 11.06 5.48 99.52
47 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 99.48
48 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 99.44
49 INT15726 Negative_regulation of Gene_expression of Fn1 8 0.32 5.25 1.04 99.44
50 INT261192 Gene_expression of Niacr1 57 0.67 24.37 1.89 99.42
51 INT141726 Gene_expression of Pdia3 4 0.59 16.67 0.58 99.28
52 INT355427 Positive_regulation of Gene_expression of Pdia3 1 0.09 13.45 0.22 99.28
53 INT139261 Positive_regulation of Gene_expression of Mtpn 8 0.05 5.95 1.22 99.28
54 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 99.28
55 INT256085 Gene_expression of Serpina3k 1 0.75 8.51 0.46 99.24
56 INT256094 Negative_regulation of Gene_expression of Serpina3k 1 0.57 4.5 0.1 99.24
57 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 99.24
58 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 99.20
59 INT139862 Negative_regulation of amd 8 0.35 10.15 0.6 99.20
60 INT103094 Binding of PPARA 308 0.47 177.26 34.75 99.12
61 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.08
62 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 99.08
63 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99 99.08
64 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 99.06
65 INT5408 Localization of Alb 30 0.73 12.1 3.84 99.06
66 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 99.04
67 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 99.04
68 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 99.00
69 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 98.96
70 INT89360 Negative_regulation of Serpina3k 2 0.57 11.06 0.81 98.96
71 INT1114 Localization of Ins1 748 0.80 192.95 165.48 98.94
72 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 98.92
73 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 98.92
74 INT26477 Regulation of ACE 26 0.45 16.31 4.33 98.92
75 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21 98.92
76 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 98.92
77 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77 98.88
78 INT237741 Positive_regulation of Serpinf1 1 0.25 3.56 0.58 98.80
79 INT8694 Binding of Lgals3 38 0.48 14.82 8.05 98.80
80 INT213722 Positive_regulation of PVR 3 0.25 2.4 0.94 98.72
81 INT321960 Regulation of Negative_regulation of PVR 1 0.12 0.93 0.05 98.72
82 INT321963 Positive_regulation of Negative_regulation of PVR 1 0.12 0.93 0.05 98.72
83 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 98.64
84 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 98.64
85 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 98.64
86 INT112783 Regulation of Gene_expression of SELE 6 0.40 6.82 0.87 98.64
87 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 98.60
88 INT10237 Binding of EDN1 40 0.48 16 8.48 98.56
89 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 98.48
90 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 98.48
91 INT243007 Positive_regulation of Transcription of Angpt2 1 0.65 0.55 0 98.48
92 INT273613 Negative_regulation of PVR 7 0.17 5.06 1.26 98.44
93 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 98.36
94 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 98.36
95 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87 98.28
96 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 98.28
97 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 98.24
98 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 98.24
99 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 98.24
100 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 98.16
101 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93 98.16
102 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28 98.16
103 INT243004 Transcription of Angpt2 1 0.67 0.55 0 98.16
104 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 98.12
105 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 98.12
106 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 98.08
107 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 98.04
108 INT14572 Binding of INS 205 0.48 175.43 13.38 98.04
109 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 97.92
110 INT102276 Gene_expression of Grin2d 10 0.71 4.74 3.37 97.84
111 INT332925 Protein_catabolism of PPARG 1 0.63 1.04 0 97.84
112 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 97.80
113 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 97.76
114 INT241010 Localization of Svop 1 0.05 0.79 0 97.76
115 INT241013 Negative_regulation of Svop 1 0.03 0.79 0 97.76
116 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 97.64
117 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 97.64
118 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 97.64
119 INT240179 Gene_expression of Tnfrsf25 4 0.45 2.87 0.12 97.64
120 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 97.64
121 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 97.64
122 INT243003 Positive_regulation of Angpt2 7 0.65 6.31 0.26 97.60
123 INT355421 Regulation of Gene_expression of Pdia3 1 0.06 0.91 0.05 97.60
124 INT122041 Binding of Ppara 308 0.48 189.17 51.48 97.40
125 INT256086 Negative_regulation of LOC299271 1 0.03 0.56 0 97.40
126 INT103625 Gene_expression of Grin3a 4 0.64 5 1.67 97.36
127 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 97.28
128 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 97.20
129 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 97.16
130 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 97.16
131 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 97.12
132 INT165460 Gene_expression of SLC1A3 15 0.75 7.19 5.43 97.12
133 INT165457 Negative_regulation of SLC1A3 3 0.42 1.46 1.56 97.12
134 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 97.04
135 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 97.00
136 INT154018 Binding of Lhb 5 0.31 1.39 1.13 96.92
137 INT245807 Gene_expression of Serpinf1 1 0.58 9.57 0.32 96.88
138 INT245801 Negative_regulation of Gene_expression of Serpinf1 1 0.44 2.72 0.12 96.88
139 INT70789 Negative_regulation of Agtrap 26 0.48 16.39 2.18 96.80
140 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 96.76
141 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 96.72
142 INT233908 Protein_catabolism of amd 1 0.08 1.73 0.04 96.68
143 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 96.66
144 INT198495 Gene_expression of Ranbp2 1 0.78 3.31 3.14 96.56
145 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 96.52
146 INT49001 Regulation of Gria1 51 0.56 18.28 31.22 96.44
147 INT182515 Binding of AGTR2 3 0.32 2.4 0.29 96.44
148 INT245795 Positive_regulation of Gene_expression of Serpinf1 1 0.52 3.54 0.09 96.44
149 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 96.28
150 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 96.24
151 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 96.24
152 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03 96.24
153 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56 96.24
154 INT152023 Regulation of Vegfa 4 0.52 3.99 0.41 96.24
155 INT178479 Gene_expression of Angpt2 17 0.73 14.19 0.27 96.20
156 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 96.16
157 INT274072 Gene_expression of Map3k5 1 0.60 6.69 0.5 96.12
158 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 96.00
159 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 95.92
160 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 95.92
161 INT202347 Gene_expression of Map2k4 13 0.74 11.68 0.4 95.88
162 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 95.76
163 INT234019 Binding of Nes 2 0.36 0.75 0.24 95.68
164 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03 95.56
165 INT237733 Binding of Lgals3bp 1 0.26 1.33 0.27 95.56
166 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 95.44
167 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 95.36
168 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 95.36
169 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 95.28
170 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89 95.24
171 INT67451 Positive_regulation of SLURP1 11 0.49 3.42 1.96 95.24
172 INT164116 Negative_regulation of 1190002H23Rik 33 0.51 18.73 2.71 94.84
173 INT200373 Binding of Omd 7 0.34 7.03 0.34 94.80
174 INT43415 Gene_expression of CYP4A11 11 0.56 7.65 5.94 94.76
175 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 94.68
176 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 94.64
177 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 94.64
178 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06 94.64
179 INT155054 Regulation of Gene_expression of Stat3 2 0.50 4.73 0.32 94.64
180 INT812 Localization of INS 1026 0.81 515.6 145.31 94.60
181 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 94.48
182 INT94835 Localization of NUDT6 13 0.52 11.57 2 94.48
183 INT39879 Positive_regulation of Gene_expression of Fn1 12 0.41 12.69 0.78 94.44
184 INT205218 Localization of Ocln 3 0.46 1.71 0.32 94.44
185 INT291085 Localization of Col4a5 1 0.12 0.91 0.3 94.44
186 INT291084 Localization of Cldn5 1 0.31 0.84 0.29 94.44
187 INT241006 Protein_catabolism of ras 1 0.15 0.63 0 94.44
188 INT50420 Transcription of Grin1 30 0.71 13.21 18.28 94.40
189 INT286064 Positive_regulation of Pdia3 2 0.06 0.95 0 94.36
190 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46 94.32
191 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 94.32
192 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7 94.32
193 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68 94.32
194 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 94.28
195 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 94.24
196 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 94.08
197 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 94.00
198 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 93.96
199 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 93.88
200 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24 93.88
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