D:Diastolic Heart Failure

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pChart

Disease Term
Synonyms Diastolic Heart Failures, Heart Failures Diastolic
Documents 46
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diastolic Heart Failure. They are ordered first by their relevance to Diastolic Heart Failure and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT260600 Binding of Ppargc1a and Siglec1 1 0.14 1.25 0 5.00
2 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 5.00
3 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 5.00
4 INT260601 Binding of ESR1 and Ppargc1a 1 0.01 0.48 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diastolic Heart Failure. They are ordered first by their pain relevance and then by number of times they were reported in Diastolic Heart Failure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171693 Positive_regulation of Ecm1 5 0.09 2.14 0.55 98.92
2 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 98.42
3 INT5440 Negative_regulation of Ina 85 0.58 10.52 28.98 95.04
4 INT178834 Localization of MR1 8 0.21 6.52 0.48 92.88
5 INT13118 Positive_regulation of Ina 48 0.69 7.39 13.85 91.80
6 INT11996 Gene_expression of Ina 34 0.67 4.8 13.82 91.80
7 INT183172 Positive_regulation of Gene_expression of Ina 5 0.34 0.94 0.53 91.80
8 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 91.76
9 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 91.32
10 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26 85.68
11 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 82.08
12 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 80.48
13 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39 79.56
14 INT174705 Phosphorylation of Gtf3a 7 0.02 4.11 0.97 77.36
15 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26 70.00
16 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14 70.00
17 INT112368 Positive_regulation of Cacna1c 8 0.46 2.94 1.97 68.32
18 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69 62.72
19 INT216261 Regulation of Gene_expression of Cacna1c 3 0.25 1.12 0.15 62.72
20 INT199810 Positive_regulation of Gene_expression of Cacna1c 2 0.43 0.81 0.13 62.72
21 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 58.48
22 INT15549 Regulation of Positive_regulation of Ca2 11 0.38 2.55 2.92 58.48
23 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 51.60
24 INT12003 Gene_expression of Ang 4 0.64 3.87 0.44 44.36
25 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96 33.44
26 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46 31.68
27 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 31.36
28 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 31.36
29 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15 30.72
30 INT250021 Negative_regulation of Positive_regulation of Gtf3a 2 0.03 2.7 0.16 26.64
31 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 24.44
32 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 24.44
33 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 23.32
34 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 20.20
35 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 20.20
36 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 20.20
37 INT196913 Regulation of Kras 3 0.10 3.81 0.28 20.20
38 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 15.76
39 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 14.96
40 INT1114 Localization of Ins1 748 0.80 192.95 165.48 13.84
41 INT6384 Regulation of Eef1a1 21 0.61 2.95 7.97 12.88
42 INT326201 Positive_regulation of Gene_expression of Kras 2 0.02 1.06 0.08 9.64
43 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 9.24
44 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 8.72
45 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15 8.64
46 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41 5.20
47 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 5.00
48 INT477 Localization of Avp 813 0.81 131.58 300.4 5.00
49 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 5.00
50 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 5.00
51 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
52 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
53 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
54 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
55 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
56 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77 5.00
57 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
58 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 5.00
59 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
60 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
61 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
62 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
63 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 5.00
64 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
65 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
66 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 5.00
67 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
68 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
69 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
70 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 5.00
71 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
72 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
73 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
74 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 5.00
75 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43 5.00
76 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
77 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
78 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 5.00
79 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
80 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 5.00
81 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
82 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
83 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
84 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
85 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 5.00
86 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
87 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
88 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
89 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
90 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
91 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57 5.00
92 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
93 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 5.00
94 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 5.00
95 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18 5.00
96 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 5.00
97 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94 5.00
98 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
99 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
100 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
101 INT4199 Binding of Agt 76 0.48 21.06 12.66 5.00
102 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 5.00
103 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
104 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
105 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
106 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 5.00
107 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
108 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
109 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
110 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
111 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04 5.00
112 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 5.00
113 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
114 INT110987 Transcription of ESR1 45 0.71 24.16 6.72 5.00
115 INT5254 Positive_regulation of Pla2g2a 22 0.68 10.42 6.37 5.00
116 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 5.00
117 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37 5.00
118 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34 5.00
119 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
120 INT62570 Binding of Pth 48 0.48 26.45 4.85 5.00
121 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41 5.00
122 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.00
123 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 5.00
124 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 5.00
125 INT72936 Gene_expression of Pparg 39 0.77 19.01 4.02 5.00
126 INT116643 Phosphorylation of Pik3cb 12 0.80 4.73 3.87 5.00
127 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24 5.00
128 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 5.00
129 INT81972 Positive_regulation of Dse 20 0.57 16.5 2.99 5.00
130 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 5.00
131 INT108338 Positive_regulation of Phosphorylation of EPHB2 13 0.67 5.42 2.92 5.00
132 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 5.00
133 INT181818 Gene_expression of Ppargc1a 50 0.78 24.33 2.71 5.00
134 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 5.00
135 INT176892 Binding of MR1 36 0.32 15.55 2.58 5.00
136 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38 5.00
137 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28 5.00
138 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26 5.00
139 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16 5.00
140 INT263046 Negative_regulation of Gene_expression of Mmp2 7 0.34 5.98 2.09 5.00
141 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98 5.00
142 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91 5.00
143 INT30168 Gene_expression of Dnahc8 20 0.65 4.17 1.73 5.00
144 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 5.00
145 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39 5.00
146 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37 5.00
147 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27 5.00
148 INT57425 Binding of MYH14 12 0.11 2.33 1.26 5.00
149 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21 5.00
150 INT127372 Gene_expression of Ager 9 0.57 14.44 0.98 5.00
151 INT215259 Negative_regulation of Siglec1 5 0.14 3.82 0.87 5.00
152 INT191458 Gene_expression of DFNA5 4 0.04 1.52 0.85 5.00
153 INT138559 Positive_regulation of Phosphorylation of RGD1565506 2 0.43 0.81 0.84 5.00
154 INT138558 Phosphorylation of RGD1565506 2 0.50 0.8 0.84 5.00
155 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83 5.00
156 INT196762 Negative_regulation of Adcy5 5 0.39 1.49 0.8 5.00
157 INT65498 Positive_regulation of F7 4 0.11 8.51 0.79 5.00
158 INT73429 Negative_regulation of Atp2a2 20 0.20 9.05 0.74 5.00
159 INT215260 Binding of Siglec1 7 0.35 7.39 0.68 5.00
160 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 5.00
161 INT279499 Negative_regulation of Tnni1 5 0.57 4.35 0.53 5.00
162 INT230238 Binding of Pik3cb 6 0.21 2.27 0.51 5.00
163 INT160254 Positive_regulation of Siglec1 6 0.16 5.58 0.44 5.00
164 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 5.00
165 INT181829 Binding of Ppargc1a 16 0.48 9.61 0.34 5.00
166 INT356392 Negative_regulation of Positive_regulation of Agtr2 1 0.07 1.01 0.32 5.00
167 INT65494 Positive_regulation of Positive_regulation of F7 2 0.08 2.66 0.28 5.00
168 INT73296 Positive_regulation of Myh7 3 0.67 1.05 0.27 5.00
169 INT214006 Negative_regulation of Gene_expression of Dnahc8 2 0.03 1.28 0.24 5.00
170 INT62068 Transcription of Pth 6 0.67 3.2 0.23 5.00
171 INT65003 Negative_regulation of Negative_regulation of Ace 5 0.37 3.45 0.23 5.00
172 INT230830 Negative_regulation of Cacna1g 5 0.42 4.91 0.22 5.00
173 INT39639 Gene_expression of F7 3 0.17 2.64 0.2 5.00
174 INT297875 Negative_regulation of Ppargc1a 1 0.39 0.39 0.19 5.00
175 INT222650 Gene_expression of Col4a2 6 0.19 1.84 0.19 5.00
176 INT178832 Gene_expression of GCOM1 2 0.06 0.43 0.19 5.00
177 INT297877 Phosphorylation of Ppargc1a 1 0.57 0.57 0.17 5.00
178 INT297872 Positive_regulation of Ppargc1a 1 0.42 0.58 0.17 5.00
179 INT356391 Negative_regulation of Gene_expression of Fli1 1 0.09 1.54 0.14 5.00
180 INT191778 Positive_regulation of Gene_expression of F7 2 0.01 2.76 0.14 5.00
181 INT356389 Gene_expression of Fli1 1 0.13 1.53 0.13 5.00
182 INT249970 Transcription of Ace 3 0.36 1.87 0.12 5.00
183 INT339798 Transcription of Ina 1 0.07 0.06 0.11 5.00
184 INT340501 Regulation of Transcription of Ace 1 0.10 0.84 0.1 5.00
185 INT178833 Positive_regulation of Localization of MR1 3 0.14 2.62 0.1 5.00
186 INT340499 Regulation of Tnni1 1 0.02 0.87 0.09 5.00
187 INT132001 Binding of Col4a2 4 0.13 0.64 0.09 5.00
188 INT240826 Negative_regulation of Gene_expression of Ppargc1a 6 0.59 3.09 0.08 5.00
189 INT340500 Negative_regulation of Transcription of Ace 1 0.10 0.78 0.07 5.00
190 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07 5.00
191 INT178831 Positive_regulation of Positive_regulation of MR1 2 0.38 1.37 0.05 5.00
192 INT272219 Negative_regulation of Rabgef1 1 0.09 0.6 0.04 5.00
193 INT297874 Positive_regulation of Lamb3 1 0.67 0.37 0.04 5.00
194 INT297870 Positive_regulation of Col4a3bp 1 0.08 0.38 0.04 5.00
195 INT297873 Gene_expression of Myh6 1 0.19 0.41 0.03 5.00
196 INT211078 Negative_regulation of Transcription of Pth 3 0.41 1.53 0.03 5.00
197 INT181821 Transcription of Ppargc1a 4 0.72 1.57 0 5.00
198 INT297871 Binding of Phospho1 1 0.02 0.19 0 5.00
199 INT260598 Negative_regulation of Transcription of Ppargc1a 1 0.59 0.92 0 5.00
200 INT356388 Positive_regulation of Negative_regulation of Pth 1 0.21 1.91 0 5.00
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