D:Diffuse Cutaneous Leishmaniasis

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Disease Term
Synonyms Cutaneous Leishmaniases Diffuse, CUTANEOUS LEISHMANIASIS DIFFUSE, Diffuse Cutaneous Leishmaniases, LEISHMANIASES DIFFUSE CUTANEOUS
Documents 9
Hot Single Events 37
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diffuse Cutaneous Leishmaniasis. They are ordered first by their relevance to Diffuse Cutaneous Leishmaniasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT341488 Binding of CD8A and TLR2 1 0.08 0.31 0 100.00
2 INT341506 TLR2 Positive_regulation of Negative_regulation of Pdcd1 1 0.01 0.54 0.03 99.20
3 INT341486 Positive_regulation of TLR2 Positive_regulation of CD8A 1 0.11 0.3 0 99.04
4 INT341507 Positive_regulation of TLR2 Negative_regulation of Gene_expression of Pdcd1 1 0.01 0.3 0 98.40
5 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0 97.68
6 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0 90.88
7 INT341503 Binding of Pdcd1 and Pdcd1lg2 1 0.00 0.53 0 90.56
8 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0 90.56
9 INT341485 Binding of CD8A and GZMB 1 0.01 0.7 0 78.16
10 INT199041 AGRP Regulation of IGHE 1 0.00 1.39 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diffuse Cutaneous Leishmaniasis. They are ordered first by their pain relevance and then by number of times they were reported in Diffuse Cutaneous Leishmaniasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 100.00
2 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97 100.00
3 INT276310 Negative_regulation of Gene_expression of Pdcd1 3 0.05 4.18 0.31 100.00
4 INT253925 Positive_regulation of Gene_expression of Pdcd1 5 0.06 5.03 1.08 100.00
5 INT36018 Negative_regulation of Gene_expression of CD8A 12 0.42 6.66 1.85 100.00
6 INT341499 Positive_regulation of Lmr1 1 0.00 2.23 0.03 100.00
7 INT339606 Regulation of Gene_expression of Pdcd1 2 0.05 1.13 0.32 100.00
8 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 99.76
9 INT56151 Positive_regulation of Positive_regulation of CD8A 11 0.34 9.74 0.94 99.76
10 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 99.56
11 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 99.56
12 INT56149 Localization of CD8A 56 0.74 30.41 5.75 99.52
13 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 99.48
14 INT58692 Regulation of Gene_expression of CD8A 11 0.42 10.16 1 99.40
15 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 99.16
16 INT150540 Binding of TLR2 50 0.45 35.86 10.43 99.12
17 INT234218 Localization of Lmr1 1 0.11 1.98 0 99.08
18 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 99.06
19 INT158410 Negative_regulation of Pdcd1 2 0.37 3.73 0.33 98.94
20 INT234219 Gene_expression of Lmr1 1 0.11 1.34 0 98.68
21 INT180531 Positive_regulation of Positive_regulation of TLR2 4 0.32 4.28 0.62 98.56
22 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 98.48
23 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 98.04
24 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 97.68
25 INT191731 Gene_expression of Lmrq1 31 0.43 14.46 0.34 95.96
26 INT341500 Regulation of Binding of TLR2 1 0.12 0.25 0 94.72
27 INT341497 Negative_regulation of Binding of Pdcd1 1 0.03 0.52 0 90.88
28 INT247955 Binding of Pdcd1 5 0.12 4.85 0.4 90.56
29 INT158295 Transcription of CD8A 11 0.53 4.02 0.7 84.64
30 INT186801 Positive_regulation of Binding of TLR2 3 0.42 2.05 0.67 83.60
31 INT135803 Regulation of Gene_expression of Fasl 6 0.36 4.35 1.24 83.36
32 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46 82.96
33 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12 82.96
34 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 81.84
35 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 81.24
36 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 80.32
37 INT28308 Localization of SLC17A5 10 0.73 6.77 0.7 80.32
38 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86 77.88
39 INT341498 Negative_regulation of Gene_expression of Tlr9 1 0.11 0.38 0 77.88
40 INT234217 Regulation of Lmr1 1 0.04 1.24 0 75.44
41 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 50.00
42 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 50.00
43 INT70761 Localization of Atp7a 2 0.06 0.06 0.41 50.00
44 INT38712 Gene_expression of Atp7a 3 0.39 0.77 0.34 50.00
45 INT135643 Binding of Atp7a 2 0.32 0.4 0.19 50.00
46 INT207891 Positive_regulation of Gene_expression of Lmrq1 5 0.28 3.87 0.05 23.16
47 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
48 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
49 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
50 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
51 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
52 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
53 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
54 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
55 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
56 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
57 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
58 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
59 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
60 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 5.00
61 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
62 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
63 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
64 INT104549 Localization of Il18 16 0.78 13.01 4.64 5.00
65 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 5.00
66 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
67 INT102843 Negative_regulation of PDC 5 0.57 4.26 1.82 5.00
68 INT81794 Regulation of AGRP 12 0.39 4.94 0.9 5.00
69 INT188754 Localization of AGRP 15 0.74 8.88 0.6 5.00
70 INT178589 Localization of IL2RA 3 0.68 1.99 0.45 5.00
71 INT189176 Positive_regulation of Localization of TH1L 5 0.23 2.93 0.42 5.00
72 INT119001 Regulation of ACLY 5 0.44 4.83 0.36 5.00
73 INT207897 Positive_regulation of TLR8 3 0.17 2.52 0.33 5.00
74 INT207896 Gene_expression of TLR8 3 0.36 2.82 0.26 5.00
75 INT217052 Localization of Lmrq1 6 0.44 3.36 0.15 5.00
76 INT207888 Negative_regulation of Lmrq1 5 0.11 2.95 0.09 5.00
77 INT191732 Regulation of Lmrq1 7 0.28 3.6 0.08 5.00
78 INT207890 Regulation of Gene_expression of Lmrq1 3 0.28 2.87 0.07 5.00
79 INT207894 Positive_regulation of Lmrq1 4 0.28 2.66 0.05 5.00
80 INT232395 Localization of LYPLA2P1 1 0.05 0 0 5.00
81 INT207893 Gene_expression of Sgpp1 1 0.03 1.36 0 5.00
82 INT207895 Positive_regulation of Gene_expression of Sgpp1 1 0.02 1.47 0 5.00
83 INT310375 Negative_regulation of ND4 1 0.41 0.07 0 5.00
84 INT207889 Regulation of Gene_expression of Sgpp1 1 0.02 1.36 0 5.00
85 INT294152 Binding of Lmrq1 6 0.23 3.93 0 5.00
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