D:Diffuse Idiopathic Skeletal Hyperostosis

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Disease Term
Synonyms Ankylosing Hyperostoses Vertebral, Ankylosing Hyperostosis Vertebral, Disease Forestier, Forestier Disease, Hyperostoses Vertebral Ankylosing, Hyperostosis Vertebral Ankylosing, Vertebral Ankylosing Hyperostoses, Vertebral Ankylosing Hyperostosis
Documents 137
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diffuse Idiopathic Skeletal Hyperostosis. They are ordered first by their relevance to Diffuse Idiopathic Skeletal Hyperostosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 29.68
2 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
3 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
4 INT238036 Binding of ENPP1 and OPLL 1 0.27 0.66 0.12 5.00
5 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09 5.00
6 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 5.00
7 INT238034 Binding of DMD and SNRNP70 1 0.00 1.18 0.04 5.00
8 INT238035 Binding of LEPR and OPLL 1 0.01 0.43 0.03 5.00
9 INT238033 Binding of COL6A1 and OPLL 1 0.13 0.13 0.03 5.00
10 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 5.00
11 INT238032 Binding of SNRNP70 and OPLL 1 0.00 0.13 0.03 5.00
12 INT270776 PTH Regulation of Negative_regulation of DMD 1 0.09 0.3 0.03 5.00
13 INT270780 BPs Positive_regulation of DMD 1 0.02 0 0 5.00
14 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0 5.00
15 INT238031 Binding of COL11A2 and OPLL 1 0.10 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diffuse Idiopathic Skeletal Hyperostosis. They are ordered first by their pain relevance and then by number of times they were reported in Diffuse Idiopathic Skeletal Hyperostosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.72
2 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 99.72
3 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 99.22
4 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46 98.48
5 INT238041 Binding of OPLL 7 0.27 2.95 0.54 98.20
6 INT70936 Localization of OPLL 1 0.51 0.61 0.43 98.20
7 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 95.96
8 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 95.16
9 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 94.32
10 INT15819 Negative_regulation of RBP1 4 0.56 2.58 0.83 90.48
11 INT2544 Localization of PTH 39 0.81 30.55 2.22 89.20
12 INT238050 Negative_regulation of OPLL 1 0.21 0.99 0.21 86.44
13 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 85.76
14 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 77.92
15 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 75.44
16 INT4342 Localization of ALPP 27 0.69 15.19 5.32 75.44
17 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 69.96
18 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 69.68
19 INT67188 Gene_expression of OPLL 10 0.52 4.58 1.12 44.80
20 INT196593 Phosphorylation of CFD 1 0.55 0.84 0.04 41.44
21 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
22 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
23 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
24 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
25 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
26 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
27 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
28 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
29 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
30 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
31 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
32 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
33 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
34 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
35 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
36 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
37 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
38 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
39 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
40 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
41 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
42 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
43 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
44 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
45 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
46 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
47 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
48 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
49 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
50 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
51 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
52 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 5.00
53 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
54 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
55 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 5.00
56 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
57 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
58 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
59 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
60 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
61 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
62 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
63 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
64 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 5.00
65 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
66 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
67 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
68 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
69 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 5.00
70 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
71 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
72 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
73 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
74 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
75 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 5.00
76 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 5.00
77 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
78 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
79 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
80 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
81 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
82 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
83 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
84 INT68444 Gene_expression of CPE 9 0.76 4.6 2.59 5.00
85 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
86 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 5.00
87 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
88 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
89 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
90 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73 5.00
91 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
92 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 5.00
93 INT125980 Binding of CFD 8 0.42 10.96 1.39 5.00
94 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38 5.00
95 INT202200 Positive_regulation of BPs 4 0.24 1.91 1.38 5.00
96 INT114664 Binding of BMP2 12 0.37 6.54 0.91 5.00
97 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
98 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8 5.00
99 INT107601 Positive_regulation of OPLL 2 0.25 1.66 0.72 5.00
100 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
101 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62 5.00
102 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
103 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59 5.00
104 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
105 INT85808 Localization of BMP2 7 0.77 1.94 0.51 5.00
106 INT233436 Localization of BPs 2 0.06 1.48 0.5 5.00
107 INT196594 Localization of CFD 4 0.65 4.36 0.39 5.00
108 INT173940 Positive_regulation of Negative_regulation of DMD 8 0.59 2.97 0.36 5.00
109 INT84945 Transcription of BMP2 5 0.61 1.8 0.36 5.00
110 INT12531 Localization of GANAB 3 0.09 2.79 0.26 5.00
111 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21 5.00
112 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18 5.00
113 INT211066 Negative_regulation of Positive_regulation of DMD 5 0.16 2.56 0.14 5.00
114 INT238048 Positive_regulation of Gene_expression of OPLL 1 0.25 0.07 0.11 5.00
115 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11 5.00
116 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 5.00
117 INT239094 Negative_regulation of Binding of GH1 2 0.34 1.61 0.06 5.00
118 INT144618 Gene_expression of COL11A2 4 0.65 2.57 0.05 5.00
119 INT196595 Regulation of Localization of CFD 1 0.39 2.03 0.04 5.00
120 INT239092 Positive_regulation of Binding of IGFBP1 1 0.04 0.6 0.04 5.00
121 INT231433 Positive_regulation of Binding of IGFBP3 2 0.34 0.6 0.04 5.00
122 INT200458 Positive_regulation of Tha1 3 0.15 0.78 0.03 5.00
123 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0 5.00
124 INT238040 Transcription of OPLL 1 0.34 0.14 0 5.00
125 INT238046 Negative_regulation of Gene_expression of OPLL 1 0.21 0.35 0 5.00
126 INT238043 Regulation of Positive_regulation of OPLL 1 0.22 0.33 0 5.00
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