D:Diffuse Scleroderma

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Disease Term
Synonyms Progressive Scleroderma, PROGRESSIVE SYSTEMIC SCLEROSIS, SCLERODERMA PROGRESSIVE, Sclerosis Progressive Systemic, Systemic Sclerosis Progressive
Documents 100
Hot Single Events 17
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diffuse Scleroderma. They are ordered first by their relevance to Diffuse Scleroderma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
2 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
3 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
4 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
5 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
6 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
7 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
8 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
9 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
10 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
11 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
12 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 5.00
13 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
14 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
15 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
16 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
17 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
18 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
19 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
20 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
21 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
22 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
23 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
24 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
25 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
26 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
27 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
28 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
29 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diffuse Scleroderma. They are ordered first by their pain relevance and then by number of times they were reported in Diffuse Scleroderma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 99.84
2 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9 99.84
3 INT254237 Negative_regulation of trm 1 0.04 0.88 0.06 99.58
4 INT3012 Positive_regulation of trm 2 0.49 0.98 0.2 99.34
5 INT52901 Localization of PLAUR 2 0.49 1.92 0.68 99.06
6 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 97.92
7 INT2774 Binding of Crp 241 0.48 195.89 44.39 91.40
8 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 90.64
9 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 86.88
10 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 85.16
11 INT285484 Negative_regulation of Col10a1 2 0.14 1.32 0.13 85.16
12 INT285491 Negative_regulation of Col12a1 1 0.15 1.08 0.1 85.16
13 INT285502 Negative_regulation of Col8a1 1 0.14 1.08 0.1 85.16
14 INT285505 Negative_regulation of Col5a2 1 0.14 1.08 0.1 85.16
15 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 84.92
16 INT14888 Gene_expression of PSS 9 0.66 6.9 1.65 83.40
17 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 82.72
18 INT181414 Gene_expression of Ccl19 12 0.74 9.8 4.11 78.88
19 INT285485 Negative_regulation of Gene_expression of Ccl19 1 0.07 1.15 0.1 78.88
20 INT285481 Positive_regulation of Gene_expression of Ccl19 1 0.08 1.15 0.1 78.88
21 INT181032 Gene_expression of Fgf7 8 0.61 5.96 1.41 77.92
22 INT285494 Positive_regulation of Gene_expression of Fgf7 2 0.40 1.48 0.13 77.92
23 INT285509 Negative_regulation of Gene_expression of Fgf7 1 0.14 1.14 0.1 77.92
24 INT53590 Gene_expression of PRF1 33 0.58 23.46 10.02 77.48
25 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93 76.88
26 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51 76.88
27 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47 76.88
28 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43 76.88
29 INT28269 Negative_regulation of Adp 18 0.36 5.98 4.74 76.28
30 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54 75.00
31 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 75.00
32 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 75.00
33 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 75.00
34 INT35669 Localization of PSS 2 0.70 1.82 1.4 75.00
35 INT80754 Localization of PRF1 6 0.78 2.78 0.42 75.00
36 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 74.24
37 INT150948 Positive_regulation of Gene_expression of Fgfr1 3 0.15 3.19 0.32 74.24
38 INT285474 Negative_regulation of Gene_expression of Fgfr1 2 0.40 2.15 0.24 74.24
39 INT93144 Gene_expression of CCR1 18 0.75 14.69 6.84 73.68
40 INT171023 Negative_regulation of Gene_expression of CCR1 2 0.37 1.53 0.36 73.68
41 INT285555 Positive_regulation of Gene_expression of CCR1 1 0.16 1.11 0.1 73.68
42 INT75158 Gene_expression of Fgf5 5 0.28 2.12 3.58 72.48
43 INT141565 Gene_expression of Cdt1 7 0.19 2.61 0.39 72.48
44 INT285497 Gene_expression of Traip 1 0.08 1.03 0.11 72.48
45 INT285504 Gene_expression of Cdc7 2 0.44 1.31 0.1 72.48
46 INT204720 Gene_expression of CD53 3 0.09 1.38 0.1 68.00
47 INT266354 Gene_expression of S100A7 9 0.58 7.35 0.75 67.20
48 INT182474 Gene_expression of Cdh5 17 0.57 14.58 1.23 66.56
49 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 66.00
50 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 65.52
51 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 65.04
52 INT285473 Gene_expression of Nid2 1 0.24 2.3 0.19 64.48
53 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 62.20
54 INT136388 Gene_expression of Cxcl5 13 0.75 21.45 2.98 62.20
55 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41 62.20
56 INT285507 Gene_expression of Col5a2 1 0.18 1.12 0.09 61.28
57 INT198613 Localization of ELOVL1 2 0.56 1.84 0.52 50.00
58 INT198614 Phosphorylation of ELOVL1 2 0.11 1.79 0.25 50.00
59 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 48.80
60 INT178483 Gene_expression of Col18a1 12 0.75 11.87 1.03 23.60
61 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54 18.80
62 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 16.68
63 INT46485 Positive_regulation of Pdgfc 3 0.18 2.74 0.92 12.84
64 INT285472 Positive_regulation of Fgfrl1 2 0.28 1.39 0.3 12.84
65 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
66 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
67 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
68 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
69 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
70 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
71 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
72 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
73 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
74 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
75 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
76 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
77 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
78 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
79 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
80 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
81 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
82 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
83 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
84 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
85 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
86 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
87 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
88 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
89 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
90 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
91 INT2463 Localization of CCK 101 0.81 37.54 47.59 5.00
92 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
93 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
94 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
95 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
96 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
97 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
98 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
99 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
100 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 5.00
101 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
102 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
103 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
104 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
105 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
106 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
107 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
108 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
109 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 5.00
110 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
111 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
112 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
113 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 5.00
114 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
115 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
116 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
117 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
118 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
119 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
120 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
121 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
122 INT57257 Gene_expression of IL7 69 0.62 50.24 20.36 5.00
123 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
124 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 5.00
125 INT182031 Gene_expression of Cia1 38 0.24 46.37 19.64 5.00
126 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
127 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
128 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 5.00
129 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
130 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
131 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
132 INT1154 Negative_regulation of CCK 24 0.59 9.3 15.32 5.00
133 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
134 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
135 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
136 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
137 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
138 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
139 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
140 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
141 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
142 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
143 INT176453 Negative_regulation of Cia1 23 0.14 28.27 12.33 5.00
144 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
145 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 5.00
146 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
147 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
148 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
149 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
150 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 5.00
151 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
152 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12 5.00
153 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
154 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 5.00
155 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
156 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 5.00
157 INT131359 Positive_regulation of Gene_expression of Cd4 40 0.58 22.43 7.53 5.00
158 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47 5.00
159 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31 5.00
160 INT67112 Positive_regulation of fc 27 0.58 21.17 7.2 5.00
161 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9 5.00
162 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
163 INT186623 Negative_regulation of Mag 13 0.42 12.22 6.48 5.00
164 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
165 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
166 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 5.00
167 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 5.00
168 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11 5.00
169 INT115947 Regulation of Il17a 17 0.37 14.26 5.97 5.00
170 INT947 Regulation of Mln 20 0.59 4.09 5.87 5.00
171 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
172 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
173 INT237051 Gene_expression of Cxcl11 24 0.64 25.74 5.77 5.00
174 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
175 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4 5.00
176 INT170056 Binding of Cxcl10 11 0.45 12.72 5.32 5.00
177 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 5.00
178 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15 5.00
179 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07 5.00
180 INT161220 Binding of Ccl2 17 0.46 17.63 4.94 5.00
181 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83 5.00
182 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
183 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
184 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
185 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
186 INT91333 Gene_expression of CXCL11 11 0.65 10.96 4.1 5.00
187 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 5.00
188 INT99778 Localization of Cxcl10 12 0.75 14.24 3.91 5.00
189 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
190 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 5.00
191 INT135408 Transcription of Il17a 8 0.64 10.7 3.39 5.00
192 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
193 INT2883 Negative_regulation of Localization of CCK 9 0.59 3.25 3.08 5.00
194 INT97599 Gene_expression of Il20 4 0.23 5.11 2.98 5.00
195 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98 5.00
196 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84 5.00
197 INT241437 Negative_regulation of OMG 3 0.42 3.21 2.48 5.00
198 INT174481 Positive_regulation of Gene_expression of IL7 9 0.56 6.19 2.46 5.00
199 INT170053 Binding of Cxcl9 5 0.46 6.34 2.43 5.00
200 INT177455 Binding of Cia1 4 0.11 6.76 2.24 5.00
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