D:Discitis

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Disease Term
Synonyms Discitides, Diskitides, Diskitis, Spondylodiscitides, Spondylodiscitis, Spondylodiskitides, Spondylodiskitis
Documents 465
Hot Single Events 25
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Discitis. They are ordered first by their relevance to Discitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5 5.00
2 INT172082 TNF Regulation of SFTPA1 1 0.05 0.85 0.5 5.00
3 INT172083 TNF Regulation of Regulation of IFNA1 1 0.03 0.91 0.22 5.00
4 INT220305 Binding of IL6 and IL10 1 0.00 0.51 0.14 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Discitis. They are ordered first by their pain relevance and then by number of times they were reported in Discitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT75230 Transcription of Crp 4 0.55 3.15 1.57 99.72
2 INT105610 Positive_regulation of Transcription of Crp 1 0.40 0.67 0.19 99.72
3 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.02
4 INT22454 Regulation of Crp 213 0.62 160.67 49.24 98.44
5 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 97.92
6 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 97.92
7 INT102178 Gene_expression of CD97 10 0.73 6.68 1.7 97.88
8 INT22738 Negative_regulation of DYNLL1 17 0.57 6.68 2.06 97.76
9 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 97.04
10 INT117754 Gene_expression of NHS 34 0.57 9.27 3.28 95.32
11 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 95.12
12 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 91.84
13 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 91.84
14 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 91.76
15 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46 91.68
16 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 91.24
17 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 90.44
18 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 87.36
19 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 86.80
20 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 86.80
21 INT9660 Regulation of TNF 363 0.62 312.94 139.99 85.60
22 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 84.76
23 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 82.64
24 INT251459 Binding of Ie 18 0.20 6.62 0.75 82.32
25 INT2065 Binding of BTG3 15 0.36 10.9 4.65 82.16
26 INT51757 Gene_expression of COBRA1 4 0.51 2.71 0.75 79.92
27 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 78.08
28 INT218795 Regulation of VCF 2 0.43 1.49 0.33 77.08
29 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 75.76
30 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 75.00
31 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 74.92
32 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 72.72
33 INT242028 Negative_regulation of Negative_regulation of CRP 3 0.43 2.39 0.24 72.24
34 INT31541 Regulation of Esr1 15 0.54 4.12 2.82 70.44
35 INT8511 Localization of Esr1 6 0.80 3.27 1.26 70.44
36 INT253882 Positive_regulation of Localization of Esr1 1 0.30 1.21 0.06 70.44
37 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 70.40
38 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 67.44
39 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 63.44
40 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 63.04
41 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 62.40
42 INT217429 Positive_regulation of SLC9A6 22 0.38 42.17 0.67 62.32
43 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 56.88
44 INT218794 Protein_catabolism of VCF 1 0.53 0.91 0.14 55.52
45 INT192587 Negative_regulation of Protein_catabolism of GOPC 4 0.22 1.15 0.41 55.04
46 INT9664 Binding of LBP 127 0.48 94.9 63.42 54.88
47 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 53.28
48 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 53.16
49 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 52.96
50 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 51.60
51 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 50.00
52 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 50.00
53 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 50.00
54 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 50.00
55 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 50.00
56 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 50.00
57 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 50.00
58 INT4891 Transcription of Calca 81 0.72 35.27 53.75 50.00
59 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 50.00
60 INT23122 Gene_expression of Ptger3 31 0.72 11.94 11.37 50.00
61 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86 50.00
62 INT2828 Positive_regulation of Ptger3 26 0.68 8.01 9.63 50.00
63 INT141349 Positive_regulation of Gene_expression of CSRP1 1 0.49 0 0 50.00
64 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 43.08
65 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 42.32
66 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 41.36
67 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 21.52
68 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 18.36
69 INT350378 Localization of Lrba 1 0.64 1.09 0.29 12.04
70 INT350379 Positive_regulation of Lrba 1 0.40 1.09 0.29 12.04
71 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 9.44
72 INT35103 Positive_regulation of Positive_regulation of SLC17A5 5 0.12 7.51 1.25 9.44
73 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 6.88
74 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.12
75 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
76 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
77 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
78 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
79 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
80 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
81 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
82 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
83 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
84 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
85 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
86 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
87 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
88 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
89 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
90 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
91 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
92 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
93 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
94 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
95 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
96 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
97 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
98 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
99 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
100 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
101 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
102 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
103 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
104 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
105 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
106 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
107 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
108 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
109 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
110 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
111 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
112 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
113 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
114 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
115 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 5.00
116 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
117 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
118 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 5.00
119 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
120 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
121 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
122 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
123 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
124 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
125 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
126 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 5.00
127 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
128 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
129 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
130 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
131 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
132 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
133 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
134 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
135 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 5.00
136 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 5.00
137 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
138 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
139 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 5.00
140 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
141 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2 5.00
142 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
143 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 5.00
144 INT168399 Localization of Cnr2 12 0.81 4.37 6.77 5.00
145 INT127023 Negative_regulation of Gene_expression of Vcam1 24 0.59 20.39 6.28 5.00
146 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 5.00
147 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
148 INT13607 Binding of Ack 11 0.36 5.77 6.01 5.00
149 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 5.00
150 INT54602 Regulation of MCS 22 0.24 10.41 5.75 5.00
151 INT26069 Positive_regulation of Positive_regulation of IFNA1 26 0.50 16.61 4.76 5.00
152 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
153 INT189842 Negative_regulation of Gene_expression of Cnr2 8 0.59 4.21 4.67 5.00
154 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 5.00
155 INT11107 Binding of Lbp 12 0.42 4.42 3.41 5.00
156 INT194661 Binding of CCL5 9 0.46 6.07 2.73 5.00
157 INT203154 Positive_regulation of Gene_expression of Lts1 6 0.17 3.68 2.67 5.00
158 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 5.00
159 INT172078 Localization of Cd3e 22 0.37 9.88 2.27 5.00
160 INT53434 Positive_regulation of T 7 0.07 3.67 2.09 5.00
161 INT185888 Gene_expression of RPSA 6 0.52 4.98 2 5.00
162 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
163 INT2519 Negative_regulation of VCF 7 0.43 5.27 1.79 5.00
164 INT351303 Regulation of Binding of Cnr2 1 0.10 0.66 1.39 5.00
165 INT351302 Regulation of Regulation of Cnr1 1 0.10 0.78 1.39 5.00
166 INT70067 Regulation of KNCN 2 0.07 1.71 1.17 5.00
167 INT23524 Positive_regulation of VCF 7 0.57 4.25 1.16 5.00
168 INT92288 Binding of Igfals 3 0.13 3.14 1 5.00
169 INT134341 Negative_regulation of CD55 12 0.58 10.06 0.95 5.00
170 INT127847 Binding of RPSA 4 0.30 1.46 0.81 5.00
171 INT15783 Regulation of SMS 6 0.23 3.2 0.75 5.00
172 INT298429 Gene_expression of CCL22 3 0.32 2.08 0.74 5.00
173 INT270304 Localization of FMOD 3 0.15 2.15 0.73 5.00
174 INT164975 Binding of ELN 6 0.35 6.38 0.64 5.00
175 INT161549 Negative_regulation of TDRD6 2 0.17 1.08 0.58 5.00
176 INT172077 Positive_regulation of Localization of Cd3e 3 0.09 3.18 0.47 5.00
177 INT319438 Binding of CCL22 2 0.22 2.2 0.37 5.00
178 INT211045 Positive_regulation of CD6 1 0.49 0.56 0.26 5.00
179 INT183473 Negative_regulation of SMS 3 0.35 2.14 0.2 5.00
180 INT247410 Binding of TDRD6 11 0.15 9.41 0.17 5.00
181 INT344944 Positive_regulation of TDRD6 1 0.20 0.64 0.14 5.00
182 INT322377 Binding of CCL17 1 0.17 1.13 0.12 5.00
183 INT344943 Regulation of TDRD6 1 0.18 0.16 0.08 5.00
184 INT208648 Positive_regulation of NCBP2 1 0.10 1.39 0.05 5.00
185 INT247411 Gene_expression of TDRD6 6 0.27 3.2 0.05 5.00
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