D:Discoid Lupus Erythematosus

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Disease Term
Synonyms Cdle Chronic Discoid Lupus Erythematosus, CHRONIC CUTANEOUS LUPUS ERYTHEMATOSUS, Chronic Discoid Lupus Erythematosus, CUTANEOUS LUPUS ERYTHEMATOSUS, Dle Discoid Lupus Erythematosus, Le Discoid Lupus Erythematosus Lupus, Lupus Discoid, Lupus Erythematosis Discoid, LUPUS ERYTHEMATOSUS CHRONIC CUTANEOUS, LUPUS ERYTHEMATOSUS CUTANEOUS CHRONIC, Lupus Erythematosus Discoid
Documents 48
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Discoid Lupus Erythematosus. They are ordered first by their relevance to Discoid Lupus Erythematosus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25 35.52
2 INT231796 Binding of Fcr and Sle1 1 0.01 1.62 0.33 34.16
3 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
4 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
5 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
6 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
7 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
8 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
9 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
10 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
11 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
12 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Discoid Lupus Erythematosus. They are ordered first by their pain relevance and then by number of times they were reported in Discoid Lupus Erythematosus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.36
2 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 96.60
3 INT119230 Negative_regulation of Htt 5 0.42 2.99 0.5 92.84
4 INT6481 Binding of TNF 624 0.48 510.2 214.82 91.68
5 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 91.36
6 INT19637 Localization of TF 14 0.73 5.74 0.86 90.96
7 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 84.84
8 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 82.80
9 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 61.64
10 INT6852 Localization of TNF 883 0.81 705.95 270.84 54.40
11 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 54.08
12 INT183979 Localization of PSIP1 2 0.73 1.37 0.59 54.08
13 INT231794 Binding of Fcr 4 0.07 3.08 1.07 34.16
14 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 23.40
15 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 22.00
16 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.72
17 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
18 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
19 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
20 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
21 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
22 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
23 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
24 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
25 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
26 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
27 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
28 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
29 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
30 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
31 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 5.00
32 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
33 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
34 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
35 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
36 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
37 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
38 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
39 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
40 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
41 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 5.00
42 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
43 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
44 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
45 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
46 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
47 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
48 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
49 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
50 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
51 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
52 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
53 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
54 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
55 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
56 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
57 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
58 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
59 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
60 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
61 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
62 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
63 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
64 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
65 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
66 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
67 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
68 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
69 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
70 INT8065 Binding of AGT 54 0.48 20.54 10.85 5.00
71 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
72 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
73 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
74 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
75 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
76 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
77 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
78 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
79 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
80 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
81 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
82 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
83 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
84 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
85 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
86 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 5.00
87 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 5.00
88 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
89 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
90 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
91 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
92 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
93 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43 5.00
94 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
95 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 5.00
96 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
97 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
98 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
99 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39 5.00
100 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39 5.00
101 INT125282 Negative_regulation of Positive_regulation of NR3C1 3 0.57 0.54 4.31 5.00
102 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
103 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16 5.00
104 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96 5.00
105 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 5.00
106 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 5.00
107 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 5.00
108 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76 5.00
109 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53 5.00
110 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
111 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
112 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
113 INT68675 Regulation of APCS 10 0.62 7.61 3.01 5.00
114 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 5.00
115 INT41545 Negative_regulation of APRT 8 0.57 2.99 2.88 5.00
116 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 5.00
117 INT113149 Gene_expression of Tmprss11d 15 0.75 8.51 2.72 5.00
118 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71 5.00
119 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
120 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
121 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27 5.00
122 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 5.00
123 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
124 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13 5.00
125 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94 5.00
126 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
127 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
128 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 5.00
129 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54 5.00
130 INT258051 Negative_regulation of Protein_catabolism of ABAT 3 0.04 1.86 1.52 5.00
131 INT108556 Negative_regulation of BCL2L10 8 0.32 7.77 1.49 5.00
132 INT258048 Regulation of TBK1 4 0.05 3.81 1.44 5.00
133 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 5.00
134 INT130998 Regulation of PRKAB1 11 0.45 5.7 1.33 5.00
135 INT187154 Regulation of SLEB1 5 0.03 6.59 1.32 5.00
136 INT128176 Regulation of RHOA 13 0.44 4.35 1.26 5.00
137 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23 5.00
138 INT45553 Negative_regulation of PCK1 3 0.43 0.73 1.17 5.00
139 INT187161 Binding of SLEB1 9 0.05 11.8 1.09 5.00
140 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02 5.00
141 INT231793 Negative_regulation of Il27ra 4 0.08 3.04 0.98 5.00
142 INT56972 Regulation of ANGPT2 6 0.44 3.48 0.86 5.00
143 INT194936 Negative_regulation of SLEB1 6 0.05 5.02 0.82 5.00
144 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 5.00
145 INT202683 Localization of FAS 6 0.73 5.86 0.8 5.00
146 INT130599 Negative_regulation of PAICS 4 0.30 2.33 0.7 5.00
147 INT37544 Binding of ANGPT2 9 0.19 6.51 0.69 5.00
148 INT102174 Gene_expression of FASN 11 0.65 6.4 0.67 5.00
149 INT62868 Gene_expression of Ifna 15 0.67 5.37 0.51 5.00
150 INT158829 Negative_regulation of FAS 5 0.41 4.12 0.48 5.00
151 INT211306 Localization of Trav6-3 6 0.21 1.79 0.43 5.00
152 INT212415 Positive_regulation of Positive_regulation of PRKAB1 4 0.36 2.63 0.37 5.00
153 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35 5.00
154 INT130999 Localization of PRKAB1 5 0.57 4.1 0.35 5.00
155 INT258059 Negative_regulation of Positive_regulation of GSR 3 0.41 1.79 0.33 5.00
156 INT258082 Negative_regulation of ABCC3 1 0.07 0.43 0.31 5.00
157 INT258080 Positive_regulation of Negative_regulation of ABCC3 1 0.06 0.44 0.31 5.00
158 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29 5.00
159 INT258074 Negative_regulation of HDLBP 2 0.06 2.76 0.28 5.00
160 INT197016 Positive_regulation of Gene_expression of LDLR 13 0.50 5.82 0.24 5.00
161 INT204183 Negative_regulation of Negative_regulation of CD4 3 0.30 1.79 0.22 5.00
162 INT50340 Negative_regulation of Ifna 5 0.57 2.54 0.2 5.00
163 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19 5.00
164 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15 5.00
165 INT258046 Binding of DUT 1 0.01 0.63 0.15 5.00
166 INT258072 Binding of RERE 2 0.07 1.14 0.15 5.00
167 INT211384 Negative_regulation of FASN 2 0.41 1.19 0.14 5.00
168 INT189633 Regulation of STK11 3 0.41 3.57 0.14 5.00
169 INT243793 Phosphorylation of PIK3CD 5 0.42 1.74 0.13 5.00
170 INT258077 Negative_regulation of Gene_expression of DNMT1 2 0.30 1.27 0.12 5.00
171 INT258071 Positive_regulation of Negative_regulation of APRT 1 0.02 1.19 0.11 5.00
172 INT258063 Negative_regulation of DNMT1 3 0.28 1.36 0.11 5.00
173 INT350125 Negative_regulation of Gene_expression of Ifna 1 0.41 0.49 0.1 5.00
174 INT258050 Regulation of Positive_regulation of PRKAB1 1 0.08 1.05 0.09 5.00
175 INT152262 Positive_regulation of FASN 3 0.32 1.22 0.09 5.00
176 INT258011 Positive_regulation of Transcription of Rassf1 1 0.45 0.51 0.06 5.00
177 INT258010 Transcription of Rassf1 1 0.69 0.51 0.06 5.00
178 INT258065 Protein_catabolism of ANGPT1 1 0.01 0.47 0.04 5.00
179 INT258058 Phosphorylation of TGFB2 1 0.08 0.89 0.04 5.00
180 INT258044 Regulation of BCL2L10 3 0.34 2.26 0.04 5.00
181 INT176033 Positive_regulation of HMGCR 8 0.33 2.56 0.03 5.00
182 INT258045 Positive_regulation of Regulation of BCL2 2 0.36 1.78 0.03 5.00
183 INT258075 Regulation of Negative_regulation of DNAH8 2 0.17 1.78 0 5.00
184 INT258049 Phosphorylation of TBC1D4 2 0.01 1.02 0 5.00
185 INT258060 Positive_regulation of Protein_catabolism of E2F1 1 0.08 0.52 0 5.00
186 INT203874 Positive_regulation of Gene_expression of GSTP1 3 0.49 1.91 0 5.00
187 INT258047 Negative_regulation of Protein_catabolism of E2F1 1 0.07 0.52 0 5.00
188 INT258076 Regulation of Gene_expression of GANAB 1 0.00 1.19 0 5.00
189 INT258073 Negative_regulation of Negative_regulation of BCL2L10 1 0.07 1.35 0 5.00
190 INT258057 Gene_expression of MARCKSL1 1 0.08 3.7 0 5.00
191 INT258056 Positive_regulation of GRK1 1 0.02 0.05 0 5.00
192 INT258070 Positive_regulation of Regulation of HMGCR 1 0.10 0.44 0 5.00
193 INT258062 Protein_catabolism of E2F1 1 0.11 1.05 0 5.00
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