D:Disease Susceptibility

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Disease Term
Synonyms DIATHESES, Diathesis, Disease Susceptibilities, Susceptibilities Disease, Susceptibility Disease
Documents 367
Hot Single Events 154
Hot Interactions 16

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Disease Susceptibility. They are ordered first by their relevance to Disease Susceptibility and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262643 Binding of HLA-DQB1 and HLA-DRB1 1 0.10 0.45 0.05 98.24
2 INT333636 Rai1 Negative_regulation of Gene_expression of IFNA1 1 0.05 1.16 0.03 97.04
3 INT333631 Thse Negative_regulation of Gene_expression of IFNA1 1 0.00 1.15 0.03 97.04
4 INT48848 Binding of HLA-B and HLA-E 3 0.34 1.95 0.45 92.96
5 INT177977 RUNX1 Regulation of CSF1R 1 0.14 1 0.27 91.80
6 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58 91.04
7 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58 91.04
8 INT333633 Thse Positive_regulation of Transcription of IRF3 1 0.00 1.13 0.03 90.08
9 INT177981 Binding of RUNX1 and SLC22A4 1 0.08 1.04 0.5 87.92
10 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61 87.68
11 INT350145 Binding of SNRNP70 and ERAL1 1 0.05 1.29 0.28 87.60
12 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26 87.28
13 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05 85.60
14 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05 85.60
15 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05 85.60
16 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05 85.60
17 INT268331 Binding of SNRNP70 and CHD7 1 0.01 1.91 0 79.92
18 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11 79.64
19 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11 79.64
20 INT329961 Binding of IL2RA and PTPN22 1 0.35 1.87 0.63 78.88
21 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64 77.24
22 INT129236 Pgis1 Regulation of Pgis2 1 0.29 1.42 0.35 75.00
23 INT129235 Pgis1 Regulation of Regulation of Pgis2 1 0.29 1.42 0.35 75.00
24 INT296786 Gopc Regulation of Positive_regulation of Il1 1 0.02 1.37 0.77 74.48
25 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77 74.48
26 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77 74.08
27 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77 74.08
28 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76 74.08
29 INT295617 UBXN11 Negative_regulation of SPTLC1 1 0.03 0.57 0 72.64
30 INT171874 Binding of SQLE and MRAP 1 0.00 1.29 0.35 68.88
31 INT350146 Binding of IL12A and RS1 1 0.01 0.97 0.23 68.08
32 INT262905 Binding of IL10 and MDD1 1 0.40 1.03 0.19 61.96
33 INT295616 ACACB Regulation of INS 1 0.02 0.6 0 59.40
34 INT177982 Binding of RUNX1 and SNRNP70 1 0.01 0.89 0.21 58.40
35 INT159710 Binding of Tap1 and ERAP1 1 0.04 0.11 0 56.36
36 INT44021 Binding of Cd86 and Klk1b27 1 0.04 0.23 0 55.28
37 INT329956 Binding of IL2 and IL23R 1 0.33 4.58 1.21 50.00
38 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06 50.00
39 INT329959 Binding of TRAF1 and HEPACAM 1 0.03 2.25 1.06 50.00
40 INT329957 Binding of STAT4 and HEPACAM 1 0.03 1.41 0.7 50.00
41 INT329963 Binding of IL21 and IL23R 1 0.30 2.28 0.6 50.00
42 INT350147 Binding of LPP and SH2B3 1 0.36 1.82 0.55 50.00
43 INT350144 Binding of LPP and NAA25 1 0.25 1.83 0.55 50.00
44 INT350150 Binding of LPP and ATXN2 1 0.35 1.82 0.54 50.00
45 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42 50.00
46 INT329958 Binding of C5 and STAT4 1 0.33 0.93 0.41 50.00
47 INT329955 Binding of STAT4 and TRAF1 1 0.38 0.93 0.4 50.00
48 INT329954 Binding of PRKCQ and SNRNP70 1 0.07 0.65 0.33 50.00
49 INT350151 Binding of SNRNP70 and SH2B3 1 0.13 1.22 0.2 50.00
50 INT350152 Binding of ATXN2 and SNRNP70 1 0.13 1.22 0.2 50.00
51 INT350149 SH2B3 Regulation of CD8A 1 0.13 0.86 0.17 50.00
52 INT271510 Binding of Glrb and rs 1 0.00 0.26 0.05 46.56
53 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09 44.00
54 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07 38.96
55 INT239041 Binding of Sqle and Gtf3a 1 0.00 1.08 0.27 36.48
56 INT177978 Binding of CSF1R and SNRNP70 1 0.02 1.49 0.28 35.76
57 INT122096 Binding of HLA-B and SFTPA1 2 0.04 1.81 0.6 31.52
58 INT349290 Binding of HLA-B and SPATA19 1 0.00 1.25 0.4 31.52
59 INT262636 Binding of HLA-DRB1 and AICDA 1 0.09 1.35 0.06 30.32
60 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06 30.12
61 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2 29.92
62 INT231116 Ros1 Positive_regulation of Protein_catabolism of Psmb8 1 0.00 1.14 0 28.08
63 INT349289 Binding of SPATA19 and SFTPA1 1 0.03 1.2 0.4 26.24
64 INT44023 Binding of Cyp27b1 and Klk1b27 1 0.00 0.1 0 25.00
65 INT44025 Binding of Cd86 and Cyp27b1 1 0.02 0.1 0 25.00
66 INT44026 Binding of Cd86 and IgG2a 1 0.29 0.09 0 25.00
67 INT44024 Binding of Klk1b27 and IgG2a 1 0.06 0.09 0 25.00
68 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48 20.92
69 INT271513 Binding of Glrb and Spha2 1 0.16 0.18 0.13 19.92
70 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11 15.08
71 INT262641 Binding of HLA-DRA and AICDA 1 0.04 0.53 0 7.04
72 INT262635 Binding of HLA-DQA1 and HLA-DRA 1 0.05 0.53 0 6.32
73 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
74 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
75 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
76 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
77 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 5.00
78 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
79 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
80 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
81 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
82 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
83 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31 5.00
84 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27 5.00
85 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26 5.00
86 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
87 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
88 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
89 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11 5.00
90 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06 5.00
91 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05 5.00
92 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05 5.00
93 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99 5.00
94 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94 5.00
95 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
96 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9 5.00
97 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
98 INT271511 Binding of Phb2 and Glrb 1 0.04 1.7 0.84 5.00
99 INT256045 Binding of BDNF and Ntrk1 3 0.34 0.65 0.83 5.00
100 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82 5.00
101 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
102 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78 5.00
103 INT242626 Binding of Ngf and Ntrk3 3 0.15 0.27 0.77 5.00
104 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76 5.00
105 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
106 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67 5.00
107 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
108 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65 5.00
109 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65 5.00
110 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65 5.00
111 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65 5.00
112 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64 5.00
113 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64 5.00
114 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
115 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 5.00
116 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55 5.00
117 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54 5.00
118 INT355878 Il17a Regulation of Eae1 1 0.06 1.52 0.54 5.00
119 INT355880 Il17a Regulation of Abi3 1 0.00 1.52 0.54 5.00
120 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53 5.00
121 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5 5.00
122 INT288376 IL17A Regulation of VEGFA 1 0.00 1.16 0.49 5.00
123 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49 5.00
124 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49 5.00
125 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45 5.00
126 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45 5.00
127 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44 5.00
128 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43 5.00
129 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43 5.00
130 INT270043 Binding of Ldlr and Hdl1 1 0.01 2.3 0.43 5.00
131 INT239042 Il17a Negative_regulation of Gene_expression of Il6 1 0.03 0.82 0.42 5.00
132 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42 5.00
133 INT350693 Mir326 Positive_regulation of Regulation of thd 1 0.00 1.32 0.41 5.00
134 INT350698 Mir326 Regulation of Ets1 1 0.01 1.27 0.4 5.00
135 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
136 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
137 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38 5.00
138 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
139 INT176009 Binding of GRHPR and ZNF677 1 0.00 0.57 0.36 5.00
140 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
141 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
142 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35 5.00
143 INT355539 Gnptg Positive_regulation of Mmp23 1 0.00 1.18 0.35 5.00
144 INT268225 TBXA2R Positive_regulation of NAAA 1 0.07 0.98 0.35 5.00
145 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35 5.00
146 INT268224 TBXA2R Positive_regulation of Gene_expression of NAAA 1 0.08 0.98 0.35 5.00
147 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
148 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33 5.00
149 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
150 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
151 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
152 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
153 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33 5.00
154 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
155 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
156 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31 5.00
157 INT288203 Binding of Cd14 and Mapk14 1 0.08 0.63 0.31 5.00
158 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31 5.00
159 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 5.00
160 INT216043 Binding of Rtn4r and Lingo1 1 0.15 0.82 0.3 5.00
161 INT288205 Binding of Cd14 and Myd88 1 0.10 0.57 0.28 5.00
162 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28 5.00
163 INT316791 Binding of HLA-DRB1 and Traf1 1 0.01 0.96 0.27 5.00
164 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
165 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27 5.00
166 INT216040 Binding of Comt and Prodh 1 0.30 1.71 0.26 5.00
167 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26 5.00
168 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24 5.00
169 INT335462 IGHE Regulation of Positive_regulation of PRKCA 1 0.07 0 0.23 5.00
170 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23 5.00
171 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23 5.00
172 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22 5.00
173 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22 5.00
174 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22 5.00
175 INT280490 Binding of Bdnf and Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.15 0.94 0.22 5.00
176 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22 5.00
177 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22 5.00
178 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22 5.00
179 INT280491 Binding of BDNF and Ntf4 1 0.01 0.14 0.2 5.00
180 INT216041 Binding of Tnfrsf1b and Rtn4r 1 0.10 0.75 0.2 5.00
181 INT280474 Binding of Ngf and Ntf4 1 0.00 0.13 0.2 5.00
182 INT280494 Binding of BDNF and Bdnf 1 0.39 0.21 0.2 5.00
183 INT280473 Binding of Ntrk1 and Ntf4 1 0.00 0.13 0.2 5.00
184 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19 5.00
185 INT273658 Dss1 Positive_regulation of Mpo 1 0.16 0.98 0.19 5.00
186 INT280485 Ntrk2 Positive_regulation of Localization of Bdnf 1 0.55 0.45 0.19 5.00
187 INT223477 Binding of Ntrk1 and Ntrk3 2 0.16 0.3 0.19 5.00
188 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18 5.00
189 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18 5.00
190 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18 5.00
191 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18 5.00
192 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18 5.00
193 INT350702 Rc3h1 Positive_regulation of Protein_catabolism of Icos 1 0.35 1.56 0.18 5.00
194 INT355882 TNF Positive_regulation of Gene_expression of Il12b 1 0.03 0.21 0.18 5.00
195 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17 5.00
196 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16 5.00
197 INT350717 MIR219-1 Negative_regulation of Zfp238 1 0.01 0.4 0.16 5.00
198 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16 5.00
199 INT216042 Binding of Rtn4r and Gtf3a 1 0.01 0.41 0.15 5.00
200 INT350719 MIR219-1 Negative_regulation of Foxj3 1 0.01 0.4 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Disease Susceptibility. They are ordered first by their pain relevance and then by number of times they were reported in Disease Susceptibility. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 100.00
2 INT182667 Binding of DLAT 11 0.31 40.75 2.8 100.00
3 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68 100.00
4 INT259691 Gene_expression of PRCD 1 0.02 1.13 0 99.84
5 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 99.76
6 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 99.66
7 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 99.56
8 INT44016 Binding of Cyp27b1 3 0.10 0.53 0.59 99.44
9 INT159709 Binding of ERAP1 12 0.47 3.42 2.91 99.36
10 INT44020 Binding of Ifi27l2b 1 0.06 0.25 0.1 99.32
11 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74 99.26
12 INT636 Binding of MRAP 54 0.48 40.36 18.77 99.12
13 INT177998 Binding of RUNX1 7 0.35 7.12 2.08 99.08
14 INT177989 Negative_regulation of Binding of RUNX1 1 0.21 0.94 0.25 99.08
15 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 98.92
16 INT44012 Phosphorylation of HLA-B 3 0.81 0.96 0.27 98.92
17 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.80
18 INT333608 Negative_regulation of IRF3 1 0.38 1.92 0.03 98.72
19 INT67162 Gene_expression of HSPA1A 16 0.68 7.13 2.17 98.68
20 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97 98.52
21 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 98.48
22 INT273677 Gene_expression of ACACB 15 0.67 9.36 0 98.44
23 INT58042 Binding of HLA-DQA1 8 0.24 5.03 1.14 98.40
24 INT9995 Localization of C6orf25 13 0.69 6.48 2.29 98.36
25 INT82551 Localization of DDAH2 2 0.68 0.28 0.23 98.36
26 INT82548 Localization of LY6G6D 1 0.50 0.28 0.04 98.36
27 INT82550 Localization of LY6G6C 1 0.49 0.28 0.04 98.36
28 INT82549 Localization of LY6G6E 1 0.50 0.28 0.04 98.36
29 INT138257 Gene_expression of Bp2 2 0.35 1.55 0.1 98.28
30 INT103910 Binding of NOD2 19 0.47 12.24 2.93 98.24
31 INT239016 Binding of Sqle 1 0.01 5.43 1.63 97.72
32 INT3961 Binding of IGKV3-20 2 0.47 1.12 0.65 97.72
33 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 97.52
34 INT23744 Protein_catabolism of Ctrc 8 0.62 1.93 2.19 97.52
35 INT41685 Positive_regulation of Protein_catabolism of Ctrc 2 0.35 0.36 0.69 97.52
36 INT192448 Positive_regulation of Gene_expression of CLTC 5 0.32 3.01 0.33 97.52
37 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 97.20
38 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88 97.08
39 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 97.04
40 INT262634 Binding of Lmx1a 1 0.02 0.74 0.17 97.04
41 INT109881 Positive_regulation of Gene_expression of F8 11 0.47 12.97 1.54 96.96
42 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 96.96
43 INT182334 Binding of Glrb 3 0.28 4.81 1.71 96.84
44 INT218018 Regulation of Gene_expression of GSTK1 5 0.37 2.74 0.11 96.00
45 INT48892 Transcription of Il10 31 0.71 27.26 16.77 95.88
46 INT67397 Transcription of Il4 15 0.54 11.36 6.06 95.88
47 INT118400 Positive_regulation of Transcription of Il4 2 0.35 1.78 1.53 95.88
48 INT90 Localization of Gast 400 0.81 137.67 113 95.36
49 INT177997 Regulation of SLC22A4 2 0.20 3.88 0.86 95.32
50 INT178004 Binding of SLC22A4 2 0.26 2.45 0.77 95.32
51 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 95.28
52 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81 95.08
53 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 95.00
54 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 94.96
55 INT130598 Negative_regulation of Gene_expression of MRAP 1 0.35 0.19 0 94.68
56 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 94.44
57 INT246029 Regulation of IL23R 1 0.21 2.83 0.35 94.32
58 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 94.26
59 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 94.20
60 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 94.20
61 INT91721 Binding of IL18 21 0.48 21.17 6.56 94.16
62 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 94.00
63 INT152433 Binding of CSF1R 6 0.33 10.97 5.54 94.00
64 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 93.60
65 INT246027 Regulation of ATG16L1 1 0.24 2.82 0.35 93.52
66 INT177990 Regulation of RUNX1 1 0.13 1.07 0.51 93.24
67 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74 93.20
68 INT178000 Positive_regulation of Gene_expression of CSF1R 1 0.46 0.85 0.46 93.20
69 INT44019 Gene_expression of Klk1b27 1 0.09 0.6 0.32 92.48
70 INT44014 Gene_expression of Ifi27l2b 1 0.11 0.3 0.16 92.48
71 INT145077 Regulation of SLC22A5 2 0.19 3 1.1 92.40
72 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 92.40
73 INT216035 Binding of Rtn4r 9 0.48 5.21 1.13 92.32
74 INT16969 Negative_regulation of CRS 28 0.37 14.77 3.35 92.28
75 INT129366 Positive_regulation of Bp2 2 0.23 1.75 0.7 91.96
76 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 91.76
77 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8 91.76
78 INT207005 Regulation of Localization of Bdnf 6 0.45 3.85 1.45 91.76
79 INT245544 Localization of Ntrk2 7 0.77 4.52 1.32 91.76
80 INT280469 Regulation of Localization of Ntrk2 1 0.43 1.74 0.14 91.76
81 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 91.60
82 INT162793 Regulation of NOD2 6 0.45 7.61 1.78 91.28
83 INT180335 Positive_regulation of Binding of Uggt1 1 0.17 2.04 0.05 91.20
84 INT180328 Binding of Uggt1 1 0.12 2.03 0.05 91.20
85 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99 91.16
86 INT9784 Binding of B2M 9 0.47 6.18 1.44 91.16
87 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 91.12
88 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 90.96
89 INT84307 Binding of Cftr 31 0.47 26.19 12.8 90.24
90 INT202208 Localization of GSTT1 3 0.74 3.91 0 90.08
91 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 90.08
92 INT333620 Transcription of IRF3 1 0.63 1.12 0.06 90.08
93 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48 89.80
94 INT38967 Positive_regulation of Ctrc 12 0.40 2.55 2.75 89.80
95 INT103378 Binding of Spink1 24 0.40 15.3 6.19 89.76
96 INT290389 Positive_regulation of Binding of CSF1R 1 0.25 1.14 0.4 89.68
97 INT99629 Localization of GSTM1 8 0.80 6.72 0.04 89.60
98 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 89.56
99 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 89.40
100 INT216030 Positive_regulation of Rtn4r 5 0.50 2.78 0.49 89.36
101 INT70820 Binding of CTRC 3 0.42 1.88 1.3 89.12
102 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 88.80
103 INT156825 Binding of Prss2 1 0.05 0.57 0.44 88.64
104 INT262644 Protein_catabolism of HLA-DQA1 1 0.20 0.4 0.03 88.64
105 INT102741 Gene_expression of Atp9b 20 0.75 8.01 3.34 88.36
106 INT219993 Regulation of Gene_expression of Atp9b 1 0.44 2.3 0.96 88.36
107 INT1542 Binding of Prss1 8 0.30 4.25 3.74 88.08
108 INT290656 Positive_regulation of Gene_expression of Tbx21 1 0.08 0.09 0.17 88.00
109 INT260345 Binding of Ncf4 1 0.02 1.93 0.36 87.92
110 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 87.72
111 INT216032 Transcription of Rtn4r 1 0.53 0.81 0 87.52
112 INT290657 Gene_expression of Tbx21 1 0.10 0.09 0.17 87.48
113 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 87.36
114 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 87.12
115 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 86.92
116 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 86.64
117 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07 86.16
118 INT271501 Binding of Tnfsf15 1 0.35 1.13 0.42 86.16
119 INT190208 Positive_regulation of MMRN1 15 0.23 14.1 3.37 86.08
120 INT192449 Binding of CLTC 5 0.23 3.57 0.09 86.08
121 INT227106 Positive_regulation of Tbrg1 1 0.04 0.45 0 85.72
122 INT8157 Binding of Tyr 14 0.09 0.64 5.89 85.48
123 INT354841 Regulation of HLA-DRB3 1 0.01 1.88 0.04 85.36
124 INT10100 Binding of ELANE 22 0.47 15.32 5.19 85.20
125 INT92348 Binding of NPEPPS 3 0.04 2.94 0.71 85.20
126 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 85.16
127 INT90026 Gene_expression of FOXI2 5 0.03 0.98 1.79 85.16
128 INT121818 Binding of STAT3 25 0.47 11.16 3.67 85.04
129 INT121909 Regulation of FAIM3 3 0.22 1.06 2.42 85.04
130 INT262909 Regulation of PIGR 1 0.10 0.97 0.17 84.76
131 INT262910 Regulation of FCAMR 1 0.20 0.97 0.17 84.36
132 INT171612 Gene_expression of Cebpz 5 0.58 2.61 0.62 84.28
133 INT183942 Binding of rs 7 0.02 8.71 0.61 83.96
134 INT177995 Phosphorylation of FOXI2 1 0.01 0.93 0.31 83.60
135 INT29094 Binding of C3 39 0.37 12.65 2.27 83.52
136 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 83.44
137 INT91368 Negative_regulation of Phosphorylation of STAT3 14 0.59 9.22 1.2 83.44
138 INT177994 Negative_regulation of Phosphorylation of CSF1R 1 0.39 1 0.34 83.20
139 INT177999 Phosphorylation of CSF1R 1 0.75 0.99 0.33 83.20
140 INT260465 Positive_regulation of Hk2 2 0.44 2.95 0.04 83.04
141 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 82.16
142 INT180369 Binding of ENAM 6 0.24 8.53 0.08 81.76
143 INT180371 Positive_regulation of Binding of ENAM 1 0.08 1.97 0.05 81.76
144 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 81.44
145 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 81.04
146 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05 81.04
147 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 80.68
148 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 80.68
149 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 80.68
150 INT6507 Binding of C5 23 0.48 15.35 3.91 80.60
151 INT329968 Binding of TRAF1 1 0.45 3.42 1.37 80.60
152 INT138833 Binding of MTHFR 12 0.46 16.08 6.4 80.48
153 INT180357 Positive_regulation of Binding of AIRE 1 0.08 1.96 0.05 80.40
154 INT180355 Binding of AIRE 1 0.06 7.13 0.05 80.40
155 INT268339 Binding of CHD7 1 0.47 2.77 0 79.92
156 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 79.76
157 INT178001 Regulation of Negative_regulation of FOXI2 1 0.00 1.01 0.34 79.56
158 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 79.20
159 INT177996 Negative_regulation of FOXI2 1 0.01 1.01 0.34 79.20
160 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 79.20
161 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 78.96
162 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32 78.96
163 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28 78.96
164 INT157357 Binding of IL2RA 6 0.44 5.18 1.63 78.88
165 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83 78.56
166 INT180361 Positive_regulation of AMELX 7 0.12 6.03 0.76 78.40
167 INT171609 Positive_regulation of Positive_regulation of Cebpz 1 0.43 2.2 0.34 78.36
168 INT231573 Binding of PTPN22 5 0.44 7.94 2.33 78.08
169 INT52509 Positive_regulation of Cebpz 9 0.59 2.63 2.42 77.92
170 INT118343 Positive_regulation of Eae1 121 0.39 136.06 34.87 77.88
171 INT348186 Binding of KIF21B 1 0.31 1.35 0.64 77.80
172 INT285547 Negative_regulation of NTSR2 1 0.23 1.81 0.77 77.32
173 INT285552 Negative_regulation of GLUD1 1 0.14 0.84 0.35 77.32
174 INT153131 Negative_regulation of Vipr1 2 0.16 0.59 0.87 77.20
175 INT137767 Gene_expression of Eae1 74 0.34 89.32 20.48 76.96
176 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 76.88
177 INT163479 Binding of Bdnf 36 0.48 25.77 14.83 76.56
178 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 76.32
179 INT174656 Binding of NCF1 5 0.37 6.46 1.65 76.20
180 INT10019 Binding of CD8A 57 0.36 31.49 10.08 76.04
181 INT159707 Gene_expression of ERAP1 4 0.66 0.69 0 75.84
182 INT78719 Binding of Ucp1 8 0.41 8.93 4.5 75.40
183 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 75.28
184 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 75.20
185 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 75.00
186 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 75.00
187 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 75.00
188 INT9655 Regulation of Il6 98 0.62 70.92 31.95 75.00
189 INT129231 Gene_expression of Ddx41 29 0.63 9.73 1.52 75.00
190 INT124956 Regulation of IgG2a 5 0.34 3.67 1.21 75.00
191 INT350153 Binding of SH2B3 1 0.34 4.41 1.19 75.00
192 INT350157 Binding of ATXN2 1 0.33 3.53 1.02 75.00
193 INT125665 Regulation of Cd14 3 0.38 3.16 0.95 75.00
194 INT47280 Negative_regulation of HLA-DRB4 1 0.15 1.01 0.46 75.00
195 INT129234 Positive_regulation of Pgis1 1 0.35 1.42 0.35 75.00
196 INT129230 Regulation of Pgis2 1 0.46 1.41 0.34 75.00
197 INT129232 Gene_expression of cac 2 0.65 1.58 0.34 75.00
198 INT129233 Gene_expression of Pgis1 1 0.45 1.37 0.34 75.00
199 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 74.64
200 INT69329 Gene_expression of Musd2 3 0.27 2.54 1.15 74.48
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