D:Disorder Of Purine Or Pyrimidine Metabolism

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pChart

Disease Term
Synonyms Adenine Phosphoribosyltransferase Deficiency, Adenosine Deaminase Deficiency, Adenylosuccinase Deficiency, CHOLINE PHOSPHOTRANSFERASE DEFICIENCY, Choreoathetosis Self Mutilation Hyperuricemia Syndrome, Complete Hgprt Deficiency Disease, Deficiency Disease Complete Hgprt, DEFICIENCY DISEASE HYPOXANTHINE PHOSPHORIBOSYL TRANSFERASE, Deficiency Diseases Hypoxanthine Phosphoribosyl Transferase, DIHYDROPYRIMIDASE DEFICIENCY, Dihyrdopyrimidine Dehydrogenase Deficiency
Documents 31
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Disorder Of Purine Or Pyrimidine Metabolism. They are ordered first by their relevance to Disorder Of Purine Or Pyrimidine Metabolism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 5.00
2 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 5.00
3 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 5.00
4 INT249151 Binding of Cfl1 and Was 1 0.01 0.18 0 5.00
5 INT249148 Binding of Was and Racgap1 1 0.03 0.18 0 5.00
6 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 5.00
7 INT249149 Binding of Cdc42 and Was 1 0.08 0.18 0 5.00
8 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 5.00
9 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 5.00
10 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Disorder Of Purine Or Pyrimidine Metabolism. They are ordered first by their pain relevance and then by number of times they were reported in Disorder Of Purine Or Pyrimidine Metabolism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT24800 Negative_regulation of AMPD1 44 0.59 21.19 6.76 100.00
2 INT58908 Positive_regulation of Negative_regulation of AMPD1 2 0.44 0.86 0.17 100.00
3 INT1189 Gene_expression of AMPD1 7 0.59 4.1 0.9 100.00
4 INT4664 Positive_regulation of Ampd1 3 0.41 0.93 0.37 99.64
5 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 93.12
6 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74 88.92
7 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5 88.84
8 INT184751 Phosphorylation of Dck 2 0.50 1.35 0.38 77.56
9 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92 75.48
10 INT47069 Localization of AMPD1 1 0.75 0.84 0 75.00
11 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13 69.84
12 INT69768 Negative_regulation of Pscs 7 0.51 4.76 2.82 63.24
13 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 56.84
14 INT249135 Gene_expression of Was 1 0.76 4.18 0.04 37.28
15 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 34.36
16 INT223031 Negative_regulation of Gene_expression of HPRT1 1 0.43 0.13 0 33.08
17 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 28.52
18 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 11.44
19 INT69769 Positive_regulation of Pscs 61 0.56 39.32 15.93 8.08
20 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
21 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
22 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
23 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
24 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
25 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
26 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
27 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
28 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
29 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
30 INT111992 Gene_expression of Pscs 40 0.76 27.47 10.74 5.00
31 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
32 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
33 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
34 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
35 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.00
36 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
37 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86 5.00
38 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 5.00
39 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
40 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 5.00
41 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26 5.00
42 INT43931 Binding of CFH 49 0.48 31.85 3.96 5.00
43 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 5.00
44 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 5.00
45 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
46 INT20373 Localization of Cd8a 28 0.64 8.22 2.07 5.00
47 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 5.00
48 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43 5.00
49 INT111996 Positive_regulation of Gene_expression of Pscs 8 0.34 4.37 1.42 5.00
50 INT147345 Localization of Dio1 7 0.50 1.72 1.38 5.00
51 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
52 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 5.00
53 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 5.00
54 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24 5.00
55 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04 5.00
56 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 5.00
57 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 5.00
58 INT257447 Binding of TBCE 4 0.08 4.68 0.66 5.00
59 INT29259 Gene_expression of Ifnb1 4 0.65 1.32 0.62 5.00
60 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 5.00
61 INT202940 Binding of AMD1 13 0.41 16.43 0.56 5.00
62 INT109904 Localization of RPE 5 0.73 4.9 0.56 5.00
63 INT29258 Positive_regulation of Gene_expression of Ifnb1 2 0.42 2.16 0.51 5.00
64 INT109903 Positive_regulation of Gene_expression of RPE 3 0.49 0.59 0.46 5.00
65 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 5.00
66 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 5.00
67 INT339593 Gene_expression of FBLN1 2 0.14 3.01 0.24 5.00
68 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
69 INT189564 Binding of TIMP3 4 0.31 2.45 0.17 5.00
70 INT223026 Regulation of XDH 2 0.32 2.38 0.15 5.00
71 INT109930 Positive_regulation of RPE 4 0.49 5.88 0.15 5.00
72 INT237986 Regulation of Gene_expression of Cd8a 3 0.24 0.83 0.1 5.00
73 INT268715 Binding of RPE 3 0.09 2.36 0.09 5.00
74 INT282593 Gene_expression of KLF4 8 0.61 1.09 0.09 5.00
75 INT282591 Positive_regulation of Gene_expression of SOX2 4 0.36 1.07 0.08 5.00
76 INT144322 Regulation of RPE 1 0.24 1.9 0.08 5.00
77 INT186637 Regulation of ABCA4 3 0.37 2.02 0.07 5.00
78 INT233399 Binding of ABCA4 9 0.46 9.49 0.07 5.00
79 INT249134 Localization of Was 1 0.64 0.06 0.05 5.00
80 INT248313 Positive_regulation of Slc22a12 1 0.02 1.55 0.04 5.00
81 INT282606 Positive_regulation of Gene_expression of KLF4 2 0.54 0.8 0.04 5.00
82 INT248314 Negative_regulation of Slc22a12 1 0.01 1.47 0.04 5.00
83 INT249136 Regulation of Was 1 0.38 0.55 0.03 5.00
84 INT249144 Gene_expression of Cd27 3 0.37 0.32 0.03 5.00
85 INT249143 Binding of Was 1 0.32 0.16 0 5.00
86 INT339590 Negative_regulation of Gene_expression of FBLN1 1 0.10 2.61 0 5.00
87 INT339598 Gene_expression of ARMS2 1 0.65 1.03 0 5.00
88 INT274183 Negative_regulation of Gene_expression of ELN 3 0.30 3.29 0 5.00
89 INT339592 Regulation of ARMS2 2 0.26 2.27 0 5.00
90 INT339591 Positive_regulation of Gene_expression of FBLN1 1 0.08 1.31 0 5.00
91 INT339599 Negative_regulation of CFHR3 1 0.33 1.05 0 5.00
92 INT213395 Positive_regulation of Gene_expression of ABCA4 2 0.41 1.22 0 5.00
93 INT249133 Negative_regulation of Was 1 0.42 0.24 0 5.00
94 INT223027 Negative_regulation of PRPSAP1 1 0.01 0.9 0 5.00
95 INT339595 Negative_regulation of RPE65 1 0.34 0.64 0 5.00
96 INT249141 Positive_regulation of Gene_expression of Was 1 0.43 0.08 0 5.00
97 INT339596 Localization of KLF4 1 0.26 0 0 5.00
98 INT249138 Protein_catabolism of Was 1 0.75 0.08 0 5.00
99 INT223028 Negative_regulation of IGKV2OR2-8 1 0.01 0.44 0 5.00
100 INT282585 Localization of POU5F1 3 0.67 0.08 0 5.00
101 INT189570 Positive_regulation of Gene_expression of TIMP3 3 0.44 1.57 0 5.00
102 INT249142 Negative_regulation of Gene_expression of Was 1 0.41 0.05 0 5.00
103 INT223029 Gene_expression of gout 1 0.65 1.08 0 5.00
104 INT339594 Localization of SOX2 2 0.69 0.7 0 5.00
105 INT339597 Gene_expression of RPE65 1 0.54 0.29 0 5.00
106 INT223030 Positive_regulation of Negative_regulation of HPRT1 1 0.46 0.69 0 5.00
107 INT190446 Gene_expression of NR2E3 11 0.10 0.89 0 5.00
108 INT249140 Transcription of Was 1 0.67 0 0 5.00
109 INT249139 Positive_regulation of Was 1 0.43 0.13 0 5.00
110 INT249137 Positive_regulation of Negative_regulation of Was 1 0.49 0.05 0 5.00
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