D:Disorders Of Creatine Metabolism

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Disease Term
Synonyms Creatine Deficiency Syndrome, Creatine Phosphokinase, Creatinine Clearance, Disorder Of Creatine Metabolism
Documents 1239
Hot Single Events 200
Hot Interactions 19

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Disorders Of Creatine Metabolism. They are ordered first by their relevance to Disorders Of Creatine Metabolism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13 100.00
2 INT60051 Ptger1 Positive_regulation of STAB2 1 0.00 0.77 0.68 100.00
3 INT22320 Binding of Cys1 and sch 1 0.02 0.45 0.15 100.00
4 INT3751 Binding of GOT1 and PIK3C2A 1 0.08 0.68 0.12 100.00
5 INT3752 Binding of GOT1 and LDHA 1 0.11 0.68 0.12 100.00
6 INT175992 TNF Positive_regulation of Gene_expression of Cys1 1 0.01 0.34 0.07 100.00
7 INT23585 Binding of KRIT1 and CCR1 1 0.40 0.97 0.19 99.84
8 INT23586 Binding of CALCR and KRIT1 1 0.40 0.97 0.19 99.84
9 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37 99.76
10 INT188964 Binding of AMBP and NAGLU 1 0.01 1.27 0.09 98.32
11 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 98.04
12 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 97.40
13 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 0.21 0.98 0.2 95.56
14 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 0.24 0.49 0.1 95.56
15 INT213392 Binding of SELPLG and XPO1 1 0.02 0.31 0.04 90.64
16 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 0.19 2.36 0.37 84.08
17 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 83.36
18 INT268809 Binding of IFNA2 and PAEP 1 0.01 0.16 0 83.28
19 INT188968 Binding of MT1F and Alb 1 0.00 0.45 0 82.36
20 INT291624 SERPINH1 Regulation of CSTA 1 0.00 0.39 0.09 78.88
21 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0 78.88
22 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0 78.88
23 INT213390 Positive_regulation of Binding of CHKB and SELPLG 1 0.01 0.46 0 76.72
24 INT213393 Binding of CHKB and SELPLG 1 0.01 0.46 0 76.72
25 INT213391 Positive_regulation of Binding of CHKB and XPO1 1 0.04 0.46 0 76.40
26 INT213394 Binding of CHKB and XPO1 1 0.03 0.46 0 76.40
27 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04 75.20
28 INT210593 TNFRSF11B Negative_regulation of Binding of TNFSF11 and TNFRSF11A 2 0.10 1.62 0.04 75.20
29 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06 74.76
30 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06 74.76
31 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06 74.76
32 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06 74.76
33 INT2194 HIST2H2BD Regulation of REN 1 0.00 0.07 0.09 72.80
34 INT291621 RAPGEF5 Regulation of CSTA 1 0.04 0.43 0.03 67.84
35 INT324344 Positive_regulation of UMOD Regulation of Scr 1 0.24 0.29 0 66.28
36 INT324341 UMOD Regulation of Scr 1 0.21 0.29 0 66.28
37 INT329479 Binding of TNFRSF11B and TNF 1 0.04 0.71 0 60.52
38 INT329480 Binding of TNFRSF11B and TNFSF10 1 0.03 0.71 0 60.52
39 INT241853 Binding of SLC40A1 and HAMP 3 0.41 5.35 0.43 58.76
40 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03 53.68
41 INT291623 Binding of CRP and CSTA 1 0.03 0.38 0 52.48
42 INT291622 HSD11B1 Regulation of CSTA 1 0.00 0.6 0.11 51.20
43 INT306925 IL36RN Positive_regulation of HAMP 1 0.01 1.39 0.1 50.40
44 INT306924 IL6 Positive_regulation of HAMP 1 0.02 1.38 0.1 50.40
45 INT213239 Binding of TNXA and Serpinc1 1 0.00 0.16 0.08 44.48
46 INT293114 Fig4 Regulation of Gene_expression of Aqp2 1 0.08 1.53 0 44.00
47 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31 41.32
48 INT262289 Regulation of Binding of PPIG and CC2D1A 1 0.01 1.52 0.13 37.40
49 INT262290 Binding of PPIG and CC2D1A 1 0.01 1.52 0.13 37.00
50 INT324343 SLC12A1 Regulation of Scr 1 0.00 0.25 0 31.92
51 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 22.80
52 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67 22.80
53 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 22.80
54 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53 22.80
55 INT278819 EDNRA Negative_regulation of Binding of EDNRA and EDNRB 1 0.04 1.65 0.53 22.80
56 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49 22.80
57 INT278820 EDNRA Negative_regulation of Binding of EDN1 and EDNRB 1 0.03 1.1 0.35 22.80
58 INT278817 EDNRA Negative_regulation of Binding of EDN1 and EDNRA 1 0.02 0.55 0.18 22.80
59 INT278818 EDNRA Negative_regulation of Binding of EDNRB and EDNRB 1 0.06 0.55 0.18 22.80
60 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15 22.80
61 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 20.48
62 INT195053 PTHLH Regulation of Gene_expression of CPOX 1 0.03 0.71 0 20.32
63 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 18.32
64 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 10.88
65 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
66 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
67 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
68 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
69 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
70 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
71 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71 5.00
72 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53 5.00
73 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
74 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
75 INT203016 CCK Positive_regulation of Localization of PYY 3 0.68 1.19 1.17 5.00
76 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
77 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03 5.00
78 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
79 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
80 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
81 INT352496 AVP Regulation of Gene_expression of CRS 1 0.27 2.47 0.59 5.00
82 INT306935 Tnfsf12 Positive_regulation of Gene_expression of Cxcl10 1 0.03 3.55 0.55 5.00
83 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
84 INT339275 Il6 Regulation of KRT20 1 0.00 3.11 0.49 5.00
85 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
86 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
87 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
88 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
89 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
90 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46 5.00
91 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46 5.00
92 INT306936 Binding of Tnfsf12 and Tnfrsf12a 1 0.05 4.84 0.45 5.00
93 INT203017 Binding of CCK and PYY 1 0.38 0.62 0.43 5.00
94 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4 5.00
95 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38 5.00
96 INT175988 Ros1 Positive_regulation of Transcription of Gtf3a 1 0.01 1.56 0.34 5.00
97 INT175990 Ros1 Positive_regulation of Gene_expression of Gtf3a 1 0.01 1.56 0.34 5.00
98 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33 5.00
99 INT175552 Binding of CASR and UPF1 1 0.01 0.89 0.33 5.00
100 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32 5.00
101 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32 5.00
102 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 5.00
103 INT203015 CCK Regulation of Localization of PYY 1 0.24 0.61 0.28 5.00
104 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28 5.00
105 INT306941 Tnfsf12 Positive_regulation of Gene_expression of CCL2 1 0.03 1.65 0.27 5.00
106 INT306937 Tnfsf12 Positive_regulation of Gene_expression of Vcam1 1 0.05 1.79 0.27 5.00
107 INT306942 Tnfsf12 Positive_regulation of Gene_expression of ICAM1 1 0.04 1.78 0.27 5.00
108 INT293118 Avp Regulation of Aqp2 1 0.04 0.7 0.27 5.00
109 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
110 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25 5.00
111 INT177661 Binding of Trib3 and Myo1f 1 0.00 0.54 0.24 5.00
112 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22 5.00
113 INT89612 Binding of FABP3 and MB 3 0.34 1.49 0.22 5.00
114 INT355503 Positive_regulation of SCN10A Positive_regulation of Localization of NPY 1 0.17 1.32 0.22 5.00
115 INT339903 Binding of SCN5A and ZGLP1 1 0.01 0.18 0.22 5.00
116 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
117 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21 5.00
118 INT180450 Positive_regulation of Acot1 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.01 0.44 0.2 5.00
119 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2 5.00
120 INT180441 Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19 5.00
121 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
122 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
123 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
124 INT180440 Positive_regulation of Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19 5.00
125 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
126 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
127 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 0.03 0.72 0.18 5.00
128 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18 5.00
129 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17 5.00
130 INT311226 DPP4 Negative_regulation of GLP1R 1 0.31 0.65 0.16 5.00
131 INT311227 INS Negative_regulation of HBA1 1 0.01 0.52 0.16 5.00
132 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16 5.00
133 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16 5.00
134 INT125770 GLP1R Negative_regulation of Localization of GCG 2 0.29 0.65 0.16 5.00
135 INT240768 Binding of F2 and F13A1 1 0.07 2.25 0.15 5.00
136 INT316769 Binding of H2-K1 and Hspa9 1 0.08 1.02 0.15 5.00
137 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14 5.00
138 INT293125 Agt Regulation of Avp Regulation of Aqp2 1 0.04 0.36 0.14 5.00
139 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14 5.00
140 INT293115 Agt Regulation of Positive_regulation of Crh 1 0.16 0.37 0.14 5.00
141 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14 5.00
142 INT293126 Agtr1a Regulation of Avp Regulation of Aqp2 1 0.03 0.36 0.14 5.00
143 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14 5.00
144 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13 5.00
145 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 5.00
146 INT203018 GHRH Positive_regulation of Localization of PYY 1 0.01 0.81 0.12 5.00
147 INT177675 Binding of CALM1 and Positive_regulation of Trib3 1 0.00 0.27 0.12 5.00
148 INT307627 Binding of BMP1 and CSF2 1 0.01 0.33 0.12 5.00
149 INT177674 CALM1 Positive_regulation of Trib3 1 0.00 0.27 0.12 5.00
150 INT293312 CTLA4 Negative_regulation of Binding of CD28 and CD80 1 0.01 0.29 0.12 5.00
151 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11 5.00
152 INT314620 Ex Positive_regulation of GLP1R Positive_regulation of Gene_expression of INS 1 0.03 0.3 0.11 5.00
153 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11 5.00
154 INT269784 Crp Positive_regulation of Vcam1 1 0.00 1.6 0.11 5.00
155 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11 5.00
156 INT352497 AGT Positive_regulation of Binding of CRS 1 0.14 0.87 0.11 5.00
157 INT314625 Ex Positive_regulation of GLP1R 1 0.03 0.3 0.11 5.00
158 INT269783 Crp Positive_regulation of Sele 1 0.00 1.69 0.11 5.00
159 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11 5.00
160 INT214032 Binding of GCAT and BPIFA4P 1 0.00 0.51 0.1 5.00
161 INT271343 Binding of CRP and PAPPA 1 0.20 0.86 0.1 5.00
162 INT280053 Negative_regulation of Dpp4 Negative_regulation of Protein_catabolism of Zglp1 1 0.02 0.71 0.1 5.00
163 INT177676 Binding of Trib3 and Myo1f Positive_regulation of Trib3 1 0.00 0.3 0.1 5.00
164 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09 5.00
165 INT274156 Negative_regulation of Cabin1 Negative_regulation of Gene_expression of Vegfa 1 0.08 0.28 0.09 5.00
166 INT164925 GIP Positive_regulation of Localization of INS 2 0.59 0.86 0.09 5.00
167 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 0.02 0.33 0.09 5.00
168 INT271349 ACCS Positive_regulation of PAPPA 1 0.06 0.87 0.09 5.00
169 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09 5.00
170 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
171 INT251623 Car2 Regulation of Gene_expression of Fig4 1 0.02 0.31 0.08 5.00
172 INT271354 MPO Regulation of Gene_expression of CRP 1 0.16 1.74 0.08 5.00
173 INT271346 Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
174 INT306945 NAMPT Positive_regulation of Positive_regulation of MAPK1 1 0.10 0.33 0.08 5.00
175 INT300246 Binding of ABCB6 and HSR 1 0.11 1.86 0.08 5.00
176 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08 5.00
177 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08 5.00
178 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08 5.00
179 INT271351 MPO Positive_regulation of CRP 1 0.07 1.69 0.08 5.00
180 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08 5.00
181 INT278059 XRCC1 Positive_regulation of Gene_expression of IL2 1 0.01 1.06 0.07 5.00
182 INT311225 GLP1R Positive_regulation of Gene_expression of INS 1 0.49 0.33 0.06 5.00
183 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 5.00
184 INT339272 VDR Positive_regulation of Gene_expression of KRT20 1 0.00 0.07 0.05 5.00
185 INT222295 Binding of CPP and Cebpz 1 0.00 0.73 0.05 5.00
186 INT296023 Positive_regulation of Apoa2 Negative_regulation of APOA1 1 0.50 0.35 0.05 5.00
187 INT248344 Binding of IL10 and SNRNP70 1 0.04 0.6 0.05 5.00
188 INT280057 Zglp1 Positive_regulation of Transcription of INS 1 0.04 0.52 0.05 5.00
189 INT296024 Apoa2 Negative_regulation of CETP 1 0.39 0.35 0.05 5.00
190 INT293122 Avp Regulation of Gene_expression of Aqp2 1 0.04 0.81 0.05 5.00
191 INT214033 OGG1 Negative_regulation of BPIFA4P 1 0.08 0.71 0.05 5.00
192 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05 5.00
193 INT106823 Binding of MBP and PAPPA 2 0.17 3.89 0.05 5.00
194 INT296025 Apoa2 Negative_regulation of APOA1 1 0.47 0.35 0.05 5.00
195 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 5.00
196 INT314622 Binding of INS and Ex 1 0.08 0.44 0.04 5.00
197 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
198 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04 5.00
199 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04 5.00
200 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Disorders Of Creatine Metabolism. They are ordered first by their pain relevance and then by number of times they were reported in Disorders Of Creatine Metabolism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 100.00
2 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 100.00
3 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 100.00
4 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 100.00
5 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 100.00
6 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 100.00
7 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 100.00
8 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 100.00
9 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 100.00
10 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 100.00
11 INT58571 Positive_regulation of ALDOB 6 0.49 5.63 0.53 100.00
12 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 100.00
13 INT82918 Binding of AMBP 23 0.39 23.31 1.71 100.00
14 INT4180 Localization of HBD 1 0.32 2.04 0.14 100.00
15 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 100.00
16 INT1940 Localization of PIK3C2A 8 0.78 7.28 1.01 100.00
17 INT46134 Positive_regulation of Gene_expression of Cys1 4 0.50 11.52 0.61 100.00
18 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 100.00
19 INT4210 Gene_expression of MB 24 0.78 11.74 2.32 100.00
20 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 100.00
21 INT45202 Regulation of Cys1 8 0.08 5.62 2.23 100.00
22 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 100.00
23 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 100.00
24 INT3979 Positive_regulation of Positive_regulation of PIK3C2A 2 0.45 1.49 0.27 100.00
25 INT58931 Binding of NAGLU 11 0.34 4.47 1.63 100.00
26 INT2140 Regulation of REN 104 0.62 28.24 24.49 100.00
27 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 100.00
28 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 100.00
29 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 100.00
30 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 100.00
31 INT1939 Localization of Cys1 6 0.73 5.9 0.64 100.00
32 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 100.00
33 INT11367 Localization of MB 9 0.78 9.34 1.24 100.00
34 INT2991 Regulation of PIK3C2A 6 0.60 4.46 0.99 100.00
35 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 100.00
36 INT4175 Gene_expression of Bdh2 1 0.01 0.96 0.09 100.00
37 INT52595 Positive_regulation of Positive_regulation of Cys1 5 0.47 5.12 0.9 100.00
38 INT4182 Gene_expression of HBD 2 0.27 1.42 0.06 100.00
39 INT151978 Negative_regulation of Positive_regulation of Cys1 3 0.41 4.15 0.24 100.00
40 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 100.00
41 INT9549 Regulation of CHKB 25 0.47 13.61 3.2 100.00
42 INT9081 Positive_regulation of Positive_regulation of IGHE 5 0.42 7.13 1 100.00
43 INT15610 Localization of GOPC 223 0.65 68.26 28.7 100.00
44 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 100.00
45 INT78025 Negative_regulation of PIK3C2A 2 0.22 1.14 0.28 100.00
46 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 100.00
47 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 100.00
48 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 100.00
49 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 100.00
50 INT4179 Positive_regulation of HBD 1 0.26 0.62 0.09 100.00
51 INT4176 Positive_regulation of Bdh2 3 0.02 1.28 0.52 100.00
52 INT3074 Negative_regulation of Chkb 29 0.57 14 12.04 100.00
53 INT2545 Negative_regulation of Cys1 6 0.17 3.22 0.43 100.00
54 INT11366 Positive_regulation of Localization of MB 2 0.33 1.6 0.22 100.00
55 INT9385 Localization of LDHA 74 0.81 31.67 10.5 100.00
56 INT20630 Positive_regulation of Gene_expression of CHKB 19 0.47 15.79 1.85 100.00
57 INT102114 Negative_regulation of Chkb 6 0.39 2.05 0.28 100.00
58 INT142340 Positive_regulation of Chkb 3 0.47 6.44 0.38 100.00
59 INT27355 Localization of STAB2 1 0.00 0.93 0.19 100.00
60 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53 100.00
61 INT151422 Negative_regulation of Positive_regulation of Chkb 2 0.30 1.15 0.11 100.00
62 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 100.00
63 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 100.00
64 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 100.00
65 INT11119 Negative_regulation of Gene_expression of RAPGEF5 1 0.41 0.89 0.06 100.00
66 INT11120 Negative_regulation of Gene_expression of NPPA 2 0.39 1.45 0.06 100.00
67 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 100.00
68 INT120456 Positive_regulation of Lalba 2 0.28 1.05 1.45 100.00
69 INT58856 Positive_regulation of Gene_expression of MB 4 0.50 4.56 1.06 100.00
70 INT28784 Positive_regulation of Gene_expression of CNDP1 3 0.22 3.87 1 100.00
71 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 100.00
72 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51 100.00
73 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 100.00
74 INT177568 Localization of Gpx1 5 0.49 1.82 0.16 100.00
75 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67 100.00
76 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 100.00
77 INT238509 Gene_expression of GTF2E2 1 0.00 1.5 0 100.00
78 INT36330 Positive_regulation of Positive_regulation of GOT1 4 0.32 4.42 1.26 100.00
79 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 100.00
80 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 100.00
81 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
82 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 100.00
83 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77 100.00
84 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 100.00
85 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 100.00
86 INT39480 Positive_regulation of Got1l1 2 0.35 1.52 1.87 100.00
87 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59 100.00
88 INT3957 Gene_expression of CNDP1 6 0.52 3.7 0.96 100.00
89 INT82861 Positive_regulation of Gene_expression of Lalba 3 0.30 1.46 0.9 100.00
90 INT241722 Gene_expression of Rapgef5 1 0.24 1.34 0.81 100.00
91 INT2812 Transcription of GPT 2 0.67 1.18 0.52 100.00
92 INT9506 Transcription of Mb 4 0.47 2.08 0.39 100.00
93 INT14293 Regulation of Localization of GGT1 1 0.44 0.9 0.37 100.00
94 INT44763 Regulation of B4galnt1 1 0.38 0.27 0.29 100.00
95 INT44765 Regulation of Localization of B4galnt1 1 0.23 0.27 0.29 100.00
96 INT39515 Gene_expression of Got1l1 1 0.52 1.21 0.1 100.00
97 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 99.98
98 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 99.98
99 INT10586 Localization of B2M 15 0.68 8.67 3.46 99.96
100 INT213406 Positive_regulation of XPO1 5 0.27 1.19 0.08 99.96
101 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04 99.92
102 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 99.92
103 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 99.92
104 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.92
105 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 99.92
106 INT28001 Gene_expression of Gpm6a 23 0.66 16.66 21.09 99.92
107 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77 99.92
108 INT68188 Gene_expression of TNNI1 5 0.75 5.17 1.72 99.92
109 INT82859 Gene_expression of Lalba 3 0.41 1.46 0.9 99.92
110 INT46877 Negative_regulation of CLEC3B 2 0.43 6.35 0.04 99.90
111 INT145074 Binding of SLC22A5 3 0.37 1.56 1.29 99.90
112 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 99.88
113 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61 99.88
114 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 99.84
115 INT3467 Positive_regulation of Ptger1 28 0.54 10.59 8.93 99.84
116 INT9854 Localization of GGT1 11 0.78 6.09 3.57 99.82
117 INT14292 Localization of Agl 2 0.10 1.31 0.53 99.82
118 INT14294 Localization of RNASE1 2 0.36 1.32 0.53 99.82
119 INT2442 Localization of Mb 38 0.80 24.74 6.33 99.80
120 INT38911 Regulation of Localization of Mb 1 0.25 0.5 0.8 99.80
121 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.78
122 INT4174 Localization of Bdh2 1 0.02 0.9 0.09 99.76
123 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 99.76
124 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 99.76
125 INT54051 Negative_regulation of Gamt 3 0.38 0.74 0.06 99.76
126 INT36767 Localization of Atp7b 11 0.20 4.13 4.5 99.74
127 INT7678 Localization of Alb 142 0.81 80.93 22.49 99.72
128 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 99.70
129 INT72053 Localization of GSTA2 15 0.78 6.12 2.78 99.68
130 INT79926 Localization of CHST5 4 0.20 1.52 0.38 99.68
131 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 99.60
132 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 99.58
133 INT74286 Regulation of Il10 42 0.44 28.06 19.44 99.58
134 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 99.58
135 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 99.58
136 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 99.58
137 INT91327 Positive_regulation of CCL4 12 0.67 8.55 4.1 99.58
138 INT91326 Regulation of CCL4 4 0.44 2.86 1.69 99.58
139 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 99.58
140 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 99.58
141 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 99.58
142 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.58
143 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.56
144 INT138784 Positive_regulation of Gene_expression of Lcn2 3 0.49 4.44 1.13 99.52
145 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.52
146 INT30370 Negative_regulation of AMY2A 7 0.49 3.36 0.36 99.52
147 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 99.50
148 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 99.48
149 INT291629 Localization of CSTA 1 0.08 1.05 0.11 99.48
150 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 99.44
151 INT17673 Negative_regulation of Localization of Lnpep 8 0.09 2.63 3.12 99.44
152 INT41560 Negative_regulation of Localization of Sis 2 0.05 1.02 0.21 99.44
153 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 99.40
154 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 99.40
155 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 99.40
156 INT1755 Gene_expression of GBE1 28 0.26 8.32 5.18 99.32
157 INT44764 Localization of B4galnt1 1 0.59 0.26 0.29 99.30
158 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 99.24
159 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 99.24
160 INT14619 Positive_regulation of Localization of NAGLU 18 0.62 7.73 3.94 99.24
161 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 99.24
162 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7 99.24
163 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 99.24
164 INT41549 Positive_regulation of Localization of B2M 5 0.59 4.26 2.42 99.24
165 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 99.24
166 INT75019 Gene_expression of Gsta2 5 0.65 2.01 0.84 99.24
167 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 99.22
168 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35 99.20
169 INT63035 Gene_expression of CSTA 10 0.56 11.56 0.57 99.16
170 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.12
171 INT654 Localization of REN 250 0.81 75.12 47.86 99.10
172 INT37248 Localization of Naglu 2 0.45 0.74 0.58 99.10
173 INT184621 Regulation of ALDOB 1 0.01 1.15 0 99.08
174 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91 99.04
175 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.04
176 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.02
177 INT479 Positive_regulation of Gfra1 25 0.69 10.71 4.76 98.96
178 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 98.94
179 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 98.92
180 INT282111 Negative_regulation of Gvhd1 4 0.22 2.96 0.44 98.88
181 INT138785 Gene_expression of Lcn2 9 0.56 9.88 2.41 98.84
182 INT151421 Negative_regulation of Positive_regulation of Sdcbp 11 0.30 6.61 3.32 98.84
183 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 98.84
184 INT57424 Positive_regulation of TNNT1 42 0.67 31.84 9.7 98.80
185 INT44997 Positive_regulation of Eef1a2 16 0.40 8.84 5.37 98.76
186 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 98.76
187 INT17803 Regulation of Edn1 14 0.54 4.75 4.71 98.76
188 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 98.72
189 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 98.64
190 INT56944 Positive_regulation of SERPINA3 8 0.67 6.56 1.32 98.64
191 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 98.62
192 INT5244 Negative_regulation of KLF6 8 0.57 1.8 0.92 98.60
193 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 98.60
194 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 98.56
195 INT142342 Regulation of Negative_regulation of Hmgcr 1 0.20 0.48 0.1 98.48
196 INT2395 Binding of MB 18 0.36 7.53 0.68 98.48
197 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9 98.44
198 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 98.34
199 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.32
200 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 98.32
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