D:Diverticulitis

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Disease Term
Synonyms Diverticular Disease, Diverticular Disorder, Diverticulitides, Diverticulosis
Documents 721
Hot Single Events 53
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Diverticulitis. They are ordered first by their relevance to Diverticulitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT299725 AFP Positive_regulation of Positive_regulation of ACPP 1 0.00 0.78 0.17 45.76
2 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
3 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69 5.00
4 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58 5.00
5 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54 5.00
6 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
7 INT329722 Binding of Il10rb and Il10 1 0.00 0.79 0.51 5.00
8 INT329721 Positive_regulation of Binding of Il10rb and Il10 1 0.00 0.79 0.51 5.00
9 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49 5.00
10 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
11 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
12 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32 5.00
13 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32 5.00
14 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24 5.00
15 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24 5.00
16 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23 5.00
17 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
18 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
19 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
20 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
21 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
22 INT253776 Binding of THBD and F2 1 0.00 1.15 0.18 5.00
23 INT345924 IL6 Regulation of Gene_expression of SPHAR 1 0.00 0.21 0.18 5.00
24 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
25 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12 5.00
26 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12 5.00
27 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12 5.00
28 INT253774 THBD Regulation of F2 1 0.00 0.61 0.08 5.00
29 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08 5.00
30 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06 5.00
31 INT329729 Binding of LCK and Fyn 1 0.00 0.21 0.03 5.00
32 INT234357 GRHPR Regulation of MRT5 1 0.00 0.05 0 5.00
33 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Diverticulitis. They are ordered first by their pain relevance and then by number of times they were reported in Diverticulitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT294596 Localization of HPD 1 0.74 0.82 0 100.00
2 INT68285 Gene_expression of SERPINB3 24 0.75 25.4 0.45 99.96
3 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 99.30
4 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28 99.30
5 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02 99.30
6 INT4866 Positive_regulation of GAL 32 0.67 13.02 16.16 99.30
7 INT59119 Positive_regulation of ADCYAP1 9 0.69 4.68 2.48 99.30
8 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 99.30
9 INT9210 Regulation of IL6 166 0.62 125.61 49.95 99.24
10 INT102311 Regulation of IL6R 4 0.12 2.37 0.74 99.24
11 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 99.10
12 INT8986 Positive_regulation of Gene_expression of Gal 24 0.67 10.96 14.09 99.02
13 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69 99.02
14 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 98.66
15 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 98.66
16 INT32900 Negative_regulation of Positive_regulation of Chat 3 0.43 1.91 1.45 98.30
17 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86 98.30
18 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 98.24
19 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11 97.86
20 INT11773 Gene_expression of Tac1 56 0.77 10 25.72 96.64
21 INT61706 Regulation of Gene_expression of Gal 17 0.62 10.09 11.96 96.64
22 INT12358 Regulation of Gene_expression of Tac1 17 0.60 3.34 8.84 96.64
23 INT15674 Positive_regulation of Gene_expression of Tac1 17 0.68 4.97 6.56 96.64
24 INT11980 Positive_regulation of Tac1 27 0.69 6.17 14.5 96.20
25 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 95.84
26 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 95.64
27 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 95.60
28 INT149174 Regulation of Positive_regulation of Gal 1 0.44 0.68 0.49 95.60
29 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 95.32
30 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 94.92
31 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 93.96
32 INT194023 Gene_expression of RQCD1 3 0.52 3.99 0.12 92.40
33 INT182807 Localization of Cuzd1 2 0.49 1.38 0.14 91.76
34 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 90.84
35 INT63536 Gene_expression of Syncrip 7 0.67 7.23 5.44 90.00
36 INT120466 Gene_expression of LCT 21 0.78 6 1.75 89.40
37 INT149175 Regulation of Cdc123 1 0.04 0.71 0.46 88.32
38 INT341438 Positive_regulation of Slc25a16 1 0.32 0.9 0 88.20
39 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 87.68
40 INT341437 Gene_expression of Slc25a16 1 0.47 2.39 0.3 86.24
41 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 85.16
42 INT139527 Positive_regulation of Gene_expression of PAEP 16 0.43 4.66 0.98 85.16
43 INT25022 Binding of PAEP 66 0.42 22.83 6.59 84.88
44 INT36703 Negative_regulation of CEACAM3 2 0.43 4.11 0.53 84.28
45 INT68286 Regulation of SERPINB3 10 0.60 3.07 0.06 84.08
46 INT68288 Positive_regulation of SERPINB3 14 0.51 16.87 0.41 84.08
47 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 83.60
48 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 82.68
49 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 82.16
50 INT61366 Positive_regulation of NFASC 16 0.26 13.75 4.11 82.08
51 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 81.40
52 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 80.76
53 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 80.56
54 INT34354 Gene_expression of SRMS 8 0.59 9.62 1.02 78.88
55 INT30 Gene_expression of Gast 158 0.78 99 41.45 74.56
56 INT212145 Gene_expression of Papd7 1 0.04 0.34 0 74.08
57 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 73.44
58 INT304836 Gene_expression of PMMoV 1 0.12 3.12 0.96 71.12
59 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74 70.20
60 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 66.56
61 INT131808 Localization of Apex1 2 0.16 13.46 4.61 66.16
62 INT6852 Localization of TNF 883 0.81 705.95 270.84 66.16
63 INT19775 Localization of Il1 183 0.78 145.5 50.91 66.16
64 INT253751 Localization of Lif 3 0.73 3.94 1.58 66.16
65 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 66.08
66 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 65.52
67 INT304835 Positive_regulation of PMMoV 1 0.09 1.94 0.71 59.88
68 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 57.68
69 INT206929 Negative_regulation of Gene_expression of XRCC1 4 0.25 6.14 0.74 57.36
70 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 55.92
71 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 55.92
72 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 55.92
73 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 55.92
74 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 55.92
75 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 55.92
76 INT103289 Binding of Il10 15 0.35 13.67 7.42 55.52
77 INT153705 Gene_expression of CLDN3 5 0.58 4.07 0.37 53.20
78 INT79168 Binding of TNC 39 0.47 16.51 7.55 52.32
79 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 51.12
80 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 51.12
81 INT9188 Localization of HBG1 12 0.75 8.14 2.24 51.12
82 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 50.56
83 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 50.00
84 INT188795 Positive_regulation of SRMS 3 0.69 3.02 0.2 47.96
85 INT259266 Negative_regulation of Positive_regulation of SRMS 1 0.37 1.58 0.16 47.96
86 INT259267 Negative_regulation of Gene_expression of ZNF135 1 0.26 1.52 0.16 46.96
87 INT259268 Gene_expression of ZNF135 1 0.41 1.52 0.15 46.56
88 INT25162 Positive_regulation of ACPP 7 0.41 4.51 0.62 45.76
89 INT127654 Positive_regulation of Gene_expression of XRCC1 11 0.38 13.7 0.26 43.84
90 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 41.52
91 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 39.56
92 INT169620 Localization of SERPINB3 3 0.55 0.46 0.28 39.00
93 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 35.76
94 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 35.52
95 INT159232 Negative_regulation of SYP 4 0.41 4.45 0.38 34.96
96 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 33.96
97 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 33.68
98 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 32.00
99 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84 31.28
100 INT153015 Positive_regulation of Gene_expression of nct 3 0.24 0.9 0.74 29.76
101 INT153016 Gene_expression of nct 4 0.32 0.97 0.89 29.32
102 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 29.20
103 INT129565 Negative_regulation of Cuzd1 5 0.43 0.65 1.24 28.40
104 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 24.48
105 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 22.52
106 INT279952 Binding of MBLAC2 1 0.37 0.82 0 21.28
107 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 20.80
108 INT34367 Negative_regulation of MBLAC2 2 0.43 1.21 0 20.72
109 INT212146 Binding of Papd7 1 0.02 0.2 0.07 17.24
110 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 15.84
111 INT182320 Binding of MTX1 14 0.18 8.5 7.65 11.72
112 INT133589 Negative_regulation of Pol 6 0.25 2.84 0.61 11.08
113 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 10.16
114 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 5.84
115 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 5.84
116 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.24
117 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
118 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
119 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
120 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
121 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
122 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
123 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
124 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
125 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
126 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
127 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
128 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
129 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
130 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
131 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
132 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
133 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
134 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
135 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
136 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
137 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
138 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
139 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
140 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
141 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
142 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
143 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
144 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
145 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
146 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
147 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
148 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
149 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
150 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
151 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
152 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
153 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
154 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
155 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
156 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
157 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
158 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
159 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
160 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
161 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
162 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
163 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 5.00
164 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
165 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
166 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
167 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
168 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
169 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 5.00
170 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
171 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
172 INT894 Binding of Avp 84 0.48 29.16 29.63 5.00
173 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
174 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
175 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
176 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
177 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
178 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
179 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
180 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
181 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
182 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26 5.00
183 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
184 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 5.00
185 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
186 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
187 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
188 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
189 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
190 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
191 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
192 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
193 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
194 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
195 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 5.00
196 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
197 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
198 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
199 INT72564 Localization of Il10 41 0.78 28.62 17.6 5.00
200 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
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