D:Dna Damage

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pChart

Disease Term
Synonyms DAMAGE DNA, Damages Dna, Dna Damages, DNA INJURIES, Dna Injury, Genotoxic Stress, Genotoxic Stresses, Injuries Dna, INJURY DNA, Stress Genotoxic, Stresses Genotoxic
Documents 33
Hot Single Events 115
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dna Damage. They are ordered first by their relevance to Dna Damage and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT96563 Binding of ADRA1D and UCN2 1 0.19 1.34 0.1 97.48
2 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 93.08
3 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64 88.36
4 INT237151 Binding of Klrk1 and Ulbp1 1 0.05 1.02 0.05 88.08
5 INT237149 Binding of H60a and Klrk1 1 0.24 1.01 0.05 87.12
6 INT237150 Binding of Klrk1 and Rae1 1 0.04 1.14 0.05 86.72
7 INT271288 Ifng Positive_regulation of Transcription of IFNA1 1 0.07 0.93 0 86.00
8 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 84.52
9 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 79.92
10 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 79.92
11 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0 78.88
12 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21 73.12
13 INT298396 CEBPB Regulation of MIR155 1 0.01 1.06 0 71.32
14 INT236468 TP53 Positive_regulation of Protein_catabolism of SNRPB 1 0.00 0.52 0 69.76
15 INT271101 PIK3CB Regulation of Akt1 1 0.01 0.72 0 58.52
16 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 56.64
17 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 54.36
18 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 51.84
19 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 51.84
20 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 51.84
21 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 51.84
22 INT271280 Stat1 Regulation of Mcl1 1 0.28 0.67 0 39.44
23 INT271282 Stat1 Regulation of Usp18 1 0.30 1.37 0 39.44
24 INT228809 Gtf3a Regulation of Rgs1 1 0.00 0.25 0.09 33.28
25 INT228811 Gtf3a Regulation of Stap1 1 0.00 0.24 0.09 33.28
26 INT228810 Vwf Regulation of Stap1 1 0.00 0.24 0.09 32.96
27 INT228807 Vwf Regulation of Rgs1 1 0.05 0.24 0.09 32.96
28 INT250796 Tlr4 Positive_regulation of Parp1 1 0.14 1 0.03 32.40
29 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09 31.00
30 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09 31.00
31 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 27.92
32 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 27.92
33 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03 25.00
34 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03 25.00
35 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03 25.00
36 INT271286 IFNA1 Positive_regulation of Stat1 1 0.09 0.14 0 16.56
37 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 5.00
38 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
39 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98 5.00
40 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.00
41 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8 5.00
42 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78 5.00
43 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78 5.00
44 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7 5.00
45 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61 5.00
46 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 5.00
47 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42 5.00
48 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41 5.00
49 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36 5.00
50 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27 5.00
51 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27 5.00
52 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
53 INT186351 Binding of Gast and Stat1 3 0.16 2.77 0.22 5.00
54 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 5.00
55 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 5.00
56 INT306261 AKT2 Negative_regulation of Phosphorylation of FOXO1 1 0.25 0.41 0.17 5.00
57 INT201609 Uvbi1 Positive_regulation of Gene_expression of Mc1r 1 0.05 0.57 0.17 5.00
58 INT201608 Binding of Mc1r and Uvbi1 1 0.03 0.93 0.15 5.00
59 INT201622 Binding of Mark3 and Mc1r 1 0.33 0.74 0.15 5.00
60 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15 5.00
61 INT306268 CRKL Positive_regulation of RASGRP1 1 0.02 0.54 0.14 5.00
62 INT306272 CRKL Positive_regulation of JUN 1 0.05 0.54 0.14 5.00
63 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13 5.00
64 INT306270 CCL4 Positive_regulation of Transcription of PTGS2 1 0.34 0.31 0.12 5.00
65 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12 5.00
66 INT327808 EPO Regulation of VEGFA 1 0.07 1.36 0.12 5.00
67 INT306265 Binding of NFKB1 and NFKBIA 1 0.21 0.48 0.11 5.00
68 INT236467 MMP9 Negative_regulation of SNRPB 1 0.01 0.45 0.1 5.00
69 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09 5.00
70 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
71 INT201618 Uvbi1 Positive_regulation of Phb 1 0.04 0.28 0.09 5.00
72 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
73 INT306266 Binding of JUN and NFAT5 1 0.10 0.22 0.08 5.00
74 INT201615 Binding of Mark3 and Uvbi1 1 0.03 0.36 0.08 5.00
75 INT201621 Binding of Cdk11b and Uvbi1 1 0.02 0.36 0.08 5.00
76 INT201616 Uvbi1 Positive_regulation of Mark3 1 0.03 0.36 0.08 5.00
77 INT271284 Binding of IFNA1 and Stat1 1 0.07 0.7 0.08 5.00
78 INT201611 Uvbi1 Negative_regulation of Bop1 1 0.03 0.3 0.08 5.00
79 INT201613 Uvbi1 Positive_regulation of Cdk11b 1 0.03 0.36 0.08 5.00
80 INT306273 Binding of FOS and NFAT5 1 0.15 0.22 0.08 5.00
81 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08 5.00
82 INT220916 Positive_regulation of Binding of JUN and JUND 2 0.18 0.53 0.07 5.00
83 INT220911 Binding of JUN and JUND 2 0.14 1.08 0.07 5.00
84 INT306255 IRF6 Positive_regulation of TFAM 1 0.01 0 0.07 5.00
85 INT306260 TLR4 Positive_regulation of TFAM 1 0.01 0 0.07 5.00
86 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06 5.00
87 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
88 INT236466 SNRPB Positive_regulation of NFKB2 1 0.00 0.21 0.05 5.00
89 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 5.00
90 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 5.00
91 INT348523 BCL2L1 Negative_regulation of NLRP1 1 0.01 0.63 0.05 5.00
92 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03 5.00
93 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03 5.00
94 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03 5.00
95 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03 5.00
96 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
97 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03 5.00
98 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0 5.00
99 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0 5.00
100 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0 5.00
101 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0 5.00
102 INT314741 Binding of VEGFA and Akt1 1 0.36 0.66 0 5.00
103 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
104 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
105 INT306257 Binding of MAPK8 and RAC2 1 0.24 0 0 5.00
106 INT348533 Positive_regulation of Binding of FOSL2 and JUN 1 0.09 0.32 0 5.00
107 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
108 INT201620 Binding of Kit and Uvbi1 1 0.03 0.2 0 5.00
109 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00
110 INT314692 Binding of TBX2 and TBX3 1 0.27 0.84 0 5.00
111 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0 5.00
112 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0 5.00
113 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0 5.00
114 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
115 INT237146 Binding of H60a and Rae1 1 0.07 0 0 5.00
116 INT314693 Binding of TBX2 and TBX5 1 0.16 0.84 0 5.00
117 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0 5.00
118 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0 5.00
119 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0 5.00
120 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0 5.00
121 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0 5.00
122 INT314682 Binding of TBX2 and TBX4 1 0.16 0.84 0 5.00
123 INT306269 Binding of MAPK8 and RAC1 1 0.25 0 0 5.00
124 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0 5.00
125 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0 5.00
126 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0 5.00
127 INT345337 Binding of TP53 and BCC1 1 0.11 1.05 0 5.00
128 INT348530 CASP10 Positive_regulation of CASP9 1 0.02 0.3 0 5.00
129 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
130 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0 5.00
131 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0 5.00
132 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0 5.00
133 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0 5.00
134 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0 5.00
135 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0 5.00
136 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0 5.00
137 INT314683 NUDT6 Positive_regulation of FGF1 1 0.02 1.17 0 5.00
138 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
139 INT314744 Binding of KDR and Akt1 1 0.13 0.66 0 5.00
140 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0 5.00
141 INT309512 Negative_regulation of Xrcc6 Positive_regulation of Phosphorylation of Gopc 1 0.20 0.17 0 5.00
142 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0 5.00
143 INT348537 TNF Positive_regulation of Gene_expression of BIRC2 1 0.03 0.23 0 5.00
144 INT348525 MAPK8 Positive_regulation of Gene_expression of JUND 1 0.01 0.28 0 5.00
145 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0 5.00
146 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0 5.00
147 INT237148 Negative_regulation of Binding of Klrk1 and Rae1 1 0.05 0.13 0 5.00
148 INT348524 Binding of FOSL2 and JUN 1 0.07 0.59 0 5.00
149 INT348536 Positive_regulation of TP63 Positive_regulation of Gene_expression of CASP9 1 0.02 0.55 0 5.00
150 INT201612 Binding of Kit and Mc1r 1 0.34 0.13 0 5.00
151 INT314689 Binding of KITLG and UBR1 1 0.00 0.71 0 5.00
152 INT314691 ERBB2 Negative_regulation of TP53 1 0.28 1.23 0 5.00
153 INT348534 ELMO1 Positive_regulation of RAC1 1 0.02 0.7 0 5.00
154 INT348527 Binding of JUN and Regulation of Gene_expression of GADD45A 1 0.11 0.24 0 5.00
155 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0 5.00
156 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0 5.00
157 INT348529 TNF Positive_regulation of Gene_expression of IKBKG 1 0.01 0.23 0 5.00
158 INT309520 Htt Negative_regulation of Binding of Xrcc6 and Xrcc5 1 0.15 0.47 0 5.00
159 INT309516 Htt Positive_regulation of Gene_expression of Xrcc6 1 0.49 0.06 0 5.00
160 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0 5.00
161 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0 5.00
162 INT309510 Htt Regulation of Gene_expression of Xrcc6 1 0.19 0.15 0 5.00
163 INT348535 CASP10 Positive_regulation of CASP3 1 0.03 0.3 0 5.00
164 INT309508 Htt Negative_regulation of Binding of Xrcc6 1 0.31 0.48 0 5.00
165 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0 5.00
166 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0 5.00
167 INT314679 NEU1 Negative_regulation of TP53 1 0.12 1.23 0 5.00
168 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0 5.00
169 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0 5.00
170 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0 5.00
171 INT309514 Positive_regulation of Binding of Xrcc6 and Htt 1 0.33 0 0 5.00
172 INT237147 Binding of Rae1 and Ulbp1 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dna Damage. They are ordered first by their pain relevance and then by number of times they were reported in Dna Damage. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04 100.00
2 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 99.98
3 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 99.96
4 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29 99.84
5 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16 99.84
6 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 99.60
7 INT124090 Gene_expression of Gadd45a 9 0.63 3.25 0.99 99.58
8 INT124093 Negative_regulation of Gene_expression of Gadd45a 2 0.35 1.52 0.71 99.58
9 INT309474 Positive_regulation of Trp73 1 0.28 0.69 0 99.50
10 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28 99.32
11 INT291510 Gene_expression of Pmaip1 1 0.29 0.5 0.04 99.26
12 INT186309 Binding of Stat1 18 0.48 5.31 1.58 99.20
13 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 99.00
14 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71 99.00
15 INT271275 Gene_expression of H2-M5 1 0.01 0.75 0 98.96
16 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 98.88
17 INT291517 Gene_expression of Sesn1 1 0.31 0.5 0.04 98.88
18 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 98.88
19 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 98.88
20 INT174156 Localization of Trp53 16 0.72 13.52 1.18 98.80
21 INT60585 Regulation of TP53 59 0.59 54.55 5.21 98.78
22 INT216460 Positive_regulation of Gene_expression of Dclre1a 1 0.49 2.48 0 98.64
23 INT216443 Gene_expression of Dclre1a 1 0.55 1.98 0 98.64
24 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03 98.60
25 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 98.60
26 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 98.60
27 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78 98.48
28 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 98.42
29 INT271262 Negative_regulation of Negative_regulation of Stat1 2 0.42 1.4 0.18 98.32
30 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 98.12
31 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 98.04
32 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83 97.84
33 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 97.40
34 INT25726 Positive_regulation of TOP2B 4 0.67 4.1 1.19 97.36
35 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34 97.16
36 INT171029 Positive_regulation of Transcription of JUN 4 0.14 2.87 1.48 97.12
37 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19 97.08
38 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 97.08
39 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 97.08
40 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97 97.08
41 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 97.08
42 INT245262 Negative_regulation of Gene_expression of Stat1 9 0.42 2.87 0.42 97.08
43 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56 96.48
44 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 96.28
45 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35 96.28
46 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 96.24
47 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18 96.20
48 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 96.08
49 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 96.08
50 INT67936 Transcription of JUN 18 0.52 9.52 4.13 96.00
51 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35 95.76
52 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 95.64
53 INT173179 Binding of MAPK14 13 0.29 4.51 2.92 95.60
54 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24 95.48
55 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 95.42
56 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 95.42
57 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36 95.28
58 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09 95.28
59 INT298408 Transcription of POLR2B 3 0.12 2.78 0 95.20
60 INT163758 Regulation of Stat1 17 0.54 5.23 0.87 95.16
61 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 94.80
62 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24 94.48
63 INT306288 Regulation of CDC25B 1 0.28 0.73 0.17 94.40
64 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 94.20
65 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0 93.76
66 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 93.64
67 INT138919 Regulation of Gene_expression of Stat1 4 0.60 4.58 0.49 93.64
68 INT11455 Regulation of MAX 6 0.44 2.49 0.56 93.24
69 INT306292 Regulation of MEF2C 1 0.31 0.72 0.17 92.88
70 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 92.60
71 INT69915 Regulation of ATF2 2 0.34 0.81 0.42 92.60
72 INT140175 Regulation of Kit 23 0.62 8.59 1.79 92.12
73 INT201605 Regulation of Uvbi1 1 0.04 1.25 0.38 92.12
74 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 91.60
75 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 91.52
76 INT228786 Regulation of Gene_expression of Gja1 2 0.29 0.49 0.04 91.20
77 INT194611 Gene_expression of Klrk1 28 0.44 19.31 1.28 91.08
78 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 90.88
79 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 90.64
80 INT94162 Binding of UCN2 3 0.36 1.8 1.18 90.64
81 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 90.64
82 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 90.08
83 INT154651 Negative_regulation of Nfe2l2 19 0.59 10.48 2.01 89.64
84 INT101619 Positive_regulation of Gene_expression of TCHP 2 0.01 1.35 0.21 88.96
85 INT325372 Negative_regulation of Gene_expression of TCHP 1 0.01 0.82 0 88.68
86 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 88.28
87 INT101620 Gene_expression of TCHP 4 0.02 2.18 0.21 88.28
88 INT174553 Localization of Stat1 17 0.80 6.62 0.73 87.96
89 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 86.56
90 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 86.56
91 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 86.56
92 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 86.00
93 INT94163 Negative_regulation of UCN2 11 0.57 6.86 1.75 85.84
94 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 85.84
95 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 85.68
96 INT228788 Gene_expression of Chaf1a 1 0.05 0.34 0.04 85.32
97 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 85.12
98 INT94156 Negative_regulation of Crem 1 0.00 1.5 0.15 84.72
99 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 84.56
100 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 84.56
101 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 84.56
102 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 84.52
103 INT86246 Binding of Bcl2l1 8 0.37 6.67 0.57 84.52
104 INT228728 Gene_expression of Rae1 10 0.23 3.54 1 83.92
105 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 82.80
106 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 82.80
107 INT200191 Gene_expression of Xpa 1 0.64 10.1 0 82.40
108 INT200196 Negative_regulation of Gene_expression of Xpa 1 0.41 1.64 0 82.40
109 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 82.36
110 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 81.92
111 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 81.24
112 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13 80.56
113 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63 80.56
114 INT291516 Negative_regulation of Transcription of Fxn 1 0.54 0.77 0 80.56
115 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 80.32
116 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 79.92
117 INT338717 Gene_expression of DKC1 1 0.01 0.41 0 79.92
118 INT309502 Positive_regulation of Xrcc6 1 0.38 1.58 0 79.28
119 INT309505 Positive_regulation of Positive_regulation of Ogg1 1 0.26 1.04 0 79.20
120 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49 79.16
121 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 79.12
122 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 79.12
123 INT123521 Phosphorylation of Bcl2 8 0.81 5 0 79.04
124 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 78.88
125 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 78.88
126 INT309484 Positive_regulation of Ogg1 1 0.26 1.03 0 78.84
127 INT282990 Negative_regulation of Binding of Becn1 6 0.08 1.44 0 77.84
128 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15 77.44
129 INT186457 Binding of TAB1 3 0.47 1.53 0.18 77.36
130 INT282974 Binding of Becn1 24 0.07 7.43 0 77.24
131 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12 77.20
132 INT127059 Positive_regulation of SF3A3 4 0.02 2.08 0.82 76.48
133 INT168304 Positive_regulation of SNRPB 17 0.25 9.62 1.64 75.92
134 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 75.12
135 INT175893 Regulation of POLR2B 2 0.08 1.34 0 74.36
136 INT298404 Regulation of Transcription of POLR2B 1 0.05 1.02 0 74.36
137 INT117392 Binding of Insr 8 0.23 4.88 0.68 74.08
138 INT87287 Phosphorylation of CDCP1 20 0.04 5.62 2.43 74.00
139 INT194317 Regulation of Binding of TOP2B 1 0.26 0.43 0 73.92
140 INT117463 Binding of TOP2B 4 0.46 1.64 0.44 73.16
141 INT243418 Binding of Htt 14 0.30 5.94 0.44 73.12
142 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 73.04
143 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 72.88
144 INT70860 Binding of SNRPB 17 0.35 7 1.46 72.88
145 INT309493 Binding of Xrcc6 1 0.37 3 0.2 71.92
146 INT291507 Regulation of Negative_regulation of Fxn 1 0.37 0.87 0 71.44
147 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 71.08
148 INT86292 Positive_regulation of Positive_regulation of Mmp2 4 0.46 3.09 1.4 71.08
149 INT98357 Binding of Gnas 11 0.41 1.87 4.35 70.80
150 INT181803 Binding of Atxn1 12 0.48 7 0.3 70.72
151 INT236476 Protein_catabolism of SNRPB 1 0.04 0.64 0 69.76
152 INT126177 Positive_regulation of Atf3 14 0.70 14.34 5.56 68.88
153 INT216461 Positive_regulation of Dclre1a 1 0.35 1.09 0 68.56
154 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25 68.32
155 INT306285 Positive_regulation of Gene_expression of IER3 1 0.15 1.13 0.03 68.08
156 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48 67.72
157 INT201602 Positive_regulation of Uvbi1 2 0.04 1.17 0.04 67.72
158 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 67.68
159 INT244552 Positive_regulation of PPP1R15A 4 0.22 2.45 0 66.84
160 INT237140 Negative_regulation of Gene_expression of Serpina6 1 0.06 0.41 0 66.80
161 INT237143 Gene_expression of Serpina6 1 0.11 0.41 0 66.80
162 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 66.72
163 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93 66.24
164 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36 65.68
165 INT188001 Phosphorylation of H2afx 10 0.80 5.6 0.04 65.60
166 INT107300 Negative_regulation of Gzmb 1 0.04 0.76 0.23 64.96
167 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 64.92
168 INT309465 Gene_expression of Xrcc6 24 0.59 5.49 0.43 64.68
169 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 64.56
170 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 63.28
171 INT75497 Regulation of JUN 28 0.61 11.04 7.09 63.16
172 INT271099 Regulation of Gene_expression of PIK3CB 1 0.08 0.62 0 63.08
173 INT348468 Regulation of RASGRF1 1 0.02 0.53 0.06 63.00
174 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 62.88
175 INT155929 Positive_regulation of Negative_regulation of PARP1 2 0.49 1.02 0.04 62.84
176 INT236481 Negative_regulation of Negative_regulation of PARP1 1 0.15 0.95 0.04 62.84
177 INT250707 Gene_expression of PIK3CB 15 0.31 5.4 1.34 62.64
178 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 62.16
179 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 61.64
180 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 61.64
181 INT125100 Positive_regulation of IL24 4 0.65 7.15 1.57 61.60
182 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 61.44
183 INT309489 Binding of Ogg1 1 0.20 1.03 0 61.08
184 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 60.64
185 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 60.64
186 INT83835 Positive_regulation of CEACAM6 3 0.24 1.53 1.01 60.64
187 INT291513 Positive_regulation of Ccar1 1 0.17 0.6 0 60.64
188 INT291521 Positive_regulation of C10orf88 1 0.19 0.58 0 60.64
189 INT291519 Positive_regulation of Sgce 1 0.16 0.61 0 60.64
190 INT291514 Positive_regulation of Impact 1 0.14 0.59 0 60.64
191 INT291522 Positive_regulation of DHFRL1 1 0.24 0.62 0 60.64
192 INT291509 Positive_regulation of Tbx3 1 0.14 0.6 0 60.64
193 INT291508 Positive_regulation of Irx2 1 0.15 0.61 0 60.64
194 INT291515 Positive_regulation of Adam23 1 0.16 0.61 0 60.64
195 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 59.68
196 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 59.48
197 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 59.48
198 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 59.28
199 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 59.04
200 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 59.04
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