D:Down Syndrome

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Disease Term
Synonyms Chromosome 21 Trisomy Syndrome, Complete Trisomy 21 Syndrome, Congenital Acromicria Syndrome, DOWN S SYNDROME, Down Syndrome Partial Trisomy 21, Downs Syndrome, G TRISOMY, Langdon Down Syndrome, Mongolism, Mongoloidism, Morbus Down
Documents 220
Hot Single Events 163
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Down Syndrome. They are ordered first by their relevance to Down Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT106823 Binding of MBP and PAPPA 2 0.17 3.89 0.05 98.40
2 INT294290 PROK1 Positive_regulation of Gene_expression of IL11 1 0.59 0.46 0.23 92.56
3 INT294307 Gene_expression of RCAN1 Negative_regulation of Gene_expression of IL11 1 0.36 0.09 0 92.56
4 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41 89.68
5 INT271349 ACCS Positive_regulation of PAPPA 1 0.06 0.87 0.09 84.12
6 INT294309 PROK1 Regulation of Gene_expression of IL11 1 0.53 0.25 0.15 82.32
7 INT178324 Pts Regulation of Akt1 1 0.00 0.23 0 81.88
8 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35 78.36
9 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16 77.08
10 INT261647 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of BDKRB1 1 0.04 0.6 0.04 76.56
11 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47 76.40
12 INT261649 Positive_regulation of PRKCA Positive_regulation of BDKRB1 1 0.04 0.59 0.04 75.96
13 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 67.84
14 INT287103 Binding of FL and Ntrk2 1 0.28 0.67 0.24 65.44
15 INT287098 Binding of FL and T 1 0.10 0.66 0.23 65.44
16 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26 65.20
17 INT294302 PROK1 Positive_regulation of Localization of IL11 1 0.40 0.36 0.08 64.00
18 INT195122 Il1 Positive_regulation of Gene_expression of Gtf3a 1 0.02 1.38 0.5 58.08
19 INT294361 PROK1 Regulation of Gene_expression of Il11 1 0.64 0.05 0 53.92
20 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 48.48
21 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 45.20
22 INT271343 Binding of CRP and PAPPA 1 0.20 0.86 0.1 25.20
23 INT294314 Binding of IL11 and NFATC1 1 0.06 0 0 18.24
24 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08 17.40
25 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81 5.00
26 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34 5.00
27 INT297463 Binding of Ntrk1 and Ngf 1 0.10 0.78 0.87 5.00
28 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69 5.00
29 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64 5.00
30 INT287096 Binding of Bdnf and FL 1 0.16 1.15 0.6 5.00
31 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
32 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41 5.00
33 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41 5.00
34 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41 5.00
35 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41 5.00
36 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41 5.00
37 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39 5.00
38 INT237415 Il1rn Regulation of Il10 1 0.03 0.96 0.39 5.00
39 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39 5.00
40 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 5.00
41 INT356114 Prkca Positive_regulation of Binding of App and Tg 1 0.02 0.12 0.26 5.00
42 INT356094 Binding of App and Tg 1 0.08 0.12 0.26 5.00
43 INT195120 Il1 Regulation of Gene_expression of Cp 1 0.06 0.98 0.25 5.00
44 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24 5.00
45 INT261650 LGR6 Positive_regulation of MAPK1 1 0.04 0.71 0.24 5.00
46 INT287101 Binding of Bdnf and Mutyh 1 0.04 0.58 0.24 5.00
47 INT356098 Prkca Regulation of Prkaca 1 0.01 0.11 0.24 5.00
48 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
49 INT89612 Binding of FABP3 and MB 3 0.34 1.49 0.22 5.00
50 INT356089 Positive_regulation of Binding of Tg and Rab11a 1 0.00 0.07 0.21 5.00
51 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21 5.00
52 INT316062 Ps Positive_regulation of Il6 1 0.04 0.77 0.21 5.00
53 INT356099 Binding of Tg and Rab11a 1 0.00 0.07 0.21 5.00
54 INT287102 FL Positive_regulation of Bdnf 1 0.20 0.61 0.2 5.00
55 INT316064 Binding of RBPJ and Csl 1 0.16 0.33 0.2 5.00
56 INT287100 FL Positive_regulation of Ntrk2 1 0.30 0.61 0.2 5.00
57 INT319311 Binding of Glud1 and Ptk2b 1 0.36 0 0.19 5.00
58 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19 5.00
59 INT319307 Rbm39 Regulation of Bdnf 1 0.00 0.76 0.18 5.00
60 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18 5.00
61 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18 5.00
62 INT294292 PROK1 Regulation of IL11 1 0.53 0.42 0.17 5.00
63 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15 5.00
64 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15 5.00
65 INT237419 Binding of Hif1a and Bace1 Positive_regulation of Bace1 1 0.06 1.2 0.15 5.00
66 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15 5.00
67 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15 5.00
68 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15 5.00
69 INT237420 Binding of Hif1a and Bace1 Positive_regulation of Positive_regulation of Bace1 1 0.06 1.2 0.15 5.00
70 INT319314 Binding of Ptk2b and Rbm39 1 0.01 0.08 0.14 5.00
71 INT319316 Binding of GRIN1 and Ptk2b 1 0.52 0.08 0.14 5.00
72 INT196436 Cdk4 Negative_regulation of Ccnd1 Positive_regulation of Ccnd1 1 0.04 1.18 0.13 5.00
73 INT316059 Ps Regulation of Binding of Cd4 1 0.06 0.86 0.13 5.00
74 INT316058 Ps Regulation of Binding of Cd8a 1 0.02 0.86 0.13 5.00
75 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 5.00
76 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13 5.00
77 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13 5.00
78 INT195121 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gopc 1 0.17 0.26 0.11 5.00
79 INT319315 Binding of Ap2a2 and Htt 1 0.28 0.64 0.11 5.00
80 INT195119 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gfap 1 0.38 0.26 0.11 5.00
81 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09 5.00
82 INT294272 PROK1 Positive_regulation of IL11 Positive_regulation of Gene_expression of NPEPPS 1 0.01 0.16 0.09 5.00
83 INT294295 PROK1 Positive_regulation of IL11 1 0.40 0.15 0.09 5.00
84 INT294289 IL11 Positive_regulation of Gene_expression of NPEPPS 1 0.01 0.06 0.09 5.00
85 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08 5.00
86 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
87 INT271354 MPO Regulation of Gene_expression of CRP 1 0.16 1.74 0.08 5.00
88 INT271346 Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
89 INT271351 MPO Positive_regulation of CRP 1 0.07 1.69 0.08 5.00
90 INT294308 PROKR1 Regulation of Gene_expression of IL11 1 0.34 0 0.08 5.00
91 INT294315 PROK1 Regulation of PROKR1 1 0.24 0 0.08 5.00
92 INT294310 PTGER2 Positive_regulation of Gene_expression of IL11 1 0.06 0.12 0.08 5.00
93 INT319309 Egr2 Regulation of Ptk2b 1 0.29 0.37 0.07 5.00
94 INT319306 Egr2 Regulation of Pitpnm2 1 0.12 0.37 0.07 5.00
95 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07 5.00
96 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06 5.00
97 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 5.00
98 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05 5.00
99 INT294291 PROK1 Regulation of Localization of IL11 1 0.53 0 0.05 5.00
100 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05 5.00
101 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05 5.00
102 INT196435 Lhb Positive_regulation of Mapk1 1 0.12 0.77 0.04 5.00
103 INT294311 Gene_expression of RCAN1 Positive_regulation of IL11 1 0.39 0 0.04 5.00
104 INT294299 Gene_expression of RCAN1 Negative_regulation of PROK1 1 0.42 0 0.04 5.00
105 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04 5.00
106 INT356113 Binding of App and Apba1 Regulation of Gene_expression of App 1 0.17 0.06 0.03 5.00
107 INT316060 Binding of Erbb4 and Ncor2 1 0.12 0.41 0.03 5.00
108 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03 5.00
109 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03 5.00
110 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03 5.00
111 INT294298 PROK1 Positive_regulation of Gene_expression of RCAN1 1 0.49 0 0.03 5.00
112 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03 5.00
113 INT240586 IRF7 Positive_regulation of Positive_regulation of IFNA1 1 0.01 0.44 0.03 5.00
114 INT294303 PTGER2 Positive_regulation of Localization of IL11 1 0.04 0.08 0.03 5.00
115 INT356115 Binding of App and Apba1 Positive_regulation of App 1 0.18 0.06 0.03 5.00
116 INT294293 Binding of RCAN1 and CABIN1 1 0.03 0 0.03 5.00
117 INT316056 Binding of Ncor2 and Tab2 1 0.12 0.41 0.03 5.00
118 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03 5.00
119 INT356116 Binding of App and Apba1 Regulation of App 1 0.10 0.06 0.03 5.00
120 INT271328 FABP3 Positive_regulation of Binding of FABP3 and MB 1 0.00 0.81 0.03 5.00
121 INT316055 Binding of Erbb4 and Tab2 1 0.23 0.4 0.03 5.00
122 INT294301 PTGER2 Positive_regulation of IL11 1 0.04 0.08 0.03 5.00
123 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03 5.00
124 INT356117 Binding of SORL1 and Apbb1 1 0.14 0.43 0 5.00
125 INT286730 Creb1 Regulation of Ppargc1a 1 0.17 0 0 5.00
126 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0 5.00
127 INT294305 PROK1 Regulation of RCAN1 1 0.26 0 0 5.00
128 INT286728 Creb1 Regulation of Ppargc1a 1 0.29 0 0 5.00
129 INT319310 Binding of Eno2 and Glud1 1 0.36 0.24 0 5.00
130 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0 5.00
131 INT356083 Binding of App and Notch1 1 0.02 0.2 0 5.00
132 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0 5.00
133 INT294312 PROKR1 Positive_regulation of Gene_expression of IL11 1 0.38 0 0 5.00
134 INT294304 RCAN1 Negative_regulation of PROK1 1 0.57 0 0 5.00
135 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0 5.00
136 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0 5.00
137 INT196434 Binding of Ccne2 and Cdc25a 1 0.01 0.48 0 5.00
138 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0 5.00
139 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0 5.00
140 INT294306 Positive_regulation of PROK1 Positive_regulation of Transcription of IL11 1 0.40 0.08 0 5.00
141 INT356087 Binding of App and Ncstn 1 0.17 0.07 0 5.00
142 INT271348 Binding of CHKB and MB 1 0.01 1.01 0 5.00
143 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0 5.00
144 INT294300 PROK1 Positive_regulation of Positive_regulation of IL11 1 0.40 0.15 0 5.00
145 INT356118 Binding of SORL1 and App 1 0.41 0.43 0 5.00
146 INT356109 Rab6a Regulation of App 1 0.14 0.05 0 5.00
147 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0 5.00
148 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0 5.00
149 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0 5.00
150 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 5.00
151 INT286729 Positive_regulation of Mapk14 Positive_regulation of Ppargc1a 1 0.44 0.1 0 5.00
152 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0 5.00
153 INT356104 Positive_regulation of Binding of App and Lrp1 1 0.40 0.52 0 5.00
154 INT294313 Gene_expression of CABIN1 Positive_regulation of IL11 1 0.03 0.06 0 5.00
155 INT294296 Binding of IL11 and PROK1 1 0.32 0.07 0 5.00
156 INT356107 Binding of Ncstn and Aph1a 1 0.05 0.06 0 5.00
157 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0 5.00
158 INT177762 GOPC Negative_regulation of Gene_expression of CHKB 1 0.11 0.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Down Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Down Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 100.00
2 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 100.00
3 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9 100.00
4 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 100.00
5 INT65977 Gene_expression of RCAN1 6 0.70 3.72 0.59 100.00
6 INT108790 Gene_expression of RGS1 2 0.58 4.36 1.76 100.00
7 INT15837 Binding of CGA 31 0.41 12.06 3.17 100.00
8 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 100.00
9 INT240593 Gene_expression of Naip1 1 0.02 2.01 0.49 100.00
10 INT213442 Gene_expression of CXCL3 8 0.57 6.3 1.41 100.00
11 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33 100.00
12 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 99.88
13 INT56386 Positive_regulation of UBXN11 6 0.49 2.79 1.05 99.84
14 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 99.84
15 INT178290 Negative_regulation of Gene_expression of Oxct1 1 0.42 0.29 0.04 99.68
16 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03 99.68
17 INT115908 Localization of TCO 3 0.48 1.76 1.39 99.60
18 INT286712 Regulation of Transcription of Rcan1 1 0.20 0.1 0 99.60
19 INT286719 Transcription of Rcan1 1 0.39 0.1 0 99.60
20 INT181055 Positive_regulation of Ctss 5 0.67 2.84 1.35 99.56
21 INT316037 Positive_regulation of Localization of Ctss 1 0.12 1.07 0.37 99.56
22 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15 99.48
23 INT178303 Gene_expression of Oxct1 1 0.75 1.64 0.36 99.48
24 INT261680 Positive_regulation of Negative_regulation of MAPK1 2 0.33 1.2 0.21 99.48
25 INT72141 Binding of Apoe 11 0.37 10.91 3.27 99.44
26 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 99.36
27 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 99.32
28 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77 99.28
29 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71 99.20
30 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86 99.20
31 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8 99.12
32 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 99.12
33 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 99.00
34 INT63779 Localization of Ado 6 0.64 4.8 3.81 99.00
35 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 98.96
36 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99 98.96
37 INT24903 Negative_regulation of Gene_expression of PAPPA 6 0.42 2.98 0.52 98.96
38 INT24904 Negative_regulation of PAPPA 13 0.57 9.93 2.74 98.96
39 INT273195 Localization of Ctss 2 0.19 1.65 0.51 98.96
40 INT65500 Gene_expression of App 605 0.78 429.94 98.31 98.94
41 INT250921 Regulation of CREG1 1 0.04 4.55 1.21 98.92
42 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41 98.92
43 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66 98.92
44 INT250920 Regulation of Negative_regulation of CREG1 1 0.02 0.92 0.18 98.92
45 INT250926 Regulation of Regulation of CREG1 1 0.03 0.92 0.18 98.92
46 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 98.88
47 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 98.84
48 INT250925 Negative_regulation of CREG1 1 0.02 2.08 0.55 98.74
49 INT204449 Gene_expression of T 17 0.32 9.77 4.77 98.68
50 INT11945 Regulation of Chat 38 0.62 7.75 14.97 98.68
51 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33 98.68
52 INT297460 Regulation of Regulation of Ngfr 1 0.33 0.32 0.21 98.68
53 INT297457 Regulation of Regulation of Chat 1 0.27 0.32 0.21 98.68
54 INT89729 Gene_expression of Sim2 3 0.78 2.85 0.45 98.56
55 INT261686 Phosphorylation of BDKRB1 1 0.13 6.07 0.92 98.56
56 INT89727 Positive_regulation of Gene_expression of Sim2 1 0.70 0.98 0.1 98.56
57 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 98.54
58 INT240595 Gene_expression of CSPG4P2Y 1 0.03 1.87 0.41 98.48
59 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 98.36
60 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 98.34
61 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 98.32
62 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 98.32
63 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 98.20
64 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.14
65 INT159543 Localization of SOD1 29 0.75 8.62 1.06 98.12
66 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 98.00
67 INT24907 Gene_expression of PAPPA 42 0.75 28.32 6.63 97.88
68 INT59983 Regulation of BDKRB1 12 0.45 10.69 5.11 97.80
69 INT7644 Positive_regulation of Gene_expression of PDYN 27 0.69 10.19 17.47 97.76
70 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 97.72
71 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 97.60
72 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51 97.56
73 INT261675 Gene_expression of ASPRV1 1 0.01 1.75 0.19 97.56
74 INT171092 Positive_regulation of Gene_expression of MCF2 6 0.05 1.57 0.1 97.56
75 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 97.40
76 INT90545 Phosphorylation of Siglec1 53 0.11 12.09 6.81 96.72
77 INT221448 Gene_expression of CREG1 8 0.05 27.44 10.87 96.64
78 INT89728 Binding of Sim2 1 0.37 1.93 0.11 96.28
79 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 96.08
80 INT117614 Positive_regulation of PAPPA 18 0.67 11.9 3.76 96.08
81 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52 95.88
82 INT59135 Positive_regulation of CTSB 15 0.67 7.53 2.53 95.88
83 INT59136 Negative_regulation of Positive_regulation of CTSB 3 0.41 2.02 1.11 95.88
84 INT193736 Regulation of Positive_regulation of CTSB 1 0.04 1.13 0.52 95.88
85 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95 95.72
86 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 95.72
87 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06 95.52
88 INT1793 Localization of CGA 379 0.81 67.38 114.69 95.16
89 INT160606 Localization of AFP 6 0.74 3.39 1.29 95.16
90 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 95.04
91 INT200806 Binding of EEC1 6 0.39 4.24 0.29 94.88
92 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 94.44
93 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 94.40
94 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 94.32
95 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 94.32
96 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 94.24
97 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 94.24
98 INT171041 Positive_regulation of IL11 5 0.55 2.49 1.22 94.08
99 INT30443 Positive_regulation of AIS 30 0.54 22.59 7.2 93.92
100 INT255313 Positive_regulation of Positive_regulation of AIS 2 0.04 3.83 0.55 93.92
101 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 93.68
102 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 93.12
103 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93 93.08
104 INT160576 Gene_expression of Psgb1 3 0.35 1.63 1.08 92.76
105 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 92.64
106 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 92.56
107 INT172179 Positive_regulation of Gene_expression of IL11 7 0.55 4.29 2.43 92.56
108 INT178291 Gene_expression of Hps1 26 0.67 8.2 2.52 92.36
109 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 92.00
110 INT272438 Gene_expression of PROK1 32 0.63 15.06 1.01 91.84
111 INT272434 Positive_regulation of Gene_expression of PROK1 2 0.47 0.86 0.14 91.84
112 INT184825 Regulation of Thy1 7 0.42 4.14 0.28 91.20
113 INT294346 Positive_regulation of Gene_expression of RCAN1 1 0.63 0.34 0.09 91.12
114 INT212444 Positive_regulation of Phosphorylation of TYR 4 0.18 4.83 0.12 90.88
115 INT261684 Positive_regulation of Phosphorylation of BDKRB1 1 0.11 0.86 0.08 90.88
116 INT286714 Transcription of Nrf1 1 0.46 0.18 0 90.80
117 INT217393 Negative_regulation of Gene_expression of Mme 3 0.43 5.98 0.46 90.80
118 INT239159 Transcription of Nfe2l2 9 0.58 3.59 0.37 90.80
119 INT286720 Positive_regulation of Transcription of Nrf1 1 0.40 0.09 0 90.80
120 INT286718 Negative_regulation of Transcription of Nrf1 1 0.37 0.09 0 90.80
121 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 90.48
122 INT71780 Phosphorylation of TYR 12 0.34 17.21 1.62 90.32
123 INT272436 Negative_regulation of Gene_expression of PROK1 3 0.40 2.3 0.17 90.32
124 INT2837 Regulation of PAEP 17 0.53 7.84 3.17 90.08
125 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 90.04
126 INT205142 Positive_regulation of TTBK1 1 0.02 0.82 0.14 89.88
127 INT203677 Negative_regulation of Gene_expression of RCAN1 2 0.39 1.31 0 89.84
128 INT172575 Gene_expression of T(16C3-4;17A2)65Dn 1 0.65 0.75 0.15 88.12
129 INT193939 Binding of PSEN1 10 0.36 6.16 1.93 87.92
130 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 87.68
131 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 87.68
132 INT756 Gene_expression of C3 138 0.75 100.6 19.2 87.68
133 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 87.68
134 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28 87.68
135 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16 87.68
136 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 86.28
137 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 86.24
138 INT2659 Positive_regulation of Psgb1 2 0.40 3.25 0.3 86.24
139 INT101411 Negative_regulation of IL11 4 0.43 1.16 0.75 86.12
140 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64 85.32
141 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 85.28
142 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09 85.28
143 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 85.20
144 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 84.80
145 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7 84.20
146 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 83.68
147 INT152647 Gene_expression of IRF7 2 0.57 4 0.4 82.64
148 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 82.64
149 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27 82.64
150 INT240587 Gene_expression of Slk 1 0.58 0.6 0.08 82.64
151 INT240594 Gene_expression of Serpinb2 1 0.18 0.68 0.08 82.64
152 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 82.04
153 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 82.00
154 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 81.88
155 INT179826 Gene_expression of Il11 29 0.75 11.5 3.75 81.76
156 INT179830 Negative_regulation of Il11 5 0.41 2.87 1.87 81.76
157 INT179831 Negative_regulation of Gene_expression of Il11 6 0.41 1.92 1.14 81.76
158 INT179833 Regulation of Gene_expression of Il11 2 0.44 0.08 0.15 81.76
159 INT294273 Regulation of Negative_regulation of Il11 1 0.44 0.15 0 81.76
160 INT6645 Positive_regulation of BDKRB1 14 0.66 12.17 13.79 81.40
161 INT319271 Positive_regulation of Dnajb5 1 0.43 1.24 0.06 81.36
162 INT178295 Regulation of Oxct2a 1 0.01 0.21 0.03 80.24
163 INT319262 Positive_regulation of Golga7b 1 0.01 1.23 0.06 80.16
164 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 79.76
165 INT278982 Regulation of EPHB2 6 0.44 1.97 0.53 79.12
166 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 78.64
167 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 78.64
168 INT148564 Localization of HAL 8 0.68 2.46 0.62 78.56
169 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 77.64
170 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 77.08
171 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 77.08
172 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 76.84
173 INT14447 Localization of F2 20 0.79 12.77 2.67 76.44
174 INT214113 Transcription of Ntrk2 2 0.72 1.84 0.96 76.04
175 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 75.92
176 INT287094 Transcription of T 1 0.29 1.41 0.8 75.84
177 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 75.84
178 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 75.20
179 INT169161 Negative_regulation of Gene_expression of HTR1A 3 0.42 2.53 1.27 75.00
180 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 75.00
181 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 75.00
182 INT103477 Negative_regulation of Gene_expression of BDNF 23 0.52 10.63 6.26 75.00
183 INT77586 Positive_regulation of Gene_expression of HTR1A 6 0.46 3.54 1.51 75.00
184 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 75.00
185 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 74.24
186 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 73.56
187 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25 72.84
188 INT5129 Regulation of Gene_expression of Lhb 10 0.55 4.79 2.09 72.80
189 INT5489 Localization of CA2 172 0.80 39.46 33.56 71.04
190 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43 70.80
191 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 70.72
192 INT217386 Negative_regulation of Positive_regulation of Car1 2 0.18 1.67 0.25 70.72
193 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39 70.60
194 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94 70.60
195 INT107381 Positive_regulation of Gene_expression of PAPPA 4 0.49 2.32 0.85 70.24
196 INT194780 Regulation of Negative_regulation of MAPK1 3 0.32 3.42 0.76 70.16
197 INT178294 Gene_expression of Acp1 1 0.75 1.29 0.36 69.92
198 INT294343 Positive_regulation of Transcription of IL11 1 0.37 0.13 0 69.84
199 INT178292 Negative_regulation of Gene_expression of Acp1 1 0.42 0.55 0.18 69.48
200 INT178297 Positive_regulation of Gene_expression of Acp1 1 0.45 0.75 0.18 69.48
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