D:Drug Dependence

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Disease Term
Synonyms Abuse Drug, Abuse Substance, Abuses Substance, Addiction Drug, Addiction Substance, Alcohol Addiction, Alcoholism, COCAINE ADDICTION, Dependence Drug, Dependence Substance, Disorder Drug Use
Documents 5977
Hot Single Events 200
Hot Interactions 58

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Drug Dependence. They are ordered first by their relevance to Drug Dependence and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16 100.00
2 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27 100.00
3 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27 100.00
4 INT209130 Binding of Riok3 and Sugt1 1 0.00 0.44 0.4 100.00
5 INT209133 Binding of Bcl2a1a and Riok3 1 0.00 0.44 0.4 100.00
6 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 99.96
7 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8 99.88
8 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35 99.60
9 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7 99.36
10 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24 99.14
11 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16 99.00
12 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42 98.92
13 INT139488 Oprm1 Positive_regulation of Cnr1 1 0.17 0.1 0.42 98.92
14 INT139489 Oprm1 Positive_regulation of Penk 1 0.23 0.1 0.42 98.92
15 INT139486 Oprm1 Positive_regulation of Crh 1 0.27 0.1 0.42 98.92
16 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31 98.78
17 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62 98.56
18 INT217075 Binding of Acsm3 and Slc26a4 1 0.04 2.11 0.04 98.12
19 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28 98.04
20 INT139893 Binding of Alb and Alms1 1 0.04 0.48 0.75 97.68
21 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17 97.32
22 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26 95.92
23 INT153897 Binding of KCNJ3 and Snx27 1 0.03 0.28 0.5 94.92
24 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23 94.84
25 INT253637 TNF Regulation of Transcription of HIVEP1 1 0.07 1.72 0.26 92.40
26 INT317640 Slc3a1 Positive_regulation of Creb1 1 0.12 0.58 0.46 92.36
27 INT143619 Bhlhe22 Positive_regulation of Regulation of Msr1 1 0.40 0.93 0.46 92.12
28 INT153896 Snx27 Regulation of KCNJ3 1 0.04 0.17 0.33 92.04
29 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22 91.32
30 INT317636 Creb1 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.55 0.45 91.32
31 INT245348 Binding of Abat and Vta1 1 0.03 0.53 2.01 89.52
32 INT296786 Gopc Regulation of Positive_regulation of Il1 1 0.02 1.37 0.77 89.44
33 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77 89.44
34 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76 89.44
35 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75 89.44
36 INT84414 Folr2 Regulation of Binding of Oprd1 1 0.03 0.18 0.84 89.28
37 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43 89.20
38 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77 89.04
39 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77 89.04
40 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76 89.04
41 INT245349 Binding of Abat and Gpr156 1 0.02 0.26 1 88.32
42 INT132585 GABBR1 Positive_regulation of Binding of Gabbr1 1 0.01 0.6 0.3 87.60
43 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7 87.12
44 INT164455 Ngf Negative_regulation of Bdnf 1 0.05 0.59 0.59 86.40
45 INT214370 Slc6a3 Regulation of Amph 1 0.14 0.44 0.82 86.12
46 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26 85.48
47 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86 85.48
48 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92 85.20
49 INT331675 Binding of Drd1a and Sptan1 1 0.03 0.33 0.4 85.20
50 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22 84.60
51 INT116019 Negative_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7 82.60
52 INT116020 Positive_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7 82.20
53 INT116021 Binding of Il4 and Mavs 1 0.02 0.08 0.7 82.20
54 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58 81.68
55 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65 81.12
56 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58 80.72
57 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89 80.56
58 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8 80.48
59 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 80.00
60 INT159457 Binding of Vamp1 and Inadl2 1 0.00 0.36 0.29 79.76
61 INT150754 GTS Negative_regulation of Gene_expression of Prkaca 1 0.32 0.08 0.65 79.52
62 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24 79.44
63 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47 78.24
64 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47 78.24
65 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16 78.16
66 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16 78.16
67 INT153895 Regulation of Snx27 Regulation of KCNJ3 1 0.04 0.08 0.16 78.08
68 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58 77.56
69 INT150755 GTS Negative_regulation of Phosphorylation of Atf6b 1 0.13 0.08 0.64 75.96
70 INT159456 Negative_regulation of Binding of Vamp1 and Ppidl1 1 0.00 0.42 0.28 75.68
71 INT159455 Binding of Vamp1 and Ppidl1 1 0.00 0.84 0.57 75.20
72 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62 75.00
73 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61 75.00
74 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58 75.00
75 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57 75.00
76 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57 75.00
77 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43 74.88
78 INT353848 Binding of SCLY and Ubash3a 1 0.30 0.47 0.04 74.48
79 INT110274 Binding of Fdps and Plin2 1 0.00 0.22 0.18 74.08
80 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12 73.64
81 INT112608 DNAJC15 Regulation of Gene_expression of Fos 1 0.02 0.14 1.12 73.64
82 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07 72.36
83 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06 72.36
84 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28 71.12
85 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27 71.12
86 INT162224 Grin1 Positive_regulation of Gene_expression of Gria1 1 0.27 0.07 0.66 70.76
87 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59 70.56
88 INT162223 Grin1 Positive_regulation of Localization of Gria2 1 0.23 0.07 0.66 70.36
89 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34 69.24
90 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23 68.48
91 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83 67.96
92 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83 67.68
93 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83 67.24
94 INT114924 Creb1 Regulation of Positive_regulation of Oprm1 1 0.09 0.13 0.79 66.08
95 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24 65.28
96 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58 64.56
97 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09 63.12
98 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43 62.80
99 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11 62.80
100 INT296293 Prkaca Regulation of Positive_regulation of Creb1 1 0.16 0.62 0.55 62.56
101 INT296291 Prkaca Regulation of Localization of Calm3 1 0.09 0.62 0.55 62.56
102 INT296273 Prkaca Regulation of Localization of Camk4 1 0.16 0.62 0.55 62.56
103 INT296302 Camk4 Regulation of Localization of Calm3 1 0.15 0.31 0.28 62.24
104 INT296287 Camk4 Regulation of Positive_regulation of Creb1 1 0.27 0.31 0.27 62.24
105 INT296284 Calm3 Regulation of Positive_regulation of Creb1 1 0.09 0.31 0.28 61.96
106 INT296281 Calm3 Regulation of Localization of Camk4 1 0.13 0.31 0.28 61.96
107 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37 61.84
108 INT151545 Adcy1 Positive_regulation of Regulation of Fmr1 1 0.48 0.37 0.37 61.84
109 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37 61.84
110 INT151544 Camk4 Positive_regulation of Regulation of Fmr1 1 0.50 0.36 0.37 61.52
111 INT151551 Regulation of Camk4 Positive_regulation of Atf2 1 0.34 0.36 0.37 61.52
112 INT151547 Camk4 Positive_regulation of Atf2 1 0.38 0.36 0.37 61.52
113 INT107933 Oprm1 Positive_regulation of Gene_expression of Mastl 1 0.33 0.61 0.71 61.40
114 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56 61.36
115 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84 60.40
116 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41 59.28
117 INT290727 Binding of Prdm6 and Arsi 1 0.01 0.17 0.04 58.80
118 INT251148 Negative_regulation of Binding of Grin2a and Dlg2 1 0.37 0.45 0.32 57.64
119 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93 57.20
120 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64 56.36
121 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62 56.00
122 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47 55.40
123 INT161871 Mors1 Positive_regulation of GRIN1 1 0.01 0.12 1.46 55.40
124 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47 55.16
125 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45 55.16
126 INT161860 OPRM1 Positive_regulation of OPRM1 Positive_regulation of GRIN1 1 0.56 0.12 1.45 55.16
127 INT153516 PLG Positive_regulation of Pas5a 1 0.57 0.05 0.83 54.68
128 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86 53.04
129 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43 52.08
130 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 52.08
131 INT97202 Binding of APLNR and Pnoc 1 0.02 0.27 0.63 51.60
132 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41 50.84
133 INT114921 Binding of Oprm1 and Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.06 0.05 0.54 50.64
134 INT114928 Positive_regulation of Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.16 0.05 0.54 50.64
135 INT264835 Binding of Creb1 and Tpr 1 0.01 0.05 0.06 50.40
136 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42 50.00
137 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24 50.00
138 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22 50.00
139 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2 50.00
140 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19 50.00
141 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19 50.00
142 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 50.00
143 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 50.00
144 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08 50.00
145 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05 50.00
146 INT251153 Dlg2 Positive_regulation of Gene_expression of Grin2a 1 0.40 0.6 0.92 50.00
147 INT251152 Dlg2 Positive_regulation of Localization of Grin2b 1 0.43 0.6 0.92 50.00
148 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 50.00
149 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 50.00
150 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55 50.00
151 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55 50.00
152 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54 50.00
153 INT223556 Churc1 Regulation of Cnr2 1 0.00 0.8 0.54 50.00
154 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54 50.00
155 INT223558 Dpcr1 Regulation of Cms1 1 0.00 0.79 0.51 50.00
156 INT114930 Binding of Oprm1 and Crebbp Positive_regulation of Positive_regulation of Creb1 1 0.06 0 0.51 49.72
157 INT114931 Binding of Oprm1 and Creb1 Positive_regulation of Positive_regulation of Creb1 1 0.16 0 0.51 49.72
158 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06 49.56
159 INT210898 IGHD1-14 Regulation of SELE 1 0.22 1.51 0 49.44
160 INT159454 Binding of Inadl2 and Ppidl1 1 0.03 1.08 0.7 49.28
161 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 0.26 0.33 0.64 48.92
162 INT233671 gr Positive_regulation of Transcription of Tsc22d3 1 0.44 0.33 0.64 48.92
163 INT190003 Binding of MVD and Slc6a3 1 0.13 0.19 0.37 48.32
164 INT190000 Binding of MVD and Slc6a3 Positive_regulation of Ubqln1 1 0.01 0.09 0.19 48.32
165 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5 46.28
166 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41 46.28
167 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31 46.28
168 INT206609 Binding of Col7a1 and Ecm1 1 0.00 0.47 0.33 46.08
169 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 45.76
170 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4 45.72
171 INT296276 Binding of Preb and Kcnip3 1 0.02 0.06 0.16 44.04
172 INT296294 Binding of Kcnip3 and Dre 1 0.13 0.06 0.16 44.04
173 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73 43.96
174 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 43.80
175 INT206608 Binding of Ecm1 and Itgb5 1 0.02 0.41 0.33 43.56
176 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91 42.36
177 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 42.20
178 INT78030 Binding of VEGFC and FCAMR 1 0.01 0.31 0.55 41.80
179 INT315185 Binding of CNOT1 and Tg(CAG-EGFP)D4Nagy 1 0.04 0.16 0.74 39.92
180 INT315182 Binding of Tg(CAG-EGFP)D4Nagy and Mors1 1 0.01 0.16 0.74 39.92
181 INT151338 Binding of Dio1 and P9Ehs1 1 0.09 0.16 0.52 39.44
182 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 39.00
183 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67 38.32
184 INT164363 Regulation of Binding of NLRP1 and VTA1 1 0.14 0.45 0.86 38.32
185 INT273938 Creb1 Positive_regulation of Transcription of Mirg 1 0.01 0.06 0 35.08
186 INT273951 Phosphorylation of Creb1 Positive_regulation of Pmp2 1 0.06 0.06 0 33.08
187 INT273952 Creb1 Positive_regulation of Pmp2 1 0.09 0.06 0 32.48
188 INT273943 Creb1 Positive_regulation of Transcription of Crem 1 0.44 0.07 0 32.48
189 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68 32.28
190 INT270938 Binding of Pick1 and Wnt2 1 0.00 0.18 0.03 30.24
191 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 30.12
192 INT143618 Msr1 Positive_regulation of Adrb3 1 0.16 0.85 0.2 28.40
193 INT111014 Binding of OPRL1 and Oprd1 1 0.02 0 0.64 26.40
194 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 0.14 0.6 1.21 25.00
195 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77 25.00
196 INT270950 Binding of Slc6a3 and Tgfb1i1 1 0.02 0.23 0.04 22.40
197 INT264839 Positive_regulation of Binding of Eno2 and Tpr 1 0.00 0.17 0.1 21.56
198 INT264838 Binding of Eno2 and Spp1 1 0.00 0.17 0.1 21.56
199 INT264836 Binding of Eno2 and Tpr 1 0.00 0.17 0.1 21.56
200 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08 21.28

Single Events

The table below shows the top 200 pain related interactions that have been reported for Drug Dependence. They are ordered first by their pain relevance and then by number of times they were reported in Drug Dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 100.00
2 INT53468 Binding of Acsm3 26 0.24 20.87 2.95 100.00
3 INT211907 Gene_expression of RIOK3 3 0.13 3.96 0.75 100.00
4 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 100.00
5 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
6 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 100.00
7 INT234003 Positive_regulation of RIOK3 1 0.10 2.33 0.58 100.00
8 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
9 INT272768 Gene_expression of Nrxn3 5 0.78 4.73 3.31 100.00
10 INT211905 Negative_regulation of RIOK3 2 0.07 2.25 0.48 100.00
11 INT83680 Gene_expression of FUT1 40 0.26 25.45 4.98 100.00
12 INT211906 Gene_expression of EPC1 15 0.19 3.75 0.61 100.00
13 INT332757 Regulation of Binding of ADHD1 1 0.34 1.71 0.13 100.00
14 INT234002 Positive_regulation of Gene_expression of RIOK3 1 0.10 1.14 0.12 100.00
15 INT155681 Negative_regulation of Gene_expression of Slc1a3 5 0.36 2.26 4.86 100.00
16 INT135120 Phosphorylation of Atf6b 13 0.61 4.01 8.03 100.00
17 INT21566 Regulation of Oprk1 10 0.62 3.4 8.63 100.00
18 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 100.00
19 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 100.00
20 INT15011 Positive_regulation of Gpi1 29 0.47 12.47 13.48 100.00
21 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 100.00
22 INT2213 Regulation of EP300 10 0.54 4.72 4.5 100.00
23 INT46298 Regulation of Ankrd23 3 0.27 1.31 0.86 100.00
24 INT74182 Positive_regulation of Binding of OPRK1 8 0.49 1.39 5.25 100.00
25 INT310381 Positive_regulation of Gene_expression of Nrxn3 1 0.03 1.19 1 100.00
26 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49 100.00
27 INT21482 Gene_expression of Morph1 3 0.12 0.35 4.19 100.00
28 INT40315 Gene_expression of Abcc1 10 0.76 5.66 2.53 100.00
29 INT210324 Localization of DDOST 3 0.65 1.78 2.4 100.00
30 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 100.00
31 INT38706 Positive_regulation of Positive_regulation of Alb 4 0.46 3.53 1.11 100.00
32 INT28728 Regulation of Cfp 49 0.46 13.15 21.43 99.98
33 INT118589 Regulation of OFC1 11 0.23 3.35 2.94 99.98
34 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59 99.98
35 INT150698 Regulation of PTPRB 1 0.45 1.52 0.89 99.96
36 INT351284 Regulation of Localization of AP1M2 1 0.04 0.85 1.9 99.96
37 INT351285 Localization of AP1M2 1 0.07 0.79 1.89 99.96
38 INT39781 Gene_expression of Sd 7 0.60 2.47 1.33 99.96
39 INT102023 Regulation of Creb1 51 0.62 16.29 16.71 99.92
40 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 99.92
41 INT2893 Localization of Oxt 219 0.80 28.96 79.43 99.92
42 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 99.92
43 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.92
44 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 99.90
45 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 99.90
46 INT226221 Binding of Dusp1 1 0.04 0.92 0.68 99.90
47 INT118678 Phosphorylation of Camk4 22 0.82 9.4 10.7 99.90
48 INT20612 Positive_regulation of Asap1 36 0.68 24.35 6.06 99.90
49 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 99.90
50 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.88
51 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 99.88
52 INT100520 Regulation of Grm1 8 0.44 1.3 4.48 99.88
53 INT78675 Gene_expression of Dbi 31 0.78 12.93 23.64 99.84
54 INT94031 Regulation of Gene_expression of Dbi 4 0.24 3.36 3.08 99.84
55 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.84
56 INT261511 Localization of CBS 1 0.02 5.06 7.27 99.84
57 INT217072 Negative_regulation of Acsm3 5 0.29 6.15 1.59 99.84
58 INT293904 Regulation of TPH2 4 0.54 2.19 0.65 99.84
59 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.84
60 INT210123 Localization of Axin1 1 0.04 0.84 0.17 99.84
61 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86 99.84
62 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95 99.84
63 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 99.82
64 INT12484 Binding of Drd2 45 0.48 15.17 24.72 99.80
65 INT147412 Binding of DRD4 11 0.47 7.57 2.77 99.80
66 INT170813 Gene_expression of Prdm6 11 0.65 4.35 0.88 99.80
67 INT65732 Binding of Msr1 9 0.47 7.28 2.42 99.80
68 INT28593 Gene_expression of Dbt 4 0.53 3.08 0.73 99.78
69 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.76
70 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 99.76
71 INT110705 Positive_regulation of Positive_regulation of Grin1 11 0.69 4.7 7.33 99.76
72 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 99.76
73 INT8527 Positive_regulation of Positive_regulation of Fos 20 0.70 6.87 9.62 99.76
74 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 99.76
75 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22 99.76
76 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21 99.76
77 INT148894 Binding of Cytl1 2 0.47 0.99 0.77 99.76
78 INT164368 Localization of VTA1 5 0.53 3.33 8.47 99.74
79 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 99.72
80 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31 99.72
81 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 99.72
82 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07 99.72
83 INT212822 Negative_regulation of Chrm5 5 0.42 0.86 2.96 99.72
84 INT152613 Positive_regulation of Morph3 1 0.04 0.1 0.77 99.72
85 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 99.70
86 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 99.70
87 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 99.68
88 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.68
89 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 99.68
90 INT251128 Regulation of Negative_regulation of Dlg2 1 0.24 1.97 2.01 99.68
91 INT200963 Regulation of UPF1 10 0.01 2.18 2.67 99.68
92 INT200980 Transcription of APOL1 1 0.67 0.84 0.54 99.68
93 INT148494 Binding of Cdk5 6 0.40 5.97 2.31 99.68
94 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.68
95 INT201021 Transcription of APOL2 1 0.56 0.45 0.38 99.68
96 INT100523 Regulation of GRM5 2 0.26 0.49 1.51 99.68
97 INT154944 Positive_regulation of APOL4 2 0.47 0.36 0.25 99.68
98 INT200948 Regulation of Transcription of APOL2 1 0.37 0.23 0.24 99.68
99 INT200997 Regulation of Transcription of APOL1 1 0.32 0.23 0.24 99.68
100 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05 99.66
101 INT99076 Regulation of Gene_expression of FosB 7 0.62 1.34 7.32 99.66
102 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 99.64
103 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 99.64
104 INT2802 Negative_regulation of Asrgl1 14 0.59 2.69 7.37 99.64
105 INT5476 Regulation of Gabbr1 21 0.45 4.01 10.26 99.64
106 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 99.62
107 INT35985 Regulation of oh 1 0.01 0.1 0.55 99.62
108 INT45389 Gene_expression of LOC681028 1 0.14 0.4 0.58 99.60
109 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 99.60
110 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 99.58
111 INT58044 Gene_expression of Slc9a2 3 0.77 0.55 3.01 99.58
112 INT78670 Positive_regulation of Gene_expression of Dbi 26 0.70 6.72 19 99.56
113 INT201004 Negative_regulation of Gene_expression of CALM2 1 0.46 1.58 0.55 99.56
114 INT200990 Gene_expression of CALM2 4 0.61 2.2 0.55 99.56
115 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 99.56
116 INT155878 Regulation of Gene_expression of Cnr2 4 0.62 7.57 7.25 99.56
117 INT290735 Regulation of Dbt 1 0.17 1.01 0.24 99.56
118 INT349605 Transcription of ADHD1 3 0.57 3.62 0 99.56
119 INT43648 Positive_regulation of Binding of Mme 3 0.50 0.24 0.94 99.56
120 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 99.52
121 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25 99.52
122 INT118675 Positive_regulation of Phosphorylation of Camk4 5 0.66 1.58 2.93 99.52
123 INT167600 Gene_expression of Chrm5 15 0.72 2.4 5.48 99.52
124 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 99.52
125 INT6934 Binding of OPRD1 51 0.48 7.72 25.73 99.50
126 INT155682 Regulation of Gene_expression of Slc1a2 6 0.43 2.41 7.81 99.48
127 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 99.48
128 INT169653 Negative_regulation of Mgll 6 0.42 3.75 6.16 99.48
129 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 99.46
130 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.44
131 INT105008 Binding of DRD3 5 0.36 3.15 2.05 99.44
132 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92 99.44
133 INT34132 Binding of Oprk1 6 0.48 2.15 4.78 99.44
134 INT21661 Regulation of Negative_regulation of Gls2 1 0.02 0.26 0.6 99.42
135 INT21663 Regulation of Negative_regulation of Asrgl1 1 0.03 0.21 0.6 99.42
136 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 99.40
137 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 99.40
138 INT304999 Localization of OPN1SW 1 0.57 0.36 0.22 99.40
139 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 99.38
140 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 99.38
141 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 99.38
142 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91 99.36
143 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 99.36
144 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.36
145 INT14778 Gene_expression of FCGR3A 25 0.75 16.25 3.86 99.36
146 INT115322 Positive_regulation of Gene_expression of FCGR3A 2 0.37 4.22 0.53 99.36
147 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 99.36
148 INT300598 Positive_regulation of Adora2b 1 0.30 0.29 0.95 99.36
149 INT112099 Negative_regulation of Dlg2 2 0.40 6.17 8.16 99.32
150 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 99.32
151 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6 99.32
152 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77 99.32
153 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 99.32
154 INT114 Binding of Oprl1 139 0.48 23 103.35 99.32
155 INT22898 Negative_regulation of Gls 2 0.45 1.52 3.19 99.32
156 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 99.30
157 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 99.28
158 INT8603 Binding of Mme 28 0.48 1.42 7.64 99.26
159 INT106017 Positive_regulation of Dbt 3 0.40 1.67 0.39 99.24
160 INT155683 Gene_expression of Slc1a2 27 0.73 9.86 15.34 99.20
161 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 99.20
162 INT49774 Binding of DRD2 48 0.48 17.42 20.73 99.20
163 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 99.20
164 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69 99.20
165 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 99.20
166 INT685 Regulation of AVP 124 0.62 34.9 39.91 99.20
167 INT14114 Binding of Adra2a 30 0.48 4.24 18.53 99.20
168 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 99.20
169 INT43483 Gene_expression of DLL4 7 0.60 0.89 2.59 99.20
170 INT160280 Positive_regulation of ipv 14 0.44 15.73 1.02 99.18
171 INT155684 Negative_regulation of Gene_expression of Slc1a2 5 0.55 2.31 6.57 99.16
172 INT20556 Negative_regulation of Slc9a2 6 0.58 1.24 3.8 99.16
173 INT67899 Localization of Arsi 1 0.60 0.28 0.38 99.16
174 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 99.16
175 INT304984 Binding of CODA 1 0.18 1.03 0.19 99.16
176 INT69561 Positive_regulation of GSTM1 23 0.50 5.69 6.36 99.14
177 INT12806 Positive_regulation of AP2M1 2 0.67 0.19 1.35 99.14
178 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.12
179 INT290736 Localization of Dbt 1 0.48 1.87 0.12 99.12
180 INT155685 Regulation of Gene_expression of Slc1a3 2 0.50 0.77 2.85 99.12
181 INT322262 Positive_regulation of Olr1740-ps 1 0.35 0.24 0 99.12
182 INT21664 Negative_regulation of Gls2 1 0.02 0.26 0.6 99.12
183 INT30008 Binding of Hrh1 17 0.45 6.8 11.41 99.08
184 INT132663 Negative_regulation of GRINA 1 0.27 0.55 0.53 99.08
185 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 99.04
186 INT169643 Binding of Ods 3 0.18 2.89 1.15 99.04
187 INT80791 Gene_expression of Slc6a3 113 0.78 11.89 25.76 99.04
188 INT150699 Binding of PTPRB 1 0.37 0.48 0.13 99.04
189 INT104226 Localization of Oprk1 12 0.75 3.22 5.41 99.04
190 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 99.00
191 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 99.00
192 INT126906 Positive_regulation of Gene_expression of H2 12 0.21 9.2 1.91 99.00
193 INT8793 Gene_expression of H2 58 0.75 26.36 7.07 99.00
194 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 99.00
195 INT287528 Gene_expression of WFS1 1 0.75 2.74 1.55 99.00
196 INT112103 Binding of Grin1 28 0.48 4.21 12.08 99.00
197 INT287524 Regulation of WFS1 1 0.40 1.34 0.78 99.00
198 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77 99.00
199 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08 99.00
200 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 98.98
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