D:Drug Induced Neurotoxicity

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Disease Term
Synonyms Encephalitides Toxic, Encephalitis Toxic, Encephalopathies Toxic, ENCEPHALOPATHY TOXIC, Nervous System Poisoning, NERVOUS SYSTEM POISONINGS, Neurotoxic Disorder, Neurotoxic Disorders, NEUROTOXICITY, Neurotoxicity Syndrome, Neurotoxicity Syndromes
Documents 1637
Hot Single Events 200
Hot Interactions 97

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Drug Induced Neurotoxicity. They are ordered first by their relevance to Drug Induced Neurotoxicity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215286 Siglec1 Negative_regulation of Gene_expression of Ros1 1 0.00 2.76 0.25 100.00
2 INT215284 Siglec1 Negative_regulation of Binding of Mpz 1 0.01 0.63 0.08 100.00
3 INT124380 Prodh2 Regulation of Wnt2 1 0.00 0.63 0.35 100.00
4 INT152835 Prkcg Regulation of Phosphorylation of Nfasc 1 0.10 0.21 0.87 100.00
5 INT152853 Prkcg Regulation of PRS 1 0.01 0.21 0.87 100.00
6 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26 100.00
7 INT333053 IL6 Positive_regulation of Gene_expression of HNRNPA1 1 0.02 2.39 0.2 100.00
8 INT127503 Mpz Positive_regulation of Ptgs1 1 0.14 0.9 0.18 99.70
9 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24 99.48
10 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25 99.40
11 INT268946 Ros1 Regulation of Gene_expression of Ca2 1 0.00 0.18 0.23 99.16
12 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85 99.12
13 INT147576 Positive_regulation of Ahr Positive_regulation of Gene_expression of Scrg1 1 0.00 0.17 0.52 99.04
14 INT215282 Siglec1 Regulation of Gene_expression of Ros1 1 0.00 0.55 0.18 98.92
15 INT215278 Siglec1 Regulation of Tlr4 1 0.01 0.55 0.18 98.92
16 INT215292 Siglec1 Regulation of Tlr4 Positive_regulation of Ros1 1 0.00 0.55 0.18 98.92
17 INT215287 Siglec1 Regulation of Ros1 1 0.00 0.55 0.18 98.92
18 INT215291 Siglec1 Regulation of Positive_regulation of Ros1 1 0.00 0.55 0.18 98.92
19 INT167618 Rho Regulation of App 1 0.17 0.88 0.55 98.76
20 INT273046 Vip Negative_regulation of Gene_expression of Adcyap1 1 0.20 1.14 0.21 98.60
21 INT151713 Binding of Alb and Ugt1a2 1 0.03 0.41 0.07 98.36
22 INT207211 Binding of Creb1 and Crem 2 0.30 1.35 0.36 98.32
23 INT324692 Binding of Cd14 and Sod1m 1 0.01 1.07 0.03 98.28
24 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21 98.24
25 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38 98.12
26 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22 98.12
27 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28 98.12
28 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55 97.88
29 INT261448 Sftpd Positive_regulation of Phospho1 1 0.01 0.58 0.12 97.72
30 INT261449 Sftpd Positive_regulation of Gene_expression of Phospho1 1 0.01 0.58 0.12 97.72
31 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06 97.16
32 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71 97.16
33 INT215290 Siglec1 Negative_regulation of Decr1 1 0.00 0.68 0.41 97.00
34 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 96.48
35 INT268258 Binding of hb and Ugt1a10 1 0.00 1.18 0 95.88
36 INT193454 Dbh Negative_regulation of Negative_regulation of Ndufaf1 1 0.02 1.22 0.05 95.76
37 INT235165 Atxn3 Regulation of Transcription of Crebbp 1 0.02 0.3 0 95.76
38 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35 95.68
39 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 95.44
40 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1 95.44
41 INT146087 Abcb1b Regulation of Binding of Abcb1a 1 0.49 0.09 0.34 94.32
42 INT146088 Abcb1b Regulation of Abcb1a 1 0.49 0.09 0.34 94.32
43 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21 94.04
44 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79 93.92
45 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93 93.92
46 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92 93.92
47 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92 93.92
48 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19 93.56
49 INT349511 Ptpn2 Positive_regulation of Ptpn2 Negative_regulation of Th 1 0.16 1.3 0.03 93.56
50 INT187519 ATIC Negative_regulation of Gene_expression of Ros1 1 0.00 1.48 0.39 93.12
51 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0 92.76
52 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0 92.76
53 INT275756 xn Regulation of Ins1 1 0.01 3.25 0 92.08
54 INT221653 Binding of Myc and Gopc 2 0.12 0.51 0.08 92.08
55 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22 91.80
56 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73 91.68
57 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03 89.12
58 INT169217 Binding of Pebp1 and Coc 1 0.00 0.22 0.67 88.96
59 INT169219 Binding of OPRM1 and Coc 1 0.01 0.22 0.67 88.96
60 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1 88.72
61 INT169215 Binding of OPRM1 and CARTPT 1 0.00 0.22 0.67 88.56
62 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67 88.56
63 INT215279 Siglec1 Regulation of Rac2 1 0.01 0.74 0.27 88.40
64 INT215289 Siglec1 Regulation of Cyba 1 0.01 0.74 0.26 88.40
65 INT215280 Siglec1 Regulation of Cybb 1 0.01 0.74 0.26 88.40
66 INT215271 Siglec1 Regulation of Ncf4 1 0.01 0.73 0.26 88.40
67 INT215273 Siglec1 Regulation of Ncf2 1 0.01 0.73 0.26 88.40
68 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34 88.08
69 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62 87.56
70 INT215276 Gene_expression of Mpz Positive_regulation of Gene_expression of Ros1 1 0.01 0.4 0.05 87.12
71 INT215281 Mpz Positive_regulation of Gene_expression of Ros1 2 0.01 1.01 0.05 87.12
72 INT338451 Nps Positive_regulation of Ros1 1 0.05 0.09 0.04 87.12
73 INT338452 Nps Positive_regulation of Nps Positive_regulation of Ros1 1 0.05 0.09 0.04 87.12
74 INT145260 Binding of CLU and App 1 0.00 0.74 0.46 86.76
75 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33 86.64
76 INT124377 Prodh2 Negative_regulation of Defb40 1 0.00 0.66 0.33 86.64
77 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33 86.64
78 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08 86.60
79 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41 86.36
80 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41 86.36
81 INT174720 Ddit3 Regulation of Gtf3a 1 0.01 0.35 0 86.00
82 INT86264 OPRK1 Negative_regulation of Gene_expression of HIVEP1 1 0.33 1.76 0.51 85.76
83 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03 85.60
84 INT215288 Gene_expression of Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 0.4 0.05 85.44
85 INT190751 Adcyap1 Positive_regulation of Vipr2 2 0.16 1.02 0.36 85.36
86 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13 84.96
87 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38 84.80
88 INT273048 Adcyap1 Positive_regulation of Adcyap1r1 1 0.11 1.02 0.19 84.56
89 INT128903 Binding of RNASE2 and Itga7 1 0.00 0.08 0.15 84.56
90 INT201736 Nfkb1 Positive_regulation of Transcription of Sod2 1 0.01 0.93 0.08 84.52
91 INT201755 ROS1 Positive_regulation of Casp3 1 0.00 1.4 0 84.24
92 INT5737 Hk1 Positive_regulation of Ca2 1 0.06 0.16 0.16 83.72
93 INT323392 SERPINH1 Negative_regulation of BCHE 1 0.02 0.52 0.04 83.28
94 INT278441 Lbp Positive_regulation of Gene_expression of ITGAX 1 0.44 1.18 0.07 82.04
95 INT217651 Binding of ROS1 and fa 1 0.01 1.09 0.07 81.76
96 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29 81.52
97 INT235231 Gopc Positive_regulation of Gene_expression of Ros1 1 0.03 0.16 0.04 80.72
98 INT215277 Siglec1 Negative_regulation of Gene_expression of Mpz 1 0.02 0.48 0.03 79.60
99 INT215285 Siglec1 Negative_regulation of Positive_regulation of Ros1 1 0.00 0.48 0.03 79.60
100 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19 79.36
101 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44 79.28
102 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44 79.28
103 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44 79.28
104 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34 79.24
105 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94 79.24
106 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6 78.48
107 INT234608 Socs3 Negative_regulation of SOAT1 1 0.01 0.54 0.39 78.44
108 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39 78.44
109 INT234605 Tlr4 Positive_regulation of Gene_expression of Gopc 2 0.16 0.15 0.08 78.16
110 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54 77.68
111 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54 77.68
112 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06 77.12
113 INT295262 Tlr4 Positive_regulation of Positive_regulation of Nos2 1 0.07 0.19 0 76.56
114 INT215272 Siglec1 Regulation of Mpz 1 0.01 0.67 0.03 76.12
115 INT274865 Positive_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.04 1.08 0.35 75.60
116 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11 75.56
117 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42 75.56
118 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 75.48
119 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54 75.16
120 INT74727 Binding of Slc6a4 and Hpic1 1 0.00 0.49 0.68 75.00
121 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68 75.00
122 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 75.00
123 INT93388 Rbm39 Positive_regulation of Positive_regulation of Pdyn 1 0.03 0.32 1.4 75.00
124 INT85742 Pdyn Positive_regulation of Rbm39 1 0.01 0.17 1.29 75.00
125 INT85744 Binding of Pdyn and Rbm39 1 0.01 0.16 1.12 75.00
126 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66 75.00
127 INT64789 ITIH4 Positive_regulation of Positive_regulation of Pla2g1b 1 0.19 0.55 0.24 75.00
128 INT223826 GSTM1 Negative_regulation of MAP3K5 1 0.02 0.71 0.03 74.16
129 INT208983 Binding of Ca2 and Kcnma1 2 0.01 0.28 0.1 73.88
130 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 73.84
131 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17 73.20
132 INT351834 Binding of Gmcl1 and GSTK1 1 0.03 0.42 0 73.12
133 INT323395 Binding of BCHE and SERPINH1 1 0.02 0.74 0.03 73.12
134 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13 72.16
135 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13 72.16
136 INT270416 PLAT Negative_regulation of Positive_regulation of PLG 1 0.00 0.48 0.15 72.08
137 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 71.32
138 INT340421 Il1a Positive_regulation of Csk 1 0.00 0.98 0.12 71.12
139 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59 71.00
140 INT235232 Tlr4 Positive_regulation of Gene_expression of Lilrb3 1 0.01 0.07 0 70.48
141 INT223824 Binding of GSTM1 and MAP3K5 1 0.02 0.68 0.03 70.44
142 INT215283 Tlr4 Positive_regulation of Localization of Ncf1 2 0.05 1.04 0.11 70.20
143 INT351761 Adar Negative_regulation of Gene_expression of Adarb1 1 0.27 0.8 0 70.16
144 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1 69.60
145 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25 69.52
146 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12 69.12
147 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39 69.08
148 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38 69.08
149 INT266382 Binding of Col4a1 and Fn1 1 0.00 0.82 0.39 68.88
150 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24 68.72
151 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01 68.40
152 INT220639 Binding of Apbb1 and Ighd 1 0.12 0.31 0.12 68.32
153 INT271635 Negative_regulation of GRIN1 Negative_regulation of Positive_regulation of Ltp 1 0.00 0.65 0.93 67.68
154 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09 67.04
155 INT187485 Trib3 Positive_regulation of Prkag1 1 0.00 0.97 0.22 66.40
156 INT235233 Gopc Positive_regulation of Nos2 1 0.06 0.15 0.04 65.68
157 INT187899 Binding of Pgp and Mir486 1 0.00 0.25 0 65.44
158 INT187898 Negative_regulation of Binding of Pgp and Mir486 1 0.01 0.25 0 65.44
159 INT215270 Binding of Ncf1 and Ncf4 1 0.05 0.38 0.17 64.80
160 INT215269 Binding of Ncf2 and Ncf4 1 0.02 0.38 0.17 64.80
161 INT338449 Nps Regulation of Alms1 1 0.04 0.13 0.14 64.48
162 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85 63.52
163 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22 63.24
164 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04 63.24
165 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16 62.16
166 INT198920 Binding of Ldlr and Lrpap1 1 0.05 0.06 0 61.40
167 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37 60.96
168 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25 60.96
169 INT288349 TNF Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.1 0.18 60.32
170 INT288351 Mcpt1 Positive_regulation of Gene_expression of TNF 1 0.02 1.1 0.18 60.32
171 INT295293 Kcnn3 Regulation of Positive_regulation of Mapk14 1 0.11 0.12 0 59.40
172 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07 58.48
173 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52 58.40
174 INT333051 Binding of HIVEP1 and NOLC1 1 0.00 4.11 0.07 58.32
175 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07 57.84
176 INT275402 Trpv1 Regulation of Gene_expression of NDRG1 1 0.00 1.25 0.39 56.56
177 INT349586 Aap Regulation of Gene_expression of Ros1 1 0.03 0.56 1.17 56.04
178 INT268947 Fig4 Positive_regulation of Ros1 1 0.01 0.06 0.18 55.68
179 INT324694 Tlr4 Positive_regulation of Gene_expression of Pnoc 1 0.05 0.56 0.24 55.60
180 INT199105 Decr1 Positive_regulation of Positive_regulation of Nos2 1 0.01 0.23 0.16 55.44
181 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83 55.20
182 INT349587 Binding of Aap and Csf2 1 0.04 0.41 1.18 54.88
183 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05 54.80
184 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53 54.56
185 INT295291 Mapk14 Positive_regulation of Gene_expression of Nos2 1 0.04 0.05 0 53.44
186 INT261459 Sftpd Negative_regulation of Ldha 1 0.08 0.63 0.18 52.96
187 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32 52.76
188 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71 52.00
189 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36 51.92
190 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35 51.92
191 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1 51.80
192 INT295294 Tlr4 Positive_regulation of Mapk14 1 0.00 0.39 0.05 51.28
193 INT268942 Binding of Crmp1 and Fig4 1 0.01 0.28 0.03 50.84
194 INT268635 Mpz Positive_regulation of Gsk3b 1 0.17 0.43 0 50.60
195 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46 50.00
196 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25 50.00
197 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23 50.00
198 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2 50.00
199 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2 50.00
200 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15 50.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Drug Induced Neurotoxicity. They are ordered first by their pain relevance and then by number of times they were reported in Drug Induced Neurotoxicity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT66392 Localization of Pdc 5 0.65 2.72 2.82 100.00
2 INT333071 Gene_expression of HNRNPA1 1 0.04 22.7 1.47 100.00
3 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4 100.00
4 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 100.00
5 INT66393 Regulation of Localization of Pdc 1 0.23 0.69 0.65 100.00
6 INT333086 Positive_regulation of Gene_expression of HNRNPA1 1 0.03 12.29 0.82 100.00
7 INT209261 Binding of Mpz 4 0.30 1.58 0.45 100.00
8 INT173877 Positive_regulation of Gene_expression of INCENP 14 0.08 7.83 1.28 100.00
9 INT11769 Regulation of Mptp1 8 0.60 6.38 2.68 100.00
10 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 100.00
11 INT71439 Negative_regulation of Negative_regulation of Pars2 1 0.32 0.95 1.03 100.00
12 INT104405 Positive_regulation of Acr 3 0.28 0.47 0.09 100.00
13 INT181375 Gene_expression of Ccl22 6 0.49 5.54 2.36 100.00
14 INT342713 Regulation of Binding of Mpz 1 0.09 0.3 0.07 100.00
15 INT37296 Binding of Esr1 117 0.43 62.51 27.33 99.98
16 INT16651 Localization of SEMA6A 5 0.68 1.72 2.03 99.98
17 INT96678 Binding of TAT 3 0.47 6.75 0.85 99.98
18 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 99.96
19 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 99.96
20 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.96
21 INT66394 Regulation of Pdc 6 0.32 1.27 3.99 99.96
22 INT64734 Positive_regulation of Mpz 17 0.67 6.81 2.55 99.96
23 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 99.96
24 INT243533 Positive_regulation of SOX10 1 0.35 3.93 0.92 99.96
25 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 99.96
26 INT93918 Localization of Amph 2 0.62 0.89 2.73 99.96
27 INT60768 Negative_regulation of Pdc 5 0.48 1.5 2.67 99.92
28 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 99.92
29 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 99.92
30 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78 99.92
31 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27 99.92
32 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2 99.92
33 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94 99.92
34 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 99.90
35 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 99.88
36 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 99.84
37 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 99.84
38 INT243536 Positive_regulation of EARS2 1 0.11 1.42 0.52 99.84
39 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.84
40 INT26337 Negative_regulation of Hmmr 6 0.30 1.11 4.01 99.84
41 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 99.82
42 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 99.82
43 INT74449 Positive_regulation of B4GALNT1 53 0.30 34.49 14.96 99.82
44 INT243530 Positive_regulation of Gene_expression of CA3 1 0.10 0.47 0.14 99.82
45 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 99.80
46 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 99.80
47 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 99.80
48 INT147574 Gene_expression of Scrg1 5 0.02 1.4 2.46 99.80
49 INT147573 Positive_regulation of Gene_expression of Scrg1 1 0.00 0.17 0.44 99.80
50 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61 99.80
51 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 99.76
52 INT6063 Positive_regulation of Bche 17 0.66 6.07 3.08 99.76
53 INT55343 Localization of Ros1 39 0.60 34.51 12.5 99.72
54 INT73608 Localization of Nos2 21 0.75 9.58 5.05 99.72
55 INT342709 Negative_regulation of Binding of Mpz 1 0.12 0.29 0.07 99.72
56 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 99.70
57 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 99.70
58 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 99.70
59 INT190479 Positive_regulation of 1190002H23Rik 6 0.07 5.64 0.53 99.70
60 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 99.70
61 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 99.68
62 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45 99.68
63 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8 99.68
64 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 99.68
65 INT104170 Phosphorylation of Nfasc 4 0.34 1.38 1.2 99.66
66 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48 99.64
67 INT333065 Negative_regulation of Gene_expression of HNRNPA1 1 0.03 1.76 0.04 99.64
68 INT38204 Gene_expression of Acr 4 0.66 4.23 2.85 99.64
69 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.64
70 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 99.62
71 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 99.62
72 INT95499 Negative_regulation of Nefh 9 0.59 8.97 7.13 99.60
73 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.60
74 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4 99.60
75 INT152838 Phosphorylation of PRS 1 0.02 0.21 0.84 99.60
76 INT354476 Negative_regulation of Gene_expression of Prnd 1 0.18 0.43 0.06 99.58
77 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 99.56
78 INT84409 Binding of TNS1 6 0.48 2.96 3.33 99.56
79 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 99.52
80 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 99.52
81 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2 99.52
82 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4 99.52
83 INT11154 Binding of EGFR 149 0.48 96.23 6.29 99.52
84 INT170768 Regulation of Gene_expression of NR3C1 3 0.42 2.61 0.58 99.50
85 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8 99.48
86 INT100821 Localization of Ros1 59 0.60 45.26 11.92 99.48
87 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 99.48
88 INT164586 Positive_regulation of MAPK10 3 0.29 2.56 0.61 99.46
89 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59 99.44
90 INT462 Regulation of Pomc 157 0.62 41.67 67.27 99.44
91 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 99.44
92 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.44
93 INT3920 Localization of Ldha 241 0.81 83.08 58.72 99.42
94 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96 99.42
95 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 99.40
96 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 99.40
97 INT265959 Gene_expression of Prnd 2 0.54 2.33 0.15 99.40
98 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 99.40
99 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 99.38
100 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 99.36
101 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03 99.36
102 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 99.36
103 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 99.36
104 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 99.36
105 INT139522 Positive_regulation of Regulation of JUN 1 0.49 0.37 0.41 99.36
106 INT142607 Positive_regulation of Gene_expression of Cd40 41 0.62 13.85 5.51 99.36
107 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 99.34
108 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 99.32
109 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 99.32
110 INT79690 Negative_regulation of Gene_expression of PPARG 10 0.59 10.48 1.55 99.32
111 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.32
112 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.32
113 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 99.32
114 INT155007 Positive_regulation of Gene_expression of RETN 4 0.27 9.17 1.3 99.32
115 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.30
116 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95 99.28
117 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 99.28
118 INT201632 Positive_regulation of Cdk5r1 20 0.40 21.6 2.75 99.28
119 INT185738 Binding of Cd14 28 0.45 14.41 3.25 99.28
120 INT35744 Binding of MAOB 13 0.46 7.52 4.26 99.28
121 INT1160 Positive_regulation of Rbm39 122 0.57 28.19 90.28 99.26
122 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 99.24
123 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 99.22
124 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.20
125 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 99.20
126 INT68473 Binding of Coc 13 0.40 2.99 8.89 99.20
127 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48 99.20
128 INT6053 Transcription of Fos 107 0.72 20.97 31.88 99.20
129 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 99.20
130 INT120004 Transcription of Tp53 8 0.72 4.92 1.48 99.20
131 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 99.18
132 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 99.18
133 INT34663 Protein_catabolism of Gpt 2 0.68 0.99 0.65 99.18
134 INT65500 Gene_expression of App 605 0.78 429.94 98.31 99.16
135 INT16794 Binding of App 103 0.48 64.87 19.79 99.16
136 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 99.16
137 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.16
138 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86 99.16
139 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 99.16
140 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 99.12
141 INT90639 Positive_regulation of Slc6a3 25 0.61 10.95 10.41 99.12
142 INT193451 Negative_regulation of Sdha 1 0.02 1.75 0.17 99.12
143 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.10
144 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72 99.08
145 INT4060 Gene_expression of Bche 17 0.70 5.23 6.59 99.06
146 INT173747 Regulation of Positive_regulation of Esr1 4 0.37 4.85 0.95 99.06
147 INT215850 Regulation of Ddit3 5 0.50 6.15 0.25 99.06
148 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61 99.04
149 INT90604 Positive_regulation of Positive_regulation of Ahr 8 0.45 3.52 1.45 99.04
150 INT306880 Localization of NOLC1 2 0.19 6.32 0.54 99.00
151 INT144391 Gene_expression of RETN 42 0.75 40.48 10.47 99.00
152 INT97798 Localization of IRF6 86 0.73 33.27 20.94 99.00
153 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 98.98
154 INT63921 Regulation of Pcdhga10 5 0.52 2.16 1.1 98.92
155 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 98.92
156 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 98.92
157 INT90371 Localization of Hrec 28 0.05 19.11 10.12 98.92
158 INT53232 Positive_regulation of Binding of Il1f5 2 0.14 1.74 0.19 98.90
159 INT272358 Gene_expression of Adarb1 19 0.73 26.94 3.11 98.88
160 INT66318 Gene_expression of NR3C1 26 0.76 20 7.55 98.88
161 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53 98.88
162 INT112070 Negative_regulation of Gene_expression of Pparg 6 0.59 3.72 3.96 98.88
163 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 98.84
164 INT51485 Localization of TAT 3 0.78 2.18 0.55 98.84
165 INT215253 Positive_regulation of Localization of Siglec1 1 0.05 0.77 0.07 98.84
166 INT215257 Localization of Siglec1 1 0.07 0.76 0.07 98.84
167 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 98.84
168 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 98.84
169 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89 98.84
170 INT4977 Binding of ITIH4 60 0.46 42.48 15.65 98.80
171 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 98.80
172 INT4822 Localization of Ca2 417 0.80 99.57 96.45 98.80
173 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01 98.80
174 INT114243 Positive_regulation of Positive_regulation of Cpox 4 0.39 3.06 1.18 98.80
175 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 98.76
176 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 98.76
177 INT133733 Positive_regulation of Localization of Lbp 6 0.43 9.19 3.61 98.76
178 INT49029 Positive_regulation of Decr1 19 0.09 6.28 3.98 98.76
179 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 98.76
180 INT167608 Regulation of Rock2 2 0.33 2.47 0.59 98.76
181 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3 98.76
182 INT14301 Binding of CSF2 82 0.48 67.95 8.98 98.74
183 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17 98.72
184 INT72151 Phosphorylation of MYOT 2 0.01 1.49 0.88 98.72
185 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76 98.72
186 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 98.70
187 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 98.68
188 INT107604 Binding of NALCN 4 0.07 3.08 0.65 98.68
189 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 98.68
190 INT1004 Regulation of Sst 140 0.62 18.52 94.84 98.68
191 INT2976 Regulation of Bche 29 0.45 8.56 9.42 98.68
192 INT84512 Binding of Myoz1 7 0.30 4.48 1.7 98.68
193 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 98.66
194 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.64
195 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 98.64
196 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 98.60
197 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 98.60
198 INT215259 Negative_regulation of Siglec1 5 0.14 3.82 0.87 98.60
199 INT9355 Binding of pcp 81 0.46 10.41 24.22 98.60
200 INT64051 Gene_expression of Col4a4 33 0.61 10.1 17.82 98.60
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