D:Dry Eye

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Disease Term
Synonyms DRY EYE SYNDROME, Dry Eye Syndromes, Dry Eyes, Syndrome Dry Eye, Syndromes Dry Eye
Documents 136
Hot Single Events 70
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dry Eye. They are ordered first by their relevance to Dry Eye and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT328626 Binding of TBCE and MUC16 1 0.15 0.79 0 99.80
2 INT279633 Binding of Ar and Abpe 1 0.01 0.99 0 98.12
3 INT328627 Binding of LGALS3 and MUC16 1 0.04 0.73 0 92.40
4 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37 82.56
5 INT279632 Positive_regulation of Binding of Ar and Nr4a1 1 0.01 0.86 0.03 81.48
6 INT279634 Binding of Ar and Nr4a1 1 0.01 0.85 0.03 81.08
7 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 54.20
8 INT273774 Binding of GPER and RB1 1 0.01 0.45 0 47.84
9 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73 5.00
10 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56 5.00
11 INT265465 CSPG4 Negative_regulation of Gene_expression of IL8 1 0.07 0.98 0.39 5.00
12 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 5.00
13 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29 5.00
14 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 5.00
15 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 5.00
16 INT209952 Binding of SNRNP70 and IGKV2-19 1 0.00 0.47 0.11 5.00
17 INT215461 Binding of MLL and TNFSF13B 1 0.01 1.62 0.1 5.00
18 INT274156 Negative_regulation of Cabin1 Negative_regulation of Gene_expression of Vegfa 1 0.08 0.28 0.09 5.00
19 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09 5.00
20 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05 5.00
21 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05 5.00
22 INT265456 CSPG4 Regulation of ROS1 1 0.05 0.24 0.04 5.00
23 INT265451 CSPG4 Positive_regulation of RNGTT 1 0.03 0.24 0.04 5.00
24 INT265453 CSPG4 Regulation of Phosphorylation of ROS1 1 0.05 0.24 0.04 5.00
25 INT265457 CSPG4 Negative_regulation of IL6 1 0.06 0.24 0.04 5.00
26 INT265462 CSPG4 Negative_regulation of Positive_regulation of CASP9 1 0.07 1.2 0.04 5.00
27 INT265461 CSPG4 Negative_regulation of Gene_expression of CASP9 1 0.06 1.2 0.04 5.00
28 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03 5.00
29 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 5.00
30 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 5.00
31 INT265458 RNGTT Positive_regulation of Gene_expression of ROS1 1 0.08 0.88 0 5.00
32 INT265468 CSPG4 Positive_regulation of Gene_expression of ROS1 1 0.08 0.4 0 5.00
33 INT265460 CSPG4 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.27 0 5.00
34 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0 5.00
35 INT279635 Ar Regulation of Abpe 1 0.01 1.55 0 5.00
36 INT265452 Binding of TNFRSF10B and RNU5A-1 1 0.05 0.67 0 5.00
37 INT209951 Binding of KCNJ13 and SNRNP70 1 0.00 0 0 5.00
38 INT265455 CSPG4 Negative_regulation of Positive_regulation of CASP8 1 0.04 0.27 0 5.00
39 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dry Eye. They are ordered first by their pain relevance and then by number of times they were reported in Dry Eye. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT205189 Gene_expression of TBCE 12 0.25 9.67 1.19 100.00
2 INT274092 Negative_regulation of Gene_expression of TBCE 1 0.08 1.17 0.03 100.00
3 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0 99.92
4 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44 99.84
5 INT328632 Regulation of Gene_expression of MUC5AC 1 0.25 2.46 0 99.84
6 INT205188 Positive_regulation of Gene_expression of TBCE 5 0.19 2.14 0.74 99.80
7 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 99.58
8 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 99.56
9 INT94881 Negative_regulation of Gene_expression of MUC16 4 0.42 2.51 0.61 99.56
10 INT11506 Binding of MUC16 20 0.48 22.89 1.03 99.52
11 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 99.48
12 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 99.44
13 INT9473 Binding of MUC1 66 0.48 46.77 2.36 99.44
14 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 99.42
15 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 99.40
16 INT122950 Binding of BAK1 16 0.41 12.85 0.31 99.32
17 INT205187 Localization of TBCE 3 0.14 4.11 2.47 99.28
18 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79 99.24
19 INT160766 Localization of HSPA9 2 0.78 1.84 0.26 99.12
20 INT46101 Regulation of TBCE 2 0.11 1.53 0.43 98.60
21 INT347547 Negative_regulation of SCNN1A 1 0.48 0.38 0.35 98.44
22 INT311605 Positive_regulation of AATF 5 0.06 6.72 1.05 98.38
23 INT264459 Gene_expression of DR1 9 0.13 0.95 0.21 98.24
24 INT273784 Negative_regulation of Gene_expression of DR1 1 0.07 0.43 0.05 98.24
25 INT264453 Positive_regulation of Gene_expression of DR1 6 0.10 0.43 0.05 98.24
26 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 98.12
27 INT44066 Gene_expression of Ltf 20 0.77 15.09 4.57 98.00
28 INT290711 Binding of Sp3 1 0.05 0.1 0.58 97.96
29 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 97.52
30 INT57526 Regulation of Ltf 8 0.45 2.73 0.56 97.48
31 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 97.36
32 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18 95.76
33 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 95.76
34 INT219108 Negative_regulation of Gene_expression of MUC5AC 11 0.31 9.74 1.08 95.72
35 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71 94.88
36 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 94.36
37 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 94.12
38 INT274090 Gene_expression of HSPA9 1 0.09 0.87 0.03 93.92
39 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 92.64
40 INT207475 Binding of LGALS3 6 0.34 2.48 0.57 92.40
41 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 92.16
42 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 92.16
43 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 92.16
44 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 91.60
45 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 91.60
46 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 90.68
47 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 90.40
48 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 89.08
49 INT20557 Localization of MUC7 6 0.42 0.43 0.59 89.08
50 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 87.48
51 INT11230 Regulation of MUC16 23 0.60 19.54 3.93 86.32
52 INT61585 Gene_expression of NALCN 25 0.52 6.52 8.18 86.24
53 INT118232 Regulation of Gene_expression of NALCN 3 0.13 1.92 2.25 86.24
54 INT164178 Gene_expression of ADCY10 9 0.65 2.72 0.39 86.16
55 INT257447 Binding of TBCE 4 0.08 4.68 0.66 85.92
56 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 85.84
57 INT340828 Regulation of ADCY10 1 0.06 5.17 0.11 85.68
58 INT18773 Localization of ALB 117 0.80 69.18 13.8 84.04
59 INT9884 Localization of CD79A 41 0.78 21.75 3.06 84.04
60 INT19637 Localization of TF 14 0.73 5.74 0.86 84.04
61 INT175097 Localization of LCN1 3 0.73 2.07 0.33 84.04
62 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 83.92
63 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 83.92
64 INT243082 Binding of Ar 2 0.11 1.81 0.06 83.44
65 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 82.24
66 INT11889 Regulation of Gene_expression of MUC16 5 0.62 3.24 0.63 81.96
67 INT257449 Regulation of Gene_expression of TBCE 1 0.09 0.85 0 81.96
68 INT114279 Positive_regulation of Nr4a1 9 0.59 3.37 1.59 81.48
69 INT290710 Positive_regulation of Sp3 1 0.07 0.44 0.54 80.76
70 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 80.52
71 INT78773 Regulation of PLA2G2A 11 0.61 9.76 1.91 79.52
72 INT104031 Regulation of ENPEP 18 0.33 13.48 1.69 78.12
73 INT238524 Localization of MGS 1 0.44 1.59 0.05 77.92
74 INT265490 Localization of CSPG4 3 0.20 1.5 0.33 77.28
75 INT265493 Positive_regulation of Localization of CSPG4 1 0.13 0.66 0.03 77.28
76 INT265433 Positive_regulation of Sprr1b 1 0.64 3.76 0.53 76.92
77 INT257448 Negative_regulation of Localization of MUC5AC 2 0.35 2.57 0 76.16
78 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 76.16
79 INT129756 Regulation of MUC5AC 7 0.34 6.45 0.7 76.16
80 INT756 Gene_expression of C3 138 0.75 100.6 19.2 75.84
81 INT347548 Transcription of SCNN1A 1 0.67 0.13 0.97 75.20
82 INT188449 Gene_expression of ENPEP 12 0.55 11.29 3.96 75.16
83 INT49802 Localization of MUC1 75 0.81 44.74 8.87 74.68
84 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 74.28
85 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83 74.16
86 INT7130 Localization of PLA2G2A 32 0.80 20.4 5.05 74.16
87 INT33845 Binding of GPER 20 0.36 5.61 1.81 74.12
88 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 73.76
89 INT274091 Negative_regulation of Binding of HSPA9 1 0.05 0.82 0.03 72.88
90 INT14500 Positive_regulation of Gene_expression of CST3 9 0.67 7.46 1.87 72.52
91 INT150703 Positive_regulation of Gene_expression of Ltf 1 0.08 1.83 0.06 72.52
92 INT677 Positive_regulation of CST3 20 0.67 17.47 6 72.28
93 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 72.28
94 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 72.24
95 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 71.88
96 INT274089 Binding of HSPA9 1 0.05 0.81 0.03 71.84
97 INT7127 Positive_regulation of Gene_expression of PLA2G2A 16 0.69 17.11 2.63 70.80
98 INT35541 Transcription of MUC16 3 0.69 6.44 0.65 70.08
99 INT679 Negative_regulation of CST3 7 0.57 4.63 1.22 69.08
100 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 67.12
101 INT204720 Gene_expression of CD53 3 0.09 1.38 0.1 67.04
102 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38 65.20
103 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 64.48
104 INT67597 Negative_regulation of Das 17 0.37 9.95 5.05 64.24
105 INT162177 Binding of EBM 12 0.32 3.34 0.27 64.00
106 INT265438 Gene_expression of Sprr1b 1 0.72 6.76 1.33 63.96
107 INT150709 Regulation of TROVE2 1 0.03 1.74 0.07 63.64
108 INT24278 Gene_expression of FUT4 33 0.75 26.7 4.29 62.72
109 INT36386 Positive_regulation of Gene_expression of FUT4 3 0.45 2.32 0.38 62.72
110 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 60.56
111 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 59.00
112 INT107401 Regulation of Das 9 0.18 3.02 1.31 57.80
113 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 57.68
114 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 55.16
115 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 54.32
116 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 54.20
117 INT265436 Binding of Sprr1b 1 0.34 0.74 0.1 53.28
118 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 53.04
119 INT257732 Regulation of Positive_regulation of RB1 2 0.39 2.35 0.09 53.04
120 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 53.00
121 INT315704 Gene_expression of lg 4 0.33 0.84 0.06 52.88
122 INT315707 Regulation of Gene_expression of lg 1 0.11 0.34 0 52.88
123 INT63905 Regulation of RB1 13 0.62 12.67 1.28 51.60
124 INT259507 Regulation of Bcr 1 0.26 0.38 0 51.44
125 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 51.32
126 INT6852 Localization of TNF 883 0.81 705.95 270.84 50.96
127 INT9660 Regulation of TNF 363 0.62 312.94 139.99 50.96
128 INT279628 Negative_regulation of Ar 5 0.04 6.1 0.25 48.48
129 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 48.32
130 INT107399 Positive_regulation of Das 7 0.28 1.55 2.74 48.32
131 INT25502 Gene_expression of RERE 6 0.53 1.74 0.32 48.28
132 INT279630 Regulation of Abpe 1 0.13 1.07 0.09 47.76
133 INT265475 Positive_regulation of Positive_regulation of IGKV1D-22 1 0.03 0.93 0.12 47.52
134 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 46.76
135 INT194993 Binding of RB1 15 0.37 10.96 0.4 46.48
136 INT68227 Positive_regulation of IGKV1D-22 4 0.09 4.78 1.94 45.12
137 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 44.56
138 INT215464 Positive_regulation of Transcription of Aqp5 1 0.45 0.42 0.13 43.52
139 INT215463 Regulation of Aqp5 1 0.44 0.42 0.13 43.52
140 INT215465 Transcription of Aqp5 1 0.52 0.42 0.13 42.96
141 INT315708 Positive_regulation of lg 1 0.10 0.91 0.3 42.92
142 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 42.64
143 INT159988 Localization of Ctsk 5 0.70 2.9 0.74 41.60
144 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 40.48
145 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79 40.48
146 INT272280 Negative_regulation of Sbnt1 1 0.01 0 0 40.16
147 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 38.24
148 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 38.24
149 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 38.24
150 INT199533 Gene_expression of Csda 2 0.06 0.65 0.32 37.68
151 INT162428 Localization of Ar 4 0.37 2.4 0.07 37.32
152 INT160264 Localization of Fn1 10 0.40 3.95 1.51 37.20
153 INT279631 Negative_regulation of Abpe 1 0.12 1.29 0.04 36.88
154 INT245259 Localization of Mmp3 6 0.68 4.49 1.58 35.44
155 INT87199 Negative_regulation of PSS 9 0.50 5.66 0.68 35.36
156 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 33.20
157 INT176260 Binding of CASP8 5 0.36 2.73 0.27 31.68
158 INT273783 Regulation of Gene_expression of RB1 1 0.29 0.67 0 29.76
159 INT11887 Localization of MUC16 16 0.80 10.66 1.26 29.28
160 INT240359 Binding of Tnc 2 0.35 11.67 1.48 28.72
161 INT89971 Localization of Sparc 10 0.80 10.25 1.85 23.28
162 INT134296 Positive_regulation of Ptges2 20 0.19 14.85 3.8 23.12
163 INT354859 Localization of Cacna1s 1 0.05 3.15 0.15 21.92
164 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 19.48
165 INT347545 Localization of SCNN1A 1 0.61 0 0.44 18.72
166 INT180580 Binding of HEYL 7 0.17 4.49 1.15 18.56
167 INT278547 Gene_expression of SCNN1A 2 0.73 0.14 2.41 17.52
168 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 15.52
169 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 12.88
170 INT195080 Positive_regulation of Tnc 4 0.45 26.67 2.34 12.88
171 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19 12.68
172 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 12.36
173 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 11.96
174 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 10.16
175 INT198094 Regulation of Gene_expression of PLA2G2A 3 0.45 2.19 0.35 8.56
176 INT45209 Positive_regulation of PLA2G2A 37 0.69 33.21 9.02 6.24
177 INT94190 Positive_regulation of ADCY10 5 0.49 3.17 0.58 5.72
178 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
179 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
180 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
181 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
182 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
183 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
184 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
185 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
186 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
187 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
188 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
189 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
190 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
191 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
192 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
193 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
194 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
195 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
196 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
197 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
198 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
199 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
200 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
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