D:Dupuytren's Disease

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms CONTRACTURE DUPUYTREN S, DUPUYTREN, Dupuytren Contracture, Dupuytren S Contracture, Dupuytren S Disease, Dupuytrens, Dupuytrens Contracture
Documents 130
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dupuytren's Disease. They are ordered first by their relevance to Dupuytren's Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311963 Ifx Negative_regulation of FBN1 1 0.00 0.44 0.5 5.00
2 INT311950 FBN1 Positive_regulation of Gene_expression of PGF 1 0.00 0.15 0.26 5.00
3 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dupuytren's Disease. They are ordered first by their pain relevance and then by number of times they were reported in Dupuytren's Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97334 Positive_regulation of Gene_expression of Timp1 11 0.49 7.44 4.14 100.00
2 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82 100.00
3 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 100.00
4 INT113268 Positive_regulation of Positive_regulation of Timp1 3 0.15 3.23 1.43 99.70
5 INT90370 Gene_expression of Mmp14 3 0.49 3.71 0.93 99.64
6 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57 99.36
7 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 98.88
8 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3 98.88
9 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 98.52
10 INT10598 Gene_expression of Ar 10 0.64 3.44 1.61 98.48
11 INT90374 Positive_regulation of Positive_regulation of MMP2 14 0.50 10.12 5.08 98.44
12 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 98.10
13 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 96.72
14 INT90372 Negative_regulation of Hrec 12 0.03 11.73 4.74 96.36
15 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 96.28
16 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 93.08
17 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 89.16
18 INT90371 Localization of Hrec 28 0.05 19.11 10.12 89.16
19 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 89.00
20 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22 88.44
21 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 82.52
22 INT45234 Binding of Ldha 20 0.37 9.8 8.18 82.28
23 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 81.88
24 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 75.00
25 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18 62.12
26 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 61.60
27 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 50.00
28 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 50.00
29 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 50.00
30 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 50.00
31 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 50.00
32 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 50.00
33 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 50.00
34 INT68243 Regulation of Gene_expression of IgG 10 0.44 4.93 2.04 50.00
35 INT38343 Regulation of IGFBP1 8 0.35 3.6 1.75 50.00
36 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36 50.00
37 INT247970 Regulation of CLTC 8 0.28 5.37 1.06 50.00
38 INT102181 Negative_regulation of CLTC 5 0.37 1.37 0.42 50.00
39 INT297020 Positive_regulation of CLTC 5 0.36 3.38 0.41 50.00
40 INT344613 Negative_regulation of Gene_expression of CLTC 2 0.31 1.19 0.37 50.00
41 INT192448 Positive_regulation of Gene_expression of CLTC 5 0.32 3.01 0.33 50.00
42 INT192447 Localization of CLTC 6 0.44 2.32 0.29 50.00
43 INT192449 Binding of CLTC 5 0.23 3.57 0.09 50.00
44 INT287956 Regulation of WNT1 2 0.26 2.38 0.04 50.00
45 INT344614 Protein_catabolism of CLTC 1 0.56 0.77 0 50.00
46 INT188896 Gene_expression of PAGE1 4 0.13 1.14 0 50.00
47 INT297019 Regulation of Gene_expression of CLTC 2 0.37 0.8 0 50.00
48 INT332262 Positive_regulation of Gene_expression of Cma1 1 0.41 4.94 0.38 46.44
49 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 46.04
50 INT5609 Regulation of Ifx 6 0.60 5.73 3.5 43.88
51 INT179523 Binding of Pip 4 0.14 2.61 0.64 39.60
52 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 39.04
53 INT280858 Localization of IFNAR1 5 0.39 4.5 1.09 37.16
54 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 30.56
55 INT98944 Gene_expression of ACTA2 14 0.59 11 3.7 24.56
56 INT146091 Negative_regulation of IFNAR1 6 0.25 9.12 4.86 20.56
57 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
58 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
59 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
60 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
61 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
62 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
63 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
64 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
65 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
66 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
67 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
68 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
69 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
70 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
71 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
72 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
73 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
74 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
75 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
76 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
77 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
78 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
79 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
80 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
81 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
82 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
83 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
84 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 5.00
85 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
86 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 5.00
87 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
88 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
89 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
90 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
91 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
92 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 5.00
93 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 5.00
94 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 5.00
95 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
96 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
97 INT39047 Gene_expression of PGF 34 0.78 17.48 6 5.00
98 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 5.00
99 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6 5.00
100 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
101 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 5.00
102 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
103 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 5.00
104 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 5.00
105 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 5.00
106 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
107 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 5.00
108 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49 5.00
109 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 5.00
110 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
111 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 5.00
112 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 5.00
113 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72 5.00
114 INT136093 Regulation of FBN1 10 0.14 4.39 2.52 5.00
115 INT17963 Gene_expression of Ldha 11 0.75 6.53 2.48 5.00
116 INT52409 Positive_regulation of FBN1 8 0.40 7.28 2.41 5.00
117 INT232414 Negative_regulation of Ifx 6 0.42 3.28 2.26 5.00
118 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
119 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18 5.00
120 INT175655 Regulation of MMRN1 16 0.12 9.96 2.12 5.00
121 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
122 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01 5.00
123 INT213431 Positive_regulation of Gene_expression of MMRN1 15 0.24 9.91 1.96 5.00
124 INT118291 Binding of TXK 19 0.10 11.77 1.94 5.00
125 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 5.00
126 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51 5.00
127 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16 5.00
128 INT222991 Negative_regulation of Gene_expression of MMRN1 10 0.13 4.39 1.14 5.00
129 INT3512 Gene_expression of Igha 9 0.60 7.71 1.13 5.00
130 INT259692 Gene_expression of TNFAIP8L2 3 0.06 3.94 1.13 5.00
131 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99 5.00
132 INT171091 Positive_regulation of SLC10A4 8 0.16 6.27 0.99 5.00
133 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 5.00
134 INT88600 Positive_regulation of Binding of NFKB1 9 0.59 2.1 0.88 5.00
135 INT187709 Regulation of Gene_expression of DBT 3 0.04 0.63 0.8 5.00
136 INT171096 Transcription of PDGFA 5 0.47 4.42 0.79 5.00
137 INT164417 Gene_expression of CRLF1 2 0.34 3.71 0.77 5.00
138 INT248470 Gene_expression of Ighmbp2 5 0.75 3.32 0.68 5.00
139 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 5.00
140 INT259689 Gene_expression of KRT35 1 0.03 6.1 0.52 5.00
141 INT259690 Localization of TNFAIP8L2 2 0.06 1.94 0.51 5.00
142 INT181026 Positive_regulation of Cma1 3 0.40 2.76 0.43 5.00
143 INT171095 Gene_expression of OR1P1 1 0.04 1.82 0.36 5.00
144 INT133874 Negative_regulation of Gene_expression of Fgf1 2 0.24 2.82 0.36 5.00
145 INT257288 Regulation of Gene_expression of COL5A2 7 0.21 2.52 0.36 5.00
146 INT252961 Localization of Fgf1 3 0.27 5.91 0.35 5.00
147 INT155832 Negative_regulation of Cma1 2 0.33 2.02 0.3 5.00
148 INT171093 Regulation of Gene_expression of OR1P1 1 0.02 1.12 0.28 5.00
149 INT308015 Phosphorylation of IFNAR1 1 0.27 1.11 0.28 5.00
150 INT171098 Regulation of OR1P1 1 0.02 1.12 0.28 5.00
151 INT180972 Transcription of MMRN1 2 0.11 0.17 0.24 5.00
152 INT311955 Negative_regulation of Transcription of MMRN1 1 0.07 0.1 0.24 5.00
153 INT171094 Binding of PPM1J 1 0.03 0.61 0.24 5.00
154 INT332259 Positive_regulation of Positive_regulation of Fgf1 1 0.18 2.33 0.23 5.00
155 INT332258 Positive_regulation of Localization of Fgf1 1 0.18 2.32 0.23 5.00
156 INT332263 Negative_regulation of Positive_regulation of Cma1 1 0.25 0.9 0.21 5.00
157 INT332260 Negative_regulation of Gene_expression of Cma1 1 0.25 0.9 0.21 5.00
158 INT259688 Positive_regulation of Localization of TNFAIP8L2 1 0.04 1.14 0.19 5.00
159 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12 5.00
160 INT171097 Positive_regulation of OR1P1 1 0.03 0.6 0.11 5.00
161 INT282122 Positive_regulation of Gene_expression of Ldha 3 0.11 1.58 0.1 5.00
162 INT171092 Positive_regulation of Gene_expression of MCF2 6 0.05 1.57 0.1 5.00
163 INT314085 Regulation of Gene_expression of CRLF1 1 0.03 1.22 0.1 5.00
164 INT259693 Positive_regulation of Gene_expression of KRT35 1 0.03 1.22 0.04 5.00
165 INT332257 Localization of Cma1 1 0.36 1.06 0.04 5.00
166 INT259687 Binding of KRT35 1 0.02 0.55 0 5.00
167 INT259691 Gene_expression of PRCD 1 0.02 1.13 0 5.00
168 INT66973 Gene_expression of Ua1 2 0.01 2.22 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox