D:Dwarfism

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Disease Term
Synonyms NANISM
Documents 95
Hot Single Events 45
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dwarfism. They are ordered first by their relevance to Dwarfism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 77.12
2 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0 76.80
3 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99 76.48
4 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 75.00
5 INT78446 Binding of GH1 and IGFBP3 1 0.11 0.48 0.1 75.00
6 INT35363 Binding of GH1 and GHRH 2 0.36 0.94 0.36 75.00
7 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06 75.00
8 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12 69.32
9 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12 69.32
10 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12 69.32
11 INT327052 Gene_expression of Akt1 Positive_regulation of Gene_expression of Myod1 1 0.19 0.18 0 65.04
12 INT327053 Gene_expression of Akt1 Positive_regulation of Gene_expression of Txlnb 1 0.04 0.18 0 63.92
13 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 57.48
14 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92 46.40
15 INT289789 Comp Positive_regulation of Gene_expression of Rer1 1 0.55 0.8 0.03 43.60
16 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0 30.56
17 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0 17.60
18 INT289788 Binding of Comp and Scn8a 1 0.16 1.37 0 11.72
19 INT289795 Binding of COMP and Comp 1 0.02 0.99 0 11.12
20 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 5.00
21 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28 5.00
22 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 5.00
23 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 5.00
24 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 5.00
25 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 5.00
26 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15 5.00
27 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14 5.00
28 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
29 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05 5.00
30 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
31 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03 5.00
32 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0 5.00
33 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0 5.00
34 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 5.00
35 INT239188 Proc Positive_regulation of Akt1 3 0.01 1.72 0 5.00
36 INT172580 Binding of CD97 and CD55 1 0.14 0 0 5.00
37 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0 5.00
38 INT279268 CARD8 Positive_regulation of CASP1 1 0.32 0.3 0 5.00
39 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 5.00
40 INT239182 Gene_expression of Gh Negative_regulation of Cat 1 0.17 0.33 0 5.00
41 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0 5.00
42 INT239184 Msr1 Negative_regulation of Msra 1 0.21 0.13 0 5.00
43 INT289791 Comp Regulation of Gene_expression of Col7a1 1 0.20 0.21 0 5.00
44 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0 5.00
45 INT189021 NOX5 Positive_regulation of ROS1 1 0.26 0.2 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dwarfism. They are ordered first by their pain relevance and then by number of times they were reported in Dwarfism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 98.76
2 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 98.70
3 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.44
4 INT67349 Localization of Ghr 6 0.66 2.53 0.23 97.68
5 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07 97.68
6 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 97.56
7 INT327031 Negative_regulation of Akt2 1 0.38 0.27 0 97.56
8 INT108866 Negative_regulation of CSH2 1 0.36 1.39 0.1 97.08
9 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5 96.72
10 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 96.68
11 INT9683 Binding of GH1 57 0.47 21.14 5.99 96.68
12 INT200191 Gene_expression of Xpa 1 0.64 10.1 0 95.36
13 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 95.04
14 INT76915 Localization of Gpx3 6 0.14 4.48 0.89 93.92
15 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 93.80
16 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22 93.80
17 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 92.64
18 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 92.40
19 INT1893 Localization of Gh 1041 0.79 340.23 256.58 91.60
20 INT200196 Negative_regulation of Gene_expression of Xpa 1 0.41 1.64 0 91.12
21 INT243058 Positive_regulation of Positive_regulation of Fgfr3 1 0.46 0.8 0 90.56
22 INT243057 Positive_regulation of Fgfr3 1 0.46 0.79 0 90.16
23 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 90.04
24 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2 89.96
25 INT108865 Gene_expression of CSH2 1 0.75 1.47 0.09 89.84
26 INT108864 Gene_expression of ERCC3 1 0.21 1.47 0.09 89.84
27 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39 89.76
28 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86 89.40
29 INT249 Localization of GHRH 215 0.80 78.02 51.87 88.24
30 INT311645 Gene_expression of Spry2 1 0.70 1.81 0 87.68
31 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 84.92
32 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 84.92
33 INT311654 Regulation of Spry2 1 0.21 0.75 0 84.80
34 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 83.68
35 INT151032 Localization of Igf1 49 0.76 26.32 5.71 83.64
36 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07 83.48
37 INT289776 Localization of Dnajc1 1 0.11 1.86 0.08 82.72
38 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 82.56
39 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 82.56
40 INT176180 Negative_regulation of Nr1h2 6 0.16 7.47 0.69 82.40
41 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 82.40
42 INT152045 Negative_regulation of Trav6-3 10 0.57 6.42 1.16 82.40
43 INT6749 Binding of Dio1 25 0.38 4.41 13.07 81.16
44 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76 81.16
45 INT185295 Gene_expression of RASL12 2 0.13 2.02 0 80.60
46 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 78.00
47 INT286386 Positive_regulation of Akt2 2 0.61 0.45 0 77.12
48 INT259848 Regulation of Slc12a3 2 0.12 2.1 0.3 76.44
49 INT327024 Gene_expression of Txlnb 1 0.05 0.82 0.07 76.40
50 INT327030 Negative_regulation of Gene_expression of Txlnb 1 0.04 0.45 0 76.40
51 INT200201 Binding of Xpa 1 0.36 2.34 0 75.32
52 INT78447 Protein_catabolism of GH1 2 0.36 1.2 0.36 75.00
53 INT252 Localization of GH1 529 0.80 227.4 122.05 75.00
54 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 75.00
55 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 75.00
56 INT921 Regulation of GH1 172 0.60 52.88 51.04 75.00
57 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 75.00
58 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 75.00
59 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 75.00
60 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 75.00
61 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13 74.92
62 INT45510 Binding of Scn8a 4 0.31 3.89 0.25 74.36
63 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86 73.96
64 INT200194 Regulation of Localization of Xpa 1 0.38 0.71 0 72.24
65 INT200181 Localization of Xpa 1 0.63 0.71 0 72.24
66 INT200210 Transcription of Apoa4 1 0.06 0.51 0 72.16
67 INT200192 Negative_regulation of Fmo3 1 0.48 1 0 69.04
68 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34 68.32
69 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97 68.08
70 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82 67.64
71 INT311633 Localization of Spry2 1 0.68 0.26 0 67.04
72 INT116314 Gene_expression of Myod1 38 0.70 16.6 0.89 65.04
73 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 62.32
74 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49 61.40
75 INT15489 Negative_regulation of Gene_expression of SGCG 10 0.42 4.78 3.18 61.24
76 INT90491 Binding of Igf1 25 0.44 9.75 1.36 61.00
77 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 60.84
78 INT28861 Binding of Gh 61 0.46 25.61 6.38 60.48
79 INT200186 Binding of Igfals 5 0.19 4.46 1.52 60.48
80 INT200190 Binding of Igf2bp3 1 0.04 0.51 0 60.48
81 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 57.92
82 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 56.56
83 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95 55.72
84 INT327033 Negative_regulation of Phosphorylation of Mtor 3 0.07 1.38 0.23 55.64
85 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 55.28
86 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 55.28
87 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78 55.24
88 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 55.20
89 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 54.12
90 INT200133 Negative_regulation of Xpa 5 0.58 9.85 0.09 53.84
91 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 53.44
92 INT200205 Regulation of Ercc6 1 0.08 1.65 0.05 53.44
93 INT200188 Regulation of Ercc5 1 0.19 1.64 0.05 53.44
94 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04 53.24
95 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 52.40
96 INT200184 Positive_regulation of Igf2bp2 2 0.08 1.21 0.07 51.44
97 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 50.52
98 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 50.00
99 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 50.00
100 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78 50.00
101 INT131671 Negative_regulation of Prlhr 3 0.59 1.61 1.48 50.00
102 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 50.00
103 INT75315 Regulation of Ghr 4 0.22 1.5 1.34 50.00
104 INT197494 Gene_expression of Apoa4 9 0.05 7.33 0.78 50.00
105 INT200206 Negative_regulation of Gene_expression of Igfals 4 0.21 3.83 0.5 50.00
106 INT200193 Gene_expression of Col4a4 8 0.12 5.75 0.43 50.00
107 INT100644 Gene_expression of Igf2bp2 3 0.19 0.68 0.31 50.00
108 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22 50.00
109 INT199768 Gene_expression of Fmo3 3 0.50 3.11 0.17 50.00
110 INT176212 Transcription of Nr1h2 5 0.29 2.92 0.15 50.00
111 INT200203 Regulation of Pou1f1 2 0.60 1.37 0.03 50.00
112 INT200197 Positive_regulation of Xpa 1 0.48 2.76 0 50.00
113 INT200204 Transcription of Igf2bp3 1 0.06 0.4 0 50.00
114 INT200182 Negative_regulation of Igf2bp3 1 0.07 0.4 0 50.00
115 INT200131 Regulation of Xpa 2 0.38 1.25 0 50.00
116 INT200195 Transcription of Igfals 1 0.22 0.39 0 50.00
117 INT200199 Negative_regulation of Ercc5 1 0.31 1.09 0 50.00
118 INT200208 Regulation of Prlr 1 0.10 0.27 0 50.00
119 INT200187 Negative_regulation of Positive_regulation of Xpa 1 0.41 0.96 0 50.00
120 INT200202 Negative_regulation of Positive_regulation of Prlhr 1 0.10 0.4 0 50.00
121 INT200209 Positive_regulation of Prlhr 1 0.12 0.4 0 50.00
122 INT200207 Negative_regulation of Ercc6 1 0.06 1.09 0 50.00
123 INT200179 Negative_regulation of Transcription of Igf2bp3 1 0.05 0.4 0 50.00
124 INT239155 Positive_regulation of Transcription of Sod2 1 0.62 1.75 0.03 47.92
125 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1 47.76
126 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 46.80
127 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85 45.92
128 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 45.88
129 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 45.68
130 INT200129 Negative_regulation of Xpc 1 0.40 0.82 0 45.32
131 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 45.20
132 INT134061 Transcription of Sod2 5 0.68 3.46 1.19 45.12
133 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 44.56
134 INT215844 Gene_expression of Ex 12 0.65 9.24 0.54 39.56
135 INT289778 Gene_expression of Rer1 1 0.65 0.67 0.03 38.40
136 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 35.76
137 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 31.84
138 INT141185 Regulation of Ros1 30 0.24 20.73 8.88 31.48
139 INT169355 Localization of Egfr 6 0.75 3.24 0.43 29.12
140 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52 24.24
141 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 23.28
142 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 23.12
143 INT167084 Binding of Cbl 3 0.10 1.34 0.39 17.60
144 INT310682 Regulation of ARSB 1 0.43 0.98 0.04 16.52
145 INT172953 Binding of Trp53 33 0.37 20.76 1.41 14.16
146 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04 13.32
147 INT184307 Positive_regulation of Gene_expression of Comp 6 0.50 2.48 0.59 13.12
148 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 11.96
149 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 9.60
150 INT289783 Negative_regulation of Hspa5 2 0.22 0.7 0 9.60
151 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 8.16
152 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45 7.36
153 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
154 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
155 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
156 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
157 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
158 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
159 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
160 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
161 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
162 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
163 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
164 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
165 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
166 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 5.00
167 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
168 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
169 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
170 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
171 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
172 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
173 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
174 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
175 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 5.00
176 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
177 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
178 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
179 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
180 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 5.00
181 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
182 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
183 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
184 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
185 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
186 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
187 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
188 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
189 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
190 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
191 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
192 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
193 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
194 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
195 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
196 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
197 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
198 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
199 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
200 INT7832 Localization of Cck 39 0.81 6.81 26.54 5.00
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