D:Dyspareunia

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Disease Term
Synonyms Dyspareunia Orgasm Disorder, Dyspareuniaorgasm, Dyspareuniaorgasm Disorder, Sexual Pain, Vaginimus, Vulvodynia
Documents 318
Hot Single Events 18
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dyspareunia. They are ordered first by their relevance to Dyspareunia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39 93.84
2 INT225690 KNG1 Positive_regulation of TRPV1 1 0.42 0.7 0.83 31.04
3 INT225691 TRPV1 Positive_regulation of Localization of CALCA 1 0.18 0.7 0.83 22.48
4 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
5 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
6 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
7 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
8 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
9 INT209250 TRPV1 Positive_regulation of Localization of DRGX 1 0.06 0.82 0.68 5.00
10 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
11 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
12 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
13 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
14 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
15 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43 5.00
16 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27 5.00
17 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
18 INT189199 JUN Positive_regulation of KRT16 1 0.31 0.58 0.22 5.00
19 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21 5.00
20 INT189195 Binding of C4A and C4B 1 0.14 2.45 0.09 5.00
21 INT189202 Binding of C4B and HAS2 1 0.02 1.25 0.05 5.00
22 INT189198 Binding of C4A and SERPINF1 1 0.12 1.17 0.04 5.00
23 INT189203 CHGB Regulation of CA2 1 0.04 0.95 0 5.00
24 INT189201 CHGB Regulation of Localization of CA2 1 0.04 0.95 0 5.00
25 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
26 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
27 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
28 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
29 INT327198 DBT Positive_regulation of Gene_expression of ESRRA 1 0.00 0.42 0 5.00
30 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
31 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dyspareunia. They are ordered first by their pain relevance and then by number of times they were reported in Dyspareunia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 100.00
2 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 100.00
3 INT148638 Protein_catabolism of Hpse 1 0.48 1.09 1.28 99.92
4 INT23331 Positive_regulation of Localization of Tac1 10 0.54 4.63 8.76 99.52
5 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53 99.48
6 INT8690 Localization of Tac1 71 0.80 22.98 50.75 99.04
7 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.00
8 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 99.00
9 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 98.92
10 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 98.80
11 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5 98.08
12 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54 95.68
13 INT103828 Negative_regulation of Gene_expression of TRPV1 23 0.59 13.63 13.81 92.52
14 INT84925 Transcription of NGF 11 0.65 4.13 3.65 91.12
15 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 89.84
16 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 89.48
17 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47 82.56
18 INT103547 Gene_expression of TRPV3 47 0.78 17.06 13.34 80.64
19 INT47127 Gene_expression of BGN 11 0.75 17.09 6.25 78.36
20 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 76.64
21 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 71.92
22 INT189249 Localization of BGN 2 0.08 2.14 0.8 69.76
23 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 64.56
24 INT137702 Binding of TTN 7 0.35 4.48 3.62 63.20
25 INT26786 Positive_regulation of Uchl1 7 0.34 1.37 1.32 50.00
26 INT160481 Negative_regulation of TRPV3 6 0.59 3.78 1.64 49.48
27 INT77902 Negative_regulation of Positive_regulation of TRPV1 30 0.59 9.36 19.2 45.28
28 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 28.92
29 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 28.52
30 INT69485 Regulation of Bcl2a1c 14 0.34 9.99 0.13 27.16
31 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 26.28
32 INT2415 Binding of MAOA 26 0.47 13.26 11.86 24.60
33 INT626 Localization of CALCA 289 0.81 125.39 221.15 22.48
34 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 21.84
35 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 19.84
36 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 14.68
37 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 7.44
38 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
39 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
40 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
41 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
42 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
43 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
44 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
45 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
46 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
47 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
48 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
49 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 5.00
50 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
51 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
52 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
53 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 5.00
54 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
55 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
56 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
57 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
58 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
59 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
60 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85 5.00
61 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
62 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
63 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78 5.00
64 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
65 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
66 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19 5.00
67 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11 5.00
68 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
69 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
70 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
71 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86 5.00
72 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 5.00
73 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6 5.00
74 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
75 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 5.00
76 INT127500 Gene_expression of TRPA1 79 0.78 24.58 23.3 5.00
77 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 5.00
78 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
79 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 5.00
80 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 5.00
81 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 5.00
82 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
83 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
84 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
85 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 5.00
86 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3 5.00
87 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
88 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
89 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
90 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 5.00
91 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
92 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
93 INT97237 Transcription of TRPV1 33 0.72 10.56 12.4 5.00
94 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32 5.00
95 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
96 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
97 INT83894 Positive_regulation of TRPM8 37 0.70 18.28 11.7 5.00
98 INT143767 Negative_regulation of Trpm8 26 0.58 12.34 10.83 5.00
99 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 5.00
100 INT85048 Regulation of NGF 19 0.62 11.61 10.5 5.00
101 INT80717 Gene_expression of Trpv3 20 0.72 10.05 9.96 5.00
102 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
103 INT134597 Binding of Trpa1 21 0.48 9.41 9.74 5.00
104 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69 5.00
105 INT81264 Positive_regulation of Localization of Ngf 13 0.58 9.82 9.53 5.00
106 INT107898 Gene_expression of Trpv2 27 0.76 10.55 9.28 5.00
107 INT119098 Positive_regulation of TRPV3 20 0.68 10.12 9.01 5.00
108 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87 5.00
109 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85 5.00
110 INT146241 Positive_regulation of Gene_expression of Trpa1 23 0.69 8.07 8.74 5.00
111 INT148864 Localization of DRGX 11 0.17 7.67 8.36 5.00
112 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
113 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
114 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
115 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 5.00
116 INT32579 Binding of C4B 14 0.36 14.99 7.79 5.00
117 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 5.00
118 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 5.00
119 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75 5.00
120 INT16869 Positive_regulation of Prl 24 0.70 15.7 7.63 5.00
121 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6 5.00
122 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
123 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48 5.00
124 INT124881 Binding of Trpv4 35 0.47 7.71 6.24 5.00
125 INT144086 Positive_regulation of Prok2 12 0.69 9.54 6.06 5.00
126 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 5.00
127 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02 5.00
128 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01 5.00
129 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
130 INT71477 Negative_regulation of Positive_regulation of Prkaca 10 0.37 1.69 5.57 5.00
131 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
132 INT146347 Negative_regulation of Gene_expression of Trpm8 9 0.55 6.96 5.42 5.00
133 INT50105 Localization of CTSB 29 0.78 10.98 5.21 5.00
134 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02 5.00
135 INT105216 Positive_regulation of Trpv2 9 0.61 4.12 4.93 5.00
136 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92 5.00
137 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86 5.00
138 INT134610 Positive_regulation of Phosphorylation of Trpv1 9 0.69 4.51 4.74 5.00
139 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53 5.00
140 INT112038 Positive_regulation of P2ry2 8 0.45 2.41 4.4 5.00
141 INT108354 Negative_regulation of Phosphorylation of Prkaca 18 0.41 6.24 4.37 5.00
142 INT15851 Positive_regulation of Trpv3 11 0.60 4.6 4.35 5.00
143 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
144 INT181495 Regulation of TRPV3 3 0.25 6.57 4.22 5.00
145 INT97128 Localization of SPP1 32 0.80 21.75 4.02 5.00
146 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98 5.00
147 INT120433 Regulation of TRPM8 11 0.62 8.56 3.78 5.00
148 INT181922 Binding of RENBP 16 0.36 13.92 3.71 5.00
149 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 5.00
150 INT102573 Protein_catabolism of Faah 8 0.80 2.89 3.52 5.00
151 INT25990 Positive_regulation of Pla2g5 11 0.69 4.93 3.32 5.00
152 INT7773 Localization of SERPINF1 18 0.55 8.54 3.25 5.00
153 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23 5.00
154 INT127717 Negative_regulation of TRPM8 9 0.59 3.09 2.92 5.00
155 INT151865 Regulation of TRPA1 5 0.45 2.78 2.7 5.00
156 INT11485 Localization of KCNMA1 7 0.09 1.81 2.6 5.00
157 INT115199 Localization of Trpv4 12 0.79 3.65 2.5 5.00
158 INT129161 Binding of TRPM8 7 0.48 1.32 2.48 5.00
159 INT11487 Positive_regulation of Localization of KCNMA1 4 0.06 1.5 2.31 5.00
160 INT195917 Regulation of Phosphorylation of Trpv1 2 0.52 1.86 2.29 5.00
161 INT261812 Positive_regulation of Negative_regulation of Trpv1 3 0.46 1.26 2.11 5.00
162 INT56342 Gene_expression of TTR 34 0.78 16.5 2.05 5.00
163 INT105536 Regulation of Myoz1 6 0.17 3.45 2.01 5.00
164 INT189239 Binding of GSN 11 0.36 9.34 1.93 5.00
165 INT47129 Positive_regulation of BGN 4 0.46 2.29 1.93 5.00
166 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73 5.00
167 INT114730 Phosphorylation of Myoz1 8 0.14 1.15 1.71 5.00
168 INT189226 Protein_catabolism of GSN 3 0.54 7.1 1.7 5.00
169 INT25988 Negative_regulation of Pla2g5 5 0.58 2.68 1.68 5.00
170 INT151096 Localization of TRPA1 8 0.80 2.06 1.65 5.00
171 INT261815 Regulation of Gene_expression of Trpv2 2 0.32 0.97 1.65 5.00
172 INT103550 Binding of TRPV3 3 0.44 1.41 1.61 5.00
173 INT149512 Positive_regulation of Gene_expression of Trpv3 2 0.49 2.48 1.57 5.00
174 INT152720 Localization of Trpv2 6 0.69 2.71 1.54 5.00
175 INT1641 Positive_regulation of Negative_regulation of FSHR 3 0.41 1.7 1.43 5.00
176 INT110942 Transcription of TRPM8 16 0.69 13.69 1.31 5.00
177 INT69124 Positive_regulation of Prlr 2 0.70 0.84 1.3 5.00
178 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23 5.00
179 INT114031 Gene_expression of ORM1 3 0.41 6.31 1.18 5.00
180 INT130246 Negative_regulation of Gene_expression of TRPM8 4 0.59 3.35 1.14 5.00
181 INT36064 Binding of CST3 14 0.47 16.38 1.12 5.00
182 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07 5.00
183 INT218776 Negative_regulation of Ccdc80 2 0.02 0.97 0.99 5.00
184 INT66618 Gene_expression of PNMA2 3 0.29 1.24 0.97 5.00
185 INT102231 Localization of HBM 8 0.60 6.14 0.88 5.00
186 INT70496 Positive_regulation of EFS 3 0.29 0.2 0.84 5.00
187 INT196060 Positive_regulation of Muted 2 0.07 0.85 0.83 5.00
188 INT39586 Transcription of CP 5 0.67 1.7 0.83 5.00
189 INT209258 Gene_expression of SUB1 5 0.75 3.3 0.7 5.00
190 INT134173 Binding of APLP1 4 0.37 2.41 0.67 5.00
191 INT187712 Negative_regulation of DBT 11 0.19 2.99 0.65 5.00
192 INT261810 Positive_regulation of Positive_regulation of Pla2g5 1 0.08 0.25 0.62 5.00
193 INT209254 Negative_regulation of Gene_expression of SUB1 1 0.01 1.4 0.56 5.00
194 INT261814 Regulation of Negative_regulation of Trpv1 1 0.23 0.07 0.56 5.00
195 INT189241 Localization of CNDP1 2 0.51 0.67 0.52 5.00
196 INT261817 Protein_catabolism of Ccdc80 1 0.02 0.86 0.45 5.00
197 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 5.00
198 INT118437 Transcription of TRPV3 3 0.60 0.88 0.4 5.00
199 INT96520 Gene_expression of PRPH 5 0.75 2.55 0.39 5.00
200 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39 5.00
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