D:Dysplastic Nevus Syndrome

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Disease Term
Synonyms B K Mole Syndrome, Dysplastic Nevi, DYSPLASTIC NEVUS, Familial Atypical Multiple Mole Melanoma, Nevi Dysplastic, Nevus Dysplastic, NEVUS SYNDROME DYSPLASTIC, Syndrome B K Mole, Syndrome Dysplastic Nevus
Documents 17
Hot Single Events 2
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dysplastic Nevus Syndrome. They are ordered first by their relevance to Dysplastic Nevus Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34 84.24
2 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3 5.00
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76 5.00
4 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02 5.00
5 INT349537 Smcp Positive_regulation of Tnfsf10 1 0.38 3.48 0.28 5.00
6 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
7 INT349538 Smcp Positive_regulation of Positive_regulation of Casp9 1 0.04 0.68 0.18 5.00
8 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18 5.00
9 INT349540 Tnfsf10 Positive_regulation of Positive_regulation of Casp8 1 0.05 0.65 0.15 5.00
10 INT349530 Tnfsf10 Negative_regulation of Smcp 1 0.28 0.88 0 5.00
11 INT349542 SCFV Positive_regulation of Tnfsf10 1 0.12 0.56 0 5.00
12 INT349535 Binding of Smcp and Tnfsf10 1 0.36 6.79 0 5.00
13 INT349543 Tnfsf10 Positive_regulation of NGFR 1 0.01 0.43 0 5.00
14 INT349532 Positive_regulation of Binding of Smcp and Tnfsf10 1 0.35 2.16 0 5.00
15 INT248387 CHD5 Regulation of Gene_expression of TP53 1 0.20 0.83 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dysplastic Nevus Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Dysplastic Nevus Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06 98.56
2 INT278253 Positive_regulation of Gene_expression of Smcp 3 0.29 1.24 0.39 94.88
3 INT308522 Positive_regulation of Positive_regulation of Ptk2 2 0.22 2.37 0.21 77.28
4 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61 75.96
5 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47 75.00
6 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 73.76
7 INT196913 Regulation of Kras 3 0.10 3.81 0.28 69.24
8 INT220783 Gene_expression of Tert 39 0.77 12.55 1.49 65.72
9 INT220777 Positive_regulation of Gene_expression of Tert 9 0.68 2.34 0.18 65.72
10 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 64.24
11 INT220785 Positive_regulation of Tert 15 0.68 6.9 0.25 63.96
12 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52 60.80
13 INT13063 Binding of RHCE 16 0.38 6.54 1.22 55.16
14 INT197252 Positive_regulation of Muc1 4 0.50 2.93 0.25 49.00
15 INT286864 Regulation of Muc1 1 0.33 0.89 0.06 45.24
16 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 33.28
17 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 31.72
18 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 31.60
19 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62 30.00
20 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42 30.00
21 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32 30.00
22 INT206820 Gene_expression of Muc1 17 0.60 13.48 0.36 28.36
23 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 27.92
24 INT248394 Gene_expression of CHD5 1 0.70 2.3 0 14.32
25 INT64465 Positive_regulation of Reg3b 5 0.69 8.36 0.99 10.32
26 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
27 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
28 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
29 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
30 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
31 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 5.00
32 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
33 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
34 INT84712 Regulation of MC1R 36 0.62 9.34 16.91 5.00
35 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 5.00
36 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 5.00
37 INT35612 Gene_expression of REG3A 37 0.78 33.33 10.13 5.00
38 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64 5.00
39 INT5481 Binding of TYR 26 0.47 1.3 7.95 5.00
40 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 5.00
41 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 5.00
42 INT69700 Transcription of MC1R 15 0.71 4.32 5.62 5.00
43 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
44 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
45 INT186063 Phosphorylation of SOAT1 29 0.28 11.77 5.34 5.00
46 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
47 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
48 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28 5.00
49 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 5.00
50 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04 5.00
51 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9 5.00
52 INT64464 Gene_expression of Reg3b 4 0.77 10.95 2.77 5.00
53 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46 5.00
54 INT174446 Positive_regulation of Smcp 7 0.33 5.47 2.24 5.00
55 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 5.00
56 INT181107 Gene_expression of Epcam 45 0.73 44.33 1.96 5.00
57 INT90219 Gene_expression of Lgals1 6 0.20 3.47 1.94 5.00
58 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
59 INT226894 Negative_regulation of Tnfsf10 14 0.57 16.64 1.87 5.00
60 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85 5.00
61 INT148051 Binding of SCFV 23 0.47 9.86 1.83 5.00
62 INT84350 Positive_regulation of Gene_expression of REG3A 10 0.70 11.6 1.71 5.00
63 INT10712 Localization of RHCE 3 0.28 1.15 1.69 5.00
64 INT224643 Positive_regulation of Gene_expression of Tnfsf10 13 0.46 11.1 1.67 5.00
65 INT19423 Positive_regulation of REG3A 9 0.70 6.05 1.63 5.00
66 INT174434 Localization of Smcp 6 0.53 2.45 1.46 5.00
67 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 5.00
68 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26 5.00
69 INT174424 Binding of Smcp 9 0.25 2.68 0.94 5.00
70 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94 5.00
71 INT139176 Gene_expression of Fadd 5 0.51 5.26 0.92 5.00
72 INT286866 Positive_regulation of Gene_expression of Reg3b 1 0.12 2.32 0.84 5.00
73 INT260803 Regulation of Tnfsf10 4 0.44 5.04 0.76 5.00
74 INT224579 Gene_expression of Cdkn2d 6 0.41 4.23 0.68 5.00
75 INT191931 Negative_regulation of Binding of Gopc 13 0.29 4.83 0.68 5.00
76 INT286861 Binding of Reg3b 1 0.07 2.08 0.67 5.00
77 INT75043 Binding of Msx1 6 0.35 2.36 0.65 5.00
78 INT178172 Localization of Tnfsf10 14 0.78 11.67 0.62 5.00
79 INT311604 Gene_expression of AATF 3 0.06 2.9 0.55 5.00
80 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 5.00
81 INT260793 Binding of Tnfsf10 12 0.36 11.93 0.47 5.00
82 INT286785 Regulation of Gt(ROSA)26Sor 2 0.26 0.76 0.45 5.00
83 INT98456 Negative_regulation of Src 17 0.42 8.3 0.42 5.00
84 INT116427 Negative_regulation of Smcp 10 0.31 2.72 0.41 5.00
85 INT271521 Phosphorylation of Ptk2 10 0.59 11.45 0.39 5.00
86 INT338169 Binding of MTAP 1 0.36 0.76 0.37 5.00
87 INT279985 Transcription of BCL2L1 5 0.69 3.76 0.34 5.00
88 INT148050 Positive_regulation of SCFV 6 0.49 3.4 0.3 5.00
89 INT232656 Localization of MLL 2 0.05 2.33 0.29 5.00
90 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26 5.00
91 INT286859 Localization of Reg3b 1 0.14 0.88 0.24 5.00
92 INT276320 Binding of Lgals1 2 0.03 1.51 0.21 5.00
93 INT286862 Positive_regulation of Gene_expression of Muc1 1 0.36 1.03 0.21 5.00
94 INT165361 Positive_regulation of APAF1 4 0.39 4.8 0.16 5.00
95 INT64461 Regulation of Gene_expression of Reg3b 2 0.61 1.42 0.16 5.00
96 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15 5.00
97 INT327399 Negative_regulation of Positive_regulation of Ptk2 7 0.43 4.75 0.13 5.00
98 INT269240 Regulation of Ptk2 6 0.42 2.84 0.13 5.00
99 INT278252 Regulation of Smcp 2 0.29 1.58 0.09 5.00
100 INT165362 Gene_expression of APAF1 5 0.50 4.37 0.08 5.00
101 INT146795 Regulation of Gla 3 0.62 1.36 0.05 5.00
102 INT286863 Regulation of Regulation of Gt(ROSA)26Sor 1 0.05 0.21 0.05 5.00
103 INT302962 Positive_regulation of Gene_expression of Fadd 2 0.27 1.45 0.04 5.00
104 INT286860 Negative_regulation of Gene_expression of Reg3b 1 0.08 0.26 0.03 5.00
105 INT248395 Regulation of CHD5 1 0.24 0.96 0 5.00
106 INT248392 Positive_regulation of Gene_expression of CHD5 1 0.45 0.87 0 5.00
107 INT248393 Binding of CHD5 1 0.33 0.22 0 5.00
108 INT349529 Phosphorylation of Tnfsf10 1 0.74 1.32 0 5.00
109 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0 5.00
110 INT308399 Gene_expression of MED23 1 0.58 1.26 0 5.00
111 INT308357 Positive_regulation of Trp53-ps 1 0.45 0.98 0 5.00
112 INT319365 Regulation of Gene_expression of Smcp 3 0.32 0.53 0 5.00
113 INT308403 Negative_regulation of Gene_expression of MED23 1 0.42 1.31 0 5.00
114 INT308398 Positive_regulation of Gene_expression of APAF1 2 0.39 1.8 0 5.00
115 INT308354 Gene_expression of Snai2 1 0.58 1.14 0 5.00
116 INT308358 Positive_regulation of Gene_expression of Snai2 1 0.45 1.14 0 5.00
117 INT248397 Positive_regulation of CHD5 1 0.39 0.24 0 5.00
118 INT349527 Phosphorylation of Smcp 1 0.58 1.93 0 5.00
119 INT319367 Negative_regulation of Gene_expression of Smcp 2 0.30 0.71 0 5.00
120 INT248389 Negative_regulation of Cdkn2d 1 0.04 1.75 0 5.00
121 INT248396 Negative_regulation of CHD5 1 0.39 0.93 0 5.00
122 INT248391 Positive_regulation of Gene_expression of Cdkn2d 1 0.05 0.85 0 5.00
123 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0 5.00
124 INT308401 Positive_regulation of MED23 1 0.45 1.27 0 5.00
125 INT248390 Negative_regulation of Gene_expression of Cdkn2d 2 0.31 0.8 0 5.00
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