D:Earache

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Disease Term
Synonyms Earaches, Otalgia, Otalgias, Pain Behind The Ear, Painful Ear
Documents 817
Hot Single Events 33
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Earache. They are ordered first by their relevance to Earache and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14 96.96
2 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74 91.24
3 INT94939 Binding of POMC and B3GAT1 1 0.40 1.04 0.12 82.68
4 INT94938 Binding of SERPINB1 and B3GAT1 1 0.01 1.04 0.12 82.68
5 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0 5.00
6 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0 5.00
7 INT293868 Binding of GREM1 and OCM 1 0.00 1.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Earache. They are ordered first by their pain relevance and then by number of times they were reported in Earache. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 99.58
2 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 98.60
3 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 98.54
4 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 96.96
5 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 95.92
6 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 95.84
7 INT150867 Regulation of COPD 54 0.48 71.38 8.8 92.88
8 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 91.24
9 INT117735 Positive_regulation of Regulation of Nfkb1 3 0.44 2.93 0.91 91.24
10 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 90.56
11 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 90.28
12 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 89.52
13 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 89.52
14 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 89.52
15 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 89.52
16 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 89.28
17 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 89.28
18 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 88.36
19 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 88.36
20 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 88.36
21 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 88.36
22 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 88.36
23 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 88.36
24 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 86.12
25 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 86.12
26 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 86.12
27 INT22454 Regulation of Crp 213 0.62 160.67 49.24 84.56
28 INT18934 Gene_expression of GER 16 0.66 14.71 1.29 84.44
29 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 83.80
30 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 83.80
31 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 82.72
32 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 81.88
33 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 81.04
34 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 79.76
35 INT38545 Gene_expression of IV 3 0.53 2.89 0.41 79.36
36 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 77.84
37 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 77.84
38 INT36970 Positive_regulation of Acpp 2 0.20 1.68 0.2 77.84
39 INT129927 Transcription of Ldha 3 0.42 1.41 0.18 77.84
40 INT129929 Transcription of LDHA 4 0.17 4.48 0.08 77.84
41 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 76.92
42 INT59010 Positive_regulation of Regulation of Crp 2 0.27 2.11 1.09 76.32
43 INT37390 Regulation of Crp 39 0.46 28.74 11.45 75.92
44 INT293876 Localization of OCM 1 0.05 0.7 0.1 72.32
45 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25 70.08
46 INT28238 Positive_regulation of Hrct1 5 0.38 3.66 0.5 69.84
47 INT175569 Binding of Pcbd1 1 0.17 0.96 0.19 63.52
48 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 63.28
49 INT169103 Negative_regulation of Hal 7 0.34 4.25 0.48 54.76
50 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 52.72
51 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 51.92
52 INT117476 Negative_regulation of Gene_expression of Mpo 10 0.43 8.25 3.33 51.92
53 INT67551 Gene_expression of Mbis1 6 0.35 3.32 0.17 47.76
54 INT293874 Positive_regulation of OCM 1 0.05 2 0 40.84
55 INT184729 Transcription of COL2A1 4 0.67 1.1 0 25.56
56 INT307700 Regulation of HOPX 4 0.53 7.64 3.5 24.88
57 INT3362 Negative_regulation of Emg1 21 0.57 10.03 15.93 23.04
58 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 17.60
59 INT179684 Protein_catabolism of COPD 4 0.25 4.25 0.27 12.16
60 INT252576 Binding of Emg1 1 0.32 0.77 0.56 7.32
61 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
62 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
63 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
64 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
65 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
66 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
67 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
68 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
69 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
70 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
71 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
72 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
73 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
74 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
75 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
76 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
77 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
78 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
79 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
80 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
81 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
82 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 5.00
83 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
84 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
85 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 5.00
86 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
87 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
88 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
89 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 5.00
90 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 5.00
91 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
92 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
93 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
94 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
95 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
96 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
97 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
98 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
99 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
100 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 5.00
101 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
102 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
103 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
104 INT49986 Transcription of Tnf 25 0.72 18.3 16.22 5.00
105 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
106 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
107 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
108 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
109 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
110 INT22213 Localization of Gpt 52 0.78 34.05 12.94 5.00
111 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
112 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64 5.00
113 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
114 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
115 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
116 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
117 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
118 INT49884 Negative_regulation of Gene_expression of Il4 18 0.55 14.06 8.9 5.00
119 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
120 INT79166 Regulation of TNC 12 0.44 9.42 8.13 5.00
121 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
122 INT68299 Binding of Tnf 17 0.39 12.55 7.49 5.00
123 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
124 INT147793 Localization of COPD 70 0.64 89.01 7.3 5.00
125 INT10507 Positive_regulation of Gene_expression of PTAFR 15 0.61 10.24 6.61 5.00
126 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 5.00
127 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
128 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
129 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
130 INT66757 Negative_regulation of Binding of Nfkb1 17 0.57 8.14 4.94 5.00
131 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
132 INT62570 Binding of Pth 48 0.48 26.45 4.85 5.00
133 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 5.00
134 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42 5.00
135 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.00
136 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
137 INT94406 Regulation of Slc17a5 10 0.44 3.71 3.77 5.00
138 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7 5.00
139 INT233945 Positive_regulation of Expi 5 0.04 2.53 3.46 5.00
140 INT104902 Regulation of ASIC1 6 0.51 5.17 3.13 5.00
141 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 5.00
142 INT78581 Positive_regulation of Binding of Nfkb1 13 0.66 7.37 2.79 5.00
143 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 5.00
144 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6 5.00
145 INT51683 Regulation of Gene_expression of PTAFR 11 0.60 5.06 2.59 5.00
146 INT54979 Gene_expression of oh 7 0.45 0.51 2.54 5.00
147 INT62511 Negative_regulation of MCS 20 0.50 6.77 2.35 5.00
148 INT15752 Positive_regulation of Ema 15 0.40 14.57 2.34 5.00
149 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 5.00
150 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
151 INT27475 Negative_regulation of oh 5 0.08 0.54 2.1 5.00
152 INT176629 Gene_expression of GREM1 9 0.10 6.89 1.66 5.00
153 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42 5.00
154 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
155 INT75746 Regulation of ZMYND10 3 0.44 0.5 1.31 5.00
156 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 5.00
157 INT263019 Gene_expression of DEFA6 4 0.25 4.14 1.17 5.00
158 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11 5.00
159 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96 5.00
160 INT213739 Gene_expression of Expi 7 0.47 1.05 0.63 5.00
161 INT169167 Positive_regulation of GREM1 1 0.08 1.83 0.6 5.00
162 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 5.00
163 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 5.00
164 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46 5.00
165 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44 5.00
166 INT153702 Positive_regulation of CLDN7 4 0.29 0.97 0.41 5.00
167 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 5.00
168 INT88070 Binding of Ema 7 0.18 7.39 0.31 5.00
169 INT116034 Negative_regulation of Transcription of Tnf 2 0.41 0.17 0.29 5.00
170 INT155590 Gene_expression of ARIH1 8 0.58 10.76 0.24 5.00
171 INT76159 Gene_expression of CEACAM1 5 0.65 5.12 0.24 5.00
172 INT263203 Negative_regulation of Localization of COPD 3 0.36 4.09 0.22 5.00
173 INT127177 Negative_regulation of Fam65c 2 0.01 0.98 0.22 5.00
174 INT245196 Negative_regulation of CD209 5 0.11 4.83 0.21 5.00
175 INT259580 Negative_regulation of Binding of COPD 2 0.10 3.44 0.17 5.00
176 INT186056 Binding of MKI67 6 0.48 4.44 0.1 5.00
177 INT281839 Localization of ARIH1 2 0.54 3.03 0.09 5.00
178 INT293877 Binding of OCM 1 0.03 1.68 0.08 5.00
179 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07 5.00
180 INT185989 Localization of GREM1 2 0.11 2.41 0.05 5.00
181 INT354590 Regulation of Gene_expression of Expi 1 0.02 0.34 0.05 5.00
182 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05 5.00
183 INT354591 Negative_regulation of Positive_regulation of PYCARD 1 0.05 0.34 0.05 5.00
184 INT349674 Regulation of Positive_regulation of PYCARD 2 0.11 0.34 0.05 5.00
185 INT354593 Regulation of Gene_expression of PLXNA2 1 0.04 0.34 0.05 5.00
186 INT156365 Gene_expression of Hhex 4 0.67 1.63 0.03 5.00
187 INT250504 Negative_regulation of URI1 1 0.10 0.71 0.03 5.00
188 INT175571 Negative_regulation of Pcbd1 1 0.19 0.93 0 5.00
189 INT159591 Positive_regulation of Binding of Tnf 1 0.43 0.06 0 5.00
190 INT336016 Binding of Mbis1 1 0.05 0.93 0 5.00
191 INT346015 Localization of CLDN7 1 0.07 0 0 5.00
192 INT288289 Positive_regulation of Cm3 3 0.09 0.74 0 5.00
193 INT226991 Gene_expression of TPCN1 4 0.09 0.8 0 5.00
194 INT293873 Negative_regulation of OCM 1 0.04 0.65 0 5.00
195 INT346016 Regulation of CLDN7 1 0.02 0 0 5.00
196 INT275886 Gene_expression of Cm3 25 0.23 4.01 0 5.00
197 INT292884 Positive_regulation of Binding of MKI67 1 0.06 0.52 0 5.00
198 INT175570 Positive_regulation of Pcbd1 1 0.21 2.07 0 5.00
199 INT293878 Positive_regulation of Localization of GREM1 1 0.01 0.47 0 5.00
200 INT338134 Positive_regulation of Gene_expression of ZMYND10 1 0.49 0.58 0 5.00
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