D:Ectromelia

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Disease Term
Synonyms Amelia, HEMIMELIA, Phocomelia, Sirenomelia
Documents 33
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ectromelia. They are ordered first by their relevance to Ectromelia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315485 Slfn1 Negative_regulation of Gopc 1 0.13 0.27 0 61.00
2 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 38.04
3 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 5.00
4 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 5.00
5 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
6 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
7 INT253929 Binding of Vcam1 and Cd99l2 1 0.00 0.61 0.13 5.00
8 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13 5.00
9 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12 5.00
10 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12 5.00
11 INT287893 VEGFA Positive_regulation of Localization of WISP1 1 0.03 1.23 0.1 5.00
12 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1 5.00
13 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08 5.00
14 INT253930 IFNA1 Positive_regulation of Cdc42ep3 1 0.00 0.65 0.08 5.00
15 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08 5.00
16 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08 5.00
17 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07 5.00
18 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
19 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05 5.00
20 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05 5.00
21 INT315986 Igf1 Positive_regulation of Pik3c3 1 0.00 0.48 0.05 5.00
22 INT315484 Slfn5 Regulation of Gopc 1 0.05 0.28 0.03 5.00
23 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
24 INT315984 Rhd Positive_regulation of Localization of Igf1 1 0.07 0.25 0 5.00
25 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0 5.00
26 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
27 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0 5.00
28 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0 5.00
29 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0 5.00
30 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
31 INT287891 Binding of CDH1 and KRT20 1 0.00 0.5 0 5.00
32 INT315486 Slfn1 Negative_regulation of Ccnd1 1 0.07 0.28 0 5.00
33 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
34 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
35 INT315487 Slfnl1 Regulation of Vmn1r176 1 0.00 0.44 0 5.00
36 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0 5.00
37 INT315985 Rhd Positive_regulation of Igf1 1 0.07 0.25 0 5.00
38 INT315483 Spna1 Regulation of Slfn5 1 0.01 0.53 0 5.00
39 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ectromelia. They are ordered first by their pain relevance and then by number of times they were reported in Ectromelia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 99.78
2 INT279863 Localization of Pds5a 1 0.47 0.93 0 96.72
3 INT279844 Localization of Pds5b 1 0.65 0.94 0 96.72
4 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 83.40
5 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 83.40
6 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 82.80
7 INT279849 Binding of Pds5b 1 0.32 0.93 0 81.52
8 INT26750 Positive_regulation of Nr3c1 6 0.46 5.46 1.75 79.52
9 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 74.56
10 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 74.40
11 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 62.80
12 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 62.64
13 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 61.52
14 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 59.64
15 INT91768 Gene_expression of HSD17B6 6 0.75 3.99 0.26 48.64
16 INT279838 Protein_catabolism of Rec8 1 0.02 0.81 0 47.52
17 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 45.52
18 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 45.32
19 INT261202 Regulation of MC3R 2 0.05 0.09 0.05 40.00
20 INT279867 Binding of Rec8 1 0.01 0.81 0 38.04
21 INT279862 Binding of Nipbl 1 0.36 1.22 0.04 37.56
22 INT32129 Gene_expression of Esrra 8 0.36 5.64 0.97 33.32
23 INT315470 Gene_expression of Slfn5 1 0.18 23.81 0.04 29.08
24 INT315472 Positive_regulation of Gene_expression of Slfn5 1 0.11 0 0 12.00
25 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
26 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
27 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
28 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
29 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
30 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
31 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
32 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
33 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
34 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
35 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
36 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
37 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
38 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22 5.00
39 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
40 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
41 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
42 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
43 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
44 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
45 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
46 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
47 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
48 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 5.00
49 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
50 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
51 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01 5.00
52 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
53 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
54 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
55 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
56 INT43226 Gene_expression of Hivep3 75 0.71 30.53 21.14 5.00
57 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
58 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
59 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
60 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
61 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
62 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
63 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
64 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 5.00
65 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
66 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
67 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
68 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
69 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
70 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
71 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
72 INT21850 Gene_expression of Spna1 107 0.50 51.4 11.81 5.00
73 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 5.00
74 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 5.00
75 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
76 INT20721 Localization of ACOT1 47 0.80 11.37 10.95 5.00
77 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83 5.00
78 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 5.00
79 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64 5.00
80 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 5.00
81 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
82 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 5.00
83 INT79693 Regulation of Il4 30 0.51 21.96 8.6 5.00
84 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 5.00
85 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
86 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
87 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
88 INT1664 Gene_expression of Kitl 30 0.65 13.63 7.47 5.00
89 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 5.00
90 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
91 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
92 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
93 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
94 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
95 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2 5.00
96 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
97 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
98 INT95616 Gene_expression of Thpo 48 0.78 21.51 5.88 5.00
99 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 5.00
100 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
101 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58 5.00
102 INT7524 Localization of Kitl 9 0.74 3.45 5.49 5.00
103 INT116229 Gene_expression of C1qa 28 0.77 18.53 5.35 5.00
104 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17 5.00
105 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
106 INT78393 Gene_expression of Adm 16 0.78 8.4 4.92 5.00
107 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
108 INT10694 Binding of Bche 19 0.48 8.03 4.85 5.00
109 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75 5.00
110 INT111739 Negative_regulation of Npy 15 0.43 4.9 4.65 5.00
111 INT181395 Gene_expression of Ccl8 11 0.67 13.88 4.56 5.00
112 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
113 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 5.00
114 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
115 INT186270 Regulation of Il13 13 0.43 11.58 4.19 5.00
116 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87 5.00
117 INT89678 Positive_regulation of Gene_expression of PRKG1 15 0.70 5.99 3.84 5.00
118 INT63121 Binding of APC 29 0.41 23.02 3.8 5.00
119 INT54848 Protein_catabolism of SGCG 12 0.96 3.8 3.78 5.00
120 INT174277 Positive_regulation of Positive_regulation of Gopc 23 0.33 8.08 3.73 5.00
121 INT134914 Binding of Gfap 21 0.37 8.25 3.67 5.00
122 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
123 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
124 INT96150 Gene_expression of H2-D1 44 0.27 16.23 3.4 5.00
125 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
126 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4 5.00
127 INT57243 Transcription of SGCG 10 0.69 3.43 3.04 5.00
128 INT20722 Regulation of Localization of ACOT1 5 0.27 1.43 2.86 5.00
129 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
130 INT194465 Gene_expression of Ldlr 27 0.76 31.36 2.73 5.00
131 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68 5.00
132 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29 5.00
133 INT163063 Positive_regulation of C1qa 10 0.67 6.06 2.29 5.00
134 INT163064 Positive_regulation of Gene_expression of C1qa 9 0.67 6.51 2.29 5.00
135 INT20720 Negative_regulation of Localization of ACOT1 6 0.35 2.66 2.25 5.00
136 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 5.00
137 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
138 INT14 Regulation of LDHA 22 0.57 15.26 2.14 5.00
139 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14 5.00
140 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
141 INT8462 Binding of MUC7 11 0.36 1.79 2.11 5.00
142 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1 5.00
143 INT171514 Binding of EP300 13 0.32 4.32 2.01 5.00
144 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
145 INT199084 Gene_expression of Cd36 31 0.53 16.94 1.94 5.00
146 INT199724 Positive_regulation of Gene_expression of Rxra 11 0.45 6.22 1.88 5.00
147 INT184031 Gene_expression of Cish 14 0.49 9.82 1.86 5.00
148 INT29833 Binding of Spna1 39 0.27 19.4 1.74 5.00
149 INT187063 Binding of CRYGD 5 0.36 5.71 1.59 5.00
150 INT216123 Negative_regulation of Cd68 2 0.41 1.96 1.48 5.00
151 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48 5.00
152 INT36148 Binding of GAD1 10 0.41 7.91 1.47 5.00
153 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46 5.00
154 INT59837 Regulation of Upf1 5 0.03 1.37 1.45 5.00
155 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42 5.00
156 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4 5.00
157 INT103907 Negative_regulation of Upf1 15 0.37 4.3 1.4 5.00
158 INT224501 Positive_regulation of Gene_expression of EPHB2 9 0.49 4.29 1.39 5.00
159 INT35742 Positive_regulation of tk 8 0.43 5.53 1.33 5.00
160 INT215380 Positive_regulation of Gene_expression of Cd36 12 0.47 8.51 1.3 5.00
161 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
162 INT172630 Binding of HNF4A 16 0.05 7.78 1.22 5.00
163 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17 5.00
164 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
165 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 5.00
166 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 5.00
167 INT253925 Positive_regulation of Gene_expression of Pdcd1 5 0.06 5.03 1.08 5.00
168 INT135039 Gene_expression of Cd1 11 0.60 5.66 1.05 5.00
169 INT172616 Regulation of HNF4A 9 0.06 4.25 1.02 5.00
170 INT305307 Gene_expression of Serpina5 88 0.78 10.09 1 5.00
171 INT116797 Gene_expression of Osmr 9 0.73 1.12 1 5.00
172 INT155093 Positive_regulation of CFLAR 6 0.67 5.02 0.88 5.00
173 INT95561 Negative_regulation of Vldlr 9 0.53 2.59 0.84 5.00
174 INT150108 Positive_regulation of Gene_expression of Slc37a4 5 0.35 2.09 0.83 5.00
175 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83 5.00
176 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82 5.00
177 INT178175 Positive_regulation of Gene_expression of Cd8a 17 0.43 13.05 0.78 5.00
178 INT174492 Positive_regulation of Gene_expression of Cd3e 8 0.39 5.08 0.77 5.00
179 INT105344 Gene_expression of Cited2 5 0.78 3.65 0.76 5.00
180 INT177716 Gene_expression of GALNT3 7 0.53 6.91 0.75 5.00
181 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75 5.00
182 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74 5.00
183 INT203035 Gene_expression of Pdcd1lg2 4 0.58 1.97 0.74 5.00
184 INT253922 Gene_expression of Otc 13 0.17 1.21 0.73 5.00
185 INT261203 Binding of HTs 5 0.32 3.01 0.71 5.00
186 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7 5.00
187 INT221108 Negative_regulation of Slc11a1 5 0.33 3.76 0.69 5.00
188 INT146109 Positive_regulation of Serping1 4 0.59 2.73 0.68 5.00
189 INT236356 Positive_regulation of Binding of Gfap 4 0.44 3.2 0.67 5.00
190 INT247954 Positive_regulation of Pdcd1 5 0.16 4.97 0.65 5.00
191 INT24735 Regulation of TF 10 0.44 5.55 0.65 5.00
192 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 5.00
193 INT194981 Regulation of IMPACT 5 0.38 1.47 0.63 5.00
194 INT224635 Positive_regulation of Lgals3bp 3 0.07 2.31 0.58 5.00
195 INT101155 Binding of AP1B1 2 0.36 0.13 0.56 5.00
196 INT129227 Binding of DNASE1 4 0.14 2.54 0.54 5.00
197 INT164196 Binding of LRP1 5 0.47 2.59 0.53 5.00
198 INT40007 Regulation of DNASE1 4 0.44 2.98 0.53 5.00
199 INT9384 Positive_regulation of Positive_regulation of LDHA 3 0.50 5.5 0.52 5.00
200 INT205268 Gene_expression of Rhd 6 0.65 0.67 0.51 5.00
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