D:Edema

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pChart

Disease Term
Synonyms ANASARCA, Angioedema, Dropsy, Fluid Overload, Hydrops, Increased Vascular Permeability, Interstitial Edema, Interstitial Oedema, Lymphatic Obstruction, Oedema, Swelling
Documents 608
Hot Single Events 200
Hot Interactions 49

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Edema. They are ordered first by their relevance to Edema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT210952 Il1 Positive_regulation of Gene_expression of Icam1 1 0.01 0.86 0.37 99.52
2 INT254641 CGA Positive_regulation of AGT 1 0.17 1.51 0.08 99.44
3 INT254640 CGA Positive_regulation of REN 1 0.07 1.51 0.08 99.44
4 INT254639 CGA Positive_regulation of Gene_expression of AGT 1 0.18 1.51 0.08 99.44
5 INT247768 Fcer2a Positive_regulation of Enpp1 1 0.00 0.29 0.04 98.90
6 INT272144 PTAFR Positive_regulation of HRASLS 1 0.08 1.08 0.89 98.60
7 INT247764 Ccrl2 Positive_regulation of Gene_expression of Fcer2a 1 0.01 0.29 0.04 96.52
8 INT247762 Binding of Ccl2 and Ccrl2 1 0.19 0.29 0.12 96.32
9 INT247771 Binding of Ccl7 and Ccrl2 1 0.17 0.29 0.04 96.32
10 INT247774 Binding of Ccl5 and Ccrl2 1 0.14 0.29 0.04 96.32
11 INT247757 Binding of Ccl8 and Ccrl2 1 0.16 0.29 0.04 96.32
12 INT247766 Binding of Ccl2 and Ccl5 1 0.14 0.28 0.04 95.00
13 INT193215 Binding of CYSLTR1 and CYSLTR2 2 0.09 1.7 0.21 94.72
14 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03 94.72
15 INT300446 VEGFA Positive_regulation of Flt1 1 0.09 2.62 0.07 94.68
16 INT300445 VEGFA Positive_regulation of Vegfa 1 0.03 1.33 0.03 94.68
17 INT252575 Rpe Negative_regulation of SOD1 1 0.03 2.39 0.14 94.20
18 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13 94.20
19 INT252571 Rpe Positive_regulation of Positive_regulation of Sdcbp 1 0.04 2.27 0.13 94.20
20 INT247759 Binding of Ccrl2 and Rarres2 1 0.26 1.19 0.9 94.16
21 INT199130 PRSS1 Positive_regulation of Prss1 1 0.15 0.8 0.09 93.72
22 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 93.28
23 INT343912 Fgg Positive_regulation of Gene_expression of IL6 1 0.00 0.83 0.35 92.96
24 INT222022 Binding of Mmp8 and Mmp9 1 0.28 1.98 0.15 92.40
25 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03 89.72
26 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21 89.60
27 INT247761 Binding of Rarres2 and Rbm39 1 0.00 0.65 0.19 88.52
28 INT247758 Ccrl2 Positive_regulation of Rarres2 1 0.25 0.87 0.27 87.72
29 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23 87.68
30 INT252572 Rpe Positive_regulation of Sdcbp 1 0.04 1.12 0.09 87.52
31 INT267596 KNG1 Positive_regulation of Gene_expression of PLA2G6 1 0.01 0.87 0.25 87.28
32 INT247760 Binding of Cmklr1 and Rarres2 1 0.05 0.75 0.41 86.88
33 INT199128 Ctsb Positive_regulation of Prss1 1 0.02 0.9 0.15 86.40
34 INT267591 CYSLTR1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.87 0.25 86.00
35 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 85.64
36 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 85.64
37 INT267584 TNF Positive_regulation of Gene_expression of PLA2G6 1 0.08 0.87 0.25 85.52
38 INT199129 Ctsb Positive_regulation of PRSS1 1 0.01 0.9 0.15 85.28
39 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25 85.12
40 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45 84.88
41 INT247755 Binding of Cmklr1 and Ccrl2 1 0.05 0.53 0.17 84.72
42 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11 83.60
43 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 83.56
44 INT247763 tryptase Positive_regulation of Rarres2 1 0.08 0.87 0.03 82.68
45 INT247765 Gpx3 Positive_regulation of Rarres2 1 0.01 0.86 0.03 82.68
46 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 82.64
47 INT267624 Klk1 Positive_regulation of KNG1 1 0.05 0.52 0.25 82.64
48 INT352521 Cnn1 Positive_regulation of Cp 1 0.00 1.45 0.5 80.60
49 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34 80.16
50 INT288617 Binding of CSF2RB and Epor 1 0.19 0.73 0 77.84
51 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91 75.00
52 INT245823 Binding of Plg and Plg 1 0.03 1.41 0 69.88
53 INT254512 Binding of CYBB and NCF1 1 0.07 0.14 0 68.24
54 INT300449 VEGFA Positive_regulation of Protein_catabolism of Ppp2r2b 1 0.00 1.51 0.05 66.52
55 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24 65.68
56 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76 63.20
57 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29 62.40
58 INT245833 Plg Negative_regulation of VEGFA 1 0.05 2.21 0.04 61.16
59 INT245827 Plg Negative_regulation of Vegfa 1 0.14 1.3 0 61.16
60 INT294436 Positive_regulation of Binding of F2 and THBD 1 0.05 0.57 0 61.00
61 INT217620 Dep1 Positive_regulation of Gene_expression of Tlr4 1 0.20 0.4 0.12 60.88
62 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48 59.16
63 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 57.84
64 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51 50.16
65 INT343864 EDA Positive_regulation of Gene_expression of TLR4 1 0.11 0.44 0.25 50.16
66 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0 49.84
67 INT254509 Binding of CYBA and CYBB 1 0.05 0 0 49.80
68 INT254510 Binding of CYBB and NCF2 1 0.06 0 0 49.80
69 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05 48.52
70 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05 48.52
71 INT351581 Binding of ALB and GOPC 1 0.11 0 0.55 48.40
72 INT220901 Regulation of Binding of Saa1 and Cd40 1 0.04 0.36 0 47.72
73 INT220908 Binding of Saa1 and Cd40 1 0.04 0.36 0 47.72
74 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71 47.20
75 INT175988 Ros1 Positive_regulation of Transcription of Gtf3a 1 0.01 1.56 0.34 47.20
76 INT175990 Ros1 Positive_regulation of Gene_expression of Gtf3a 1 0.01 1.56 0.34 47.20
77 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59 46.24
78 INT142990 Serpinc1 Positive_regulation of Phosphorylation of S1pr1 1 0.03 0.05 0.59 46.24
79 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2 44.80
80 INT343832 Positive_regulation of EDA Positive_regulation of TLR4 1 0.11 0.43 0.27 44.20
81 INT292811 Zfp787 Negative_regulation of Phosphorylation of Kdr 1 0.01 0.45 0.06 43.80
82 INT292812 Zfp787 Negative_regulation of Trib3 1 0.00 0.48 0.06 43.80
83 INT247780 Ccrl2 Positive_regulation of Localization of IFN1@ 1 0.40 0.27 0.07 43.12
84 INT247776 Ccrl2 Positive_regulation of Localization of Gopc 1 0.14 0.27 0.07 42.56
85 INT327789 Binding of IgG and Alms1 1 0.01 1.1 0.17 40.88
86 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17 40.88
87 INT327791 Binding of AQP4 and Alms1 1 0.03 1.1 0.17 40.88
88 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 38.64
89 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 38.64
90 INT220679 Binding of F3 and Gtf3a 1 0.00 0.98 0.15 37.96
91 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 37.84
92 INT292813 Zfp787 Negative_regulation of Phosphorylation of VEGFA 1 0.01 0.45 0.03 37.04
93 INT343856 Binding of S100A9 and ABCC8 1 0.04 0.9 0.28 36.32
94 INT100771 Binding of Itga1 and Vcam1 3 0.11 3.91 1.79 35.12
95 INT245832 VEGFA Positive_regulation of Phosphorylation of Ocln 1 0.04 1.61 0 31.36
96 INT245830 VEGFA Regulation of Ocln 1 0.02 0.83 0 31.36
97 INT245821 Binding of Ppp2r2b and Ocln 1 0.00 0.81 0 26.40
98 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 26.36
99 INT353125 Negative_regulation of Binding of VEGFA and Kdr 1 0.04 5.92 0 26.36
100 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31 25.24
101 INT182100 Positive_regulation of Binding of TNF and Il6 1 0.03 0.66 0.41 25.24
102 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 24.92
103 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53 24.92
104 INT208372 Il13 Positive_regulation of Ahr 1 0.21 1.22 0.59 22.24
105 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25 18.64
106 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09 14.68
107 INT175992 TNF Positive_regulation of Gene_expression of Cys1 1 0.01 0.34 0.07 12.92
108 INT220677 Binding of Mfi2 and Gtf3a 1 0.00 0.77 0.04 12.36
109 INT222295 Binding of CPP and Cebpz 1 0.00 0.73 0.05 10.48
110 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92 7.04
111 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
112 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
113 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
114 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 5.00
115 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
116 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
117 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95 5.00
118 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 5.00
119 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
120 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75 5.00
121 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
122 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32 5.00
123 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27 5.00
124 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
125 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
126 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
127 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07 5.00
128 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07 5.00
129 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
130 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
131 INT195219 Binding of CPB2 and CSRP1 1 0.03 0.99 0.96 5.00
132 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95 5.00
133 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91 5.00
134 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91 5.00
135 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9 5.00
136 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87 5.00
137 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85 5.00
138 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84 5.00
139 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84 5.00
140 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83 5.00
141 INT208946 Positive_regulation of Tacr1 Positive_regulation of Gene_expression of S100a8 1 0.02 1.11 0.8 5.00
142 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79 5.00
143 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76 5.00
144 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75 5.00
145 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75 5.00
146 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75 5.00
147 INT178575 CNTN2 Positive_regulation of PTHLH Positive_regulation of Positive_regulation of PTHLH 1 0.26 2.16 0.75 5.00
148 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
149 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71 5.00
150 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
151 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7 5.00
152 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
153 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69 5.00
154 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
155 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66 5.00
156 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
157 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
158 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59 5.00
159 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 5.00
160 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56 5.00
161 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
162 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54 5.00
163 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
164 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53 5.00
165 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51 5.00
166 INT343860 Binding of CD14 and TBCE 1 0.03 1.1 0.51 5.00
167 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5 5.00
168 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
169 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 5.00
170 INT195220 Binding of CPB2 and IL6 1 0.04 0.5 0.49 5.00
171 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
172 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48 5.00
173 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47 5.00
174 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
175 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
176 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46 5.00
177 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46 5.00
178 INT258636 Binding of Alb and Is(HSR;1)1Icg 1 0.05 0 0.44 5.00
179 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44 5.00
180 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43 5.00
181 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 5.00
182 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 5.00
183 INT343916 Hspa1a Positive_regulation of Gene_expression of TNF 1 0.16 1.17 0.41 5.00
184 INT343919 Hspa1a Positive_regulation of Gene_expression of IL6 1 0.02 1.17 0.4 5.00
185 INT343907 Hspa1a Positive_regulation of Gene_expression of Cxcl2 1 0.01 1.17 0.4 5.00
186 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4 5.00
187 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 5.00
188 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4 5.00
189 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
190 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39 5.00
191 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
192 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
193 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
194 INT182497 IL1B Regulation of Localization of GH1 1 0.00 0.84 0.38 5.00
195 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38 5.00
196 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38 5.00
197 INT319729 Binding of Rela and Crebbp 1 0.02 0.88 0.37 5.00
198 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 5.00
199 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 5.00
200 INT344238 MCRS1 Regulation of TREX1 1 0.08 1.02 0.34 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Edema. They are ordered first by their pain relevance and then by number of times they were reported in Edema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
2 INT259689 Gene_expression of KRT35 1 0.03 6.1 0.52 100.00
3 INT15765 Localization of PON1 8 0.75 3.61 2.08 100.00
4 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 100.00
5 INT220888 Negative_regulation of Arhgap4 5 0.42 2.19 0.78 100.00
6 INT259692 Gene_expression of TNFAIP8L2 3 0.06 3.94 1.13 99.92
7 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85 99.80
8 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 99.80
9 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.76
10 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 99.76
11 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 99.70
12 INT225966 Regulation of Gene_expression of Aqp4 18 0.62 20.39 2.3 99.70
13 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 99.68
14 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 99.68
15 INT19847 Positive_regulation of Localization of Alb 21 0.70 13.89 4.16 99.68
16 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 99.66
17 INT45147 Gene_expression of C2 21 0.58 6.18 3.98 99.64
18 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 99.54
19 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 99.54
20 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 99.52
21 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.48
22 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 99.48
23 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 99.48
24 INT299864 Transcription of Prox1 4 0.52 1.13 0.06 99.48
25 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.44
26 INT153156 Negative_regulation of KLKB1 5 0.48 7.88 1.6 99.40
27 INT233497 Positive_regulation of Ccrl2 2 0.58 2.7 0.74 99.36
28 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 99.36
29 INT113987 Localization of IK 29 0.23 16.73 8.25 99.36
30 INT259952 Negative_regulation of Negative_regulation of ALB 1 0.42 1.24 0.04 99.30
31 INT7678 Localization of Alb 142 0.81 80.93 22.49 99.28
32 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 99.26
33 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 99.26
34 INT210523 Positive_regulation of Negative_regulation of Tenc1 2 0.43 2.42 0.68 99.24
35 INT654 Localization of REN 250 0.81 75.12 47.86 99.18
36 INT136304 Negative_regulation of Aqp4 54 0.59 48.42 7.4 99.16
37 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 99.16
38 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 99.12
39 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 99.12
40 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 99.12
41 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 99.04
42 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75 99.04
43 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 99.00
44 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 98.96
45 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 98.96
46 INT546 Binding of ALB 311 0.48 85.98 60.14 98.92
47 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 98.92
48 INT299866 Gene_expression of Prox1 12 0.76 1.12 0.06 98.92
49 INT190227 Gene_expression of Prot 1 0.58 0.65 0 98.88
50 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 98.88
51 INT15812 Localization of CALCB 10 0.30 8.77 6.36 98.84
52 INT45109 Binding of C5AR1 10 0.37 5.77 2.69 98.84
53 INT97623 Negative_regulation of Adc 17 0.56 3.81 8.14 98.84
54 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 98.84
55 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 98.80
56 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 98.76
57 INT5008 Localization of Calca 204 0.81 80.35 125.16 98.76
58 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 98.76
59 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 98.76
60 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 98.76
61 INT22275 Negative_regulation of TBXA2R 25 0.54 8.67 7.34 98.72
62 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 98.68
63 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 98.68
64 INT14947 Localization of SPARCL1 7 0.46 11.97 3.6 98.64
65 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.64
66 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 98.64
67 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 98.64
68 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 98.64
69 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 98.56
70 INT18773 Localization of ALB 117 0.80 69.18 13.8 98.52
71 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77 98.52
72 INT206031 Regulation of Adc 7 0.33 6.85 1.48 98.48
73 INT51083 Gene_expression of Adc 14 0.53 8.24 2.25 98.44
74 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 98.28
75 INT13634 Gene_expression of CYSLTR1 19 0.75 11.24 2.88 98.28
76 INT233493 Gene_expression of Ccrl2 59 0.65 11.61 4.71 98.24
77 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 98.24
78 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 98.20
79 INT338740 Transcription of Src 1 0.43 1.24 0.07 98.16
80 INT1701 Localization of Neu1 11 0.69 6.36 4.18 98.08
81 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 97.96
82 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 97.96
83 INT142983 Positive_regulation of S1pr3 2 0.57 1.66 0.57 97.96
84 INT95917 Gene_expression of CYSLTR2 10 0.64 6.1 0.82 97.84
85 INT193257 Positive_regulation of CYSLTR2 4 0.18 1.81 0.27 97.84
86 INT27554 Regulation of Eln 6 0.52 6.76 0.39 97.80
87 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 97.76
88 INT344123 Regulation of Regulation of Adc 1 0.02 0.91 0.14 97.76
89 INT232021 Positive_regulation of Gene_expression of SERPING1 8 0.49 4.99 0.31 97.76
90 INT34808 Binding of Ec 14 0.24 17.27 2.65 97.74
91 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 97.72
92 INT7035 Regulation of CGA 87 0.45 29.04 28.45 97.72
93 INT46 Localization of Ren 233 0.81 46.15 62.44 97.72
94 INT200217 Localization of PAH 10 0.36 15.51 2.46 97.72
95 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.68
96 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 97.60
97 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 97.56
98 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 97.52
99 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 97.44
100 INT49808 Localization of tryptase 11 0.78 8.74 2.67 97.36
101 INT207137 Positive_regulation of Localization of tryptase 2 0.13 1.6 0.41 97.36
102 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 97.36
103 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 97.32
104 INT66699 Negative_regulation of Tmprss5 1 0.11 0.47 0.49 97.30
105 INT66702 Negative_regulation of Xpnpep3 1 0.09 0.47 0.49 97.30
106 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 97.24
107 INT222017 Regulation of Gene_expression of Mmp8 1 0.27 1 0.04 97.24
108 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 97.20
109 INT82646 Gene_expression of malformation 1 0.35 1.06 0.07 97.20
110 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 97.16
111 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.12
112 INT142984 Positive_regulation of S1pr1 13 0.70 7.9 3.84 97.12
113 INT142987 Negative_regulation of Positive_regulation of S1pr1 1 0.31 0.19 0.39 97.12
114 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 97.08
115 INT174838 Localization of INCENP 80 0.64 19.05 12.89 97.08
116 INT222401 Regulation of Localization of INCENP 2 0.01 0.81 0.32 97.08
117 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14 97.04
118 INT55343 Localization of Ros1 39 0.60 34.51 12.5 97.04
119 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 97.00
120 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 96.96
121 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 96.84
122 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 96.80
123 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 96.68
124 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 96.60
125 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 96.52
126 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 96.48
127 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 96.48
128 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 96.48
129 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 96.44
130 INT259693 Positive_regulation of Gene_expression of KRT35 1 0.03 1.22 0.04 96.40
131 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 96.32
132 INT152523 Gene_expression of Rpe 5 0.56 2.55 0.74 96.28
133 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 96.24
134 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 96.16
135 INT112003 Localization of ROS1 94 0.73 66.32 12.16 96.16
136 INT247736 Localization of Rarres2 1 0.52 0.52 0.29 96.12
137 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 96.00
138 INT220667 Negative_regulation of Gene_expression of Vwf 2 0.18 1 0.07 96.00
139 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91 95.68
140 INT182143 Positive_regulation of Negative_regulation of Slco1c1 2 0.32 1.12 0.08 95.28
141 INT144992 Positive_regulation of Epor 3 0.67 2.09 1.57 95.16
142 INT49884 Negative_regulation of Gene_expression of Il4 18 0.55 14.06 8.9 95.12
143 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 95.12
144 INT208369 Negative_regulation of Gene_expression of Il13 1 0.23 0.89 0.43 95.12
145 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 95.08
146 INT150851 Positive_regulation of Cxcl1 45 0.57 20.83 11.88 94.92
147 INT153478 Transcription of Cxcl1 7 0.59 2.98 2.31 94.92
148 INT153477 Positive_regulation of Transcription of Cxcl1 2 0.57 1.06 0.55 94.92
149 INT8112 Regulation of EPO 38 0.58 22.04 2.76 94.88
150 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 94.76
151 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5 94.72
152 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 94.72
153 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93 94.72
154 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4 94.72
155 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 94.64
156 INT3275 Negative_regulation of Slco1c1 28 0.37 10.93 5.15 94.64
157 INT1939 Localization of Cys1 6 0.73 5.9 0.64 94.64
158 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 94.56
159 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 94.52
160 INT49985 Transcription of Il6 62 0.72 40.13 20.29 94.52
161 INT39116 Regulation of Gene_expression of Ptger2 29 0.51 10.25 6.46 94.52
162 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 94.48
163 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 94.32
164 INT316315 Negative_regulation of Binding of SERPING1 2 0.37 1.4 0.34 94.28
165 INT94026 Regulation of SERPING1 12 0.61 10.28 0.37 94.28
166 INT28617 Negative_regulation of ITPA 7 0.45 1.27 1.65 94.28
167 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5 94.24
168 INT7134 Localization of KNG1 127 0.79 65.73 67.97 94.24
169 INT225771 Negative_regulation of Gene_expression of Enpp1 4 0.43 3.68 0.13 94.24
170 INT247731 Binding of Ccrl2 1 0.35 1.38 0.87 94.16
171 INT190611 Gene_expression of Cnn1 13 0.56 5.87 0.75 94.16
172 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61 94.12
173 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 94.00
174 INT70996 Positive_regulation of Positive_regulation of Icam1 8 0.60 6.02 3.74 94.00
175 INT247722 Binding of Rarres2 1 0.36 1.34 0.54 93.92
176 INT3167 Binding of KNG1 48 0.48 23.26 26.77 93.88
177 INT209949 Protein_catabolism of CPN1 1 0.02 0.9 0.37 93.84
178 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 93.76
179 INT24581 Negative_regulation of LTC4S 2 0.40 2.05 0.91 93.76
180 INT6852 Localization of TNF 883 0.81 705.95 270.84 93.68
181 INT662 Gene_expression of ATP6AP2 3 0.28 2.06 0.35 93.68
182 INT91225 Positive_regulation of Pla2g2a 22 0.57 14.77 5.01 93.64
183 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 93.60
184 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82 93.52
185 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 93.48
186 INT282214 Negative_regulation of Gene_expression of Adc 2 0.07 1.34 0.21 93.44
187 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 93.40
188 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 93.40
189 INT23788 Negative_regulation of Kcne1 7 0.39 0.73 2.38 93.36
190 INT221987 Negative_regulation of Gene_expression of Cpn1 1 0.41 1.19 0.07 93.36
191 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27 93.32
192 INT97912 Gene_expression of Sod3 25 0.78 22.44 3.28 93.32
193 INT97910 Positive_regulation of Gene_expression of Sod3 13 0.70 15.56 2.46 93.32
194 INT66704 Negative_regulation of Dlgap4 2 0.05 0.23 0.72 93.20
195 INT25503 Gene_expression of C5AR1 22 0.75 21.88 4.16 93.16
196 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 93.12
197 INT656 Positive_regulation of ATP6AP2 10 0.18 2.89 0.58 93.12
198 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 93.08
199 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58 93.04
200 INT7350 Negative_regulation of Anpep 30 0.59 2.89 11.28 92.96
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