D:Ehlers-danlos Syndrome

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Disease Term
Synonyms Cutis Elastica, Disease Ehlers Danlos, E D Syndrome, Eds, EHLERS DANLOS DISEASE, Ehlers Danlos Syndrome, Syndrome Ehlers Danlos
Documents 160
Hot Single Events 31
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ehlers-danlos Syndrome. They are ordered first by their relevance to Ehlers-danlos Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT87037 Binding of FBXO6 and Col5a3 1 0.00 0.48 0.09 97.64
2 INT87038 Binding of ADRA1D and Col5a3 1 0.03 0.48 0.09 97.64
3 INT180496 Binding of CTS and PDXK 1 0.04 0.69 0.77 84.00
4 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
5 INT281896 KNG1 Regulation of Binding of KNG1 and NOS3 1 0.02 0.17 0.22 5.00
6 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22 5.00
7 INT281903 BDKRB1 Positive_regulation of KNG1 1 0.03 0.32 0.21 5.00
8 INT281911 Binding of ANG and MAS1 1 0.05 0.39 0.13 5.00
9 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13 5.00
10 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1 5.00
11 INT293411 IL8 Regulation of IL11 1 0.03 1.17 0.1 5.00
12 INT293417 HRAS Regulation of IL11 1 0.00 1.17 0.1 5.00
13 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1 5.00
14 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1 5.00
15 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1 5.00
16 INT281898 Binding of ANG and ACE Positive_regulation of KNG1 1 0.03 0.37 0.1 5.00
17 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1 5.00
18 INT293408 HRAS Regulation of VEGFA 1 0.00 1.18 0.1 5.00
19 INT293409 IL8 Regulation of VEGFA 1 0.04 1.18 0.1 5.00
20 INT293415 HRAS Positive_regulation of Localization of IL8 1 0.01 0.73 0.09 5.00
21 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07 5.00
22 INT281909 Binding of AGT and AGTR1 1 0.09 0.16 0.06 5.00
23 INT281906 BDKRB2 Positive_regulation of ANG 1 0.11 0.51 0.05 5.00
24 INT336576 Binding of HCRTR1 and IGHG3 1 0.01 5.01 0 5.00
25 INT281908 VEGFA Positive_regulation of NOS3 1 0.14 0.14 0 5.00
26 INT281897 VEGFA Regulation of VEGFA Positive_regulation of NOS3 1 0.04 0.09 0 5.00
27 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0 5.00
28 INT206705 Negative_regulation of Binding of FLT1 and VEGFA 3 0.11 1.9 0 5.00
29 INT281902 Binding of AGT and AKR1A1 1 0.01 0.08 0 5.00
30 INT267257 BCL11B Regulation of Transcription of BMI1 1 0.28 0.74 0 5.00
31 INT336574 Binding of CD40LG and HCRTR1 1 0.05 0.1 0 5.00
32 INT293412 GOPC Regulation of Localization of VEGFA 1 0.04 0.61 0 5.00
33 INT267258 Binding of TP53 and BCL11B 1 0.09 0.42 0 5.00
34 INT281907 VEGFA Positive_regulation of Gene_expression of PTGIS 1 0.03 0.14 0 5.00
35 INT281910 Binding of REN and AKR1A1 1 0.01 0.08 0 5.00
36 INT281904 ANG Positive_regulation of PTGIS 1 0.04 0 0 5.00
37 INT267259 BCL11B Regulation of BMI1 1 0.65 1.48 0 5.00
38 INT293413 GOPC Regulation of Localization of IL11 1 0.03 0.6 0 5.00
39 INT293410 HRAS Regulation of Localization of SPP1 1 0.00 0.8 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ehlers-danlos Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Ehlers-danlos Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT127927 Positive_regulation of ADCY4 2 0.15 0.67 0.07 100.00
2 INT87035 Binding of EDS8 1 0.04 0.29 0.1 100.00
3 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 99.86
4 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 99.52
5 INT20981 Binding of HRAS 42 0.48 24.49 4.23 99.48
6 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 98.56
7 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 98.24
8 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 97.84
9 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 97.72
10 INT49610 Positive_regulation of Gene_expression of CTS 7 0.43 7.45 3.58 97.72
11 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 94.16
12 INT27813 Regulation of CENPJ 12 0.29 14.26 0.99 94.08
13 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 93.80
14 INT272228 Localization of TGFBR1 1 0.34 0.74 0 93.00
15 INT272225 Localization of Tgfbr2 1 0.29 0.74 0 93.00
16 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95 92.84
17 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 92.24
18 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 92.00
19 INT156827 Localization of MRI1 25 0.65 16.06 8.33 91.96
20 INT246083 Positive_regulation of Cacna1d 1 0.02 0.89 0.22 91.24
21 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 90.68
22 INT157605 Localization of COL3A1 3 0.80 0.55 0.29 90.40
23 INT87036 Gene_expression of FBXO6 1 0.00 0.17 0 87.08
24 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 82.68
25 INT106057 Negative_regulation of Hcrt 27 0.57 15.5 3.47 82.68
26 INT106055 Negative_regulation of Gene_expression of Hcrt 15 0.46 5.64 2.09 82.68
27 INT148886 Negative_regulation of Gene_expression of HCRTR1 2 0.23 3.42 0.05 82.68
28 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 82.52
29 INT148883 Gene_expression of HCRTR1 8 0.36 24.82 1.35 82.20
30 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16 81.56
31 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 80.84
32 INT36354 Localization of CTs 26 0.64 20.84 9.31 79.20
33 INT9702 Localization of SUPT7L 6 0.68 1.11 1.85 78.32
34 INT169475 Localization of HRAS 14 0.73 9.02 3.9 75.40
35 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 72.00
36 INT87034 Positive_regulation of FBXO6 2 0.38 0.89 0.14 69.00
37 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31 67.72
38 INT58852 Positive_regulation of Enc1 20 0.49 7.51 13.25 65.36
39 INT81154 Gene_expression of HCRT 10 0.75 5.32 2.22 64.24
40 INT308434 Regulation of Esd 1 0.22 0.36 0 60.16
41 INT264171 Positive_regulation of Positive_regulation of CD4 5 0.49 4.74 0.94 59.16
42 INT99281 Negative_regulation of HCRT 3 0.57 2.26 0.71 58.20
43 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 57.72
44 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 57.24
45 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 57.24
46 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 57.24
47 INT267269 Gene_expression of BCL11B 62 0.78 48.75 0.55 37.80
48 INT198448 Gene_expression of SM1 2 0.65 0.85 0.04 30.16
49 INT27536 Gene_expression of Caf 4 0.52 0.41 1.13 27.60
50 INT177643 Binding of CENPJ 12 0.36 8.59 0.22 21.80
51 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 18.32
52 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 18.32
53 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 16.20
54 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 15.92
55 INT63686 Gene_expression of Esd 7 0.58 1.69 0.95 12.96
56 INT308435 Negative_regulation of Gene_expression of Esd 1 0.21 0.2 0 12.00
57 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
58 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
59 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
60 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
61 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 5.00
62 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
63 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
64 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
65 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
66 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
67 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
68 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 5.00
69 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
70 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
71 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
72 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
73 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
74 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
75 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
76 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
77 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
78 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
79 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
80 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
81 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
82 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
83 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
84 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
85 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
86 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
87 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02 5.00
88 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
89 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
90 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
91 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
92 INT3167 Binding of KNG1 48 0.48 23.26 26.77 5.00
93 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
94 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
95 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
96 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
97 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
98 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
99 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
100 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 5.00
101 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04 5.00
102 INT135629 Binding of COMT 33 0.48 16.68 19.37 5.00
103 INT75742 Binding of RLS 86 0.42 95.27 19.04 5.00
104 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
105 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
106 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
107 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
108 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
109 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
110 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 5.00
111 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
112 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 5.00
113 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 5.00
114 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
115 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
116 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
117 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
118 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6 5.00
119 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
120 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
121 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
122 INT48912 Localization of NOS1 52 0.77 24.14 10.92 5.00
123 INT8065 Binding of AGT 54 0.48 20.54 10.85 5.00
124 INT74272 Localization of CPOX 39 0.63 25.12 10.53 5.00
125 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
126 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86 5.00
127 INT18830 Localization of TBXA2R 25 0.81 7.14 9.28 5.00
128 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07 5.00
129 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
130 INT54368 Positive_regulation of VTA1 13 0.59 3.81 8.13 5.00
131 INT165228 Binding of BMI1 13 0.47 25.36 7.97 5.00
132 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
133 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
134 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36 5.00
135 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
136 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 5.00
137 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 5.00
138 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 5.00
139 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 5.00
140 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
141 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15 5.00
142 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
143 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06 5.00
144 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 5.00
145 INT102836 Binding of LRP2 12 0.38 11.27 5.58 5.00
146 INT64176 Transcription of CPOX 35 0.41 15.1 5.5 5.00
147 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 5.00
148 INT52512 Positive_regulation of SLC43A3 21 0.41 5.39 5.27 5.00
149 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05 5.00
150 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69 5.00
151 INT68260 Localization of BGLAP 34 0.78 16.04 4.63 5.00
152 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 5.00
153 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6 5.00
154 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 5.00
155 INT80626 Binding of KCNIP3 46 0.43 9.84 4.27 5.00
156 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 5.00
157 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 5.00
158 INT97128 Localization of SPP1 32 0.80 21.75 4.02 5.00
159 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8 5.00
160 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 5.00
161 INT232667 Binding of Pd 17 0.16 20.76 3.58 5.00
162 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
163 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
164 INT117754 Gene_expression of NHS 34 0.57 9.27 3.28 5.00
165 INT22274 Negative_regulation of Gene_expression of TBXA2R 12 0.58 3.32 3.28 5.00
166 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24 5.00
167 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
168 INT58756 Binding of GPI 10 0.48 7.17 3 5.00
169 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 5.00
170 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
171 INT37363 Localization of PTHLH 14 0.68 13.23 2.92 5.00
172 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9 5.00
173 INT162957 Positive_regulation of STON1 5 0.35 4.83 2.77 5.00
174 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57 5.00
175 INT244283 Negative_regulation of Gene_expression of MAOA 2 0.27 1.7 2.5 5.00
176 INT229111 Localization of SLC6A3 5 0.68 1.12 2.48 5.00
177 INT56084 Negative_regulation of SLC43A3 11 0.39 5.39 2.27 5.00
178 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23 5.00
179 INT3533 Binding of REN 24 0.37 10.84 2.16 5.00
180 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14 5.00
181 INT281928 Gene_expression of ARG2 3 0.77 63.17 2.14 5.00
182 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04 5.00
183 INT91594 Localization of NOS3 12 0.78 5.39 2.02 5.00
184 INT53998 Positive_regulation of MAOB 8 0.61 1.22 2 5.00
185 INT246089 Negative_regulation of Negative_regulation of MAOA 2 0.41 2.42 1.92 5.00
186 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 5.00
187 INT258135 Gene_expression of CARTPT 3 0.40 5.25 1.88 5.00
188 INT22448 Regulation of GPI 4 0.33 1.95 1.85 5.00
189 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75 5.00
190 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73 5.00
191 INT26451 Gene_expression of KLK1 14 0.75 5.79 1.66 5.00
192 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 5.00
193 INT68766 Positive_regulation of Transcription of CPOX 10 0.30 4.76 1.49 5.00
194 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 5.00
195 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 5.00
196 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 5.00
197 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 5.00
198 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43 5.00
199 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38 5.00
200 INT244284 Binding of SLC18A2 1 0.23 1.87 1.34 5.00
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