D:Emphysema

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Disease Term
Synonyms Centriobular Emphysema, DISTAL ACINAR EMPHYSEMA, Panacinar Emphysema
Documents 631
Hot Single Events 200
Hot Interactions 27

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Emphysema. They are ordered first by their relevance to Emphysema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2 100.00
2 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2 100.00
3 INT311010 SNRPB Positive_regulation of SERPINA10 1 0.00 0.69 0.07 98.94
4 INT179683 Binding of Col7a1 and Eln 2 0.00 3.02 0.19 98.12
5 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 97.68
6 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 97.68
7 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 97.68
8 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11 96.84
9 INT273185 PDE4A Regulation of Gene_expression of Mmp12 1 0.08 0.57 0.13 96.44
10 INT259628 Cxcl10 Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.64 0.15 96.32
11 INT259627 Cxcl10 Positive_regulation of Gene_expression of Mmp12 1 0.02 0.64 0.15 96.32
12 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 95.80
13 INT269014 Binding of EGR1 and COPD 1 0.12 0.96 0 95.60
14 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 95.52
15 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 95.16
16 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23 92.56
17 INT339020 SERPINA1 Negative_regulation of ELANE 1 0.07 0.59 0.05 92.40
18 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 91.36
19 INT259638 COPD Positive_regulation of NFE2L2 1 0.03 1.31 0.05 90.88
20 INT318387 Binding of Slc40a1 and Hrct1 1 0.02 0.88 0.08 90.76
21 INT273171 PDE4A Regulation of IL8 1 0.05 0.53 0.15 87.80
22 INT259670 CSE Positive_regulation of Hmox1 1 0.06 0.97 0 86.40
23 INT335446 Binding of PDX1 and COPD 1 0.02 1.99 0.3 85.92
24 INT337536 Binding of Klrk1 and COPD 1 0.03 3.09 0.09 83.92
25 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13 80.52
26 INT192102 Regulation of Binding of Rxrg and Retsat 1 0.01 0.83 0.13 80.52
27 INT192101 Binding of Rxrg and Regulation of Retsat 1 0.00 0.83 0.13 80.52
28 INT192103 Binding of Rxrg and Retsat 1 0.01 0.83 0.13 79.76
29 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13 79.76
30 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1 78.16
31 INT219686 Binding of CEL and COPD 1 0.12 11.35 1.26 74.64
32 INT291642 Binding of DST and GGT1 1 0.00 1.4 0.19 72.32
33 INT288537 Binding of Ccr3 and Ccl11 1 0.17 2.92 0.35 69.76
34 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03 64.08
35 INT310937 Binding of CD8A and COPD 1 0.16 1.21 0.16 61.92
36 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76 60.00
37 INT190145 Binding of JUN and MMP12 Positive_regulation of Positive_regulation of PIK3CA 1 0.01 0.57 0.57 60.00
38 INT190146 Positive_regulation of PIK3CA Positive_regulation of Binding of JUN and MMP12 1 0.01 0.57 0.57 60.00
39 INT190148 Binding of JUN and MMP12 Positive_regulation of MMP12 1 0.33 0.57 0.57 60.00
40 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56 56.32
41 INT259634 Elane Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17 54.08
42 INT259633 Mmp9 Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17 54.08
43 INT189555 EGLN1 Regulation of Gene_expression of VEGFA 1 0.07 0.57 0 50.04
44 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85 45.56
45 INT190168 BSG Regulation of CDCP1 1 0.00 1.18 0.84 45.36
46 INT190147 MMP12 Positive_regulation of MMP2 Positive_regulation of Protein_catabolism of MMRN1 1 0.03 0.87 0.9 44.56
47 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85 40.16
48 INT289510 Binding of ODF2 and Ezr 1 0.10 0.47 0 38.80
49 INT332255 Ptger2 Positive_regulation of Localization of Col7a1 1 0.00 0.92 0.31 36.32
50 INT322206 CCL18 Positive_regulation of Gene_expression of COL7A1 1 0.05 0.28 0.05 28.40
51 INT328004 Binding of CYBB and Gnb5 1 0.00 1.13 0.15 25.44
52 INT243119 Binding of amd and Sod2 1 0.29 3.25 0.06 25.20
53 INT259621 Serpinc1 Regulation of Gene_expression of Mmp12 1 0.01 0.89 0.03 18.28
54 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34 17.84
55 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34 17.20
56 INT352232 VEGFA Negative_regulation of Vegfa 1 0.02 0.21 0.34 16.40
57 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74 6.56
58 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47 5.00
59 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
60 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
61 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
62 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 5.00
63 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
64 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 5.00
65 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
66 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
67 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02 5.00
68 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
69 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
70 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
71 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8 5.00
72 INT219685 Binding of MMP12 and COPD 1 0.27 5.59 0.74 5.00
73 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74 5.00
74 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 5.00
75 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71 5.00
76 INT190177 Gene_expression of IL13 Regulation of Gene_expression of IL4 1 0.04 0.05 0.68 5.00
77 INT190172 Gene_expression of IL13 Regulation of MMP12 1 0.12 0.05 0.68 5.00
78 INT190171 Gene_expression of IL4 Regulation of Gene_expression of IL13 1 0.04 0.05 0.68 5.00
79 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68 5.00
80 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 5.00
81 INT335456 Binding of PDX1 and hb 1 0.02 2.59 0.66 5.00
82 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65 5.00
83 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65 5.00
84 INT190170 IL4 Regulation of Gene_expression of IL13 1 0.04 0 0.62 5.00
85 INT190175 IL13 Regulation of Gene_expression of IL4 1 0.04 0 0.62 5.00
86 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6 5.00
87 INT190166 IL13 Regulation of MMP12 1 0.12 0 0.59 5.00
88 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 5.00
89 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
90 INT327999 Binding of FPR2 and FPR3 1 0.02 3.72 0.53 5.00
91 INT356351 Binding of CALM1 and TNC 1 0.02 0 0.52 5.00
92 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51 5.00
93 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49 5.00
94 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47 5.00
95 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46 5.00
96 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46 5.00
97 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46 5.00
98 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
99 INT331799 IL8 Negative_regulation of Mapk14 1 0.01 1.6 0.42 5.00
100 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42 5.00
101 INT300652 Ephb6 Regulation of Gene_expression of Cxcl10 1 0.01 0.59 0.41 5.00
102 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38 5.00
103 INT219683 Binding of CEL and GOPC 1 0.04 3.11 0.38 5.00
104 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37 5.00
105 INT335457 Binding of SRA1 and hb 1 0.00 1.83 0.37 5.00
106 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36 5.00
107 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36 5.00
108 INT186769 Dep1 Positive_regulation of Gene_expression of IgG 2 0.03 1.3 0.36 5.00
109 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35 5.00
110 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35 5.00
111 INT190173 BSG Regulation of MMRN1 1 0.00 0.29 0.35 5.00
112 INT322208 HRCT1 Positive_regulation of PDX1 1 0.01 1.31 0.34 5.00
113 INT335455 Negative_regulation of Binding of PDX1 and hb 1 0.02 1.3 0.33 5.00
114 INT299258 Dep1 Positive_regulation of Hspb8 1 0.00 2.06 0.33 5.00
115 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32 5.00
116 INT281981 Binding of MDK and Gtf3a 1 0.00 0.76 0.31 5.00
117 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
118 INT281734 MT1JP Positive_regulation of Localization of IL8 1 0.02 0.64 0.3 5.00
119 INT281970 Cyp3a23/3a1 Negative_regulation of Gene_expression of Tie1 1 0.00 0.46 0.3 5.00
120 INT275555 Binding of Ltb4r1 and COPD 1 0.01 1.02 0.3 5.00
121 INT275548 Il10 Regulation of Mmp9 1 0.00 0.86 0.28 5.00
122 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
123 INT291641 Binding of DST and ESRRG 1 0.16 1.8 0.28 5.00
124 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28 5.00
125 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
126 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27 5.00
127 INT281980 Scn9a Positive_regulation of MDK 1 0.06 0.24 0.26 5.00
128 INT281963 SCN11A Positive_regulation of MDK 1 0.12 0.24 0.26 5.00
129 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26 5.00
130 INT335458 hb Positive_regulation of SRA1 1 0.00 0.87 0.25 5.00
131 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25 5.00
132 INT180982 SERPINC1 Negative_regulation of IRF6 Positive_regulation of IL6 1 0.00 0.54 0.24 5.00
133 INT335447 PDX1 Regulation of Gene_expression of COPD 1 0.02 1.03 0.24 5.00
134 INT273352 Pde7a Positive_regulation of Localization of Pde4b 1 0.43 0.68 0.24 5.00
135 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24 5.00
136 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22 5.00
137 INT285640 Eln Regulation of Tnfrsf12a 1 0.14 0.16 0.22 5.00
138 INT299261 Dep1 Positive_regulation of Localization of Csf2 1 0.02 0.83 0.21 5.00
139 INT299257 Dep1 Positive_regulation of Localization of Tslp 1 0.03 0.84 0.21 5.00
140 INT189553 DCN Negative_regulation of Transcription of VEGFA 1 0.06 0.78 0.2 5.00
141 INT327112 HCCS Positive_regulation of Gene_expression of SLCO1B3 1 0.03 0.65 0.19 5.00
142 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19 5.00
143 INT332253 Il13 Positive_regulation of Stat6 1 0.08 1.18 0.19 5.00
144 INT332245 Pdgfa Positive_regulation of Stat6 1 0.07 1.22 0.19 5.00
145 INT189563 Binding of SLIT2 and ROBO4 1 0.03 0.71 0.18 5.00
146 INT332251 Il13 Positive_regulation of Stat1 1 0.14 1.4 0.18 5.00
147 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
148 INT299259 Dep1 Positive_regulation of Gene_expression of Hspb8 1 0.00 1.62 0.16 5.00
149 INT267138 Binding of CDH5 and PECAM1 2 0.16 2.69 0.16 5.00
150 INT298717 Fgf2 Positive_regulation of Gene_expression of PDGFA 1 0.01 0.23 0.15 5.00
151 INT332244 Il13 Positive_regulation of Gtf3a 1 0.01 1.21 0.15 5.00
152 INT298716 Ngf Positive_regulation of Gene_expression of PDGFA 1 0.01 0.22 0.15 5.00
153 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
154 INT332254 Pdgfa Positive_regulation of Stat3 1 0.02 0.52 0.14 5.00
155 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
156 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14 5.00
157 INT332256 Pdgfa Positive_regulation of SOAT1 1 0.01 0.51 0.14 5.00
158 INT332243 Pdgfa Positive_regulation of Stat1 1 0.06 0.52 0.14 5.00
159 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14 5.00
160 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00
161 INT223084 Binding of Pdgfa and Pdgfb 2 0.17 0.83 0.13 5.00
162 INT299262 Dep1 Positive_regulation of Gene_expression of Il4 1 0.03 0.82 0.13 5.00
163 INT336503 Parp1 Positive_regulation of Tubgcp2 1 0.11 0.52 0.13 5.00
164 INT336504 Parp1 Positive_regulation of Mcpt3 1 0.11 0.52 0.13 5.00
165 INT336506 Parp1 Positive_regulation of Cxcl2 1 0.16 0.52 0.13 5.00
166 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13 5.00
167 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13 5.00
168 INT332250 Stat6 Positive_regulation of Gene_expression of Pdgfa 1 0.05 1.33 0.12 5.00
169 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
170 INT299260 Nudc Regulation of Gene_expression of Hspb8 1 0.00 1.61 0.12 5.00
171 INT332252 Stat6 Positive_regulation of Gene_expression of Il13 1 0.08 1.32 0.12 5.00
172 INT331797 Ugcg Regulation of Negative_regulation of Mapk14 1 0.01 1.03 0.11 5.00
173 INT331795 Ugcg Regulation of Negative_regulation of gr 1 0.01 1.04 0.11 5.00
174 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11 5.00
175 INT269013 Binding of CSRP1 and COPD 1 0.08 1.3 0.11 5.00
176 INT331794 Binding of Ugcg and Regulation of Negative_regulation of Mapk14 1 0.01 1.05 0.11 5.00
177 INT189559 STK11 Positive_regulation of SNRK 1 0.03 0.36 0.11 5.00
178 INT259636 Binding of Tbce and COPD 1 0.04 1 0.11 5.00
179 INT331792 Binding of Ugcg and Regulation of Negative_regulation of gr 1 0.01 1.05 0.11 5.00
180 INT236467 MMP9 Negative_regulation of SNRPB 1 0.01 0.45 0.1 5.00
181 INT311009 Binding of LCN2 and SNRPB 1 0.01 0.35 0.1 5.00
182 INT322207 CCL18 Regulation of Gene_expression of COL7A1 1 0.07 0.88 0.09 5.00
183 INT259622 Elane Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.38 0.08 5.00
184 INT189550 Binding of BMPR2 and PAH 1 0.06 2.68 0.08 5.00
185 INT300655 Il4 Positive_regulation of Gene_expression of IFN1@ 1 0.22 0.82 0.08 5.00
186 INT180983 IRF6 Regulation of Localization of IL8 1 0.06 0.38 0.08 5.00
187 INT331796 Akt1 Negative_regulation of Negative_regulation of Pik3r1 1 0.04 0.88 0.08 5.00
188 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
189 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07 5.00
190 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07 5.00
191 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07 5.00
192 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
193 INT267137 ICAM1 Regulation of ITGAL 2 0.12 0.57 0.07 5.00
194 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06 5.00
195 INT259635 Plau Positive_regulation of PLG 1 0.13 0.22 0.06 5.00
196 INT331793 Akt1 Positive_regulation of Binding of Ugcg 1 0.02 0.75 0.05 5.00
197 INT236466 SNRPB Positive_regulation of NFKB2 1 0.00 0.21 0.05 5.00
198 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05 5.00
199 INT224150 Binding of TREM1 and COPD 1 0.07 0.7 0.05 5.00
200 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Emphysema. They are ordered first by their pain relevance and then by number of times they were reported in Emphysema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
2 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 100.00
3 INT179665 Protein_catabolism of Elane 3 0.15 3.19 0.52 100.00
4 INT147793 Localization of COPD 70 0.64 89.01 7.3 100.00
5 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 100.00
6 INT179684 Protein_catabolism of COPD 4 0.25 4.25 0.27 100.00
7 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 99.90
8 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 99.84
9 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 99.84
10 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39 99.84
11 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18 99.84
12 INT179666 Positive_regulation of Gene_expression of Elane 3 0.21 1.84 0.5 99.84
13 INT274184 Regulation of Gene_expression of ELN 3 0.36 0.82 0.21 99.84
14 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 99.84
15 INT189591 Regulation of SPARCL1 3 0.25 2.99 0.4 99.84
16 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 99.76
17 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.76
18 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6 99.74
19 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 99.68
20 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 99.64
21 INT194611 Gene_expression of Klrk1 28 0.44 19.31 1.28 99.64
22 INT145168 Negative_regulation of Serpina3a 2 0.17 1.17 0.18 99.60
23 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 99.58
24 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.56
25 INT142419 Regulation of Sptan1 2 0.38 2.52 0.55 99.52
26 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 99.48
27 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31 99.48
28 INT47298 Localization of Ctsl 13 0.79 3.77 4.08 99.44
29 INT273195 Localization of Ctss 2 0.19 1.65 0.51 99.44
30 INT179686 Regulation of Gene_expression of COPD 10 0.34 14.1 1.52 99.40
31 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 99.28
32 INT209138 Negative_regulation of Negative_regulation of PDE4A 4 0.42 3.84 1.21 99.20
33 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 99.20
34 INT132996 Positive_regulation of Gene_expression of Igfbp3 4 0.49 3.2 0.5 99.20
35 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 99.04
36 INT9884 Localization of CD79A 41 0.78 21.75 3.06 99.04
37 INT272869 Negative_regulation of Negative_regulation of Elane 1 0.06 1.02 0.14 99.00
38 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4 99.00
39 INT58532 Negative_regulation of MMP12 4 0.37 2.61 3.2 98.98
40 INT150867 Regulation of COPD 54 0.48 71.38 8.8 98.82
41 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 98.82
42 INT215301 Binding of PQBP1 9 0.27 10.36 0.59 98.80
43 INT48141 Binding of Csf3 18 0.39 9.93 1.71 98.80
44 INT100821 Localization of Ros1 59 0.60 45.26 11.92 98.76
45 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59 98.72
46 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 98.72
47 INT101301 Gene_expression of Aif1 17 0.42 16.43 4.06 98.68
48 INT175455 Gene_expression of Hspb8 54 0.76 59.87 3.9 98.68
49 INT179664 Negative_regulation of Eln 3 0.19 2.35 0.12 98.64
50 INT265794 Regulation of SRA1 3 0.23 3.05 0.35 98.64
51 INT179668 Positive_regulation of Gene_expression of Mmp12 6 0.47 4.08 0.58 98.62
52 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66 98.54
53 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53 98.52
54 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 98.48
55 INT352219 Negative_regulation of Gene_expression of Cd19 1 0.29 0.75 0.33 98.40
56 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01 98.32
57 INT179662 Negative_regulation of Mmp12 2 0.33 3.04 0.93 98.20
58 INT179659 Gene_expression of Mmp12 13 0.52 11.56 2.23 98.16
59 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 98.16
60 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 98.16
61 INT75939 Positive_regulation of SPARCL1 6 0.28 8.74 2.11 98.16
62 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 98.16
63 INT272873 Gene_expression of Epas1 1 0.05 1.57 0.13 98.16
64 INT272871 Positive_regulation of Gene_expression of Epas1 1 0.03 1.58 0.13 98.16
65 INT179653 Localization of Eln 3 0.15 2.75 0.65 98.12
66 INT179657 Negative_regulation of Binding of Eln 1 0.05 0.93 0.13 98.12
67 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 98.12
68 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 98.12
69 INT179671 Binding of Eln 5 0.31 5.32 0.23 98.12
70 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 98.12
71 INT244226 Binding of Ccl11 4 0.25 1.81 0.65 98.08
72 INT31719 Negative_regulation of Ctsa 6 0.47 6.1 1.43 98.04
73 INT57336 Gene_expression of Cd19 5 0.46 4.8 1.6 97.92
74 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98 97.92
75 INT139678 Positive_regulation of Hspb8 23 0.68 23.94 1.85 97.88
76 INT237991 Positive_regulation of Aif1 4 0.04 4.87 0.77 97.88
77 INT275340 Positive_regulation of Localization of Gfm1 3 0.03 1.43 0.04 97.80
78 INT137679 Localization of Gfm1 18 0.08 9.58 3.24 97.80
79 INT259601 Positive_regulation of Mmp12 8 0.48 5.67 1.03 97.68
80 INT139008 Positive_regulation of Gfm1 21 0.35 7.79 2.34 97.68
81 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 97.68
82 INT220858 Positive_regulation of Mmp1a 15 0.38 9.11 2.77 97.68
83 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 97.64
84 INT169352 Negative_regulation of Timp3 10 0.58 6.94 1.92 97.62
85 INT139261 Positive_regulation of Gene_expression of Mtpn 8 0.05 5.95 1.22 97.40
86 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 97.32
87 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43 97.28
88 INT113186 Gene_expression of Prf1 46 0.53 21.06 5.32 97.28
89 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 97.28
90 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 97.28
91 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 97.24
92 INT274183 Negative_regulation of Gene_expression of ELN 3 0.30 3.29 0 97.20
93 INT146759 Positive_regulation of LCN2 18 0.69 18.44 1.08 97.20
94 INT190208 Positive_regulation of MMRN1 15 0.23 14.1 3.37 97.12
95 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 97.08
96 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 97.04
97 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5 97.04
98 INT179663 Localization of Mmp12 8 0.51 4.97 1.53 96.92
99 INT11815 Regulation of Il2 16 0.59 4.81 2.83 96.92
100 INT186739 Regulation of Ccl11 4 0.39 1.99 0.75 96.92
101 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 96.76
102 INT164189 Gene_expression of TREM1 82 0.62 60.77 5.85 96.76
103 INT224156 Negative_regulation of Gene_expression of TREM1 7 0.32 4.93 0.9 96.76
104 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 96.72
105 INT15585 Gene_expression of Serpina3a 3 0.43 1.47 0.42 96.56
106 INT145169 Positive_regulation of Gene_expression of Serpina3a 1 0.20 0.36 0.08 96.56
107 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 96.52
108 INT116420 Localization of Elane 16 0.14 7.8 6 96.52
109 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 96.52
110 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 96.48
111 INT2649 Regulation of Calca 433 0.62 146.05 330.95 96.44
112 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 96.36
113 INT134964 Regulation of Ecm1 13 0.10 7.45 2.37 96.32
114 INT197568 Regulation of NFE2L2 17 0.59 7.85 0.15 96.16
115 INT49379 Localization of MMP12 26 0.77 13.07 16.93 96.12
116 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 96.12
117 INT272889 Negative_regulation of Smad6 2 0.20 1.31 0.19 96.12
118 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.00
119 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 95.96
120 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 95.92
121 INT4053 Regulation of GRP 27 0.58 5.57 13.76 95.92
122 INT273173 Regulation of Gene_expression of Mmp12 1 0.18 0.56 0.12 95.80
123 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72 95.72
124 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89 95.60
125 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 95.60
126 INT69009 Regulation of Binding of Nfkb1 9 0.27 9.86 2.58 95.60
127 INT271477 Negative_regulation of Localization of Mmp12 1 0.31 1.71 0.42 95.48
128 INT179660 Protein_catabolism of Mmp12 1 0.50 0.75 0.05 95.44
129 INT74684 Gene_expression of Mmp12 8 0.31 5.69 3.68 95.36
130 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 95.36
131 INT46392 Regulation of SERPINA1 4 0.44 2.23 0.68 95.28
132 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 95.24
133 INT199332 Binding of Igfbp2 2 0.36 1.46 0.41 95.04
134 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 94.96
135 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 94.88
136 INT352218 Negative_regulation of Cd19 1 0.29 0.59 0.25 94.88
137 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 94.84
138 INT67279 Localization of PRTN3 11 0.50 14.18 4.3 94.80
139 INT275352 Positive_regulation of Localization of PRTN3 1 0.01 0.73 0.11 94.80
140 INT186735 Regulation of Gene_expression of Ccl11 4 0.40 2.07 0.64 94.76
141 INT189475 Regulation of Gene_expression of Ccr3 4 0.32 3.17 0.54 94.76
142 INT179658 Protein_catabolism of Serpina1a 1 0.01 1.39 0.1 94.64
143 INT179651 Negative_regulation of Protein_catabolism of Elane 1 0.04 0.75 0.05 94.64
144 INT32087 Regulation of Lrrc23 2 0.13 0.34 0.66 94.64
145 INT179661 Gene_expression of Eln 9 0.56 7.59 0.58 94.60
146 INT43907 Binding of CD79A 28 0.48 28.11 3.04 94.48
147 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 94.44
148 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 94.32
149 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 94.28
150 INT250193 Positive_regulation of Gene_expression of Adamts12 1 0.07 0.69 0.13 94.24
151 INT250194 Gene_expression of Adamts12 1 0.09 0.69 0.13 94.24
152 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 94.16
153 INT89294 Gene_expression of Ccr3 53 0.68 43.9 12.62 94.12
154 INT6852 Localization of TNF 883 0.81 705.95 270.84 93.92
155 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 93.88
156 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 93.84
157 INT139863 Binding of amd 27 0.41 41.3 0.91 93.76
158 INT113101 Gene_expression of Ccl11 41 0.76 22.36 5.47 93.76
159 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 93.48
160 INT120510 Gene_expression of Lrdg1 1 0.16 1.43 0.28 93.44
161 INT73359 Gene_expression of GLB1 8 0.75 3.18 1.92 93.40
162 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 93.36
163 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 93.36
164 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 93.20
165 INT97799 Regulation of IRF6 23 0.26 6.54 3.75 93.20
166 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 93.16
167 INT74944 Positive_regulation of Gene_expression of HGF 31 0.70 17.69 6.68 93.16
168 INT48691 Negative_regulation of Tacr1 20 0.59 4.96 11.25 93.16
169 INT202424 Gene_expression of HRCT1 3 0.07 3.47 0.36 93.12
170 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 92.92
171 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 92.92
172 INT142972 Gene_expression of ID2 6 0.54 5.92 0.49 92.76
173 INT311017 Localization of LCN2 1 0.75 1.83 0.18 92.68
174 INT151032 Localization of Igf1 49 0.76 26.32 5.71 92.68
175 INT199340 Localization of Igf2 4 0.75 4.47 0.39 92.68
176 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 92.36
177 INT117571 Gene_expression of Myh7 5 0.27 1.43 0.2 92.32
178 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 92.00
179 INT199343 Positive_regulation of Igfbp2 8 0.67 7.85 0.28 92.00
180 INT97859 Localization of Npc1 12 0.75 6.66 0.35 91.96
181 INT259610 Negative_regulation of Gene_expression of Mmp12 2 0.37 2.22 0.66 91.88
182 INT132587 Negative_regulation of Gene_expression of Tacr1 3 0.57 1.22 0.85 91.88
183 INT175655 Regulation of MMRN1 16 0.12 9.96 2.12 91.72
184 INT6481 Binding of TNF 624 0.48 510.2 214.82 91.64
185 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 91.60
186 INT49802 Localization of MUC1 75 0.81 44.74 8.87 91.52
187 INT179667 Negative_regulation of Mfap5 1 0.01 0.65 0 91.52
188 INT142970 Positive_regulation of Gene_expression of ID2 2 0.40 2.39 0.11 91.52
189 INT142968 Negative_regulation of Gene_expression of ID2 1 0.19 0.98 0.11 91.52
190 INT96776 Positive_regulation of Gene_expression of Pdgfa 8 0.40 7.79 3.93 91.44
191 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 91.32
192 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25 91.32
193 INT79140 Binding of HCC 36 0.31 46.96 1.87 91.20
194 INT22872 Positive_regulation of Gene_expression of ELN 2 0.49 0.77 0.14 91.12
195 INT172479 Positive_regulation of NFE2L2 74 0.70 35.22 0.79 90.88
196 INT2609 Localization of ELANE 111 0.81 50.22 26.63 90.80
197 INT265312 Gene_expression of Myo1f 3 0.10 1.44 0.04 90.72
198 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 90.56
199 INT272891 Positive_regulation of Positive_regulation of Elane 1 0.08 1.01 0.25 90.24
200 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 90.20
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