D:Empty Sella Syndrome

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Disease Term
Synonyms Empty Sella, Empty Sella Syndrome Primary, Empty Sella Syndrome Secondary, Empty Sella Syndromes, Empty Sella Turcica Syndrome, Primary Empty Sella Syndrome, Secondary Empty Sella Syndrome
Documents 123
Hot Single Events 59
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Empty Sella Syndrome. They are ordered first by their relevance to Empty Sella Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 83.92
2 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15 78.08
3 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 72.76
4 INT295432 FSHR Positive_regulation of PCOS1 1 0.06 1.24 0 66.60
5 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
6 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
7 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
8 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
9 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
10 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
11 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
12 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
13 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
14 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
15 INT295430 BRD2 Positive_regulation of PLOD1 1 0.02 0.33 0.22 5.00
16 INT295434 BRD2 Positive_regulation of Gene_expression of GNRH1 1 0.02 0.07 0.2 5.00
17 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16 5.00
18 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16 5.00
19 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Empty Sella Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Empty Sella Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT58769 Binding of MSSE 2 0.31 1.34 0.1 100.00
2 INT58771 Regulation of Gene_expression of MSSE 1 0.24 0.95 0.08 100.00
3 INT58770 Gene_expression of MSSE 9 0.56 5.75 0.08 100.00
4 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 99.90
5 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.84
6 INT7035 Regulation of CGA 87 0.45 29.04 28.45 99.72
7 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 99.64
8 INT18660 Binding of Gnrhr 45 0.41 10.6 16.85 99.64
9 INT51953 Positive_regulation of Binding of Gnrhr 2 0.36 0.73 0.59 99.64
10 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.46
11 INT252 Localization of GH1 529 0.80 227.4 122.05 99.44
12 INT425 Localization of PRL 455 0.81 189.64 144.8 99.44
13 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 99.28
14 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97 99.26
15 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.20
16 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 99.20
17 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 99.08
18 INT921 Regulation of GH1 172 0.60 52.88 51.04 99.08
19 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05 99.02
20 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 98.84
21 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 98.68
22 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 98.68
23 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 98.38
24 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 98.28
25 INT1893 Localization of Gh 1041 0.79 340.23 256.58 98.28
26 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 98.28
27 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 98.12
28 INT162 Regulation of Prl 794 0.62 165.01 322.24 97.68
29 INT1378 Negative_regulation of Regulation of Prl 27 0.43 9.16 9.9 97.68
30 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 97.54
31 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 97.52
32 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 97.32
33 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 97.20
34 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 96.96
35 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 96.96
36 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 96.36
37 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 96.16
38 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 95.36
39 INT13735 Negative_regulation of Regulation of GH1 14 0.42 4.35 5.39 95.16
40 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 94.84
41 INT847 Regulation of Lhb 131 0.61 22.08 46.54 94.32
42 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 93.60
43 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 93.56
44 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 91.76
45 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 91.44
46 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 91.44
47 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 89.84
48 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 89.44
49 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 88.56
50 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 88.52
51 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 88.52
52 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98 88.52
53 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 86.96
54 INT15837 Binding of CGA 31 0.41 12.06 3.17 85.28
55 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 85.20
56 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 82.40
57 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 82.24
58 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 82.20
59 INT987 Localization of TRH 37 0.78 10.53 11.1 81.36
60 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 79.44
61 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 78.24
62 INT1530 Regulation of Gh 382 0.61 115.96 112.47 75.00
63 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 75.00
64 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 74.96
65 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 72.44
66 INT477 Localization of Avp 813 0.81 131.58 300.4 71.84
67 INT397 Localization of SST 232 0.81 58.05 101.19 66.48
68 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 66.48
69 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 61.80
70 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 50.20
71 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 49.44
72 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 46.24
73 INT212607 Localization of Ssta1 1 0.03 0.67 0.31 34.16
74 INT212615 Localization of PTPRF 2 0.68 0.34 0.28 34.16
75 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 33.68
76 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 31.52
77 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32 27.24
78 INT232442 Negative_regulation of Gene_expression of DDC 1 0.05 1.44 0.58 27.24
79 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 26.68
80 INT11157 Binding of EGF 88 0.48 53.73 21.25 26.64
81 INT2036 Localization of EGF 42 0.77 21.5 9.74 26.64
82 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16 26.64
83 INT626 Localization of CALCA 289 0.81 125.39 221.15 26.24
84 INT6761 Binding of CALCA 100 0.48 26.71 62.05 26.24
85 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 26.24
86 INT691 Binding of SST 67 0.48 24.66 32.67 25.28
87 INT10237 Binding of EDN1 40 0.48 16 8.48 25.28
88 INT58750 Binding of GAL 16 0.47 5.48 4.92 25.28
89 INT812 Localization of INS 1026 0.81 515.6 145.31 25.00
90 INT34777 Localization of IGF1 82 0.80 42.68 8.62 25.00
91 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78 25.00
92 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 21.04
93 INT9191 Localization of EDN1 94 0.81 57.01 14.78 20.24
94 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 20.24
95 INT7587 Localization of GAL 27 0.78 4.79 14.29 19.28
96 INT232444 Regulation of Localization of GAL 1 0.44 0.28 0.27 19.28
97 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
98 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
99 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
100 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
101 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
102 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
103 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
104 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
105 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
106 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
107 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
108 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 5.00
109 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
110 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
111 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
112 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
113 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 5.00
114 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
115 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
116 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
117 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
118 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
119 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
120 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
121 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
122 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
123 INT912 Localization of FSHR 91 0.79 23.61 15.58 5.00
124 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
125 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
126 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 5.00
127 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
128 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
129 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
130 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
131 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
132 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
133 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
134 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
135 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
136 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
137 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
138 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
139 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
140 INT24191 Binding of VIP 14 0.40 2.16 6.2 5.00
141 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
142 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23 5.00
143 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07 5.00
144 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
145 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
146 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 5.00
147 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 5.00
148 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 5.00
149 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
150 INT48499 Transcription of GNRH1 11 0.67 0.74 3.48 5.00
151 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
152 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 5.00
153 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 5.00
154 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 5.00
155 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 5.00
156 INT7971 Regulation of Gene_expression of GNRH1 12 0.58 1.72 2.43 5.00
157 INT34891 Transcription of PRL 4 0.72 0.69 2.36 5.00
158 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 5.00
159 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 5.00
160 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 5.00
161 INT5344 Negative_regulation of BRD2 12 0.56 4.71 1.89 5.00
162 INT4028 Regulation of HYAL1 8 0.54 1.55 1.8 5.00
163 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 5.00
164 INT31047 Localization of HRH2 5 0.75 1.84 1.53 5.00
165 INT7033 Binding of FSHR 19 0.37 6.66 1.52 5.00
166 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 5.00
167 INT232445 Positive_regulation of Transcription of PRL 1 0.50 0 1.32 5.00
168 INT39955 Positive_regulation of Negative_regulation of PRL 3 0.70 0.47 0.9 5.00
169 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 5.00
170 INT34889 Regulation of Transcription of PRL 2 0.42 0.55 0.67 5.00
171 INT17698 Positive_regulation of Regulation of GH1 6 0.46 0.9 0.65 5.00
172 INT232453 Negative_regulation of DNAJA3 1 0.41 0 0.54 5.00
173 INT252612 Regulation of Gene_expression of SCN5A 5 0.35 0.56 0.53 5.00
174 INT27643 Negative_regulation of Gene_expression of BRD2 2 0.42 0.19 0.51 5.00
175 INT307615 Negative_regulation of Positive_regulation of CSF2 4 0.36 3.55 0.48 5.00
176 INT105457 Regulation of Binding of CGA 2 0.45 0.48 0.33 5.00
177 INT232449 Negative_regulation of Transcription of PRL 1 0.59 0 0.3 5.00
178 INT232452 Positive_regulation of Binding of PRL 1 0.50 0.18 0.27 5.00
179 INT187722 Positive_regulation of Gene_expression of BRD2 3 0.49 0.43 0.23 5.00
180 INT295437 Negative_regulation of Protein_catabolism of CGA 1 0.36 0.05 0.19 5.00
181 INT288255 Protein_catabolism of CGA 5 0.75 1.87 0.19 5.00
182 INT212605 Gene_expression of Ssta1 1 0.02 0.39 0.18 5.00
183 INT212606 Negative_regulation of Gene_expression of Ssta1 1 0.02 0.39 0.18 5.00
184 INT232448 Positive_regulation of Gene_expression of TRH 1 0.32 0.08 0.17 5.00
185 INT164291 Regulation of Positive_regulation of SCN5A 2 0.38 0.73 0.15 5.00
186 INT291909 Binding of BRD2 2 0.03 0.08 0.09 5.00
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