D:Endometrial Stromal Sarcoma

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Disease Term
Synonyms Endometrial Stromal Sarcomas, Sarcomas Endometrial Stromal, Stromal Sarcoma Endometrial, Stromal Sarcomas Endometrial
Documents 48
Hot Single Events 48
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Endometrial Stromal Sarcoma. They are ordered first by their relevance to Endometrial Stromal Sarcoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 84.00
2 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
3 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
4 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
5 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
6 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
7 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
8 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
9 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
10 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
11 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
12 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
13 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
14 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
15 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
16 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
17 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Endometrial Stromal Sarcoma. They are ordered first by their pain relevance and then by number of times they were reported in Endometrial Stromal Sarcoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 99.88
2 INT113980 Gene_expression of Cald1 4 0.05 7.16 0.33 99.88
3 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 99.84
4 INT304057 Regulation of JAZF1 1 0.24 1 0 99.84
5 INT304070 Regulation of SUZ12 1 0.22 1 0 99.84
6 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 99.72
7 INT78038 Gene_expression of Oxtr 43 0.78 18.72 9.38 99.70
8 INT20462 Binding of ESR1 210 0.44 102.7 26.34 99.48
9 INT268686 Gene_expression of JAZF1 2 0.68 9.33 0 99.44
10 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0 99.44
11 INT304048 Negative_regulation of Gene_expression of SFRP4 1 0.34 0.97 0 99.24
12 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.08
13 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 99.08
14 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 98.96
15 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51 98.68
16 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 98.08
17 INT139201 Localization of TP63 4 0.32 2.56 0.15 98.00
18 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 97.60
19 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 97.18
20 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 97.12
21 INT85184 Negative_regulation of Gene_expression of Oxtr 2 0.26 1.19 0.07 96.96
22 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 96.88
23 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 96.88
24 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 96.66
25 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 95.52
26 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 95.52
27 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 95.28
28 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 95.08
29 INT70654 Gene_expression of Actg2 27 0.67 18.62 4.79 94.96
30 INT70760 Positive_regulation of Actg2 8 0.48 6.23 0.61 94.96
31 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 94.48
32 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 93.36
33 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 92.56
34 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 92.56
35 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 92.56
36 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 92.12
37 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 92.12
38 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 91.52
39 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 89.44
40 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 88.76
41 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 88.40
42 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 87.92
43 INT13267 Binding of Pgr 15 0.40 3.5 2.22 87.88
44 INT304052 Binding of MSI1 8 0.05 12.19 0 87.36
45 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 86.04
46 INT78033 Positive_regulation of Gene_expression of Oxtr 10 0.70 2.5 4.15 85.48
47 INT77523 Positive_regulation of ADC 14 0.63 13.81 1.81 85.20
48 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 83.08
49 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 77.72
50 INT11157 Binding of EGF 88 0.48 53.73 21.25 76.96
51 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 76.92
52 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 76.84
53 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 74.08
54 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 71.72
55 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 71.72
56 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 69.28
57 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7 45.36
58 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 32.68
59 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 29.64
60 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 14.16
61 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.04
62 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
63 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
64 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
65 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
66 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
67 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
68 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
69 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
70 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
71 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
72 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
73 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
74 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
75 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
76 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
77 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
78 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
79 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
80 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
81 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
82 INT118124 Binding of USE1 24 0.16 16.64 5.44 5.00
83 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 5.00
84 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
85 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
86 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
87 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81 5.00
88 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 5.00
89 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
90 INT192676 Binding of PTEN 14 0.46 10.58 3.06 5.00
91 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
92 INT200670 Gene_expression of AKT2 25 0.75 16.25 3 5.00
93 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 5.00
94 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 5.00
95 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
96 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
97 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
98 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 5.00
99 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
100 INT68496 Binding of PGR 26 0.48 16.36 2.09 5.00
101 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
102 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
103 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
104 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 5.00
105 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
106 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 5.00
107 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
108 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 5.00
109 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41 5.00
110 INT304045 Transcription of PTEN 2 0.51 4.12 1.4 5.00
111 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 5.00
112 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
113 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
114 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23 5.00
115 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22 5.00
116 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19 5.00
117 INT135556 Localization of AKT1 38 0.69 12.78 1.17 5.00
118 INT220206 Gene_expression of CCNB2 4 0.67 3.75 1.16 5.00
119 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 5.00
120 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 5.00
121 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
122 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12 5.00
123 INT92139 Binding of MLH1 12 0.42 15.62 1 5.00
124 INT156326 Positive_regulation of SMARCB1 20 0.67 8.77 0.97 5.00
125 INT257453 Positive_regulation of USE1 12 0.20 6.7 0.94 5.00
126 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87 5.00
127 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81 5.00
128 INT275575 Gene_expression of FOLR1 12 0.66 2.81 0.8 5.00
129 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 5.00
130 INT99290 Positive_regulation of STS 16 0.43 6.96 0.75 5.00
131 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 5.00
132 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
133 INT304060 Positive_regulation of AGR2 2 0.70 13 0.63 5.00
134 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 5.00
135 INT161322 Localization of PTEN 9 0.73 5.65 0.57 5.00
136 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54 5.00
137 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47 5.00
138 INT148882 Regulation of LTF 9 0.12 4.8 0.44 5.00
139 INT12089 Positive_regulation of MSX2 4 0.46 3.92 0.39 5.00
140 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37 5.00
141 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 5.00
142 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27 5.00
143 INT181920 Gene_expression of MSH3 2 0.50 2.54 0.18 5.00
144 INT206869 Gene_expression of ALDH1A2 3 0.38 2.51 0.16 5.00
145 INT292659 Positive_regulation of Gene_expression of FOLR1 2 0.47 1.59 0.14 5.00
146 INT200671 Gene_expression of AKT3 4 0.69 1.88 0.13 5.00
147 INT165516 Regulation of MSX2 8 0.23 3.41 0.09 5.00
148 INT184985 Regulation of TFF3 2 0.26 1.43 0.07 5.00
149 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06 5.00
150 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05 5.00
151 INT105948 Gene_expression of AURKA 5 0.65 4.26 0.03 5.00
152 INT207233 Transcription of KRAS 3 0.48 1.56 0.03 5.00
153 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03 5.00
154 INT105949 Positive_regulation of Gene_expression of AURKA 3 0.49 1.91 0.03 5.00
155 INT219360 Regulation of MMP11 2 0.54 1.71 0.03 5.00
156 INT172329 Binding of MRC1 8 0.36 3.88 0.03 5.00
157 INT282953 Regulation of MSI1 2 0.03 1.63 0.03 5.00
158 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0 5.00
159 INT304067 Positive_regulation of Transcription of GEMIN2 1 0.09 0.57 0 5.00
160 INT320099 Protein_catabolism of STS 1 0.68 1.84 0 5.00
161 INT304078 Regulation of Phosphorylation of KRT20 1 0.00 1 0 5.00
162 INT304046 Positive_regulation of Transcription of SNAI2 1 0.49 0.57 0 5.00
163 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0 5.00
164 INT304074 Binding of MSH5 1 0.14 1.11 0 5.00
165 INT236621 Regulation of KRAS 7 0.53 6.16 0 5.00
166 INT304066 Gene_expression of BUB1 1 0.07 1.41 0 5.00
167 INT304063 Positive_regulation of ALDH1A2 1 0.29 0.97 0 5.00
168 INT304075 Regulation of AURKA 1 0.15 1.38 0 5.00
169 INT304059 Gene_expression of GEMIN2 1 0.12 0.66 0 5.00
170 INT304058 Positive_regulation of MSI1 1 0.07 2.74 0 5.00
171 INT198037 Regulation of PIK3CA 2 0.28 2.63 0 5.00
172 INT291934 Regulation of FOXA2 2 0.26 2.15 0 5.00
173 INT190053 Gene_expression of CASP5 3 0.45 2.46 0 5.00
174 INT304076 Regulation of Localization of KRAS 2 0.36 2.39 0 5.00
175 INT304049 Transcription of SNAI2 1 0.67 0.56 0 5.00
176 INT304051 Regulation of SCGB2A1 1 0.17 1.19 0 5.00
177 INT209451 Regulation of Gene_expression of TP63 3 0.16 4.32 0 5.00
178 INT304065 Transcription of GEMIN2 1 0.12 0.57 0 5.00
179 INT180396 Localization of KRAS 3 0.69 2.89 0 5.00
180 INT304053 Gene_expression of KIAA1324 1 0.18 0.98 0 5.00
181 INT304064 Positive_regulation of KIAA1324 1 0.14 0.98 0 5.00
182 INT185004 Positive_regulation of TFF3 4 0.47 3.77 0 5.00
183 INT304073 Regulation of CCNB2 1 0.10 1.39 0 5.00
184 INT304079 Regulation of AGR2 2 0.27 1.2 0 5.00
185 INT304068 Regulation of VPS11 1 0.12 1.24 0 5.00
186 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0 5.00
187 INT304071 Binding of MSH6 1 0.28 1.11 0 5.00
188 INT304061 Regulation of BUB1 1 0.07 1.39 0 5.00
189 INT304072 Positive_regulation of FOXA2 1 0.15 1.29 0 5.00
190 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0 5.00
191 INT304055 Transcription of TWIST1 1 0.14 0.57 0 5.00
192 INT304056 Gene_expression of SNAI2 1 0.65 0.66 0 5.00
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