D:Enterocolitis

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Disease Term
Synonyms Enterocolitides
Documents 159
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Enterocolitis. They are ordered first by their relevance to Enterocolitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 16.00
2 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11 14.00
3 INT301674 Binding of APC and CD80 1 0.01 0.53 0 14.00
4 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 11.92
5 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
6 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
7 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71 5.00
8 INT327727 Atp6v0a2 Negative_regulation of Gene_expression of Kit 1 0.05 0.83 0.41 5.00
9 INT316493 Il6 Positive_regulation of Il11ra1 1 0.64 1.69 0.4 5.00
10 INT316488 Il22 Positive_regulation of Il10 1 0.29 0.63 0.32 5.00
11 INT316483 Il22ra1 Positive_regulation of Il10 1 0.27 0.62 0.31 5.00
12 INT316487 Il22 Regulation of Il22ra1 1 0.12 0.61 0.31 5.00
13 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
14 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
15 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
16 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24 5.00
17 INT316491 Socs3 Positive_regulation of Il11ra1 1 0.45 0.92 0.22 5.00
18 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
19 INT316477 Stat3 Positive_regulation of Il10 1 0.39 0.35 0.18 5.00
20 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16 5.00
21 INT316479 Il6 Positive_regulation of Snai1 1 0.24 0.33 0.15 5.00
22 INT316482 Il6 Positive_regulation of Cdh1 1 0.03 0.33 0.15 5.00
23 INT316490 Il6 Positive_regulation of Positive_regulation of Stat3 1 0.50 0.33 0.15 5.00
24 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
25 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
26 INT316492 Stat3 Positive_regulation of Socs3 1 0.46 0.19 0.06 5.00
27 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04 5.00
28 INT316489 Stat3 Positive_regulation of Transcription of Ccnb1 1 0.02 1.27 0.04 5.00
29 INT316486 Stat3 Positive_regulation of Transcription of Cdc2b 1 0.28 1.27 0.04 5.00
30 INT316499 Stat3 Positive_regulation of Transcription of MYC 1 0.55 1.27 0.04 5.00
31 INT195195 IL4 Regulation of Gene_expression of IGHE 1 0.10 0.68 0.04 5.00
32 INT316478 Binding of Stat3 and Hist1h3f 1 0.05 1.08 0.03 5.00
33 INT316496 Il17a Positive_regulation of VEGFA 1 0.11 0.65 0.03 5.00
34 INT316481 Positive_regulation of Stat3 Positive_regulation of Localization of Hand1 1 0.19 1.48 0.03 5.00
35 INT195199 Gene_expression of IL4 Positive_regulation of Gene_expression of IGHE 1 0.08 1.76 0 5.00
36 INT316497 Negative_regulation of Stat3 Negative_regulation of Gene_expression of VEGFA 1 0.13 0.93 0 5.00
37 INT195198 Gene_expression of IL5 Positive_regulation of Gene_expression of IGHE 1 0.09 1.76 0 5.00
38 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 5.00
39 INT316498 Il6 Positive_regulation of IL6 1 0.49 0.89 0 5.00
40 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0 5.00
41 INT195197 Gene_expression of IL9 Positive_regulation of Gene_expression of IGHE 1 0.05 1.77 0 5.00
42 INT195196 IL13 Positive_regulation of Gene_expression of IGHE 1 0.06 1.79 0 5.00
43 INT301677 Binding of APC and CD8A 1 0.03 1.48 0 5.00
44 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
45 INT195200 IL10 Positive_regulation of Gene_expression of IGHE 1 0.07 1.78 0 5.00
46 INT214886 Binding of Atcay and FIP1L1 1 0.08 4.06 0 5.00
47 INT301676 Binding of CD8A and HLA-E 1 0.02 2.24 0 5.00
48 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 5.00
49 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
50 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Enterocolitis. They are ordered first by their pain relevance and then by number of times they were reported in Enterocolitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT148892 Binding of HPS1 13 0.37 19.21 3.35 99.92
2 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.82
3 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 99.82
4 INT222005 Regulation of HPS1 2 0.33 3.3 0.6 99.52
5 INT110766 Binding of Hps1 3 0.41 2.23 0.19 99.12
6 INT305172 Phosphorylation of Gnb5 1 0.05 1.41 0 99.12
7 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 99.08
8 INT27466 Negative_regulation of Kng1 7 0.10 7.79 3.56 98.76
9 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27 95.88
10 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 91.60
11 INT70563 Localization of ABCB1 14 0.78 2.03 3.09 91.52
12 INT27325 Positive_regulation of Pyy 15 0.62 13.69 6.54 90.64
13 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 90.36
14 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 89.84
15 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 87.04
16 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 86.76
17 INT194380 Negative_regulation of Gene_expression of IL5 22 0.42 15.78 4.1 84.92
18 INT171021 Negative_regulation of IL5 18 0.41 14.74 3.39 84.92
19 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 84.72
20 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 84.40
21 INT184185 Transcription of Kng1 1 0.05 1.66 0.62 84.08
22 INT181489 Localization of Spg21 16 0.12 10.89 6.84 82.16
23 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 82.00
24 INT97596 Localization of S100a8 94 0.78 90.69 40.41 81.08
25 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 76.16
26 INT3926 Regulation of Bdkrb1 22 0.61 16.72 16.1 75.84
27 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 75.00
28 INT166268 Positive_regulation of Lcp1 2 0.49 2.79 0.21 75.00
29 INT166269 Negative_regulation of Positive_regulation of Lcp1 1 0.42 1.89 0.15 75.00
30 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 71.84
31 INT205477 Transcription of Stat3 4 0.68 3.15 0.5 71.52
32 INT316433 Regulation of Transcription of Stat3 1 0.44 0.67 0 71.52
33 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 69.88
34 INT35359 Negative_regulation of LCT 23 0.59 9.13 2.29 69.84
35 INT44540 Binding of GPT 3 0.36 6.14 0.23 69.04
36 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 62.84
37 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 62.84
38 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 55.28
39 INT2609 Localization of ELANE 111 0.81 50.22 26.63 47.04
40 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 46.88
41 INT49802 Localization of MUC1 75 0.81 44.74 8.87 46.88
42 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37 44.04
43 INT58527 Gene_expression of Prtn3 20 0.71 15.99 2.9 43.64
44 INT181637 Gene_expression of CMA1 10 0.66 4.16 0.72 43.64
45 INT327720 Gene_expression of Mcpt4 1 0.49 0.49 0.21 43.64
46 INT25163 Positive_regulation of Gene_expression of IL2RA 8 0.45 5.37 1.71 38.60
47 INT50954 Regulation of IL2RA 5 0.25 3.09 0.77 34.08
48 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 33.32
49 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97 33.32
50 INT285617 Gene_expression of Etohd1 2 0.04 0.68 0.26 30.24
51 INT245272 Gene_expression of Cldn3 8 0.62 1.73 0.36 29.84
52 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 25.84
53 INT9884 Localization of CD79A 41 0.78 21.75 3.06 25.28
54 INT205476 Binding of Stat3 12 0.47 4.73 0.72 25.08
55 INT327722 Positive_regulation of Localization of Spg21 1 0.05 0.85 0.17 11.12
56 INT73504 Binding of CD28 35 0.45 15.99 10.04 10.88
57 INT316449 Negative_regulation of Binding of Stat3 2 0.42 0.4 0.05 7.92
58 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 7.52
59 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
60 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
61 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
62 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
63 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
64 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
65 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
66 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
67 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
68 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
69 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
70 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
71 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
72 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
73 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
74 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
75 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
76 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
77 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
78 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
79 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
80 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
81 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
82 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
83 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
84 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
85 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
86 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
87 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
88 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
89 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
90 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
91 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
92 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
93 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
94 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
95 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
96 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
97 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
98 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
99 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
100 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
101 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
102 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
103 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
104 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
105 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
106 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
107 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
108 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
109 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
110 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
111 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
112 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
113 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
114 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
115 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
116 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
117 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
118 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
119 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
120 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
121 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 5.00
122 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 5.00
123 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
124 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
125 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
126 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 5.00
127 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
128 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
129 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
130 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
131 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
132 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
133 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
134 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 5.00
135 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
136 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 5.00
137 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
138 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
139 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
140 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
141 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
142 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
143 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
144 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
145 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
146 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
147 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
148 INT75929 Gene_expression of IL9 61 0.43 24.71 16.17 5.00
149 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
150 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34 5.00
151 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 5.00
152 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 5.00
153 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
154 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 5.00
155 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
156 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
157 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
158 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
159 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
160 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
161 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
162 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
163 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
164 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
165 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 5.00
166 INT160563 Localization of Il17a 34 0.74 26.53 10.24 5.00
167 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
168 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
169 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 5.00
170 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68 5.00
171 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
172 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
173 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
174 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
175 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
176 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 5.00
177 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
178 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
179 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 5.00
180 INT39457 Positive_regulation of SOAT1 32 0.67 22.8 8.28 5.00
181 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27 5.00
182 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
183 INT116605 Binding of Nos2 28 0.37 16.88 8.18 5.00
184 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
185 INT32454 Gene_expression of Ptafr 3 0.65 15.19 7.87 5.00
186 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 5.00
187 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
188 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.00
189 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 5.00
190 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
191 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
192 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
193 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 5.00
194 INT159632 Localization of DCPS 24 0.21 18.24 6.8 5.00
195 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
196 INT35712 Regulation of Sdcbp 19 0.23 5.3 6.58 5.00
197 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
198 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 5.00
199 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 5.00
200 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
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