D:Eosinophilic Esophagitis

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Disease Term
Synonyms Chronic Esophagitides Eosinophilic, Chronic Esophagitis Eosinophilic, EOSINOPHILIC CHRONIC ESOPHAGITIDES, Eosinophilic Chronic Esophagitis, Eosinophilic Esophagitides, Esophagitides Eosinophilic, ESOPHAGITIDES EOSINOPHILIC CHRONIC, Esophagitis Eosinophilic, Esophagitis Eosinophilic Chronic
Documents 56
Hot Single Events 105
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Eosinophilic Esophagitis. They are ordered first by their relevance to Eosinophilic Esophagitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT342551 Binding of IL13 and EOE2 1 0.02 1.43 0 100.00
2 INT342556 CCL11 Positive_regulation of Positive_regulation of EOE2 1 0.02 0.68 0 100.00
3 INT342553 NUDT6 Positive_regulation of Positive_regulation of EOE2 1 0.02 0.67 0 100.00
4 INT319382 Binding of IL13 and CRISP3 1 0.09 0.87 0.03 100.00
5 INT342554 Positive_regulation of Binding of MAPK1 and CCL11 1 0.06 1.07 0 99.84
6 INT342552 Binding of MAPK1 and CCL11 1 0.05 1.07 0 99.84
7 INT342559 FGF2 Positive_regulation of MAPK1 1 0.08 1.22 0 90.40
8 INT342555 FGF9 Positive_regulation of MAPK1 1 0.07 1.22 0 90.40
9 INT342557 FGF2 Positive_regulation of MAPK3 1 0.03 1.21 0 89.68
10 INT342558 FGF9 Positive_regulation of MAPK3 1 0.03 1.21 0 89.68
11 INT319383 Binding of CCL18 and CCL22 1 0.19 1.07 0.25 45.08
12 INT319384 Binding of AR and SCGB2A2 1 0.01 1.36 0.04 44.76
13 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53 16.84
14 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18 16.52
15 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15 5.00
16 INT304172 Il5 Positive_regulation of Bcl2l1 1 0.02 0.91 0.05 5.00
17 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0 5.00
18 INT304175 IL1B Positive_regulation of Gene_expression of Vcam1 1 0.02 0.96 0 5.00
19 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0 5.00
20 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0 5.00
21 INT304176 Binding of IL1B and Il13 1 0.00 0.96 0 5.00
22 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.94 0 5.00
23 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0 5.00
24 INT304171 Il13 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.89 0 5.00
25 INT304174 Binding of IL1B and Il4 1 0.00 0.96 0 5.00
26 INT214886 Binding of Atcay and FIP1L1 1 0.08 4.06 0 5.00
27 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Eosinophilic Esophagitis. They are ordered first by their pain relevance and then by number of times they were reported in Eosinophilic Esophagitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT218867 Gene_expression of EOE2 3 0.16 16.19 0.63 100.00
2 INT160533 Gene_expression of NUDT6 24 0.20 18.6 1.7 100.00
3 INT342562 Positive_regulation of EOE2 1 0.10 5.7 0 100.00
4 INT342571 Positive_regulation of Gene_expression of NUDT6 1 0.12 8.05 0.67 100.00
5 INT158812 Binding of EOE2 2 0.46 3.53 0.1 100.00
6 INT342566 Positive_regulation of Gene_expression of EOE2 1 0.14 3.81 0.13 100.00
7 INT85277 Binding of NUDT6 6 0.38 6.03 1.6 100.00
8 INT342564 Negative_regulation of EOE2 1 0.10 1.47 0.03 100.00
9 INT78704 Binding of CCL11 10 0.37 11.38 1.44 100.00
10 INT342563 Regulation of EOE2 1 0.06 1.2 0.06 100.00
11 INT319425 Regulation of CCL26 1 0.17 1.43 0.16 100.00
12 INT113101 Gene_expression of Ccl11 41 0.76 22.36 5.47 99.96
13 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 99.92
14 INT76891 Positive_regulation of NUDT6 3 0.32 11.64 0.86 99.92
15 INT342570 Negative_regulation of Gene_expression of NUDT6 1 0.07 0.92 0.03 99.92
16 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 99.84
17 INT94835 Localization of NUDT6 13 0.52 11.57 2 99.84
18 INT304139 Gene_expression of Ccl26 1 0.36 1.33 0.08 99.74
19 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98 99.66
20 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48 99.64
21 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 99.56
22 INT115108 Negative_regulation of Gene_expression of FAS 9 0.57 9.16 1.23 99.56
23 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 99.54
24 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24 99.48
25 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 99.44
26 INT342568 Positive_regulation of Positive_regulation of NUDT6 1 0.08 1.27 0.13 99.38
27 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39 99.36
28 INT319398 Transcription of CRISP3 1 0.40 2.93 0.25 99.36
29 INT319440 Negative_regulation of Transcription of CRISP3 1 0.32 2.25 0.11 99.36
30 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 99.30
31 INT78702 Positive_regulation of CCL11 13 0.68 12.94 2.74 99.28
32 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 99.28
33 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12 99.20
34 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3 99.20
35 INT304149 Positive_regulation of Transcription of Il5 1 0.09 1.81 0.08 99.20
36 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 99.16
37 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 99.16
38 INT158829 Negative_regulation of FAS 5 0.41 4.12 0.48 99.12
39 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 99.12
40 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 99.08
41 INT342569 Positive_regulation of Gene_expression of FGF9 1 0.11 1.05 0 99.08
42 INT139662 Gene_expression of FGF9 7 0.65 2.26 0.17 99.08
43 INT281972 Gene_expression of POSTN 3 0.65 14.9 0.22 99.04
44 INT319397 Positive_regulation of Gene_expression of POSTN 2 0.48 4.56 0.16 99.04
45 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 98.88
46 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36 98.80
47 INT228727 Transcription of Il5 4 0.27 5.13 0.9 98.76
48 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0 98.64
49 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 98.60
50 INT342567 Regulation of Gene_expression of NUDT6 1 0.08 2.17 0.07 98.52
51 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 98.52
52 INT71302 Regulation of Gene_expression of CCL11 2 0.44 3.59 0.37 98.52
53 INT190389 Transcription of MAPK1 2 0.44 2.58 0.15 98.48
54 INT24671 Binding of FGF2 14 0.35 8.73 1.43 98.12
55 INT115317 Transcription of FGF2 14 0.62 12.79 3 98.12
56 INT122587 Negative_regulation of Gene_expression of S100A8 2 0.41 1.57 0.6 98.08
57 INT248319 Negative_regulation of Gene_expression of S100A9 2 0.23 0.9 0.03 98.08
58 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 98.04
59 INT273600 Positive_regulation of FGF9 2 0.15 1.46 0 98.04
60 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 97.88
61 INT24672 Localization of FGF2 27 0.71 14.59 2.48 97.72
62 INT342561 Negative_regulation of FGF9 1 0.09 0.78 0 97.72
63 INT17061 Positive_regulation of POSTN 12 0.42 5.33 2.28 97.72
64 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 97.68
65 INT157342 Gene_expression of S100A9 19 0.60 21.27 3.37 97.68
66 INT222810 Positive_regulation of CD209 4 0.48 3.14 0.16 97.28
67 INT342565 Localization of FGF9 1 0.16 0.79 0 96.84
68 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 96.40
69 INT319423 Positive_regulation of Transcription of PIP 1 0.23 0.69 0.14 96.20
70 INT319407 Positive_regulation of Transcription of STATH 1 0.40 0.69 0.14 96.20
71 INT319428 Positive_regulation of Transcription of AZGP1 1 0.27 0.69 0.14 96.20
72 INT319430 Positive_regulation of Transcription of CRISP3 1 0.33 0.69 0.14 96.20
73 INT124186 Negative_regulation of PIP 2 0.44 0.94 0.43 96.12
74 INT319441 Transcription of STATH 1 0.58 0.69 0.14 95.80
75 INT319421 Transcription of PIP 1 0.33 0.69 0.14 95.80
76 INT319405 Transcription of AZGP1 1 0.39 0.69 0.14 95.80
77 INT142732 Negative_regulation of STATH 3 0.42 1.72 0.16 95.76
78 INT319412 Negative_regulation of AZGP1 1 0.23 0.67 0.16 95.48
79 INT319395 Positive_regulation of CCL13 1 0.32 1.75 0.2 93.36
80 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 92.96
81 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 92.92
82 INT102525 Gene_expression of CCR3 24 0.71 16.19 10 92.48
83 INT105403 Positive_regulation of Gene_expression of CCR3 10 0.60 7.99 4.74 92.48
84 INT319437 Transcription of CRISP2 1 0.36 0.87 0.04 91.44
85 INT319413 Negative_regulation of Transcription of CRISP2 1 0.21 0.87 0.04 91.44
86 INT123994 Localization of Chi3l3 1 0.09 1.49 0.26 90.96
87 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 90.48
88 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 89.52
89 INT319402 Positive_regulation of Transcription of S100A9 1 0.37 0.8 0.06 88.28
90 INT72454 Transcription of S100A9 2 0.69 1.18 0.12 87.88
91 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 86.16
92 INT319404 Positive_regulation of Localization of CCL13 1 0.32 1.4 0.26 85.64
93 INT171014 Localization of CCL13 3 0.48 5.01 1.49 85.64
94 INT221037 Positive_regulation of Localization of CCL18 5 0.67 7.7 1.44 85.36
95 INT146807 Localization of CCL18 17 0.78 11.8 4.79 85.36
96 INT319426 Positive_regulation of Localization of CRISP3 1 0.28 1.39 0.26 85.08
97 INT319409 Localization of CRISP3 1 0.41 0.6 0.13 85.08
98 INT319419 Positive_regulation of Localization of EMR3 1 0.30 1.39 0.26 84.76
99 INT319434 Localization of EMR3 1 0.44 0.59 0.13 84.76
100 INT319433 Positive_regulation of Localization of IL1RL1 1 0.35 1.39 0.26 84.36
101 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07 84.36
102 INT319396 Positive_regulation of Localization of ST2 1 0.21 1.39 0.26 84.04
103 INT226490 Localization of ST2 5 0.31 1.99 0.44 84.04
104 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 81.44
105 INT64224 Localization of FUT3 3 0.06 3.16 0.2 81.44
106 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 77.12
107 INT297918 Positive_regulation of Gene_expression of S100A9 2 0.37 2.15 0.07 77.12
108 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 76.12
109 INT221049 Positive_regulation of Transcription of CCL18 3 0.45 4.47 1.15 73.12
110 INT319406 Positive_regulation of Transcription of CCL22 1 0.67 2.36 0.52 73.12
111 INT319429 Positive_regulation of Transcription of CXCL13 1 0.23 1.19 0.26 73.12
112 INT139660 Transcription of CCL18 13 0.70 7.12 3.05 72.72
113 INT319427 Transcription of CCL22 1 0.69 2.35 0.52 72.72
114 INT182227 Transcription of CXCL13 2 0.60 2.07 0.81 72.72
115 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 71.92
116 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 69.08
117 INT35359 Negative_regulation of LCT 23 0.59 9.13 2.29 66.96
118 INT319394 Positive_regulation of Transcription of EMR3 1 0.41 2.23 0.16 65.68
119 INT319416 Positive_regulation of Transcription of EMR1 1 0.37 1.67 0.12 65.68
120 INT319424 Transcription of EMR3 1 0.42 2.17 0.16 63.44
121 INT319393 Transcription of EMR1 1 0.38 1.61 0.12 63.44
122 INT134325 Positive_regulation of IL4R 3 0.36 4.75 0.63 59.48
123 INT319408 Negative_regulation of Binding of PDGFB 1 0.15 0.89 0.09 56.00
124 INT74529 Binding of PDGFB 13 0.36 7.41 0.62 55.20
125 INT345973 Binding of EVL 1 0.07 1.4 0.14 49.88
126 INT319401 Transcription of MYH11 1 0.36 1.01 0.09 48.68
127 INT261746 Transcription of CNN1 2 0.47 1.01 0.09 48.40
128 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 48.36
129 INT172598 Gene_expression of EMR1 3 0.65 1.36 0.15 48.32
130 INT319415 Transcription of FHL1 1 0.31 1.01 0.09 48.16
131 INT319414 Transcription of ACTG2 1 0.24 0.99 0.08 45.88
132 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 45.40
133 INT319399 Transcription of MYRIP 1 0.29 0.99 0.08 45.12
134 INT221041 Binding of CCL18 3 0.47 2.08 0.59 45.08
135 INT319422 Transcription of PLN 1 0.14 0.99 0.08 44.84
136 INT319438 Binding of CCL22 2 0.22 2.2 0.37 44.68
137 INT319403 Binding of SCGB2A2 1 0.04 1.34 0.04 42.92
138 INT275621 Positive_regulation of Atcay 3 0.06 2.15 0.04 41.04
139 INT152434 Localization of CCL11 6 0.78 9.47 2.68 39.56
140 INT319436 Positive_regulation of SCGB2A2 1 0.05 1.38 0.04 39.24
141 INT74449 Positive_regulation of B4GALNT1 53 0.30 34.49 14.96 36.48
142 INT319420 Positive_regulation of CST4 1 0.45 1.46 0.06 36.48
143 INT319411 Negative_regulation of Transcription of PDGFB 1 0.15 1.03 0.07 33.88
144 INT74530 Transcription of PDGFB 7 0.65 4.56 1.47 33.48
145 INT165779 Binding of CXCL9 2 0.32 0.49 0.31 30.80
146 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 28.76
147 INT98225 Regulation of Il5 8 0.45 5.07 2.06 28.24
148 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 28.16
149 INT304147 Gene_expression of Fip1l1 1 0.32 2.07 0 26.80
150 INT7346 Localization of Hrh2 15 0.69 5.78 4.79 26.24
151 INT164916 Binding of IL1RL1 9 0.33 1.84 0.66 22.96
152 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 15.28
153 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 6.24
154 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 6.24
155 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 6.24
156 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 6.24
157 INT119103 Gene_expression of FIP1L1 2 0.49 2.95 0.11 6.24
158 INT126984 Positive_regulation of Gene_expression of Il5 29 0.69 20.61 6.72 5.52
159 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49 5.44
160 INT319432 Positive_regulation of Localization of IL33 1 0.26 1.02 0.13 5.20
161 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
162 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
163 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
164 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
165 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
166 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
167 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
168 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
169 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
170 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
171 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
172 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
173 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
174 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
175 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
176 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
177 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
178 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
179 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
180 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
181 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
182 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 5.00
183 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
184 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
185 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 5.00
186 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
187 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
188 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79 5.00
189 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
190 INT304151 Gene_expression of Siglec5 2 0.74 17.33 6.03 5.00
191 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 5.00
192 INT177526 Negative_regulation of Il5 17 0.36 11.13 5.31 5.00
193 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29 5.00
194 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 5.00
195 INT99091 Regulation of AR 70 0.45 31.68 5.05 5.00
196 INT18995 Binding of CEL 23 0.47 14.46 4.5 5.00
197 INT108342 Negative_regulation of EPHB2 18 0.57 9.48 4.46 5.00
198 INT74531 Regulation of PDGFB 14 0.26 7.57 4.38 5.00
199 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1 5.00
200 INT123752 Regulation of Bax 19 0.60 16.45 4 5.00
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