D:Ependymoma

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Disease Term
Synonyms ANAPLASTIC EPENDYMOMA, Anaplastic Ependymomas, Cellular Ependymoma, Cellular Ependymomas, CLEAR CELL EPENDYMOMA, Clear Cell Ependymomas, Ependymoma Anaplastic, EPENDYMOMA CELLULAR, Ependymoma Clear Cell, Ependymoma Myxopapillary, Ependymoma Papillary
Documents 229
Hot Single Events 37
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ependymoma. They are ordered first by their relevance to Ependymoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252851 Binding of GFAP and Ema 1 0.05 1.98 0 98.42
2 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0 65.48
3 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0 65.12
4 INT239559 MSC Regulation of Gene_expression of BDNF 1 0.05 1 0.09 5.00
5 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09 5.00
6 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05 5.00
7 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05 5.00
8 INT352623 Tpt1 Regulation of Olig2 1 0.02 0.54 0.05 5.00
9 INT352622 Olig2 Negative_regulation of Tpt1 1 0.06 0.54 0.05 5.00
10 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04 5.00
11 INT239560 MSC Regulation of Gene_expression of IFN1@ 1 0.11 0.87 0.04 5.00
12 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04 5.00
13 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04 5.00
14 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03 5.00
15 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0 5.00
16 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0 5.00
17 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0 5.00
18 INT352620 Gnb5 Positive_regulation of Gene_expression of Myc 1 0.01 1.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ependymoma. They are ordered first by their pain relevance and then by number of times they were reported in Ependymoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT105761 Binding of GFAP 13 0.36 14.94 2.32 99.98
2 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 99.88
3 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 99.84
4 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 99.84
5 INT132194 Positive_regulation of Gene_expression of KRT7 5 0.58 4.18 0.14 99.84
6 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 99.84
7 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 99.62
8 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 99.62
9 INT83375 Gene_expression of CALM3 3 0.58 1.57 0.78 99.44
10 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.18
11 INT67098 Regulation of MIB1 3 0.24 4.23 0.42 99.00
12 INT15753 Negative_regulation of Ema 6 0.37 5.04 1.17 98.72
13 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 98.72
14 INT95693 Negative_regulation of SLC4A1 4 0.41 2.46 0.38 98.72
15 INT252844 Negative_regulation of Localization of Ema 1 0.05 1.71 0 98.68
16 INT252845 Localization of Ema 1 0.08 1.7 0 98.68
17 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 98.44
18 INT259041 Binding of D18Tlj1e 1 0.03 1.98 0.57 98.40
19 INT150208 Positive_regulation of RBFOX3 3 0.49 0.95 0.12 97.92
20 INT122813 Binding of Krt20 11 0.32 13.77 0.88 97.60
21 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 97.56
22 INT61948 Positive_regulation of FYN 4 0.45 2.49 1.19 97.20
23 INT117660 Gene_expression of Prom1 50 0.73 39.62 3.07 96.84
24 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 96.56
25 INT98205 Gene_expression of PCBD1 10 0.61 14.78 7.27 95.92
26 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 95.28
27 INT150207 Positive_regulation of NES 3 0.34 2.06 0.08 89.68
28 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 89.04
29 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 88.44
30 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 88.24
31 INT179888 Localization of KRT7 3 0.39 2.85 0.22 88.12
32 INT252846 Localization of SLC4A1 2 0.73 1.08 0.09 88.12
33 INT129771 Regulation of SMARCB1 5 0.58 8.92 0.58 87.52
34 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 85.36
35 INT8159 Binding of ELL 7 0.36 12.62 0.84 83.24
36 INT351538 Binding of Prom1 8 0.38 4.44 0.49 83.04
37 INT73627 Binding of Fap 8 0.36 11.14 0.4 80.96
38 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 79.04
39 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 77.96
40 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 75.12
41 INT80025 Positive_regulation of MIB1 5 0.40 5.41 0.64 75.00
42 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 75.00
43 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 75.00
44 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 75.00
45 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 75.00
46 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 74.32
47 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 70.84
48 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 70.32
49 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0 70.32
50 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 70.32
51 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 68.48
52 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 67.44
53 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13 66.80
54 INT51066 Binding of S100B 24 0.48 13.5 0.97 66.00
55 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 65.36
56 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 62.72
57 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29 62.52
58 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 62.12
59 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 60.48
60 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 60.48
61 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 59.72
62 INT35103 Positive_regulation of Positive_regulation of SLC17A5 5 0.12 7.51 1.25 59.72
63 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 54.24
64 INT35407 Positive_regulation of C2 25 0.69 7.74 2.59 50.00
65 INT159557 Localization of Fes 1 0.10 0 0 50.00
66 INT159558 Negative_regulation of Fes 1 0.06 0 0 50.00
67 INT68367 Negative_regulation of PCBD1 4 0.59 2.8 2.42 44.32
68 INT172953 Binding of Trp53 33 0.37 20.76 1.41 43.64
69 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 37.60
70 INT171716 Regulation of Fap 4 0.27 4.05 0.23 34.24
71 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 29.60
72 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 28.56
73 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 27.60
74 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 27.16
75 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 25.00
76 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 24.16
77 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 23.68
78 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 23.04
79 INT323078 Negative_regulation of Phosphorylation of SERPINA5 1 0.23 1.05 0 22.48
80 INT132885 Regulation of SYP 4 0.44 3.92 0.44 21.04
81 INT323079 Phosphorylation of SERPINA5 1 0.44 1.04 0 20.08
82 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41 18.32
83 INT142435 Gene_expression of NES 86 0.78 47.53 4.92 14.64
84 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 12.48
85 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61 8.24
86 INT201140 Transcription of Sox2 4 0.67 1.31 0.1 8.24
87 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 8.16
88 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 6.64
89 INT2223 Gene_expression of Fank1 3 0.02 0.81 0.1 5.44
90 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
91 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
92 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
93 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
94 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
95 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
96 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
97 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
98 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
99 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
100 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
101 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
102 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
103 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
104 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
105 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
106 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
107 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
108 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
109 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
110 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
111 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
112 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
113 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
114 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
115 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
116 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
117 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
118 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
119 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
120 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
121 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
122 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
123 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
124 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
125 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
126 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
127 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
128 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 5.00
129 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
130 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
131 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 5.00
132 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
133 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
134 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
135 INT28122 Gene_expression of MSC 111 0.58 26.83 6.57 5.00
136 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
137 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
138 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
139 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
140 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
141 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
142 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
143 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73 5.00
144 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
145 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
146 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29 5.00
147 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
148 INT9144 Localization of MSC 18 0.56 10.17 3.69 5.00
149 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19 5.00
150 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
151 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08 5.00
152 INT154334 Localization of S100A12 9 0.80 9.32 2.89 5.00
153 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
154 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8 5.00
155 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
156 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 5.00
157 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59 5.00
158 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
159 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
160 INT48664 Negative_regulation of Gene_expression of GFAP 11 0.57 5.05 2.47 5.00
161 INT60765 Gene_expression of LAMB2 28 0.49 13.93 2.38 5.00
162 INT313711 Gene_expression of Pet1 4 0.76 1.91 2.29 5.00
163 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
164 INT132383 Gene_expression of Olig2 16 0.75 5.46 2.07 5.00
165 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06 5.00
166 INT47628 Regulation of CEL 9 0.60 4.5 1.85 5.00
167 INT5331 Positive_regulation of Gene_expression of NPEPPS 6 0.49 3.74 1.81 5.00
168 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
169 INT174656 Binding of NCF1 5 0.37 6.46 1.65 5.00
170 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
171 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
172 INT28123 Positive_regulation of Gene_expression of MSC 17 0.43 4.02 1.54 5.00
173 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 5.00
174 INT75694 Regulation of Gene_expression of CEL 9 0.60 6.08 1.53 5.00
175 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 5.00
176 INT228249 Binding of Pten 7 0.48 3.26 1.45 5.00
177 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 5.00
178 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 5.00
179 INT45155 Negative_regulation of Polymerase 18 0.51 15.18 1.38 5.00
180 INT21581 Gene_expression of IL4I1 9 0.24 4.21 1.37 5.00
181 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
182 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 5.00
183 INT44529 Positive_regulation of Pdgfb 11 0.43 7.98 1.36 5.00
184 INT242902 Gene_expression of NCF1 12 0.78 9.34 1.36 5.00
185 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
186 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
187 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
188 INT160606 Localization of AFP 6 0.74 3.39 1.29 5.00
189 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 5.00
190 INT48192 Gene_expression of Setd1a 8 0.42 4.41 1.26 5.00
191 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
192 INT154333 Positive_regulation of Localization of S100A12 4 0.69 3.9 1.19 5.00
193 INT70886 Positive_regulation of Gene_expression of Pdgfb 13 0.45 12.57 1.17 5.00
194 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 5.00
195 INT190031 Binding of Scrib 19 0.36 21.9 1.01 5.00
196 INT156326 Positive_regulation of SMARCB1 20 0.67 8.77 0.97 5.00
197 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.00
198 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
199 INT203739 Negative_regulation of NCF1 2 0.27 1.22 0.82 5.00
200 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 5.00
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