D:Epidermolysis Bullosa Acquisita

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Disease Term
Synonyms Acquired Epidermolysis Bullosa, EPIDERMOLYSIS BULLOSA ACQUIRED
Documents 8
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Epidermolysis Bullosa Acquisita. They are ordered first by their relevance to Epidermolysis Bullosa Acquisita and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT235008 Binding of DSG1 and Dsg3 1 0.11 4.82 0 79.84
2 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26 5.00
3 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26 5.00
4 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2 5.00
5 INT235014 Car2 Positive_regulation of DSP 1 0.06 0.28 0.2 5.00
6 INT234968 IgG Negative_regulation of Jup 1 0.02 1.09 0.06 5.00
7 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05 5.00
8 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05 5.00
9 INT234990 Binding of Cish and Dsp 1 0.01 0.24 0.04 5.00
10 INT235003 Binding of NKS1 and Rdh2 1 0.00 0.18 0.04 5.00
11 INT234986 Binding of Rdh2 and Dsp 1 0.00 0.24 0.04 5.00
12 INT234994 Binding of NKS1 and Dsg3 1 0.00 0.5 0.04 5.00
13 INT235012 Binding of NKS1 and Dsp 1 0.00 0.24 0.04 5.00
14 INT234998 Binding of NKS1 and Cish 1 0.00 0.18 0.04 5.00
15 INT234991 Binding of Dsg3 and Positive_regulation of Pik3r1 1 0.05 0.32 0.03 5.00
16 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03 5.00
17 INT234984 Binding of Dsg3 and Positive_regulation of Akt1 1 0.03 0.32 0.03 5.00
18 INT234978 Binding of Dsg3 and Positive_regulation of Inppl1 1 0.00 0.32 0.03 5.00
19 INT234975 Binding of Dsg3 and Negative_regulation of Gsk3a 1 0.03 0.3 0.03 5.00
20 INT235004 Binding of PKP1 and Dsp 1 0.00 0.14 0 5.00
21 INT234995 Binding of CDH16 and Jup 1 0.00 0.27 0 5.00
22 INT234972 IgG Positive_regulation of Gene_expression of Dsg3 1 0.05 0.8 0 5.00
23 INT235002 Negative_regulation of Binding of DSG1 and Dsg3 1 0.13 1.08 0 5.00
24 INT235011 Ctnnd1 Positive_regulation of RAC1 1 0.00 0.07 0 5.00
25 INT234969 Jup Regulation of Gene_expression of Dsp 1 0.01 0.54 0 5.00
26 INT235007 Binding of DSG1 and Jup 1 0.08 0.36 0 5.00
27 INT234996 Ctnnd1 Positive_regulation of CDC42 1 0.01 0.07 0 5.00
28 INT235005 Positive_regulation of Binding of DSG1 and Jup 1 0.08 0.36 0 5.00
29 INT234985 Binding of Dsg3 and Pitx3 1 0.00 0.3 0 5.00
30 INT234979 IgG Negative_regulation of Binding of Dsg3 1 0.06 1.59 0 5.00
31 INT234983 IgG Positive_regulation of Protein_catabolism of Jup 1 0.03 0.61 0 5.00
32 INT234970 Binding of Jup and Lat 1 0.01 0 0 5.00
33 INT235019 Binding of DSC1 and DSP 1 0.39 0.07 0 5.00
34 INT235018 Binding of DSP and GOPC 1 0.02 0.19 0 5.00
35 INT234997 Binding of DSG1 and Car2 1 0.03 0.1 0 5.00
36 INT235000 IgG Negative_regulation of DSG1 1 0.04 0.86 0 5.00
37 INT234987 Binding of Jup and Dsp 1 0.01 0.18 0 5.00
38 INT234999 IgG Positive_regulation of Gene_expression of DSG1 1 0.05 0.8 0 5.00
39 INT235015 Binding of DSP and Dsp 1 0.02 0.25 0 5.00
40 INT192044 Binding of DSP and Jup 2 0.24 2.39 0 5.00
41 INT234974 Binding of Lat and Dsp 1 0.00 0 0 5.00
42 INT234988 Negative_regulation of Binding of Dsg3 and IgG 1 0.04 0.83 0 5.00
43 INT234989 IgG Positive_regulation of Positive_regulation of Car2 1 0.01 0.98 0 5.00
44 INT234993 Binding of Car2 and Dsp 1 0.00 0 0 5.00
45 INT234966 Phosphorylation of Jup Regulation of Binding of DSP and Jup 1 0.03 0.49 0 5.00
46 INT234982 Binding of Jup and Pkp1 1 0.00 0 0 5.00
47 INT235001 Binding of PKP1 and Sergef 1 0.01 0.06 0 5.00
48 INT235021 PKP1 Regulation of CDC42EP5 1 0.00 0.06 0 5.00
49 INT234967 Binding of Dsg3 and IgG 1 0.03 0.83 0 5.00
50 INT235016 IgG Negative_regulation of Binding of DSG1 1 0.04 2.89 0 5.00
51 INT235009 Binding of DSG1 and Cdh1 1 0.02 0.87 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Epidermolysis Bullosa Acquisita. They are ordered first by their pain relevance and then by number of times they were reported in Epidermolysis Bullosa Acquisita. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT17646 Gene_expression of HSPA8 8 0.77 6.75 0.64 98.76
2 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 98.12
3 INT234954 Negative_regulation of DSG1 22 0.42 19.5 0.62 85.04
4 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 65.12
5 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 65.12
6 INT140647 Gene_expression of DSG1 45 0.75 27.95 1.33 43.64
7 INT234857 Gene_expression of Dsg3 42 0.78 27.75 0.14 43.24
8 INT234930 Binding of Dsg3 25 0.48 20.73 0.44 33.08
9 INT9205 Binding of DSP 12 0.44 9.9 1.21 8.32
10 INT221859 Binding of Jup 2 0.14 2.21 0 7.80
11 INT234858 Binding of Cdh1 11 0.47 4.58 0.22 7.16
12 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
13 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
14 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
15 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
16 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
17 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
18 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
19 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
20 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
21 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
22 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
23 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
24 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
25 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
26 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 5.00
27 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
28 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
29 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
30 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
31 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
32 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 5.00
33 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
34 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
35 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
36 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
37 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15 5.00
38 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
39 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
40 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32 5.00
41 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
42 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64 5.00
43 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
44 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
45 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
46 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
47 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 5.00
48 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 5.00
49 INT29556 Negative_regulation of CALM1 26 0.57 9.08 6.04 5.00
50 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 5.00
51 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 5.00
52 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56 5.00
53 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
54 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 5.00
55 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
56 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06 5.00
57 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53 5.00
58 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
59 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 5.00
60 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96 5.00
61 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75 5.00
62 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11 5.00
63 INT1653 Positive_regulation of DSP 8 0.49 3.3 2.93 5.00
64 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61 5.00
65 INT97748 Positive_regulation of BCL2L1 12 0.67 9.83 2.26 5.00
66 INT92316 Gene_expression of Plaur 30 0.61 22.06 2.21 5.00
67 INT102752 Positive_regulation of Gene_expression of BCL2L1 14 0.67 13.8 2.19 5.00
68 INT152771 Gene_expression of TJP1 19 0.75 14.95 1.98 5.00
69 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85 5.00
70 INT62692 Localization of Nanog 3 0.73 0.82 1.85 5.00
71 INT40322 Binding of Pnp 12 0.38 11.13 1.78 5.00
72 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66 5.00
73 INT146566 Transcription of Car2 8 0.56 1.51 1.6 5.00
74 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4 5.00
75 INT41381 Positive_regulation of Gene_expression of Plg 8 0.44 3.29 1.3 5.00
76 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22 5.00
77 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19 5.00
78 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 5.00
79 INT154057 Gene_expression of Ear1 14 0.41 9.72 1.12 5.00
80 INT140052 Binding of Cish 12 0.39 1.63 1.1 5.00
81 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07 5.00
82 INT71498 Binding of Hspb1 7 0.42 7.38 1.05 5.00
83 INT101889 Negative_regulation of DSP 3 0.42 1.61 1.05 5.00
84 INT234952 Protein_catabolism of DSG1 3 0.96 5.86 0.98 5.00
85 INT95577 Gene_expression of Afm 2 0.20 1.76 0.97 5.00
86 INT178391 Localization of Mapk14 9 0.68 5.27 0.97 5.00
87 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96 5.00
88 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
89 INT80498 Gene_expression of DSP 15 0.75 7.06 0.79 5.00
90 INT131286 Binding of Egfr 26 0.44 13.58 0.78 5.00
91 INT234950 Binding of DSG1 29 0.36 23.67 0.69 5.00
92 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67 5.00
93 INT234928 Phosphorylation of Hspb1 3 0.72 17.04 0.65 5.00
94 INT19606 Negative_regulation of Ear1 3 0.22 3.25 0.61 5.00
95 INT200797 Positive_regulation of Ptprv 4 0.14 3.19 0.58 5.00
96 INT73524 Positive_regulation of Ear1 7 0.27 4.82 0.54 5.00
97 INT234872 Phosphorylation of Hspb2 4 0.24 3.12 0.49 5.00
98 INT172558 Positive_regulation of Cdh1 11 0.49 8.92 0.42 5.00
99 INT51148 Gene_expression of CDH16 6 0.34 2.42 0.42 5.00
100 INT234876 Negative_regulation of Dsg3 29 0.59 25.47 0.4 5.00
101 INT90354 Negative_regulation of Myc 6 0.57 4.24 0.4 5.00
102 INT234864 Gene_expression of Dsp 30 0.47 17.72 0.37 5.00
103 INT151662 Negative_regulation of Gsk3a 3 0.15 0.55 0.37 5.00
104 INT234962 Positive_regulation of Gene_expression of DSG1 5 0.48 5.41 0.37 5.00
105 INT226835 Gene_expression of Cdh2 14 0.22 8.04 0.31 5.00
106 INT234949 Phosphorylation of CTNND1 1 0.61 1.9 0.28 5.00
107 INT221860 Negative_regulation of Jup 9 0.15 6.82 0.26 5.00
108 INT234865 Binding of Dsp 1 0.02 2.48 0.25 5.00
109 INT106733 Regulation of CDK2 6 0.44 4.76 0.23 5.00
110 INT102071 Negative_regulation of Gene_expression of Myc 8 0.57 3.5 0.22 5.00
111 INT161779 Positive_regulation of Gene_expression of Ear1 3 0.27 1.91 0.22 5.00
112 INT234855 Localization of Dsp 1 0.03 1.65 0.22 5.00
113 INT186734 Protein_catabolism of IgG 3 0.26 2.36 0.21 5.00
114 INT234933 Gene_expression of Dsg2 3 0.71 38.52 0.2 5.00
115 INT234903 Gene_expression of Jup 1 0.23 7.1 0.2 5.00
116 INT234908 Negative_regulation of Binding of Dsg3 1 0.31 7.18 0.19 5.00
117 INT234925 Positive_regulation of Phosphorylation of Hspb2 1 0.11 3.52 0.19 5.00
118 INT164682 Gene_expression of PKP1 3 0.78 3.04 0.17 5.00
119 INT234929 Negative_regulation of Negative_regulation of Dsg3 1 0.31 3.12 0.16 5.00
120 INT211098 Negative_regulation of Msra 1 0.01 1.36 0.16 5.00
121 INT234895 Positive_regulation of Binding of Dsp 1 0.02 0.13 0.15 5.00
122 INT84750 Negative_regulation of Gene_expression of DSP 2 0.42 0.41 0.11 5.00
123 INT234888 Binding of Dsg2 9 0.34 11.73 0.11 5.00
124 INT234869 Negative_regulation of Binding of Dsg2 1 0.12 5.34 0.11 5.00
125 INT234958 Gene_expression of DSC3 1 0.10 2.75 0.11 5.00
126 INT234909 Phosphorylation of Dnajc27 1 0.01 1.47 0.11 5.00
127 INT228409 Localization of DSP 5 0.73 2.39 0.11 5.00
128 INT234932 Negative_regulation of Phosphorylation of Hspb2 1 0.09 1.43 0.1 5.00
129 INT234907 Protein_catabolism of Dsg2 1 0.13 1.82 0.1 5.00
130 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09 5.00
131 INT234917 Negative_regulation of Gene_expression of Dsg3 1 0.31 3.16 0.09 5.00
132 INT231161 Gene_expression of Vcl 3 0.26 0.77 0.08 5.00
133 INT234922 Negative_regulation of Dsp 1 0.02 6.01 0.08 5.00
134 INT234894 Negative_regulation of Protein_catabolism of Jup 1 0.17 2.87 0.08 5.00
135 INT234887 Positive_regulation of Binding of Dsg3 1 0.26 0.8 0.08 5.00
136 INT211097 Negative_regulation of Binding of Pnp 1 0.08 1.27 0.08 5.00
137 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08 5.00
138 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08 5.00
139 INT234955 Positive_regulation of Gene_expression of DSC3 1 0.06 0.1 0.07 5.00
140 INT178721 Positive_regulation of DSG1 2 0.34 0.1 0.06 5.00
141 INT234866 Regulation of Jup 2 0.08 0.58 0.06 5.00
142 INT234899 Positive_regulation of Protein_catabolism of Jup 1 0.21 0.88 0.06 5.00
143 INT17893 Positive_regulation of Myc 4 0.67 3.28 0.06 5.00
144 INT234931 Protein_catabolism of Jup 1 0.29 2.23 0.06 5.00
145 INT234915 Positive_regulation of Gene_expression of Jup 1 0.15 2.7 0.06 5.00
146 INT234959 Negative_regulation of DSC3 1 0.05 0.14 0.05 5.00
147 INT232850 Phosphorylation of Krt8 7 0.52 3.8 0.05 5.00
148 INT234920 Negative_regulation of Positive_regulation of IgG 3 0.16 2.17 0.04 5.00
149 INT234905 Positive_regulation of Dsg3 1 0.26 0.73 0.04 5.00
150 INT234919 Negative_regulation of Dsg2 5 0.39 6.76 0.04 5.00
151 INT234884 Negative_regulation of Binding of Dsp 1 0.03 1.49 0.04 5.00
152 INT234961 Binding of NKS1 1 0.01 0.5 0.04 5.00
153 INT201426 Phosphorylation of IgG 2 0.10 0.56 0.04 5.00
154 INT234951 Negative_regulation of Binding of DSG1 1 0.29 11.2 0.03 5.00
155 INT234890 Phosphorylation of Jup 1 0.24 1.56 0.03 5.00
156 INT234880 Regulation of Gene_expression of Dsp 1 0.02 4.75 0.03 5.00
157 INT234867 Localization of Jup 1 0.24 2.84 0.03 5.00
158 INT234898 Negative_regulation of Gene_expression of Dsp 1 0.02 3.92 0.03 5.00
159 INT234944 Positive_regulation of Binding of DSG1 1 0.23 0.84 0 5.00
160 INT234860 Protein_catabolism of Dsg3 1 0.52 0.85 0 5.00
161 INT234936 Regulation of CCND2 1 0.04 1.15 0 5.00
162 INT234927 Positive_regulation of Protein_catabolism of Dsg3 1 0.36 0.25 0 5.00
163 INT234859 Negative_regulation of Positive_regulation of Dsp 1 0.02 0.85 0 5.00
164 INT234886 Regulation of Dsg2 1 0.09 0.67 0 5.00
165 INT234912 Protein_catabolism of Dsp 1 0.05 2.04 0 5.00
166 INT211096 Positive_regulation of Tpmt 1 0.30 0.21 0 5.00
167 INT234885 Localization of Dsg3 1 0.39 0.33 0 5.00
168 INT234856 Localization of Dsc2 1 0.21 1.28 0 5.00
169 INT175216 Negative_regulation of Binding of GOPC 5 0.10 2.05 0 5.00
170 INT234923 Binding of Dsc2 2 0.34 1.8 0 5.00
171 INT234956 Localization of PKP1 1 0.14 0.2 0 5.00
172 INT234901 Positive_regulation of Gene_expression of Dsg3 1 0.36 1.94 0 5.00
173 INT234877 Positive_regulation of Binding of Jup 1 0.21 0.24 0 5.00
174 INT234916 Gene_expression of Lef1 1 0.04 0.25 0 5.00
175 INT199086 Binding of Sergef 2 0.08 0.28 0 5.00
176 INT89582 Binding of PKP1 3 0.36 0.85 0 5.00
177 INT234939 Positive_regulation of Negative_regulation of DSG1 1 0.23 0.74 0 5.00
178 INT234945 Negative_regulation of PKP3 1 0.04 1.22 0 5.00
179 INT234938 Regulation of Negative_regulation of DSG1 1 0.22 1.21 0 5.00
180 INT234941 Gene_expression of DSC1 1 0.28 0.67 0 5.00
181 INT234942 Negative_regulation of CDH16 1 0.01 1.14 0 5.00
182 INT234879 Binding of Pitx3 2 0.11 1.21 0 5.00
183 INT234948 Negative_regulation of DSC1 1 0.07 0.07 0 5.00
184 INT234868 Regulation of Dsp 1 0.02 0.83 0 5.00
185 INT234957 Positive_regulation of Phosphorylation of DSG1 1 0.34 0.53 0 5.00
186 INT234914 Localization of Pkp2 1 0.06 1.47 0 5.00
187 INT234873 Regulation of Dsc2 1 0.08 1.2 0 5.00
188 INT234940 Regulation of DSG1 2 0.21 2.29 0 5.00
189 INT234883 Regulation of Pkp2 1 0.02 1.2 0 5.00
190 INT234892 Gene_expression of Pkp2 1 0.06 0.41 0 5.00
191 INT234870 Binding of Pkp1 1 0.01 0 0 5.00
192 INT234918 Positive_regulation of Jup 1 0.15 1.08 0 5.00
193 INT234910 Positive_regulation of Phosphorylation of Dsg3 1 0.26 0.37 0 5.00
194 INT234861 Binding of Pkp2 1 0.03 1.2 0 5.00
195 INT232851 Positive_regulation of Phosphorylation of Krt8 1 0.32 0.47 0 5.00
196 INT98696 Regulation of Dsg3 4 0.45 5.45 0 5.00
197 INT234862 Gene_expression of Dsc2 8 0.70 3.29 0 5.00
198 INT234913 Regulation of Negative_regulation of Dsg2 1 0.09 1.11 0 5.00
199 INT234881 Negative_regulation of Dsc2 1 0.12 1.21 0 5.00
200 INT234937 Localization of DSG1 5 0.66 4.14 0 5.00
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