D:Epidermolysis Bullosa Simplex

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Disease Term
Synonyms Epidermolysis Bullosa Herpetiformis Dowling Meara, Epidermolysis Bullosa Simplex Generalized, Epidermolysis Bullosa Simplex Kobner, Epidermolysis Bullosa Simplex Localized, Weber Cockayne Syndrome
Documents 17
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Epidermolysis Bullosa Simplex. They are ordered first by their relevance to Epidermolysis Bullosa Simplex and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT232897 Binding of Rab27a and SAMSN1 1 0.00 0.73 0.08 5.00
2 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
3 INT232902 Binding of YWHAQ and Krt18 1 0.34 0.96 0.07 5.00
4 INT232901 Regulation of Binding of YWHAQ and Krt18 1 0.41 0.96 0.07 5.00
5 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
6 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
7 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
8 INT248493 Pdss1 Positive_regulation of Gene_expression of Smn1 1 0.16 0.4 0.03 5.00
9 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03 5.00
10 INT248497 Positive_regulation of Upf1 Positive_regulation of Pdss1 1 0.01 0.15 0 5.00
11 INT248494 Upf1 Positive_regulation of Pdss1 1 0.01 0.15 0 5.00
12 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
13 INT248501 Binding of Upf1 and Pdss1 1 0.01 0.21 0 5.00
14 INT232890 Binding of Rab27a and Gopc 1 0.01 0.3 0 5.00
15 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0 5.00
16 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0 5.00
17 INT248491 Binding of Smn1 and Pdss1 1 0.12 0.21 0 5.00
18 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0 5.00
19 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
20 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
21 INT248495 Pdss1 Positive_regulation of Smn1 1 0.13 0.25 0 5.00
22 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
23 INT248496 Smn1 Positive_regulation of Gene_expression of Snrpn 1 0.16 0.09 0 5.00
24 INT248499 Smn1 Regulation of Snrpn 1 0.15 0.06 0 5.00
25 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
26 INT248492 Upf1 Positive_regulation of Smn1 1 0.03 0.15 0 5.00
27 INT232898 Binding of KRT1 and Krt8 1 0.27 1.22 0 5.00
28 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
29 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0 5.00
30 INT232892 Krt18 Positive_regulation of Gene_expression of Krt8 1 0.30 0.09 0 5.00
31 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
32 INT232889 Binding of Krt18 and Krt8 1 0.22 1.09 0 5.00
33 INT248500 Positive_regulation of Upf1 Positive_regulation of Smn1 1 0.03 0.15 0 5.00
34 INT248498 Smn1 Positive_regulation of Pdss1 1 0.16 0.09 0 5.00
35 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
36 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00
37 INT232894 Binding of ABR and Rab27a 1 0.08 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Epidermolysis Bullosa Simplex. They are ordered first by their pain relevance and then by number of times they were reported in Epidermolysis Bullosa Simplex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT35558 Binding of Sts 4 0.32 3.76 0.48 100.00
2 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 98.92
3 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 98.92
4 INT164683 Negative_regulation of Gene_expression of PKP1 1 0.59 1.5 0.17 93.96
5 INT164682 Gene_expression of PKP1 3 0.78 3.04 0.17 93.64
6 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 93.52
7 INT164348 Positive_regulation of KRT14 5 0.49 2 0.08 92.20
8 INT232969 Positive_regulation of KRT5 1 0.27 1.24 0 91.88
9 INT70450 Binding of KRT5 6 0.47 5.72 0.08 79.44
10 INT248468 Negative_regulation of Smn1 6 0.39 5.55 0.25 78.64
11 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 77.20
12 INT123303 Gene_expression of Smn1 40 0.71 15.5 1.18 68.72
13 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87 68.52
14 INT232923 Negative_regulation of Krt27 1 0.00 0.62 0 67.60
15 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 66.32
16 INT232960 Negative_regulation of Binding of KRT5 1 0.20 1.68 0 62.68
17 INT232882 Transcription of ABR 1 0.09 0.61 0 60.04
18 INT248475 Regulation of Ighmbp2 2 0.05 0.96 0.03 54.32
19 INT123305 Positive_regulation of Gene_expression of Smn1 2 0.55 2.55 0.53 49.56
20 INT232991 Localization of KRT5 1 0.33 1.36 0.04 42.92
21 INT248477 Regulation of Gene_expression of Smn1 1 0.41 2.17 0.25 40.48
22 INT136831 Gene_expression of Nodal 6 0.22 5.68 0.97 38.48
23 INT232949 Positive_regulation of KRT10 1 0.25 0.38 0 35.92
24 INT232947 Positive_regulation of RBPJP3 1 0.05 0.19 0 35.60
25 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 32.72
26 INT164684 Transcription of PKP1 1 0.69 0.75 0.13 25.00
27 INT164680 Negative_regulation of PKP1 1 0.43 0.38 0.07 25.00
28 INT164681 Transcription of PKP2 1 0.57 0.38 0.07 25.00
29 INT164685 Negative_regulation of PKP2 1 0.35 0.38 0.07 25.00
30 INT85379 Gene_expression of Pdss1 19 0.55 3.42 0.72 19.32
31 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 19.08
32 INT159519 Positive_regulation of Smn1 2 0.64 4.96 0.64 11.68
33 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06 7.92
34 INT202193 Gene_expression of Krt19 4 0.45 5.02 1.17 6.56
35 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 6.56
36 INT232826 Gene_expression of Krt18 26 0.68 14.24 0.48 6.56
37 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
38 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
39 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
40 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
41 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
42 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
43 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
44 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
45 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 5.00
46 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
47 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
48 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
49 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
50 INT75800 Gene_expression of Cyp2a5 12 0.77 5.15 5.37 5.00
51 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
52 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
53 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 5.00
54 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
55 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
56 INT232842 Gene_expression of Tnfaip8 15 0.66 5.81 2.34 5.00
57 INT95580 Positive_regulation of Afm 5 0.21 5.51 2.04 5.00
58 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 5.00
59 INT184031 Gene_expression of Cish 14 0.49 9.82 1.86 5.00
60 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85 5.00
61 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
62 INT233010 Gene_expression of PERP 5 0.26 6.04 1.66 5.00
63 INT199222 Gene_expression of SAMSN1 14 0.57 18.97 1.61 5.00
64 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 5.00
65 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
66 INT153129 Positive_regulation of Pdss1 25 0.21 5.83 1.1 5.00
67 INT127064 Gene_expression of KRT76 7 0.75 1.71 1.1 5.00
68 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 5.00
69 INT5006 Transcription of KRT20 9 0.46 7.11 1.03 5.00
70 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 5.00
71 INT17554 Regulation of ABR 6 0.54 2.21 0.98 5.00
72 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 5.00
73 INT102842 Binding of YWHAQ 6 0.47 3.48 0.86 5.00
74 INT110208 Binding of ABR 2 0.35 10.49 0.81 5.00
75 INT117120 Gene_expression of Krt14 20 0.75 6.53 0.77 5.00
76 INT127633 Localization of KRT18 5 0.52 5.93 0.75 5.00
77 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74 5.00
78 INT151525 Gene_expression of Olfr148 7 0.67 8.5 0.74 5.00
79 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71 5.00
80 INT232841 Gene_expression of Scap 11 0.02 8.68 0.7 5.00
81 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 5.00
82 INT248470 Gene_expression of Ighmbp2 5 0.75 3.32 0.68 5.00
83 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
84 INT117437 Protein_catabolism of KRT18 3 0.46 4.64 0.61 5.00
85 INT163221 Protein_catabolism of Krt18 2 0.81 2.18 0.56 5.00
86 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51 5.00
87 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
88 INT70445 Binding of KRT1 10 0.35 5.38 0.47 5.00
89 INT232886 Regulation of Gene_expression of ABR 3 0.06 1.42 0.45 5.00
90 INT232840 Positive_regulation of Gene_expression of Krt8 1 0.44 4.51 0.42 5.00
91 INT232825 Positive_regulation of Krt8 1 0.44 6.83 0.42 5.00
92 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 5.00
93 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 5.00
94 INT111822 Binding of Krt8 6 0.34 4.61 0.39 5.00
95 INT186794 Gene_expression of Gm3813 11 0.65 0.82 0.38 5.00
96 INT80543 Negative_regulation of Pdss1 4 0.42 0.95 0.36 5.00
97 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
98 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 5.00
99 INT232821 Positive_regulation of Gene_expression of Krt18 11 0.50 4.38 0.31 5.00
100 INT202195 Negative_regulation of Krt19 2 0.32 2.28 0.3 5.00
101 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 5.00
102 INT232828 Regulation of Krt18 1 0.50 2.2 0.26 5.00
103 INT232844 Localization of Krt19 1 0.42 2.63 0.24 5.00
104 INT232845 Positive_regulation of Krt18 1 0.41 4.5 0.24 5.00
105 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24 5.00
106 INT199221 Binding of SAMSN1 2 0.29 2.36 0.24 5.00
107 INT232945 Positive_regulation of Gene_expression of KRT18 2 0.49 3.54 0.23 5.00
108 INT232970 Localization of KRT19 4 0.41 3.41 0.23 5.00
109 INT232982 Localization of KRT8 2 0.44 2.65 0.23 5.00
110 INT232967 Positive_regulation of Gene_expression of KRT8 2 0.29 3.54 0.23 5.00
111 INT172442 Binding of Rab27a 3 0.37 1.5 0.21 5.00
112 INT232831 Binding of Krt18 7 0.39 4.61 0.21 5.00
113 INT232824 Regulation of Krt8 1 0.29 1.64 0.21 5.00
114 INT232944 Transcription of KRT75 1 0.43 0.59 0.18 5.00
115 INT232962 Binding of KRT18 4 0.26 2.38 0.18 5.00
116 INT217463 Positive_regulation of Nup62 5 0.39 1.79 0.17 5.00
117 INT232989 Gene_expression of KRT71 1 0.46 0.45 0.17 5.00
118 INT232887 Binding of MBTPS2 2 0.23 0.99 0.16 5.00
119 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16 5.00
120 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 5.00
121 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15 5.00
122 INT248488 Transcription of Smn1 1 0.55 0.64 0.14 5.00
123 INT232877 Negative_regulation of Binding of ABR 1 0.06 1.88 0.14 5.00
124 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13 5.00
125 INT232880 Phosphorylation of ABR 1 0.79 0.76 0.13 5.00
126 INT232875 Negative_regulation of Phosphorylation of ABR 1 0.41 0.76 0.13 5.00
127 INT232955 Gene_expression of KRT38 1 0.47 0.12 0.13 5.00
128 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 5.00
129 INT232987 Gene_expression of KRT85 1 0.10 1.2 0.11 5.00
130 INT233008 Gene_expression of KRT75 1 0.56 1.07 0.11 5.00
131 INT217454 Positive_regulation of Gene_expression of Nup62 2 0.39 1.56 0.11 5.00
132 INT232829 Positive_regulation of Scap 6 0.02 2.97 0.11 5.00
133 INT232951 Gene_expression of KRT81 1 0.39 0.31 0.11 5.00
134 INT25530 Positive_regulation of ABR 3 0.33 0.34 0.1 5.00
135 INT233005 Gene_expression of CAPN9 1 0.02 1.76 0.1 5.00
136 INT233003 Negative_regulation of Gene_expression of KRT17 1 0.25 2.13 0.1 5.00
137 INT145490 Binding of KRT76 2 0.36 0.29 0.09 5.00
138 INT232839 Phosphorylation of Krt18 1 0.67 1.78 0.09 5.00
139 INT232848 Negative_regulation of Gene_expression of Krt18 5 0.36 2.3 0.08 5.00
140 INT232822 Negative_regulation of Gene_expression of Krt8 5 0.36 2.3 0.08 5.00
141 INT232996 Gene_expression of KRT27 1 0.44 0 0.07 5.00
142 INT232883 Regulation of Binding of YWHAQ 1 0.26 0.95 0.07 5.00
143 INT224981 Gene_expression of Snrpn 6 0.70 3 0.07 5.00
144 INT221377 Localization of Krt18 4 0.61 1.82 0.07 5.00
145 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07 5.00
146 INT232885 Positive_regulation of Binding of ABR 1 0.07 0.5 0.07 5.00
147 INT248484 Positive_regulation of Gene_expression of Pdss1 1 0.15 0.31 0.07 5.00
148 INT232974 Gene_expression of KRT25 1 0.36 0 0.06 5.00
149 INT190034 Transcription of Ighmbp2 3 0.07 0.95 0.06 5.00
150 INT248483 Positive_regulation of Snrpn 1 0.14 0.56 0.06 5.00
151 INT230117 Binding of KRT8 6 0.31 2.44 0.05 5.00
152 INT232981 Positive_regulation of Gene_expression of KRT17 1 0.25 1.06 0.05 5.00
153 INT232972 Gene_expression of KRT34 1 0.30 0 0.05 5.00
154 INT232850 Phosphorylation of Krt8 7 0.52 3.8 0.05 5.00
155 INT232971 Negative_regulation of KRT17 1 0.22 0.45 0.05 5.00
156 INT175895 Negative_regulation of KRT1 5 0.37 3.23 0.05 5.00
157 INT232957 Binding of KRT19 3 0.23 0.97 0.05 5.00
158 INT232984 Gene_expression of KRT36 1 0.14 0 0.05 5.00
159 INT232833 Positive_regulation of Gene_expression of Cyp2a5 2 0.38 0.79 0.04 5.00
160 INT232986 Negative_regulation of KRT81 1 0.18 0 0.04 5.00
161 INT232952 Gene_expression of KRT40 1 0.27 0 0.04 5.00
162 INT232920 Regulation of Gene_expression of Krt27 1 0.00 0.11 0.04 5.00
163 INT232919 Gene_expression of Krt27 1 0.01 0.11 0.04 5.00
164 INT233000 Negative_regulation of KRT86 1 0.23 0 0.04 5.00
165 INT233006 Binding of KRT17 1 0.28 0.8 0.04 5.00
166 INT232994 Gene_expression of KRT10 6 0.40 8.2 0.03 5.00
167 INT232999 Positive_regulation of Localization of KRT16 1 0.32 0.37 0 5.00
168 INT233002 Binding of KRT2 1 0.29 0 0 5.00
169 INT232953 Binding of RBPJP3 1 0.03 0.26 0 5.00
170 INT248482 Localization of Smn1 1 0.69 0.5 0 5.00
171 INT233004 Localization of KRT17 1 0.36 0.19 0 5.00
172 INT232819 Binding of Grap2 2 0.24 0.42 0 5.00
173 INT248481 Positive_regulation of pMU3 1 0.02 0.08 0 5.00
174 INT248466 Regulation of Localization of Pdss1 1 0.14 0.57 0 5.00
175 INT232978 Localization of KRT4 1 0.35 0.2 0 5.00
176 INT232948 Positive_regulation of Phosphorylation of KRT20 1 0.41 0.67 0 5.00
177 INT248476 Localization of Pdss1 1 0.23 0.85 0 5.00
178 INT232879 Protein_catabolism of KRT1 1 0.64 0.92 0 5.00
179 INT232832 Localization of Krt8 1 0.48 0.84 0 5.00
180 INT232975 Binding of KRT9 2 0.14 0.8 0 5.00
181 INT225958 Gene_expression of KRT12 13 0.68 1.57 0 5.00
182 INT248478 Negative_regulation of Gene_expression of Smn1 1 0.39 0.14 0 5.00
183 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
184 INT232847 Negative_regulation of Protein_catabolism of Krt8 1 0.33 0.13 0 5.00
185 INT232990 Localization of KRT6A 1 0.43 0.37 0 5.00
186 INT232922 Gene_expression of Krt71 1 0.65 0 0 5.00
187 INT232820 Protein_catabolism of Krt8 1 0.55 0.13 0 5.00
188 INT232827 Negative_regulation of Scap 1 0.01 0.57 0 5.00
189 INT248479 Positive_regulation of Positive_regulation of Smn1 1 0.46 0.08 0 5.00
190 INT232983 Negative_regulation of KRT13 1 0.26 2.44 0 5.00
191 INT232881 Regulation of Binding of ABR 1 0.07 1.43 0 5.00
192 INT232997 Positive_regulation of KRT6A 1 0.40 0.82 0 5.00
193 INT248485 Positive_regulation of Gene_expression of Ighmbp2 1 0.05 0.1 0 5.00
194 INT232878 Protein_catabolism of ABR 1 0.96 0.09 0 5.00
195 INT232979 Gene_expression of RBPJP3 1 0.06 0.24 0 5.00
196 INT232843 Negative_regulation of Krt18 1 0.30 0.2 0 5.00
197 INT232985 Positive_regulation of Localization of KRT6A 1 0.29 0.37 0 5.00
198 INT232965 Binding of KRT10 3 0.19 1.66 0 5.00
199 INT233009 Binding of KRT13 1 0.16 1.13 0 5.00
200 INT232849 Negative_regulation of Phosphorylation of Krt8 1 0.27 0.24 0 5.00
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