D:Erectile Dysfunction

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Disease Term
Synonyms Dysfunction Erectile, Dysfunctions Erectile, Erectile Dysfunctions, IMPOTENCE, MALE ERECTILE DYSFUNCTION, Male Impotence, Penile Erection
Documents 199
Hot Single Events 141
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Erectile Dysfunction. They are ordered first by their relevance to Erectile Dysfunction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03 100.00
2 INT348723 ED Positive_regulation of PTEN 1 0.04 1.3 0 100.00
3 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03 89.76
4 INT252426 Binding of SLURP1 and Negative_regulation of Gene_expression of TNF 1 0.01 1.13 0.49 88.28
5 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55 87.88
6 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21 63.68
7 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 60.68
8 INT348715 Positive_regulation of Binding of Ca2 and Mylk 1 0.02 0.47 0.05 60.68
9 INT348716 Binding of Ca2 and Mylk 1 0.02 0.47 0.05 60.68
10 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64 5.00
11 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
12 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 0.32 0.42 1.07 5.00
13 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89 5.00
14 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81 5.00
15 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79 5.00
16 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77 5.00
17 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7 5.00
18 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
19 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 5.00
20 INT252425 Positive_regulation of AR Positive_regulation of Gene_expression of CXCL10 1 0.00 0.9 0.44 5.00
21 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35 5.00
22 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26 5.00
23 INT252427 IGKV2D-29 Regulation of Gene_expression of AR 1 0.02 0 0.24 5.00
24 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24 5.00
25 INT181646 interleukin-17 Positive_regulation of ISYNA1 1 0.01 0.26 0.2 5.00
26 INT181617 IL17A Positive_regulation of ISYNA1 1 0.01 0.27 0.2 5.00
27 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 5.00
28 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 5.00
29 INT341896 Oxt Regulation of Localization of POMC 1 0.07 0.91 0.19 5.00
30 INT252423 Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 5.00
31 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16 5.00
32 INT252428 Negative_regulation of Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 5.00
33 INT341895 Oxt Positive_regulation of Localization of POMC 1 0.08 0.49 0.15 5.00
34 INT327808 EPO Regulation of VEGFA 1 0.07 1.36 0.12 5.00
35 INT350164 Binding of DURS1 and ELOVL1 1 0.00 1.47 0.11 5.00
36 INT350163 Regulation of Binding of DURS1 and ELOVL1 1 0.00 1.48 0.11 5.00
37 INT341879 Oxt Negative_regulation of Positive_regulation of Hpse 1 0.01 0.83 0.11 5.00
38 INT341880 Oxt Positive_regulation of Ca2 1 0.09 0 0.1 5.00
39 INT341877 Oxtr Regulation of Ca2 1 0.08 0 0.09 5.00
40 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 5.00
41 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07 5.00
42 INT341882 Positive_regulation of Oxtr Positive_regulation of Positive_regulation of Ptgs2 1 0.02 0.11 0.05 5.00
43 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 5.00
44 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 5.00
45 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 5.00
46 INT293625 Binding of BGLAP and SHBG 1 0.03 0.1 0 5.00
47 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0 5.00
48 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Erectile Dysfunction. They are ordered first by their pain relevance and then by number of times they were reported in Erectile Dysfunction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259240 Binding of ED 2 0.32 12.98 1.04 100.00
2 INT114746 Gene_expression of Sepp1 15 0.60 3.33 1.86 100.00
3 INT259242 Gene_expression of ED 2 0.58 5.38 0.47 100.00
4 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 100.00
5 INT259241 Negative_regulation of ED 3 0.37 5.09 0.34 100.00
6 INT348711 Positive_regulation of ED 1 0.05 2.85 0.1 100.00
7 INT348712 Regulation of Binding of 1 0.02 1.92 0.07 100.00
8 INT227944 Binding of EDAR 5 0.25 2.88 0.07 100.00
9 INT119076 Positive_regulation of PEPD 3 0.63 1.15 0.52 100.00
10 INT348714 Negative_regulation of Binding of 1 0.04 0.68 0.22 100.00
11 INT83404 Positive_regulation of Gucy1b2 9 0.68 5.18 2.74 99.96
12 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87 99.84
13 INT126628 Positive_regulation of Rock2 4 0.70 3.56 0.52 99.84
14 INT6761 Binding of CALCA 100 0.48 26.71 62.05 99.84
15 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 99.84
16 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 99.80
17 INT257299 Binding of Pde5a 14 0.27 4.31 2.45 99.80
18 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 99.76
19 INT121087 Gene_expression of Pde7a 3 0.17 2.69 0.31 99.76
20 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 99.76
21 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 99.54
22 INT50328 Positive_regulation of Vgf 8 0.70 13.98 6.37 99.44
23 INT123589 Positive_regulation of Positive_regulation of Vgf 7 0.50 2.92 0.88 99.44
24 INT66424 Regulation of SLC43A3 7 0.32 2.33 2.33 99.44
25 INT50327 Negative_regulation of Vgf 2 0.43 0.48 0.33 99.28
26 INT355122 Negative_regulation of ODF3B 1 0.01 0.48 0.08 99.28
27 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18 99.22
28 INT183429 Localization of Pde5a 5 0.56 1.61 0.25 99.22
29 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 98.96
30 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 98.90
31 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 98.88
32 INT51803 Negative_regulation of Pde7a 14 0.59 14.98 4.85 98.88
33 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.84
34 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 98.84
35 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 98.82
36 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 98.68
37 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 98.48
38 INT242945 Localization of PDE5A 9 0.75 4.57 1.28 98.40
39 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 98.40
40 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.34
41 INT7786 Positive_regulation of Ptgdr 26 0.47 5.62 14.99 98.24
42 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 98.24
43 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57 98.12
44 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 97.92
45 INT817 Negative_regulation of Abp1 15 0.49 4.25 3.56 97.92
46 INT123588 Localization of Vgf 3 0.81 2.35 2.07 97.68
47 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 97.68
48 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 97.64
49 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58 97.56
50 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 97.40
51 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 97.28
52 INT876 Localization of Gh1 843 0.80 67.75 340.82 97.00
53 INT228148 Localization of Sepp1 2 0.39 0.89 0.03 96.72
54 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6 96.60
55 INT78823 Negative_regulation of SLURP1 6 0.24 2.22 1.79 96.60
56 INT261279 Localization of GNAQ 1 0.05 1.1 0 96.36
57 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97 96.32
58 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 96.32
59 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 95.96
60 INT1782 Regulation of Gh1 125 0.62 22 55.74 95.88
61 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22 95.44
62 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 95.40
63 INT1375 Negative_regulation of Pde4dl1 13 0.57 5.54 4.63 95.36
64 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 95.28
65 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 94.84
66 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 94.84
67 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 94.84
68 INT170062 Negative_regulation of Gene_expression of HBM 3 0.16 4.82 0.25 94.84
69 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 94.76
70 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 94.72
71 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 94.60
72 INT65929 Positive_regulation of Nbl1 6 0.17 1.2 3.09 94.60
73 INT72897 Regulation of Positive_regulation of Nbl1 1 0.09 0.24 0.32 94.60
74 INT95585 Negative_regulation of Pde12 18 0.43 8.32 11.23 94.60
75 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 94.56
76 INT46168 Positive_regulation of Sepp1 12 0.50 8.02 7.47 94.48
77 INT318712 Gene_expression of Sept3 2 0.34 2.2 0.35 94.40
78 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 94.36
79 INT51047 Regulation of Drd3 4 0.53 2 2.2 94.32
80 INT1613 Binding of Nts 58 0.48 10.55 28.18 94.24
81 INT199601 Positive_regulation of FGF7 9 0.50 6.13 1.22 93.84
82 INT199602 Positive_regulation of Gene_expression of FGF7 12 0.70 7.47 0.55 93.84
83 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 93.68
84 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 93.52
85 INT26281 Negative_regulation of Negative_regulation of Oxt 5 0.43 0.31 1.91 93.40
86 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 93.36
87 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 92.96
88 INT3579 Localization of Oxt 555 0.81 43.35 292.44 92.96
89 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 92.92
90 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 92.80
91 INT83374 Gene_expression of FGF7 83 0.78 44.18 2.6 92.80
92 INT117529 Negative_regulation of Pde9a 2 0.06 1.55 0.71 92.16
93 INT40343 Negative_regulation of Pde8a 2 0.46 1.11 0.6 91.68
94 INT62094 Binding of GNAQ 2 0.36 0.71 0.38 91.28
95 INT67710 Binding of Sepp1 3 0.41 1.77 1.83 91.28
96 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 91.28
97 INT21020 Localization of Rtcd1 3 0.14 0.85 0.51 91.28
98 INT118302 Positive_regulation of Localization of Rtcd1 1 0.00 0.21 0 91.28
99 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 91.12
100 INT60999 Localization of Nos3 12 0.74 5.28 1.75 91.00
101 INT84673 Localization of Nos1 19 0.80 5.01 5.62 91.00
102 INT5533 Binding of Oxt 43 0.48 8.69 18.35 90.28
103 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 90.16
104 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 90.16
105 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34 90.16
106 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74 89.88
107 INT72896 Negative_regulation of Positive_regulation of Nbl1 2 0.14 0.39 1.17 89.80
108 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 89.76
109 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 89.20
110 INT106038 Regulation of PEPD 3 0.43 3.93 1.01 88.68
111 INT52512 Positive_regulation of SLC43A3 21 0.41 5.39 5.27 88.64
112 INT216840 Binding of Adora2b 3 0.47 5.23 4.85 88.28
113 INT92186 Binding of SLURP1 13 0.36 4.21 5.77 88.28
114 INT17975 Positive_regulation of Localization of OXTR 11 0.69 1.72 3.72 88.00
115 INT129 Localization of OXTR 51 0.80 11.08 15.36 88.00
116 INT545 Binding of GC 15 0.45 10.74 3.47 87.96
117 INT261273 Negative_regulation of Pde6a 5 0.02 1.11 0.28 87.20
118 INT212562 Positive_regulation of Adrm1 16 0.10 5.08 0.62 87.16
119 INT331894 Localization of SEPT8 1 0.14 0.61 0 86.76
120 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 86.40
121 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27 86.32
122 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 85.16
123 INT99834 Gene_expression of Gucy1b2 5 0.73 1.02 1.74 84.64
124 INT121086 Gene_expression of Gucy2g 1 0.10 0.17 0.22 84.64
125 INT91045 Negative_regulation of ESRRB 2 0.35 0.45 0.18 84.24
126 INT102729 Gene_expression of APCS 20 0.65 8.86 2.52 83.84
127 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 83.68
128 INT158 Localization of Prl 2431 0.81 378.96 952.2 83.68
129 INT331893 Binding of Sept3 1 0.19 0.59 0 83.60
130 INT318710 Positive_regulation of Gene_expression of Sept3 2 0.25 3.24 0.71 83.60
131 INT37170 Binding of APCS 6 0.36 4.79 0.97 83.24
132 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 83.16
133 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 83.16
134 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 82.56
135 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 82.32
136 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29 81.84
137 INT2149 Positive_regulation of Oxt 181 0.70 24.8 85.43 81.56
138 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 80.80
139 INT331895 Gene_expression of SEPT4 1 0.27 0.57 0 80.20
140 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 80.16
141 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 80.16
142 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 79.92
143 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 79.88
144 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 79.88
145 INT124655 Negative_regulation of PECAM1 13 0.23 10.32 3.78 79.88
146 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 79.60
147 INT230374 Regulation of ARG1 2 0.60 1.94 0 79.60
148 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 79.20
149 INT123542 Regulation of Sepp1 9 0.59 0.94 1.1 78.88
150 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 78.84
151 INT8363 Localization of Nts 135 0.81 14.29 61.71 78.80
152 INT12231 Positive_regulation of Localization of Nts 17 0.70 4.54 13.85 78.80
153 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03 77.48
154 INT38144 Positive_regulation of HRH1 7 0.57 2.57 2.51 77.36
155 INT5048 Binding of Edn1 55 0.47 18.86 19.16 77.16
156 INT5363 Negative_regulation of PEPD 11 0.56 6.49 3.11 76.76
157 INT76434 Negative_regulation of PRKG1 25 0.58 10.36 10.81 75.96
158 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 75.60
159 INT327817 Negative_regulation of ADORA2A 1 0.17 1.83 0.27 75.52
160 INT66425 Positive_regulation of Positive_regulation of SLC43A3 3 0.40 0.59 1.94 75.00
161 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 75.00
162 INT82495 Binding of ABCC6 2 0.31 1.05 0.25 75.00
163 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 75.00
164 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41 75.00
165 INT190275 Positive_regulation of THAS 5 0.10 2.6 0.14 74.40
166 INT162 Regulation of Prl 794 0.62 165.01 322.24 74.24
167 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 74.24
168 INT331896 Localization of SEPT4 1 0.30 0.14 0 73.72
169 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99 73.60
170 INT102856 Positive_regulation of Srgn 7 0.61 1.27 2.54 73.48
171 INT31761 Positive_regulation of Itpr3 32 0.58 5.95 8.22 73.32
172 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73 73.32
173 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 73.08
174 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 73.04
175 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41 72.96
176 INT22738 Negative_regulation of DYNLL1 17 0.57 6.68 2.06 72.88
177 INT1512 Binding of Prl 73 0.48 26.22 20.63 72.48
178 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 71.92
179 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 71.00
180 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 70.64
181 INT159955 Phosphorylation of Ppp1r12a 3 0.21 1.14 0.04 70.56
182 INT104771 Positive_regulation of Gucy1b3 4 0.70 1.14 0.42 69.48
183 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23 69.36
184 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 66.64
185 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 66.64
186 INT116053 Binding of Gucy1b2 2 0.20 1.04 0.19 66.00
187 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72 65.96
188 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18 65.92
189 INT159956 Phosphorylation of Rock2 3 0.79 1.57 0.2 65.92
190 INT4822 Localization of Ca2 417 0.80 99.57 96.45 65.32
191 INT72738 Positive_regulation of Prkg1 8 0.47 1.76 2.18 65.00
192 INT256830 Regulation of GNAQ 2 0.26 0.36 0.04 64.88
193 INT35366 Binding of AR 87 0.47 30.52 8.9 64.60
194 INT67451 Positive_regulation of SLURP1 11 0.49 3.42 1.96 62.64
195 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89 62.32
196 INT246173 Phosphorylation of EEF2 4 0.48 0.44 0.24 61.76
197 INT19799 Binding of Ca2 71 0.48 13.69 12.92 60.68
198 INT348722 Positive_regulation of Positive_regulation of Mylk 1 0.13 0.42 0.05 59.92
199 INT57785 Positive_regulation of SGCB 25 0.69 5.01 1.49 59.84
200 INT55704 Positive_regulation of Gucy1a2 6 0.50 1.24 1.7 59.32
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