D:Erythermalgia

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Disease Term
Synonyms Erythermalgias, ERYTHROMELALGIA, Erythromelalgias, Gerhardt Disease, Mitchell Disease, Weir Mitchell Disease, WEIR MITCHELL S DISEASE, Weir Mitchell Syndrome
Documents 231
Hot Single Events 75
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Erythermalgia. They are ordered first by their relevance to Erythermalgia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3 100.00
2 INT163364 Thim Regulation of Mmd 1 0.00 0.91 0.62 95.40
3 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27 25.28
4 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 18.96
5 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 18.96
6 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
7 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
8 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
9 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
10 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
11 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65 5.00
12 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 5.00
13 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
14 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
15 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
16 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
17 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
18 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
19 INT236489 Gtf3a Regulation of Pain1 1 0.00 0.52 0.56 5.00
20 INT236492 Gtf3a Regulation of SNRNP70 1 0.00 0.52 0.56 5.00
21 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26 5.00
22 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Erythermalgia. They are ordered first by their pain relevance and then by number of times they were reported in Erythermalgia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 100.00
2 INT113021 Gene_expression of ADAM18 2 0.37 2.94 4.49 100.00
3 INT106037 Gene_expression of PEPD 10 0.75 4.18 3.11 100.00
4 INT5363 Negative_regulation of PEPD 11 0.56 6.49 3.11 100.00
5 INT140401 Binding of PEPD 3 0.47 2.22 2.97 100.00
6 INT123419 Binding of NAV1 37 0.48 7.09 26.43 100.00
7 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 99.92
8 INT247621 Gene_expression of PAMR1 4 0.06 1.49 0.44 99.92
9 INT247614 Positive_regulation of Gene_expression of PAMR1 1 0.05 0.19 0.09 99.92
10 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 99.80
11 INT139546 Gene_expression of URI1 3 0.75 3 1.49 99.72
12 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 99.54
13 INT112207 Binding of Nav1 27 0.47 7.1 15.43 99.52
14 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 99.52
15 INT140446 Positive_regulation of Scn9a 2 0.49 0.35 1.19 99.44
16 INT247615 Binding of URI1 2 0.20 1.17 1.13 99.36
17 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 99.16
18 INT247617 Positive_regulation of PAMR1 1 0.06 2.3 2.07 99.16
19 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 99.06
20 INT111053 Positive_regulation of Positive_regulation of Nav1 4 0.46 2.97 3.53 98.98
21 INT247619 Regulation of Positive_regulation of DRGX 1 0.03 1 0.97 98.96
22 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 98.84
23 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 98.74
24 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 98.56
25 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 98.54
26 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 98.40
27 INT91932 Positive_regulation of Scn10a 18 0.67 10.39 10.9 98.38
28 INT150525 Positive_regulation of Scn11a 1 0.11 0.2 0.34 98.38
29 INT148864 Localization of DRGX 11 0.17 7.67 8.36 98.16
30 INT226597 Regulation of Localization of DRGX 1 0.08 0.32 0.21 98.16
31 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 98.08
32 INT36676 Gene_expression of Pepd 2 0.36 1.41 0.82 98.06
33 INT140400 Binding of Scn9a 4 0.36 3.59 2.15 97.24
34 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 96.68
35 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 96.56
36 INT14962 Gene_expression of Pf4 27 0.76 22.48 10.88 96.56
37 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97 96.56
38 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 96.52
39 INT341482 Gene_expression of NMNAT1 1 0.01 3.24 2.79 96.40
40 INT16460 Negative_regulation of PPBP 21 0.57 13.86 8.54 96.30
41 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 96.16
42 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 96.16
43 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 96.04
44 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 95.20
45 INT202526 Positive_regulation of ADAM18 1 0.01 1.77 8.31 95.00
46 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 94.52
47 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58 94.32
48 INT202527 Negative_regulation of Gene_expression of DRGX 5 0.07 1.53 2.54 94.20
49 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 94.12
50 INT65832 Positive_regulation of PIRT 4 0.07 0.83 1.42 93.68
51 INT69313 Regulation of Scn10a 5 0.60 4.45 3.14 92.60
52 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 92.56
53 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 92.00
54 INT115481 Gene_expression of CDSN 6 0.10 2.53 1.03 90.56
55 INT312392 Positive_regulation of Regulation of DRGX 1 0.05 1.51 0.94 90.04
56 INT113384 Regulation of Gene_expression of Nav1 20 0.62 8.57 16.15 89.96
57 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 89.96
58 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 89.52
59 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92 88.72
60 INT262317 Binding of TAF9 7 0.31 9.67 2.15 88.72
61 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 88.52
62 INT93308 Gene_expression of PIRT 13 0.09 2 2.92 87.36
63 INT226596 Localization of DIS3L 1 0.05 0.26 0.12 86.44
64 INT285167 Binding of PSMC4 2 0.04 0.56 0.72 85.80
65 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3 85.36
66 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 84.16
67 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 83.20
68 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49 83.20
69 INT55223 Regulation of Gene_expression of DRGX 6 0.09 3.77 5.15 83.04
70 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 82.68
71 INT179309 Regulation of Gene_expression of KCNMA1 8 0.39 2.36 1.36 81.40
72 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 80.96
73 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 80.80
74 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 80.80
75 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 80.04
76 INT19107 Positive_regulation of Tbxa2r 23 0.62 12.54 8.44 79.92
77 INT60161 Gene_expression of EPHA3 43 0.75 3.66 6.25 78.88
78 INT168312 Positive_regulation of Gene_expression of EPHA3 8 0.49 0.97 1.32 78.88
79 INT106036 Negative_regulation of Negative_regulation of PEPD 2 0.42 0.68 0.98 78.88
80 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 76.00
81 INT94934 Negative_regulation of COX1 3 0.57 3.27 1.75 76.00
82 INT236437 Negative_regulation of ARHGAP8 1 0.04 0.88 1.07 75.36
83 INT279818 Gene_expression of Gm4425 1 0.01 0.77 0.47 74.40
84 INT279823 Gene_expression of Pepd 1 0.19 2 1.14 74.40
85 INT106039 Negative_regulation of Gene_expression of PEPD 5 0.56 1.37 1.18 72.96
86 INT152352 Negative_regulation of Localization of DRGX 2 0.07 0.87 2.14 72.44
87 INT319920 Negative_regulation of Localization of SCN9A 1 0.29 0.31 0.92 72.44
88 INT319919 Localization of SCN9A 1 0.51 0.31 0.92 71.80
89 INT81827 Positive_regulation of Kcnk2 7 0.70 0.42 1.79 70.40
90 INT149518 Regulation of Gene_expression of NAV1 7 0.62 6.73 9.62 69.76
91 INT157366 Positive_regulation of Positive_regulation of KCNMA1 2 0.05 2.43 1.74 69.72
92 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 69.08
93 INT25283 Negative_regulation of Positive_regulation of Vwf 2 0.21 2.7 0.69 69.08
94 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5 69.04
95 INT10146 Negative_regulation of Vwf 27 0.40 17.11 3.69 68.72
96 INT279817 Regulation of Gm4425 1 0.00 1.18 0.45 67.44
97 INT236441 Localization of ARHGAP8 1 0.06 0.57 0.55 65.44
98 INT106038 Regulation of PEPD 3 0.43 3.93 1.01 64.52
99 INT275954 Regulation of Lat 4 0.54 0.75 0.37 64.52
100 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68 63.68
101 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 63.04
102 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 63.04
103 INT279821 Regulation of Scn9a 2 0.44 2.79 0.83 62.36
104 INT233112 Gene_expression of Kcnk2 15 0.78 0.9 2.01 62.24
105 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 62.08
106 INT226598 Localization of PSMC1 1 0.21 0.33 0.22 59.68
107 INT46691 Negative_regulation of SCN9A 5 0.50 1.37 3.44 59.36
108 INT97693 Gene_expression of REST 29 0.75 5.51 5.26 57.52
109 INT103262 Localization of Nav1 53 0.81 19.23 34.44 56.00
110 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 55.44
111 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 55.16
112 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 54.64
113 INT341483 Positive_regulation of NMNAT1 1 0.01 0.6 0.76 54.08
114 INT113377 Positive_regulation of Localization of Nav1 2 0.70 0.23 1.46 53.72
115 INT220070 Negative_regulation of ASIC2 1 0.02 1.09 1.39 53.36
116 INT236440 Binding of ARHGAP8 1 0.03 0.31 0.38 52.84
117 INT341334 Negative_regulation of Localization of Nav1 1 0.41 0.22 0.42 50.92
118 INT158843 Regulation of NALCN 6 0.04 2.89 3.63 50.88
119 INT94623 Localization of ADAM18 2 0.62 1.17 2.94 50.00
120 INT236438 Regulation of ARHGAP8 1 0.02 0.42 0.57 46.08
121 INT123420 Negative_regulation of Gene_expression of KCNMA1 7 0.58 0.25 0.33 44.32
122 INT150140 Negative_regulation of Timd4 3 0.02 1.95 1.92 38.24
123 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 37.92
124 INT236439 Gene_expression of ARHGAP8 1 0.06 0.62 0.88 37.12
125 INT75742 Binding of RLS 86 0.42 95.27 19.04 35.44
126 INT341481 Binding of SCN8A 1 0.28 1.47 1.23 33.12
127 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 24.84
128 INT143768 Negative_regulation of Positive_regulation of Trpm8 3 0.43 0.57 0.57 24.84
129 INT23598 Binding of SCN5A 32 0.40 16 5.35 22.88
130 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 21.12
131 INT166120 Gene_expression of Pla2g5 3 0.43 1.54 0.64 21.08
132 INT186228 Regulation of Timd4 3 0.00 3.38 4.74 14.40
133 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 13.68
134 INT341484 Negative_regulation of SCN1A 1 0.53 1.27 0.94 12.88
135 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 12.08
136 INT93200 Gene_expression of ASIC2 6 0.60 3.27 3.7 12.08
137 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 11.68
138 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 10.40
139 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 10.40
140 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11 8.48
141 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
142 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
143 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
144 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
145 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 5.00
146 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
147 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
148 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
149 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
150 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
151 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
152 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
153 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
154 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
155 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
156 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
157 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
158 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 5.00
159 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
160 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
161 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
162 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
163 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 5.00
164 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
165 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
166 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
167 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
168 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
169 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
170 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
171 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
172 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85 5.00
173 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
174 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
175 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 5.00
176 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
177 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
178 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 5.00
179 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
180 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
181 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
182 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
183 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
184 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
185 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96 5.00
186 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
187 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86 5.00
188 INT136268 Localization of NAV1 22 0.75 2.84 26.23 5.00
189 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01 5.00
190 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
191 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
192 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 5.00
193 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41 5.00
194 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
195 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 5.00
196 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 5.00
197 INT135629 Binding of COMT 33 0.48 16.68 19.37 5.00
198 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
199 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
200 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
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