D:Erythropoietic Protoporphyria

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Disease Term
Synonyms Erythropoietic Protoporphyrias, Protoporphyrias Erythropoietic
Documents 37
Hot Single Events 38
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Erythropoietic Protoporphyria. They are ordered first by their relevance to Erythropoietic Protoporphyria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08 100.00
2 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2 100.00
3 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 5.00
4 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 5.00
5 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 5.00
6 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0 5.00
7 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0 5.00
8 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0 5.00
9 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Erythropoietic Protoporphyria. They are ordered first by their pain relevance and then by number of times they were reported in Erythropoietic Protoporphyria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 100.00
2 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 100.00
3 INT282679 Localization of FECH 1 0.12 9.57 0.23 100.00
4 INT115264 Binding of FECH 9 0.41 7.93 1.1 100.00
5 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 100.00
6 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34 100.00
7 INT158469 Regulation of FECH 3 0.36 1.76 1.13 100.00
8 INT53568 Positive_regulation of Negative_regulation of FECH 1 0.47 0.78 0.05 100.00
9 INT315643 Negative_regulation of Gene_expression of FECH 1 0.29 0.71 0.1 100.00
10 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85 99.64
11 INT282678 Negative_regulation of Ssbp3 1 0.02 1.53 0.08 99.52
12 INT16070 Gene_expression of MTG1 6 0.75 5.42 1.65 99.52
13 INT158461 Positive_regulation of Localization of Alas1 1 0.04 1.48 0.52 98.88
14 INT158460 Localization of Alas1 1 0.06 0.74 0.26 98.88
15 INT53569 Negative_regulation of Positive_regulation of FECH 1 0.40 0.52 0 98.70
16 INT16069 Gene_expression of Tmod1 1 0.12 0.49 0.19 98.60
17 INT47555 Positive_regulation of endogenous protoporphyrin 1 0.21 0.98 0.1 97.58
18 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 97.58
19 INT112991 Positive_regulation of Gene_expression of PPY 7 0.29 6.26 0.99 97.58
20 INT40216 Positive_regulation of Alas1 11 0.65 6.08 1.8 97.56
21 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 93.60
22 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 92.84
23 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 92.16
24 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 91.60
25 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34 91.12
26 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 91.12
27 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08 91.12
28 INT45263 Gene_expression of Alas1 3 0.29 1.39 0.24 91.12
29 INT46650 Localization of Trf 13 0.61 4.4 2.91 90.08
30 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 89.56
31 INT127038 Gene_expression of Alas1 6 0.72 3.94 1.48 89.48
32 INT19637 Localization of TF 14 0.73 5.74 0.86 87.52
33 INT282677 Gene_expression of Ssbp3 1 0.03 0.89 0 86.16
34 INT38834 Positive_regulation of Positive_regulation of PPY 2 0.42 4.18 0.61 85.32
35 INT158463 Regulation of Hmbs 7 0.31 4.87 0.4 82.32
36 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 81.84
37 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56 81.44
38 INT45236 Positive_regulation of Gene_expression of Trf 3 0.62 1.67 0.28 80.08
39 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 79.96
40 INT321657 Positive_regulation of Positive_regulation of Fech 1 0.02 0.8 0 75.52
41 INT321658 Positive_regulation of Fech 1 0.02 0.8 0 75.08
42 INT31226 Localization of PPY 20 0.78 9.93 6.8 75.00
43 INT315554 Localization of NFS1 1 0.43 0.28 0.07 74.44
44 INT315598 Localization of FXN 1 0.43 1.04 0.07 74.08
45 INT170444 Binding of Gopc 172 0.39 45.05 20.71 66.84
46 INT315640 Gene_expression of NUBP1 1 0.41 0.32 0 47.60
47 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 47.36
48 INT50291 Positive_regulation of HMBS 10 0.67 8.89 0.73 36.48
49 INT315585 Localization of SLC25A37 1 0.13 0.47 0 29.56
50 INT50290 Binding of Cpox 29 0.27 17.19 8.01 25.00
51 INT315621 Gene_expression of CIAO1 1 0.34 4.11 0 18.04
52 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1 17.44
53 INT131139 Binding of ACO1 3 0.27 1.81 0.1 17.12
54 INT315631 Protein_catabolism of IREB2 1 0.44 0.4 0 14.44
55 INT252722 Binding of IREB2 2 0.16 1.31 0 14.44
56 INT315632 Positive_regulation of Protein_catabolism of IREB2 1 0.22 0.4 0 14.44
57 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0 8.52
58 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13 8.20
59 INT315580 Negative_regulation of Localization of SLC40A1 1 0.25 0.64 0 7.00
60 INT296387 Localization of SLC40A1 2 0.44 0.94 0 7.00
61 INT315558 Negative_regulation of SLC40A1 1 0.25 0.63 0 6.48
62 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
63 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 5.00
64 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
65 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
66 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
67 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 5.00
68 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
69 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 5.00
70 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 5.00
71 INT302084 Negative_regulation of WNT2 2 0.09 0.83 1.26 5.00
72 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08 5.00
73 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 5.00
74 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 5.00
75 INT158136 Binding of FGFR2 9 0.26 4.5 0.63 5.00
76 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 5.00
77 INT302086 Gene_expression of WNT2 3 0.14 0.97 0.38 5.00
78 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32 5.00
79 INT166958 Gene_expression of LYRM4 4 0.18 2.9 0.27 5.00
80 INT221496 Localization of ISCA1 4 0.73 2.12 0.23 5.00
81 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 5.00
82 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 5.00
83 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 5.00
84 INT236980 Gene_expression of ISCA1 9 0.53 2.43 0.19 5.00
85 INT170629 Negative_regulation of Gene_expression of ABCB7 2 0.37 1.32 0.17 5.00
86 INT174848 Gene_expression of ISCU 2 0.59 2.79 0.08 5.00
87 INT315622 Protein_catabolism of FECH 1 0.77 0.49 0.07 5.00
88 INT315626 Localization of DLEU1 2 0.35 4.17 0.07 5.00
89 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05 5.00
90 INT315624 Positive_regulation of Gene_expression of ISCU 1 0.38 0.23 0.03 5.00
91 INT315583 Positive_regulation of Binding of NFS1 1 0.25 0 0 5.00
92 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0 5.00
93 INT315581 Positive_regulation of Phosphorylation of ISCU 1 0.44 0.33 0 5.00
94 INT315617 Positive_regulation of Gene_expression of SLC25A37 1 0.10 0.39 0 5.00
95 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0 5.00
96 INT315602 Binding of ISCA1 1 0.30 0 0 5.00
97 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0 5.00
98 INT315587 Positive_regulation of Gene_expression of CIAO1 1 0.22 1.6 0 5.00
99 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0 5.00
100 INT315620 Regulation of Gene_expression of GLRX5 1 0.40 0.5 0 5.00
101 INT315550 Transcription of GLRX5 1 0.53 0.66 0 5.00
102 INT315575 Transcription of SLC40A1 1 0.40 0.85 0 5.00
103 INT315637 Transcription of FXN 1 0.40 1.44 0 5.00
104 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0 5.00
105 INT315634 Negative_regulation of Binding of ISCU 1 0.33 0.28 0 5.00
106 INT315597 Negative_regulation of ISCU 1 0.51 0.22 0 5.00
107 INT315600 Regulation of CIAO1 1 0.20 0.39 0 5.00
108 INT315571 Binding of NFS1 1 0.19 0 0 5.00
109 INT315613 Positive_regulation of WNT2 1 0.09 0.41 0 5.00
110 INT315627 Binding of GLRX5 1 0.33 0 0 5.00
111 INT315606 Regulation of Gene_expression of WNT2 1 0.08 0.84 0 5.00
112 INT315644 Negative_regulation of Transcription of DLEU1 1 0.21 0.64 0 5.00
113 INT315555 Binding of FXN 1 0.28 1.29 0 5.00
114 INT315605 Binding of ABCB7 1 0.33 1.84 0 5.00
115 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0 5.00
116 INT315567 Positive_regulation of Negative_regulation of CIAO1 1 0.22 1.29 0 5.00
117 INT315556 Positive_regulation of Binding of ALAS2 1 0.43 1.05 0 5.00
118 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0 5.00
119 INT315635 Positive_regulation of FXN 2 0.41 5.76 0 5.00
120 INT315608 Localization of NFU1 1 0.14 0 0 5.00
121 INT315596 Localization of ISCA2 1 0.11 0 0 5.00
122 INT315601 Positive_regulation of NFU1 1 0.22 0.13 0 5.00
123 INT315642 Negative_regulation of Gene_expression of NFU1 1 0.16 0.37 0 5.00
124 INT315636 Negative_regulation of ABCB7 1 0.38 0.17 0 5.00
125 INT315588 Regulation of ACO1 1 0.18 0.57 0 5.00
126 INT315570 Negative_regulation of Positive_regulation of TFRC 1 0.19 0.08 0 5.00
127 INT315573 Negative_regulation of Gene_expression of NFS1 1 0.24 0.74 0 5.00
128 INT315568 Regulation of Gene_expression of CIAO1 1 0.20 0.15 0 5.00
129 INT174850 Binding of ISCU 2 0.33 0.51 0 5.00
130 INT315638 Gene_expression of GLRX3 1 0.25 0 0 5.00
131 INT315564 Binding of NFU1 1 0.16 0 0 5.00
132 INT315619 Regulation of Gene_expression of NFS1 1 0.26 0.74 0 5.00
133 INT315607 Positive_regulation of Gene_expression of GLRX5 1 0.61 2.28 0 5.00
134 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0 5.00
135 INT315549 Negative_regulation of Binding of WNT2 1 0.08 0.65 0 5.00
136 INT315641 Gene_expression of ISCA2 1 0.22 0 0 5.00
137 INT315590 Negative_regulation of Transcription of CIAO1 1 0.19 0.33 0 5.00
138 INT315612 Gene_expression of NFS1 1 0.39 1.68 0 5.00
139 INT315610 Transcription of DLEU1 1 0.25 0.64 0 5.00
140 INT315576 Positive_regulation of Binding of CIAO1 1 0.22 0.67 0 5.00
141 INT315615 Positive_regulation of ISCU 1 0.44 0.11 0 5.00
142 INT315589 Binding of CIAO1 1 0.16 0.67 0 5.00
143 INT315599 Binding of ISCA2 1 0.12 0 0 5.00
144 INT315639 Localization of ISCU 1 0.66 0 0 5.00
145 INT315560 Gene_expression of SLC19A2 1 0.55 1.32 0 5.00
146 INT315629 Phosphorylation of ISCU 1 0.71 0.33 0 5.00
147 INT315586 Gene_expression of SLC25A38 1 0.52 0.51 0 5.00
148 INT315604 Negative_regulation of Positive_regulation of WNT2 1 0.08 0.41 0 5.00
149 INT315552 Negative_regulation of GLRX5 1 0.38 2.17 0 5.00
150 INT315559 Negative_regulation of CIAO1 1 0.19 2.53 0 5.00
151 INT315618 Gene_expression of SLC25A37 1 0.14 0.38 0 5.00
152 INT315574 Localization of ACO1 1 0.30 0.79 0 5.00
153 INT315616 Positive_regulation of Gene_expression of ACO1 1 0.20 0.79 0 5.00
154 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0 5.00
155 INT315569 Transcription of CIAO1 1 0.30 0.33 0 5.00
156 INT315572 Positive_regulation of ACO1 1 0.20 0.94 0 5.00
157 INT315566 Negative_regulation of Binding of ABCB7 1 0.37 0.62 0 5.00
158 INT315548 Gene_expression of NFU1 1 0.29 0.67 0 5.00
159 INT315561 Regulation of ISCU 2 0.35 1.1 0 5.00
160 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0 5.00
161 INT315579 Binding of WNT2 1 0.07 0.65 0 5.00
162 INT315553 Positive_regulation of GLRX5 1 0.44 0.68 0 5.00
163 INT315603 Positive_regulation of Gene_expression of SLC19A2 1 0.41 0.48 0 5.00
164 INT315611 Binding of LYRM4 1 0.14 0 0 5.00
165 INT315577 Regulation of Gene_expression of NFU1 1 0.17 0.37 0 5.00
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