D:Esophageal Motility Disorder

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Disease Term
Synonyms Disorder Esophageal Motility, Disorders Esophageal Motility, Dyskinesia Of The Esophagus, DYSKINESIA OF THE OESOPHAGUS, Dysmotilities Esophageal, Dysmotility Esophageal, Esophageal Dyskinesia, ESOPHAGEAL DYSMOTILITIES, Esophageal Dysmotility, Esophageal Motility Disorders, ESOPHAGEAL MOTOR DISORDER
Documents 311
Hot Single Events 22
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Esophageal Motility Disorder. They are ordered first by their relevance to Esophageal Motility Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08 80.32
2 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 36.92
3 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 25.60
4 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
5 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
6 INT218857 INPP5E Regulation of ATP12A 1 0.01 1.95 0.09 5.00
7 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
8 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
9 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
10 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Esophageal Motility Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Esophageal Motility Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT248755 Binding of SS18L1 1 0.31 5.25 0.35 100.00
2 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 100.00
3 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 99.86
4 INT158812 Binding of EOE2 2 0.46 3.53 0.1 99.80
5 INT18935 Positive_regulation of GER 9 0.69 4.91 1.5 99.56
6 INT81211 Transcription of Rac1 4 0.54 1.05 0.89 98.28
7 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 98.02
8 INT667 Negative_regulation of Hrh2 38 0.58 18.11 18.01 97.92
9 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33 97.36
10 INT182667 Binding of DLAT 11 0.31 40.75 2.8 94.16
11 INT245648 Gene_expression of SEPHS1 5 0.49 4.53 0.59 93.24
12 INT153782 Localization of SEPHS1 2 0.62 0.9 0.12 93.24
13 INT97036 Binding of ASPH 1 0.02 1.04 0.29 93.20
14 INT78719 Binding of Ucp1 8 0.41 8.93 4.5 88.32
15 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 86.52
16 INT213215 Gene_expression of SS18L1 2 0.58 3.71 0.29 86.12
17 INT283509 Regulation of Binding of DLAT 1 0.29 1.99 0.23 84.60
18 INT18933 Binding of GER 11 0.37 11.56 0.3 83.84
19 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 81.72
20 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 80.32
21 INT120664 Positive_regulation of TACC2 3 0.01 7.43 1.08 80.20
22 INT67248 Gene_expression of TACC2 12 0.50 13.51 3.65 80.20
23 INT143228 Positive_regulation of Amh-rs3 1 0.02 6.36 1.32 79.12
24 INT143227 Gene_expression of Amh-rs3 1 0.03 4.2 0.86 79.12
25 INT143231 Positive_regulation of CRYGD 20 0.49 14.87 3.67 79.12
26 INT143229 Positive_regulation of Positive_regulation of CRYGD 2 0.49 2.49 0.47 79.12
27 INT143226 Positive_regulation of Positive_regulation of Amh-rs3 1 0.02 2.12 0.44 79.12
28 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 78.24
29 INT18934 Gene_expression of GER 16 0.66 14.71 1.29 77.56
30 INT51803 Negative_regulation of Pde7a 14 0.59 14.98 4.85 76.96
31 INT214692 Negative_regulation of Gene_expression of FUT3 3 0.24 2.2 0.17 73.12
32 INT83891 Gene_expression of FUT3 20 0.61 10.49 1.41 72.68
33 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 70.56
34 INT209114 Binding of Etfdh 7 0.32 4.27 0 66.68
35 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84 66.16
36 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28 66.16
37 INT353117 Negative_regulation of Positive_regulation of Casp1 1 0.06 1.25 0 66.16
38 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 62.16
39 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 60.24
40 INT143225 Regulation of Amh-rs3 1 0.01 2.11 0.48 59.96
41 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 58.16
42 INT300712 Negative_regulation of Gene_expression of Elpt 1 0.07 1.02 0.09 55.32
43 INT300716 Gene_expression of Elpt 1 0.11 1.02 0.09 54.96
44 INT105618 Binding of SEPHS1 4 0.27 5.62 1.14 53.32
45 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 52.64
46 INT36148 Binding of GAD1 10 0.41 7.91 1.47 45.36
47 INT299511 Negative_regulation of Elpt 2 0.07 1.79 0.4 43.56
48 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 41.60
49 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 40.48
50 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 39.68
51 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 39.68
52 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 38.24
53 INT16012 Binding of Rac1 17 0.37 6.9 0.53 33.72
54 INT7346 Localization of Hrh2 15 0.69 5.78 4.79 32.08
55 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 31.48
56 INT94189 Positive_regulation of FUT3 11 0.31 6.61 1.5 30.96
57 INT7383 Localization of VIP 53 0.81 17.7 22.65 26.24
58 INT5045 Regulation of VIP 26 0.62 7.15 11.61 17.72
59 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
60 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
61 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
62 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
63 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
64 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
65 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
66 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
67 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
68 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 5.00
69 INT2463 Localization of CCK 101 0.81 37.54 47.59 5.00
70 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
71 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
72 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
73 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
74 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 5.00
75 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
76 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
77 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 5.00
78 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
79 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
80 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
81 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
82 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 5.00
83 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
84 INT1154 Negative_regulation of CCK 24 0.59 9.3 15.32 5.00
85 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
86 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
87 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 5.00
88 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
89 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
90 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
91 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
92 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
93 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
94 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
95 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
96 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
97 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
98 INT18025 Binding of Pah 32 0.45 30.72 7.93 5.00
99 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
100 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75 5.00
101 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 5.00
102 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
103 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42 5.00
104 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 5.00
105 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 5.00
106 INT947 Regulation of Mln 20 0.59 4.09 5.87 5.00
107 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 5.00
108 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 5.00
109 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
110 INT151387 Gene_expression of Cav3 14 0.78 4 5.31 5.00
111 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
112 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 5.00
113 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 5.00
114 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
115 INT209118 Regulation of Etfdh 12 0.18 7.77 3.91 5.00
116 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
117 INT137702 Binding of TTN 7 0.35 4.48 3.62 5.00
118 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58 5.00
119 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
120 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 5.00
121 INT2883 Negative_regulation of Localization of CCK 9 0.59 3.25 3.08 5.00
122 INT120529 Positive_regulation of ABCC2 7 0.49 2.32 2.94 5.00
123 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 5.00
124 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
125 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 5.00
126 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 5.00
127 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 5.00
128 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97 5.00
129 INT56221 Regulation of MPO 8 0.61 8.44 1.84 5.00
130 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
131 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63 5.00
132 INT139254 Negative_regulation of Per1 12 0.56 3.17 1.62 5.00
133 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58 5.00
134 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57 5.00
135 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48 5.00
136 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
137 INT283506 Gene_expression of SLC4A2 7 0.47 4 1.4 5.00
138 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 5.00
139 INT162037 Negative_regulation of Regulation of TRPV1 2 0.43 2.47 1.31 5.00
140 INT169363 Negative_regulation of PTGIS 4 0.20 3.35 1.22 5.00
141 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 5.00
142 INT209961 Binding of GAGE4 3 0.03 1.8 1.16 5.00
143 INT163747 Negative_regulation of Cav3 3 0.54 0.56 1.16 5.00
144 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16 5.00
145 INT181879 Negative_regulation of Apoa1 8 0.55 8.18 1.11 5.00
146 INT92988 Protein_catabolism of Eln 6 0.47 5.48 1.03 5.00
147 INT246311 Protein_catabolism of Snap25 6 0.66 1.15 0.89 5.00
148 INT283494 Positive_regulation of ABCB11 1 0.13 0.81 0.87 5.00
149 INT283514 Localization of NR1I2 2 0.74 3.15 0.87 5.00
150 INT137082 Regulation of ABCC2 2 0.16 1.11 0.85 5.00
151 INT130582 Gene_expression of ABCB4 3 0.67 1.05 0.82 5.00
152 INT145986 Positive_regulation of CTLA4 8 0.56 2.66 0.82 5.00
153 INT32835 Negative_regulation of Pde3a 5 0.10 3.65 0.82 5.00
154 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 5.00
155 INT11657 Gene_expression of ALPI 11 0.71 5.13 0.74 5.00
156 INT283501 Positive_regulation of Gene_expression of SLC4A2 1 0.19 1.66 0.73 5.00
157 INT283516 Localization of SLC4A2 1 0.21 0.8 0.69 5.00
158 INT283502 Positive_regulation of Gene_expression of ABCB4 1 0.40 0.76 0.62 5.00
159 INT283515 Regulation of ABCB11 2 0.09 0.9 0.58 5.00
160 INT136074 Regulation of ELOVL1 5 0.23 3.6 0.49 5.00
161 INT283507 Negative_regulation of Gene_expression of DLAT 1 0.28 2.2 0.48 5.00
162 INT283518 Negative_regulation of Gene_expression of SLC4A2 1 0.16 0.87 0.48 5.00
163 INT283500 Positive_regulation of Gene_expression of ABCB11 1 0.08 0.41 0.48 5.00
164 INT283495 Gene_expression of ABCB11 1 0.10 0.41 0.47 5.00
165 INT283496 Localization of CASR 2 0.76 2.04 0.41 5.00
166 INT220506 Binding of Cav1 13 0.45 5.46 0.38 5.00
167 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38 5.00
168 INT283504 Negative_regulation of Localization of SLC4A2 1 0.11 0.41 0.32 5.00
169 INT121087 Gene_expression of Pde7a 3 0.17 2.69 0.31 5.00
170 INT227415 Regulation of DLAT 2 0.29 2.93 0.28 5.00
171 INT309915 Negative_regulation of F2RL3 2 0.01 2.06 0.27 5.00
172 INT227414 Localization of DLAT 2 0.49 5.14 0.26 5.00
173 INT64224 Localization of FUT3 3 0.06 3.16 0.2 5.00
174 INT283503 Binding of SLC4A2 3 0.09 3.39 0.19 5.00
175 INT283508 Negative_regulation of Negative_regulation of DLAT 1 0.28 1.87 0.19 5.00
176 INT207867 Gene_expression of H2-Ob 1 0.01 5.46 0.18 5.00
177 INT300718 Negative_regulation of Ptrf 1 0.34 4.1 0.18 5.00
178 INT283513 Localization of PDHX 1 0.15 2.06 0.18 5.00
179 INT309916 Negative_regulation of NR2F2 1 0.02 0.7 0.18 5.00
180 INT300717 Gene_expression of Ptrf 1 0.61 3.64 0.18 5.00
181 INT345973 Binding of EVL 1 0.07 1.4 0.14 5.00
182 INT283498 Negative_regulation of Localization of DLAT 1 0.28 1.77 0.14 5.00
183 INT214975 Localization of Cav1 7 0.75 2.7 0.13 5.00
184 INT237337 Binding of Cav3 3 0.44 2.63 0.11 5.00
185 INT218859 Negative_regulation of ATP12A 2 0.11 2.86 0.09 5.00
186 INT207866 Binding of H2-Ob 1 0.01 1.04 0.09 5.00
187 INT214926 Negative_regulation of INPP5E 5 0.03 3.93 0.09 5.00
188 INT345972 Binding of HGD 1 0.02 1.95 0.08 5.00
189 INT283459 Localization of Nup210 1 0.73 0.73 0.08 5.00
190 INT209115 Localization of Etfdh 3 0.17 0.44 0.06 5.00
191 INT283499 Negative_regulation of Positive_regulation of CTLA4 1 0.09 1.02 0.05 5.00
192 INT193358 Localization of ST3GAL4 2 0.52 1.65 0.05 5.00
193 INT300711 Localization of Cav3 1 0.69 1.17 0.04 5.00
194 INT300719 Regulation of Binding of Cav3 1 0.25 1.17 0.04 5.00
195 INT300713 Regulation of Localization of Cav1 2 0.42 1.37 0.04 5.00
196 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04 5.00
197 INT300721 Regulation of Localization of Cav3 1 0.41 1.17 0.04 5.00
198 INT300714 Positive_regulation of Gene_expression of Ptrf 1 0.55 1.16 0.04 5.00
199 INT300715 Regulation of Localization of Ptrf 1 0.36 1.18 0.03 5.00
200 INT283512 Positive_regulation of Binding of CTLA4 1 0.11 1.03 0.03 5.00
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