D:Exfoliative Dermatitis

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Disease Term
Synonyms Dermatitides Exfoliative, Dermatitis Exfoliativa, ERYTHRODERMA, Erythrodermas, Exfoliative Dermatitides
Documents 61
Hot Single Events 27
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Exfoliative Dermatitis. They are ordered first by their relevance to Exfoliative Dermatitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 68.84
2 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
3 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
4 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
5 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
6 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
7 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
8 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
9 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
10 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31 5.00
11 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
12 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
13 INT351007 Binding of IL2 and IL2RA 1 0.33 1.33 0.26 5.00
14 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
15 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00
16 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
17 INT313913 Binding of Il23a and Il23r 1 0.24 0.43 0.13 5.00
18 INT313914 Binding of Il12a and Il23r 1 0.14 0.44 0.13 5.00
19 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 0.03 0.23 0.13 5.00
20 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
21 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08 5.00
22 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
23 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
24 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
25 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 5.00
26 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 0.31 0.46 0.05 5.00
27 INT351009 IL2RG Positive_regulation of Transcription of IL2 1 0.27 0.44 0.05 5.00
28 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 0.10 0.42 0.05 5.00
29 INT351008 IL2RB Positive_regulation of Gene_expression of IL2 1 0.18 0.42 0.05 5.00
30 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
31 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
32 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 5.00
33 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
34 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0 5.00
35 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
36 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00
37 INT351013 PROK1 Regulation of ISG20 1 0.01 0.76 0 5.00
38 INT234378 MAPK7 Positive_regulation of PPARA 1 0.21 0.05 0 5.00
39 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Exfoliative Dermatitis. They are ordered first by their pain relevance and then by number of times they were reported in Exfoliative Dermatitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234419 Phosphorylation of TSPYL2 1 0.16 2.05 0.06 99.20
2 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 98.88
3 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 98.82
4 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 98.62
5 INT234409 Gene_expression of TSPYL2 2 0.21 5.16 0.03 96.84
6 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 95.96
7 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 94.72
8 INT11807 Gene_expression of Il2 266 0.78 112 64.97 94.48
9 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 94.48
10 INT20381 Localization of Il2 71 0.77 34.23 13.03 94.48
11 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 92.56
12 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 92.56
13 INT19509 Localization of Ifng 55 0.78 28.25 18.67 92.56
14 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 92.56
15 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 90.64
16 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 90.32
17 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 90.32
18 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 90.32
19 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 90.28
20 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 90.16
21 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 90.08
22 INT174515 Negative_regulation of CD7 2 0.14 2.15 0.39 86.84
23 INT162 Regulation of Prl 794 0.62 165.01 322.24 85.04
24 INT90792 Localization of Il10 144 0.80 87.88 30.03 84.72
25 INT20379 Localization of Il4 85 0.73 51.22 20.55 83.92
26 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 83.88
27 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 80.48
28 INT82379 Negative_regulation of Cd7 1 0.16 1.18 0 79.52
29 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 70.88
30 INT27628 Gene_expression of IL2RG 28 0.75 20.95 6.16 70.08
31 INT88051 Regulation of Gene_expression of IL2RG 2 0.24 1.57 0.65 70.08
32 INT11049 Gene_expression of IL2RB 8 0.60 3.73 0.76 69.36
33 INT52968 Regulation of Gene_expression of IL2RB 2 0.16 1.57 0 69.36
34 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 68.48
35 INT261118 Binding of Tnfrsf10b 3 0.07 4.03 0.1 68.32
36 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 62.00
37 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 62.00
38 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25 60.72
39 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 57.60
40 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21 57.60
41 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 56.88
42 INT9081 Positive_regulation of Positive_regulation of IGHE 5 0.42 7.13 1 56.76
43 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 54.32
44 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 51.12
45 INT19775 Localization of Il1 183 0.78 145.5 50.91 49.92
46 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 47.12
47 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 44.04
48 INT157357 Binding of IL2RA 6 0.44 5.18 1.63 42.24
49 INT173159 Localization of PPARA 96 0.74 64.55 10.26 31.36
50 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 30.92
51 INT136991 Localization of HBEGF 5 0.59 3.62 1.28 29.92
52 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 26.52
53 INT351019 Negative_regulation of Binding of EEF2 1 0.03 0.53 0.03 26.36
54 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 26.12
55 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 25.68
56 INT116727 Gene_expression of Flg 3 0.53 3.13 0.34 25.00
57 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 25.00
58 INT116726 Negative_regulation of Gene_expression of Flg 1 0.01 0.45 0 25.00
59 INT351015 Binding of EEF2 1 0.03 0.47 0.03 24.96
60 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 22.72
61 INT16322 Gene_expression of Il2rb 19 0.51 15.88 12.18 20.96
62 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 19.84
63 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 19.44
64 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 18.96
65 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 18.40
66 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 18.32
67 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 17.92
68 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 17.84
69 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 17.44
70 INT97108 Phosphorylation of IL2 5 0.73 2.47 1.7 12.76
71 INT351018 Phosphorylation of IL2RA 1 0.79 0.64 0.05 12.76
72 INT53196 Binding of Cd4 44 0.47 27.28 5.85 12.60
73 INT10019 Binding of CD8A 57 0.36 31.49 10.08 8.60
74 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 6.84
75 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 6.84
76 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79 6.84
77 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28 6.84
78 INT178589 Localization of IL2RA 3 0.68 1.99 0.45 5.68
79 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
80 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
81 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
82 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
83 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
84 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
85 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
86 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
87 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
88 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
89 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
90 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
91 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
92 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
93 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
94 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
95 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
96 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
97 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
98 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
99 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
100 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
101 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
102 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
103 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
104 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
105 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
106 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
107 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
108 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
109 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
110 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
111 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
112 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
113 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
114 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
115 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 5.00
116 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
117 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
118 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
119 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 5.00
120 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
121 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
122 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
123 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
124 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
125 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
126 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
127 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
128 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
129 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
130 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
131 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
132 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
133 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
134 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
135 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
136 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
137 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
138 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 5.00
139 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
140 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
141 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
142 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
143 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
144 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
145 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 5.00
146 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
147 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
148 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
149 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
150 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
151 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
152 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
153 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 5.00
154 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
155 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
156 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
157 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
158 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
159 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
160 INT66213 Localization of RELA 63 0.78 14.71 8.77 5.00
161 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 5.00
162 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
163 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 5.00
164 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
165 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
166 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 5.00
167 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
168 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
169 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 5.00
170 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
171 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93 5.00
172 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
173 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
174 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
175 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
176 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
177 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
178 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 5.00
179 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 5.00
180 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69 5.00
181 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
182 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63 5.00
183 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
184 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
185 INT164656 Negative_regulation of Gene_expression of CD36 24 0.57 6.51 5.39 5.00
186 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
187 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
188 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
189 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 5.00
190 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
191 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11 5.00
192 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
193 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
194 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 5.00
195 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
196 INT160565 Gene_expression of Il23r 6 0.56 10.01 4.51 5.00
197 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
198 INT56562 Positive_regulation of Gene_expression of Il2rb 6 0.45 3.17 4.34 5.00
199 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 5.00
200 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
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