D:Exocrine Pancreatic Insufficiency

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Disease Term
Synonyms Exocrine Pancreatic Insufficiencies, INSUFFICIENCIES EXOCRINE PANCREATIC, Insufficiencies Pancreatic, Insufficiency Exocrine Pancreatic, Insufficiency Pancreatic, PANCREATIC INSUFFICIENCIES, Pancreatic Insufficiencies Exocrine, Pancreatic Insufficiency, PANCREATIC INSUFFICIENCY EXOCRINE
Documents 375
Hot Single Events 105
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Exocrine Pancreatic Insufficiency. They are ordered first by their relevance to Exocrine Pancreatic Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT35859 PRSS1 Regulation of Regulation of CCK 1 0.13 0.18 0.3 96.80
2 INT35863 PRSS1 Regulation of Positive_regulation of CCK 1 0.22 0.18 0.3 96.80
3 INT35858 PRSS1 Regulation of Positive_regulation of SCT 1 0.17 0.18 0.3 96.80
4 INT35862 PRSS1 Regulation of Localization of GBE1 1 0.00 0.35 0.59 94.24
5 INT35861 PRSS1 Regulation of Localization of CCK 1 0.26 0.17 0.33 82.80
6 INT35860 PRSS1 Regulation of Localization of SCT 1 0.10 0.08 0.16 80.80
7 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 77.40
8 INT10079 Cp Regulation of Trh 1 0.01 0.59 0.53 61.04
9 INT72180 Binding of CTRC and Cela1 1 0.00 0.65 0.34 58.40
10 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 5.00
11 INT352521 Cnn1 Positive_regulation of Cp 1 0.00 1.45 0.5 5.00
12 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28 5.00
13 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 5.00
14 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
15 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1 5.00
16 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
17 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09 5.00
18 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
19 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09 5.00
20 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
21 INT215880 Car2 Regulation of Hspa5 1 0.09 0.66 0.08 5.00
22 INT215879 Ddit3 Regulation of Regulation of Atf4 1 0.26 0.29 0.07 5.00
23 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07 5.00
24 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
25 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06 5.00
26 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06 5.00
27 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06 5.00
28 INT215887 Positive_regulation of Eif2ak3 Positive_regulation of Eif2ak3 Regulation of Musd1 1 0.01 0.87 0.06 5.00
29 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06 5.00
30 INT215876 Atf4 Regulation of Hspa5 1 0.22 0.43 0.04 5.00
31 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
32 INT215871 Atf4 Regulation of Ddit3 1 0.26 0.43 0.04 5.00
33 INT215882 Atf4 Regulation of Xbp1 1 0.28 0.43 0.04 5.00
34 INT215875 Atf4 Regulation of Mapkap1 1 0.29 0.43 0.04 5.00
35 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 5.00
36 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
37 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
38 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
39 INT201490 Gene_expression of SPINK1 Negative_regulation of PRSS1 1 0.44 0.82 0.03 5.00
40 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03 5.00
41 INT308747 Binding of Cftr and Prkag1 1 0.02 0 0 5.00
42 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
43 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
44 INT308745 Binding of Alb and Fas 1 0.00 0 0 5.00
45 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Exocrine Pancreatic Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Exocrine Pancreatic Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 100.00
2 INT5025 Positive_regulation of Gene_expression of Cck 63 0.70 10.96 47.11 100.00
3 INT89114 Binding of Cftr 13 0.37 11.29 4.99 100.00
4 INT6544 Negative_regulation of Localization of Cck 67 0.59 8.05 47.23 99.96
5 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48 99.92
6 INT2883 Negative_regulation of Localization of CCK 9 0.59 3.25 3.08 99.88
7 INT1154 Negative_regulation of CCK 24 0.59 9.3 15.32 99.88
8 INT2463 Localization of CCK 101 0.81 37.54 47.59 99.44
9 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 99.44
10 INT1484 Positive_regulation of Pnlip 8 0.35 5.09 3.01 99.44
11 INT182667 Binding of DLAT 11 0.31 40.75 2.8 99.38
12 INT287 Localization of Cck 518 0.81 86.84 364.04 99.36
13 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 99.28
14 INT12239 Regulation of Localization of CCK 11 0.62 6.03 6.61 99.28
15 INT10286 Positive_regulation of Positive_regulation of Cck 20 0.70 4.05 18.46 99.28
16 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 99.20
17 INT2885 Positive_regulation of Localization of CCK 19 0.70 9.92 8.94 99.18
18 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23 98.88
19 INT287799 Positive_regulation of Gene_expression of AIP 1 0.42 7.39 1.19 98.88
20 INT47186 Localization of SCTR 8 0.50 5.07 1.55 98.84
21 INT2886 Gene_expression of SCT 13 0.78 4.55 3.57 98.82
22 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 98.68
23 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12 98.68
24 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03 98.68
25 INT15362 Negative_regulation of Cela1 4 0.21 2.47 0.83 98.60
26 INT330760 Positive_regulation of Gene_expression of LETMD1 1 0.04 1.46 0.38 98.44
27 INT330759 Gene_expression of LETMD1 1 0.04 1.39 0.35 98.44
28 INT330761 Positive_regulation of LETMD1 1 0.03 1.36 0.34 98.44
29 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 98.20
30 INT38897 Regulation of CELA3B 3 0.32 1.9 0.15 98.20
31 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 98.04
32 INT73572 Positive_regulation of S100A8 10 0.67 6.6 1 98.04
33 INT95881 Gene_expression of IGES 4 0.16 1.79 0.95 98.04
34 INT95882 Positive_regulation of Gene_expression of IGES 1 0.01 0.83 0.9 98.04
35 INT34595 Negative_regulation of Reg1 12 0.36 4.29 2.77 97.96
36 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 97.92
37 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55 97.84
38 INT31226 Localization of PPY 20 0.78 9.93 6.8 97.80
39 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72 97.80
40 INT3948 Regulation of Cck 291 0.62 58.07 255.88 97.76
41 INT19983 Positive_regulation of Localization of Lipf 2 0.50 0.7 0.24 97.36
42 INT109318 Gene_expression of CRISP3 1 0.77 1.5 0.92 97.36
43 INT12159 Transcription of Cck 46 0.72 9.36 37.58 97.16
44 INT1636 Gene_expression of Sct 58 0.77 16.14 11.57 97.08
45 INT812 Localization of INS 1026 0.81 515.6 145.31 97.08
46 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 97.08
47 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 97.00
48 INT2884 Positive_regulation of CCK 66 0.69 25.25 30.6 96.80
49 INT2408 Regulation of CCK 37 0.61 10.01 26.66 96.80
50 INT11708 Regulation of SCT 12 0.44 2.29 4.07 96.80
51 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 96.80
52 INT2131 Positive_regulation of Localization of SCT 6 0.47 2.01 0.88 96.80
53 INT19982 Localization of Lipf 4 0.58 1.96 0.77 96.60
54 INT68447 Positive_regulation of PDP1 11 0.64 5.69 0.83 96.32
55 INT2132 Localization of SCT 29 0.81 8.39 5.43 96.08
56 INT109317 Positive_regulation of Gene_expression of CRISP3 1 0.50 0.79 0.5 95.92
57 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 95.04
58 INT103378 Binding of Spink1 24 0.40 15.3 6.19 94.92
59 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 94.32
60 INT14442 Localization of GBE1 19 0.31 9.09 5.03 94.24
61 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 94.12
62 INT19981 Positive_regulation of Lipf 3 0.49 1.64 0.51 93.96
63 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55 93.92
64 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 93.60
65 INT38834 Positive_regulation of Positive_regulation of PPY 2 0.42 4.18 0.61 93.60
66 INT15363 Gene_expression of CELA1 10 0.78 3.22 1.59 93.36
67 INT68448 Negative_regulation of Positive_regulation of PDP1 4 0.40 1.84 0.24 93.04
68 INT46438 Negative_regulation of RAB3GAP2 1 0.00 0.58 0.15 92.88
69 INT15044 Localization of Nts 30 0.75 4.58 13.72 92.80
70 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 92.48
71 INT860 Regulation of ALB 48 0.60 25.11 8.95 92.28
72 INT144475 Protein_catabolism of Sod2 1 0.17 0.58 0.33 92.24
73 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46 92.08
74 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 91.48
75 INT144473 Protein_catabolism of Gstp1 1 0.60 0.57 0.33 90.80
76 INT112729 Positive_regulation of Negative_regulation of COQ7 1 0.43 1.31 0.26 90.80
77 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5 90.56
78 INT144474 Protein_catabolism of Gstp1 1 0.06 0.57 0.33 90.52
79 INT9814 Localization of Ctrl 1 0.05 0.28 0.24 90.40
80 INT112728 Negative_regulation of COQ7 1 0.50 4.8 0.89 90.36
81 INT8725 Gene_expression of Mln 32 0.77 14.9 12.22 90.32
82 INT139270 Gene_expression of C16orf62 1 0.00 0.79 0.24 90.04
83 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72 89.72
84 INT44793 Regulation of NAAA 5 0.23 1.61 0.65 89.60
85 INT2364 Localization of Sct 134 0.80 26.21 41.47 88.68
86 INT35562 Regulation of CELA1 4 0.04 1.67 0.65 88.16
87 INT30 Gene_expression of Gast 158 0.78 99 41.45 87.96
88 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 87.28
89 INT2409 Binding of SCT 7 0.48 2.69 1.94 86.12
90 INT60407 Regulation of Reg1 1 0.09 0.77 0.1 85.56
91 INT34490 Negative_regulation of Localization of GBE1 3 0.01 2.08 1.02 84.88
92 INT10078 Positive_regulation of Gene_expression of Trh 17 0.50 4.23 5.19 84.24
93 INT215846 Positive_regulation of Atf4 3 0.58 2.03 0.12 84.00
94 INT224424 Regulation of TNFRSF11B 12 0.61 6.29 1.61 83.80
95 INT35864 Regulation of PRSS1 19 0.61 8.14 3.63 83.60
96 INT14750 Localization of Olr305 1 0.34 0.34 0.16 83.44
97 INT2862 Positive_regulation of Localization of Cck 108 0.70 20.75 94.25 83.12
98 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 82.96
99 INT215886 Positive_regulation of Transcription of DDIT3 2 0.49 2.32 0.13 82.40
100 INT215856 Positive_regulation of Transcription of Ddit3 2 0.60 2.12 0.03 82.40
101 INT21269 Positive_regulation of Gene_expression of Sct 14 0.50 5.41 2.8 82.08
102 INT202373 Transcription of Ddit3 6 0.62 5.52 0.29 81.92
103 INT215885 Transcription of DDIT3 3 0.69 2.57 0.13 81.92
104 INT17625 Localization of GCG 210 0.80 55.69 24.97 81.84
105 INT21990 Negative_regulation of Ctrc 17 0.42 8.45 4.47 80.96
106 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 79.92
107 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 79.76
108 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 78.16
109 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 77.64
110 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 77.64
111 INT169756 Binding of CFTR 9 0.35 9.65 4.55 77.40
112 INT171998 Binding of DMD 58 0.47 38.13 3.35 77.40
113 INT3214 Localization of Ins1 527 0.80 196.9 79.26 77.16
114 INT23333 Gene_expression of OR7E16P 1 0.01 0.81 0.17 76.40
115 INT2491 Regulation of Cea 38 0.61 26.18 10.95 76.08
116 INT4015 Positive_regulation of SCTR 5 0.37 6.45 1.62 75.00
117 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 75.00
118 INT4691 Regulation of Lipg 10 0.61 4.7 1.99 75.00
119 INT27687 Regulation of Cp 20 0.53 9.75 10.8 75.00
120 INT95883 Regulation of IGES 2 0.11 0.7 1.18 75.00
121 INT42531 Gene_expression of Ctrc 5 0.40 1.01 1.03 75.00
122 INT38968 Localization of Ctrc 4 0.69 1 0.64 75.00
123 INT44755 Regulation of Lipf 2 0.44 0.25 0.1 75.00
124 INT86994 Gene_expression of Lipf 1 0.48 0.17 0.09 75.00
125 INT686 Negative_regulation of Sct 35 0.59 9.59 11.32 74.00
126 INT121801 Binding of Aip 18 0.36 24.1 5.26 70.56
127 INT63905 Regulation of RB1 13 0.62 12.67 1.28 70.36
128 INT2741 Regulation of Localization of SCT 3 0.26 0.16 1.2 69.80
129 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 69.20
130 INT196675 Localization of CFTR 4 0.64 1.95 1.19 68.08
131 INT38992 Negative_regulation of Pnlip 6 0.48 3.91 1.14 67.56
132 INT202522 Negative_regulation of Gene_expression of Cftr 11 0.57 5.9 2.24 65.52
133 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73 65.20
134 INT35604 Localization of CELA3B 2 0.08 1.55 0.1 64.48
135 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 64.20
136 INT83548 Negative_regulation of Positive_regulation of GCG 1 0.42 1.06 0.46 64.20
137 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14 63.36
138 INT24166 Localization of Mln 40 0.80 9.11 10.32 61.88
139 INT43350 Regulation of Localization of Mln 8 0.61 0.6 2.24 61.88
140 INT242855 Negative_regulation of Gene_expression of CELA3B 1 0.03 1.19 0.08 61.20
141 INT84307 Binding of Cftr 31 0.47 26.19 12.8 61.04
142 INT170759 Positive_regulation of Binding of Cftr 2 0.50 1.82 0.6 61.04
143 INT26491 Negative_regulation of Localization of Mln 7 0.58 2.07 2.15 60.96
144 INT48803 Gene_expression of CELA3B 9 0.22 7.24 2.06 60.40
145 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57 60.36
146 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 60.08
147 INT40293 Regulation of CTRC 3 0.04 1.35 0.96 60.08
148 INT17715 Positive_regulation of CELA1 8 0.61 3.76 1 58.64
149 INT2490 Regulation of Sct 44 0.62 9.45 13.11 58.16
150 INT11711 Regulation of Ctrc 1 0.01 0.62 0.24 56.48
151 INT7827 Binding of Cck 32 0.48 4.66 23.73 56.32
152 INT93565 Gene_expression of NAAA 7 0.65 3.75 0.91 56.32
153 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 56.24
154 INT8153 Regulation of Localization of Cck 52 0.62 11.22 54.83 54.84
155 INT13826 Positive_regulation of Negative_regulation of Dbp 5 0.42 2.19 0.74 54.48
156 INT294931 Positive_regulation of Negative_regulation of Gc 1 0.05 0.62 0.26 54.48
157 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 54.20
158 INT147213 Negative_regulation of Gene_expression of Dbp 5 0.34 2.88 1.16 54.20
159 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 54.20
160 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 53.80
161 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 53.80
162 INT144179 Localization of Aip 4 0.61 2.59 0.33 52.48
163 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 52.40
164 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 52.20
165 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 52.12
166 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73 50.40
167 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 50.00
168 INT86995 Negative_regulation of Localization of Lipf 1 0.31 0 0 50.00
169 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 48.44
170 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 47.32
171 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 47.32
172 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 46.72
173 INT15290 Gene_expression of Cela1 17 0.52 7.56 2.22 46.32
174 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 44.48
175 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84 44.48
176 INT287796 Regulation of Positive_regulation of IGHG3 1 0.02 1.19 0.03 44.48
177 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 44.40
178 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 42.80
179 INT86119 Regulation of Cftr 13 0.45 14.08 5.75 42.08
180 INT110425 Gene_expression of ITGAE 7 0.58 4.48 0.91 39.00
181 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 38.92
182 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43 38.76
183 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 36.48
184 INT251 Regulation of INS 398 0.62 232.47 55.04 34.36
185 INT94381 Negative_regulation of Col4a2 2 0.31 0.57 0.43 31.64
186 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 31.52
187 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 27.24
188 INT135273 Negative_regulation of Tcrb 3 0.05 2.71 0.14 27.24
189 INT222650 Gene_expression of Col4a2 6 0.19 1.84 0.19 27.00
190 INT135274 Positive_regulation of RQCD1 2 0.36 1.24 0.08 25.00
191 INT291134 Gene_expression of PDP1 4 0.62 0.64 0.26 19.72
192 INT283509 Regulation of Binding of DLAT 1 0.29 1.99 0.23 17.24
193 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 15.96
194 INT215859 Gene_expression of Cela1 1 0.25 0.65 0 7.52
195 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 6.88
196 INT22083 Regulation of Pth 55 0.62 22.32 8.9 6.88
197 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
198 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
199 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
200 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
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