D:Exophthalmos

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Disease Term
Synonyms Bulging Eyes, Exophthalmia, Exophthalmos Disorder, EYE DISPLACED FORWARDS, Ocular Proptosis, PROPTOSES, Proptosis
Documents 468
Hot Single Events 32
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Exophthalmos. They are ordered first by their relevance to Exophthalmos and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25 27.08
2 INT311432 Binding of TSHR and TAOK1 1 0.12 1.05 0.07 26.64
3 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
4 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
5 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 5.00
6 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 5.00
7 INT322733 CD40LG Positive_regulation of Gene_expression of CD40 1 0.08 0.62 0.18 5.00
8 INT322734 Binding of CD40LG and Positive_regulation of CD40 1 0.07 0.62 0.18 5.00
9 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 5.00
10 INT289625 Binding of RS1 and PSORS1C1 1 0.02 1.15 0.17 5.00
11 INT289630 Binding of CDSN and RS1 1 0.02 1.1 0.17 5.00
12 INT289624 HLA-DMB Regulation of Binding of RS1 1 0.03 0.84 0.11 5.00
13 INT289629 Binding of HLA-DMB and HLA-E 1 0.10 0.84 0.11 5.00
14 INT289627 Binding of HLA-E and RS1 1 0.01 0.83 0.11 5.00
15 INT289623 Binding of HLA-E and RS1 Regulation of Binding of RS1 1 0.00 0.84 0.11 5.00
16 INT289622 Binding of HLA-DMB and HLA-E Regulation of Binding of RS1 1 0.01 0.84 0.11 5.00
17 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
18 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 5.00
19 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
20 INT289626 Binding of SNRNP70 and SUGT1 3 0.03 2.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Exophthalmos. They are ordered first by their pain relevance and then by number of times they were reported in Exophthalmos. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT33517 Gene_expression of TSHR 20 0.71 14.65 1.45 99.04
2 INT208224 Protein_catabolism of TAOK1 1 0.05 0.94 0.04 98.44
3 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 96.08
4 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 95.72
5 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 95.24
6 INT38672 Binding of KRT20 69 0.39 48.01 6.31 95.24
7 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 94.00
8 INT311439 Positive_regulation of Gene_expression of TAOK1 1 0.15 1.48 0.18 93.44
9 INT311448 Gene_expression of TAOK1 1 0.21 2.47 0.31 93.00
10 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73 90.00
11 INT86771 Positive_regulation of TAOK1 2 0.38 4.55 0.29 89.48
12 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 88.96
13 INT75299 Binding of Atxn3 8 0.43 5.3 0.26 88.56
14 INT208140 Localization of PITX1 2 0.73 6.18 0.14 88.36
15 INT75688 Binding of KITLG 24 0.30 11.73 4.06 85.84
16 INT242419 Negative_regulation of Gene_expression of Sdc1 1 0.03 1.31 0.03 83.64
17 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 83.36
18 INT153610 Positive_regulation of SPN 3 0.49 3.04 0.44 83.36
19 INT139474 Negative_regulation of Tnfrsf11b 9 0.34 5.74 1.05 82.32
20 INT179856 Gene_expression of Sdc1 4 0.75 3.88 0.03 82.08
21 INT123798 Gene_expression of NFATC3 1 0.00 0.67 0.13 81.88
22 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 80.72
23 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 80.72
24 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 80.72
25 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 80.72
26 INT167675 Positive_regulation of CNN1 2 0.49 1.57 0.25 80.72
27 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 80.64
28 INT76472 Gene_expression of Dntt 14 0.65 8.51 0.95 80.36
29 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 80.32
30 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 80.32
31 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 80.32
32 INT92386 Gene_expression of Tnfrsf8 14 0.54 13.55 1.67 80.32
33 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 79.04
34 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 79.04
35 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 78.92
36 INT208225 Positive_regulation of Gene_expression of TSHR 2 0.46 2.84 0.22 78.44
37 INT178841 Localization of SNRNP70 27 0.78 10.35 1.71 78.08
38 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 77.60
39 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 77.52
40 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 77.52
41 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 77.52
42 INT106972 Gene_expression of MAP2 36 0.75 9.72 3.87 77.52
43 INT169454 Binding of ATD 2 0.21 2.51 0.86 76.84
44 INT322739 Localization of TAOK1 1 0.02 1.24 0 75.84
45 INT197627 Localization of RB1 3 0.69 4.16 0.13 72.92
46 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 69.24
47 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 69.24
48 INT1893 Localization of Gh 1041 0.79 340.23 256.58 68.84
49 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 67.00
50 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 66.12
51 INT1650 Regulation of TSHR 3 0.28 0.88 1.99 66.12
52 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25 66.12
53 INT207035 Gene_expression of CFB 4 0.63 18.4 1.72 62.32
54 INT289632 Gene_expression of NRM 1 0.62 2.27 0.58 62.32
55 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 62.24
56 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 61.64
57 INT171747 Gene_expression of ACD 4 0.57 4.44 0.68 54.96
58 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 53.08
59 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 52.80
60 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 49.28
61 INT121347 Binding of GNAS 8 0.13 3.99 1.47 48.96
62 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 48.96
63 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 47.84
64 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 46.24
65 INT293961 Binding of PITX1 1 0.31 1.73 0.1 45.60
66 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76 36.20
67 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 35.52
68 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 34.76
69 INT158471 Negative_regulation of El1 2 0.37 0.72 0.75 31.60
70 INT311438 Gene_expression of COL13A1 1 0.24 6.56 0.17 31.20
71 INT311452 Gene_expression of CASQ1 1 0.74 7.58 0.14 31.20
72 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 29.96
73 INT244657 Regulation of Lch 3 0.40 6.63 0.13 29.96
74 INT33516 Positive_regulation of TSHR 4 0.49 2.5 0.93 28.80
75 INT311441 Binding of COL13A1 1 0.11 1 0.04 28.08
76 INT185332 Regulation of El2 1 0.36 0.9 0 27.52
77 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53 26.28
78 INT311453 Binding of CASQ1 1 0.31 0.44 0 26.24
79 INT49360 Localization of Igf1 22 0.76 6.96 4.26 25.88
80 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 24.96
81 INT185331 Regulation of El1 1 0.44 0.45 0 20.60
82 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 17.60
83 INT311447 Negative_regulation of Gene_expression of TSHR 1 0.39 2.24 0.08 15.60
84 INT311450 Regulation of Gene_expression of TSHR 1 0.25 1.16 0.06 15.60
85 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 7.20
86 INT82398 Binding of HLA-DMB 3 0.35 3.82 1.66 6.96
87 INT5147 Binding of BTNL2 4 0.36 4.77 1.43 6.96
88 INT214235 Binding of CDSN 3 0.34 3.5 1.15 6.96
89 INT220465 Binding of BAG6 7 0.30 6.41 1.07 6.96
90 INT289633 Binding of ZSCAN23 1 0.25 1.78 0.95 6.96
91 INT289634 Binding of TRIM40 1 0.22 1.78 0.95 6.96
92 INT289638 Binding of VARS2 1 0.24 1.72 0.92 6.96
93 INT289637 Binding of ELF1 1 0.31 1.71 0.91 6.96
94 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
95 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
96 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
97 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
98 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
99 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
100 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
101 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
102 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
103 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
104 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
105 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
106 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
107 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
108 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
109 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
110 INT23222 Binding of Phax 52 0.31 7.61 30.4 5.00
111 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
112 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
113 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
114 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
115 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 5.00
116 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
117 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 5.00
118 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 5.00
119 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 5.00
120 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
121 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
122 INT50580 Binding of PPIG 39 0.36 11.17 12.34 5.00
123 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
124 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
125 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 5.00
126 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
127 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
128 INT44602 Gene_expression of TNFSF13B 37 0.75 30.98 9.96 5.00
129 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
130 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 5.00
131 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
132 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 5.00
133 INT213886 Binding of IL23R 7 0.46 16.79 6.94 5.00
134 INT12924 Negative_regulation of Gene_expression of NA 25 0.30 6.59 6.71 5.00
135 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
136 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86 5.00
137 INT211133 Negative_regulation of MTX1 8 0.19 3.86 4.87 5.00
138 INT479 Positive_regulation of Gfra1 25 0.69 10.71 4.76 5.00
139 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
140 INT67279 Localization of PRTN3 11 0.50 14.18 4.3 5.00
141 INT100384 Regulation of SNRNP70 24 0.60 11 3.56 5.00
142 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 5.00
143 INT107514 Positive_regulation of Akr1b1 6 0.70 7.64 3.21 5.00
144 INT113996 Gene_expression of RS1 23 0.72 7.7 3.16 5.00
145 INT146300 Binding of RS1 31 0.22 29.55 3.04 5.00
146 INT15027 Positive_regulation of Localization of NA 11 0.26 3.4 2.98 5.00
147 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
148 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
149 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 5.00
150 INT11787 Positive_regulation of Positive_regulation of NA 14 0.21 2.97 2.46 5.00
151 INT150222 Positive_regulation of Gene_expression of TNFSF13B 12 0.11 7.49 2.43 5.00
152 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28 5.00
153 INT29094 Binding of C3 39 0.37 12.65 2.27 5.00
154 INT155218 Binding of ABCB6 18 0.35 13.93 2.25 5.00
155 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 5.00
156 INT171010 Binding of IL5 6 0.36 4.11 2.12 5.00
157 INT216074 Gene_expression of ATD 2 0.55 5.47 1.74 5.00
158 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
159 INT99720 Positive_regulation of SAT1 21 0.69 26.55 1.56 5.00
160 INT93350 Binding of Lepr 17 0.05 27.21 1.5 5.00
161 INT39376 Positive_regulation of HK1 6 0.53 2.44 1.49 5.00
162 INT18158 Negative_regulation of Positive_regulation of NA 11 0.36 1.45 1.45 5.00
163 INT125980 Binding of CFD 8 0.42 10.96 1.39 5.00
164 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 5.00
165 INT254308 Negative_regulation of TNFSF13B 10 0.42 5.12 1.25 5.00
166 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19 5.00
167 INT180580 Binding of HEYL 7 0.17 4.49 1.15 5.00
168 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 5.00
169 INT182852 Regulation of AAVS1 4 0.12 4.6 1.03 5.00
170 INT190418 Positive_regulation of AAVS1 15 0.49 4.71 0.98 5.00
171 INT10373 Gene_expression of ADI1 8 0.25 5.97 0.92 5.00
172 INT71601 Positive_regulation of ACD 11 0.60 6.55 0.9 5.00
173 INT37105 Binding of CHRNE 3 0.31 6.88 0.87 5.00
174 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
175 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 5.00
176 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 5.00
177 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5 5.00
178 INT163872 Negative_regulation of TSHR 4 0.42 3.52 0.49 5.00
179 INT318301 Negative_regulation of DHODH 1 0.03 0.6 0.44 5.00
180 INT289631 Localization of RS1 4 0.21 3.17 0.42 5.00
181 INT69282 Binding of PHEX 4 0.15 1.43 0.41 5.00
182 INT15588 Regulation of PHEX 4 0.26 1.48 0.39 5.00
183 INT196594 Localization of CFD 4 0.65 4.36 0.39 5.00
184 INT268558 Regulation of CTGF 5 0.23 4.7 0.37 5.00
185 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 5.00
186 INT188706 Localization of HLA-E 8 0.33 2.43 0.32 5.00
187 INT229392 Negative_regulation of Positive_regulation of MPO 2 0.20 2.18 0.32 5.00
188 INT166755 Localization of PHEX 2 0.73 1.16 0.28 5.00
189 INT220699 Positive_regulation of CHRNE 5 0.32 2.26 0.26 5.00
190 INT205040 Gene_expression of CLTA 7 0.19 7.64 0.25 5.00
191 INT289635 Binding of PDZK1IP1 1 0.04 1.18 0.25 5.00
192 INT289636 Binding of ABCA2 1 0.01 1.16 0.25 5.00
193 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 5.00
194 INT52348 Positive_regulation of CHM 7 0.44 4.18 0.25 5.00
195 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 5.00
196 INT311446 Negative_regulation of Gene_expression of PLXNA2 1 0.12 1.1 0.18 5.00
197 INT203271 Transcription of CHM 3 0.72 11.28 0.17 5.00
198 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16 5.00
199 INT261721 Negative_regulation of Stl2 1 0.07 1.38 0.16 5.00
200 INT82433 Binding of LAT2 2 0.27 0.53 0.15 5.00
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