D:Exostoses

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Disease Term
Synonyms Cartilaginous Exostosis, Chondrosteoma, Chondrosteomas, ECCHONDROMA, EXOSTOSIS, Osteocartilaginous Exostosis, OSTEOCHONDROMA
Documents 202
Hot Single Events 9
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Exostoses. They are ordered first by their relevance to Exostoses and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT150351 Binding of EXT1 and MMP12 1 0.04 3.68 0.29 85.08
2 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0 33.08
3 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0 33.08
4 INT265230 Binding of APC and FKBP1A Regulation of APC 1 0.01 0.41 0 33.08
5 INT234113 COL18A1 Negative_regulation of Phosphorylation of VEGFA 1 0.26 0.17 0.16 26.56
6 INT234112 Binding of VEGFA and COL18A1 1 0.21 0.16 0.15 26.56
7 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0 23.36
8 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0 23.08
9 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
10 INT324053 Binding of Banf1 and Lemd3 1 0.20 0.15 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Exostoses. They are ordered first by their pain relevance and then by number of times they were reported in Exostoses. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147083 Gene_expression of Cdkal1 4 0.35 1.5 0.3 100.00
2 INT147088 Gene_expression of HHEX 5 0.65 4.86 0.99 100.00
3 INT100644 Gene_expression of Igf2bp2 3 0.19 0.68 0.31 100.00
4 INT147079 Gene_expression of Ext2 2 0.66 1.04 0.1 100.00
5 INT147087 Gene_expression of SLC30A8 8 0.74 1.79 0.24 99.96
6 INT147078 Phosphorylation of Ext2 1 0.07 0.37 0.1 99.36
7 INT168505 Localization of S100A10 2 0.58 2.03 0.08 98.94
8 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 95.44
9 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 92.04
10 INT265241 Regulation of FGFR1OP 1 0.33 0.88 0.05 79.24
11 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 78.76
12 INT265243 Binding of FGFR1OP 1 0.20 0.74 0 76.48
13 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 76.00
14 INT80179 Negative_regulation of Arp 1 0.00 1 0.09 74.88
15 INT238768 Localization of BHLHE40 1 0.01 0.33 0 74.76
16 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 72.28
17 INT339527 Negative_regulation of Eaf2 1 0.01 0.42 0.11 69.64
18 INT301360 Gene_expression of Ext1 3 0.68 1.01 0 69.36
19 INT324046 Gene_expression of Lemd3 1 0.67 1.69 0.1 69.36
20 INT265238 Positive_regulation of FGFR1OP 1 0.26 0.76 0.04 63.28
21 INT301358 Negative_regulation of Ext1 2 0.42 1.09 0 54.32
22 INT324044 Negative_regulation of Lemd3 1 0.43 2.86 0 52.00
23 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 50.20
24 INT324043 Localization of Lemd3 1 0.75 0 0 43.44
25 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 43.36
26 INT265244 Positive_regulation of Phosphorylation of MLLT10 1 0.13 0.55 0.03 39.56
27 INT265242 Positive_regulation of Binding of MLLT10 1 0.13 0.55 0.03 39.56
28 INT265235 Positive_regulation of MLLT10 1 0.12 0.55 0.03 39.56
29 INT265236 Binding of MLLT10 1 0.10 0.54 0.03 39.00
30 INT265245 Phosphorylation of MLLT10 1 0.22 0.54 0.03 39.00
31 INT142005 Gene_expression of COL18A1 6 0.75 4.53 0.62 37.56
32 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 37.12
33 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 36.88
34 INT57062 Regulation of APC 24 0.58 14.3 0.7 33.08
35 INT339529 Gene_expression of Eaf2 1 0.01 0.75 0 28.72
36 INT231466 Binding of COL18A1 2 0.25 1.19 0.18 26.56
37 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 25.32
38 INT443 Localization of POMC 1020 0.81 284.52 443.17 25.00
39 INT301355 Binding of Ext1 2 0.37 4.07 0.03 25.00
40 INT324047 Binding of Lemd3 1 0.48 3.18 0 25.00
41 INT324041 Localization of Mro 1 0.33 1.48 0 25.00
42 INT25087 Negative_regulation of FEA 3 0.37 0.28 0.99 24.40
43 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3 24.20
44 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22 24.20
45 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 23.84
46 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 23.00
47 INT265249 Positive_regulation of ACVR1 1 0.50 0.97 0 17.56
48 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 14.04
49 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 9.28
50 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 9.00
51 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
52 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
53 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
54 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
55 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
56 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
57 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
58 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
59 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
60 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
61 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
62 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
63 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
64 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
65 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
66 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
67 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
68 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
69 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
70 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
71 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
72 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
73 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
74 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
75 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
76 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
77 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
78 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
79 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
80 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
81 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
82 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
83 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
84 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
85 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
86 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
87 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
88 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
89 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
90 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
91 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
92 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
93 INT8793 Gene_expression of H2 58 0.75 26.36 7.07 5.00
94 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
95 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
96 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67 5.00
97 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
98 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
99 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
100 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
101 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
102 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
103 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
104 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 5.00
105 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
106 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
107 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
108 INT234116 Positive_regulation of MID1 9 0.03 3.78 1.61 5.00
109 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61 5.00
110 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
111 INT56219 Gene_expression of KDM5D 16 0.53 5.59 1.23 5.00
112 INT85941 Binding of MMP12 3 0.31 4.91 1.12 5.00
113 INT118054 Regulation of ARMC9 23 0.34 11.32 1.06 5.00
114 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
115 INT296720 Protein_catabolism of AOS 1 0.05 1.28 0.69 5.00
116 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
117 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
118 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 5.00
119 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
120 INT212271 Binding of ARMC9 14 0.27 3.29 0.43 5.00
121 INT286234 Binding of Tcf7l2 11 0.21 13.29 0.36 5.00
122 INT12531 Localization of GANAB 3 0.09 2.79 0.26 5.00
123 INT147084 Binding of Slc30a8 4 0.37 1.95 0.2 5.00
124 INT158803 Gene_expression of ACVR1 2 0.67 1.27 0.19 5.00
125 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18 5.00
126 INT263849 Binding of H2 7 0.16 5.19 0.14 5.00
127 INT339530 Regulation of Eaf2 1 0.00 0.76 0.1 5.00
128 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 5.00
129 INT339528 Protein_catabolism of Eaf2 1 0.01 0.84 0.08 5.00
130 INT239094 Negative_regulation of Binding of GH1 2 0.34 1.61 0.06 5.00
131 INT239092 Positive_regulation of Binding of IGFBP1 1 0.04 0.6 0.04 5.00
132 INT231433 Positive_regulation of Binding of IGFBP3 2 0.34 0.6 0.04 5.00
133 INT156365 Gene_expression of Hhex 4 0.67 1.63 0.03 5.00
134 INT265246 Negative_regulation of ACVR1 1 0.37 0.08 0 5.00
135 INT234117 Positive_regulation of Binding of MRI1 2 0.44 0.19 0 5.00
136 INT321921 Gene_expression of FEA 1 0.34 0.48 0 5.00
137 INT265247 Regulation of Gene_expression of FGFR1OP 1 0.24 0.21 0 5.00
138 INT265240 Regulation of Gene_expression of ACVR1 1 0.45 0.47 0 5.00
139 INT286235 Gene_expression of Tcf7l2 2 0.30 2.86 0 5.00
140 INT324042 Regulation of Gene_expression of Ext1 1 0.45 0.12 0 5.00
141 INT147082 Binding of Cdkal1 2 0.20 1.82 0 5.00
142 INT265237 Negative_regulation of Gene_expression of ACVR1 1 0.43 0.47 0 5.00
143 INT147085 Binding of Cdkn2b 1 0.10 0.07 0 5.00
144 INT265239 Gene_expression of FGFR1OP 1 0.36 0.41 0 5.00
145 INT324052 Binding of Banf1 1 0.18 0.48 0 5.00
146 INT324048 Positive_regulation of Negative_regulation of Lemd3 1 0.50 0.2 0 5.00
147 INT265248 Gene_expression of ST6GALNAC1 2 0.65 0.27 0 5.00
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